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Dosage compensation protein dpy-30 (Protein dumpy-30)

 DPY30_CAEEL             Reviewed;         123 AA.
Q10661;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
28-MAR-2018, entry version 118.
RecName: Full=Dosage compensation protein dpy-30;
AltName: Full=Protein dumpy-30;
Name=dpy-30; ORFNames=ZK863.6;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
DEVELOPMENTAL STAGE.
STRAIN=Bristol N2;
PubMed=7588066;
Hsu D.R., Chuang P.-T., Meyer B.J.;
"DPY-30, a nuclear protein essential early in embryogenesis for
Caenorhabditis elegans dosage compensation.";
Development 121:3323-3334(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[3]
FUNCTION.
PubMed=8939869; DOI=10.1126/science.274.5293.1732;
Lieb J.D., Capowski E.E., Meneely P., Meyer B.J.;
"DPY-26, a link between dosage compensation and meiotic chromosome
segregation in the nematode.";
Science 274:1732-1736(1996).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=23884442; DOI=10.1242/dev.094292;
Webster C.M., Wu L., Douglas D., Soukas A.A.;
"A non-canonical role for the C. elegans dosage compensation complex
in growth and metabolic regulation downstream of TOR complex 2.";
Development 140:3601-3612(2013).
[5]
FUNCTION, INTERACTION WITH JMJD-3.1, AND DISRUPTION PHENOTYPE.
PubMed=25124442; DOI=10.1126/science.1255885;
Zuryn S., Ahier A., Portoso M., White E.R., Morin M.C., Margueron R.,
Jarriault S.;
"Sequential histone-modifying activities determine the robustness of
transdifferentiation.";
Science 345:826-829(2014).
-!- FUNCTION: Essential for dosage compensation (PubMed:7588066).
Required for the sex-specific association of the dosage
compensation complex proteins dpy-27 and dpy-26 with the
hermaphrodite X chromosomes (PubMed:7588066, PubMed:8939869).
Plays a role in developmental rate and body fat regulation
downstream of the TOR complex 2 (PubMed:23884442). Required for
the robust transdifferentiation of the Y rectal cell to the PDA
motor neuron during larval development (PubMed:25124442).
{ECO:0000269|PubMed:23884442, ECO:0000269|PubMed:25124442,
ECO:0000269|PubMed:7588066, ECO:0000269|PubMed:8939869}.
-!- SUBUNIT: Interacts with jmjd-3.1. {ECO:0000269|PubMed:25124442}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7588066}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically in
all stages. {ECO:0000269|PubMed:7588066}.
-!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown suppresses the
growth delay and elevated body fat index of the TOR complex 2
mutant rict-1 (PubMed:23884442). Results in disruption of the
invariant transdifferentiation of the Y rectal cell to the PDA
motor neuron (PubMed:25124442). {ECO:0000269|PubMed:23884442,
ECO:0000269|PubMed:25124442}.
-!- SIMILARITY: Belongs to the dpy-30 family. {ECO:0000305}.
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EMBL; U21302; AAA92286.1; -; Genomic_DNA.
EMBL; Z78019; CAB01452.1; -; Genomic_DNA.
PIR; T28060; T28060.
RefSeq; NP_506058.1; NM_073657.4.
UniGene; Cel.18028; -.
ProteinModelPortal; Q10661; -.
SMR; Q10661; -.
BioGrid; 44694; 4.
DIP; DIP-27173N; -.
IntAct; Q10661; 6.
STRING; 6239.ZK863.6.2; -.
EPD; Q10661; -.
PaxDb; Q10661; -.
PeptideAtlas; Q10661; -.
EnsemblMetazoa; ZK863.6.1; ZK863.6.1; WBGene00001088.
EnsemblMetazoa; ZK863.6.2; ZK863.6.2; WBGene00001088.
GeneID; 179671; -.
KEGG; cel:CELE_ZK863.6; -.
UCSC; ZK863.6.1; c. elegans.
CTD; 179671; -.
WormBase; ZK863.6; CE15445; WBGene00001088; dpy-30.
eggNOG; KOG4109; Eukaryota.
eggNOG; ENOG41123UZ; LUCA.
GeneTree; ENSGT00390000008808; -.
HOGENOM; HOG000022465; -.
InParanoid; Q10661; -.
KO; K14965; -.
OMA; LKHSNGC; -.
OrthoDB; EOG091G1311; -.
PhylomeDB; Q10661; -.
Reactome; R-CEL-3214841; PKMTs methylate histone lysines.
Reactome; R-CEL-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
PRO; PR:Q10661; -.
Proteomes; UP000001940; Chromosome V.
Bgee; WBGene00001088; -.
GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
GO; GO:0044666; C:MLL3/4 complex; IEA:InterPro.
GO; GO:0005634; C:nucleus; IDA:WormBase.
GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
GO; GO:0006348; P:chromatin silencing at telomere; IBA:GO_Central.
GO; GO:0042464; P:dosage compensation by hypoactivation of X chromosome; IMP:WormBase.
GO; GO:0051568; P:histone H3-K4 methylation; IEA:GOC.
GO; GO:0040011; P:locomotion; IMP:WormBase.
GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
GO; GO:0040014; P:regulation of multicellular organism growth; IMP:WormBase.
GO; GO:0060290; P:transdifferentiation; IMP:WormBase.
InterPro; IPR007858; Dpy-30_motif.
InterPro; IPR037856; DPY30.
PANTHER; PTHR23356:SF0; PTHR23356:SF0; 1.
Pfam; PF05186; Dpy-30; 1.
1: Evidence at protein level;
Complete proteome; Nucleus; Reference proteome.
CHAIN 1 123 Dosage compensation protein dpy-30.
/FTId=PRO_0000114682.
SEQUENCE 123 AA; 12837 MW; D54E5AD91CD53929 CRC64;
MADQTASAEV ATEKMDTAEA PAAAPAASAA APAEAESNEN TTVPSNVLSA NGGQQTGNQS
APRNTSTVPT RQYLDSTVVP ILLQGLGALA KDRPENPIEF LANFLLREKD RYNAENQNPA
GQQ


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