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Doublesex- and mab-3-related transcription factor 1Y (Y-linked doublesex- and mab-3-related transcription factor) (Y-specific doublesex- and mab-3-related transcription factor) (DMY)

 DMT1Y_ORYLA             Reviewed;         267 AA.
Q8JIR6; Q8AY26;
18-APR-2012, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
15-FEB-2017, entry version 57.
RecName: Full=Doublesex- and mab-3-related transcription factor 1Y;
AltName: Full=Y-linked doublesex- and mab-3-related transcription factor;
AltName: Full=Y-specific doublesex- and mab-3-related transcription factor;
Short=DMY;
Name=dmrt1y; Synonyms=dmy;
Oryzias latipes (Japanese rice fish) (Japanese killifish).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
Oryziinae; Oryzias.
NCBI_TaxID=8090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
DISRUPTION PHENOTYPE.
STRAIN=HNI;
PubMed=12037570; DOI=10.1038/nature751;
Matsuda M., Nagahama Y., Shinomiya A., Sato T., Matsuda C.,
Kobayashi T., Morrey C.E., Shibata N., Asakawa S., Shimizu N.,
Hori H., Hamaguchi S., Sakaizumi M.;
"DMY is a Y-specific DM-domain gene required for male development in
the medaka fish.";
Nature 417:559-563(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=HNI;
PubMed=12193652; DOI=10.1073/pnas.182314699;
Nanda I., Kondo M., Hornung U., Asakawa S., Winkler C., Shimizu A.,
Shan Z., Haaf T., Shimizu N., Shima A., Schmid M., Schartl M.;
"A duplicated copy of DMRT1 in the sex-determining region of the Y
chromosome of the medaka, Oryzias latipes.";
Proc. Natl. Acad. Sci. U.S.A. 99:11778-11783(2002).
-!- FUNCTION: Transcription factor that plays a key role in male sex
determination and differentiation by controlling testis
development and germ cell proliferation. Acts both as a
transcription repressor and activator.
{ECO:0000269|PubMed:12037570}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00070}.
-!- TISSUE SPECIFICITY: Testis-specific. Localizes to Sertoli cells.
{ECO:0000269|PubMed:12193652}.
-!- DEVELOPMENTAL STAGE: Expression starts at the neurula stage and
persists during embryogenesis and larval stages until adulthood.
At hatching and 5 days after hatching, present in XY embryos, but
not in XX embryos. Detected only in the somatic cells surrounding
germ cells in XY embryos. {ECO:0000269|PubMed:12037570}.
-!- DISRUPTION PHENOTYPE: Feminization of XY offsprings.
{ECO:0000269|PubMed:12037570}.
-!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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EMBL; AB071534; BAB92012.1; -; mRNA.
EMBL; AY129240; AAN05398.1; -; mRNA.
EMBL; AY129241; AAN05399.1; -; Genomic_DNA.
RefSeq; NP_001098150.1; NM_001104680.1.
UniGene; Ola.109; -.
UniGene; Ola.17762; -.
ProteinModelPortal; Q8JIR6; -.
SMR; Q8JIR6; -.
GeneID; 100049231; -.
KEGG; ola:100049231; -.
CTD; 100049231; -.
HOGENOM; HOG000059585; -.
HOVERGEN; HBG055845; -.
InParanoid; Q8JIR6; -.
KO; K19488; -.
Proteomes; UP000001038; Unplaced.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0030238; P:male sex determination; IMP:UniProtKB.
GO; GO:0046661; P:male sex differentiation; IMP:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 4.10.1040.10; -; 1.
InterPro; IPR001275; DM_DNA-bd.
InterPro; IPR026607; DMRT/dsx/mab-3.
InterPro; IPR022114; DMRT1-like.
PANTHER; PTHR12322; PTHR12322; 1.
Pfam; PF00751; DM; 1.
Pfam; PF12374; Dmrt1; 1.
SMART; SM00301; DM; 1.
SUPFAM; SSF82927; SSF82927; 1.
PROSITE; PS40000; DM_1; 1.
PROSITE; PS50809; DM_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; Developmental protein; Differentiation;
DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
Sexual differentiation; Transcription; Transcription regulation; Zinc.
CHAIN 1 267 Doublesex- and mab-3-related
transcription factor 1Y.
/FTId=PRO_0000416901.
DNA_BIND 16 63 DM. {ECO:0000255|PROSITE-
ProRule:PRU00070}.
COMPBIAS 119 128 Poly-Ser.
CONFLICT 23 23 S -> G (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 41 50 HCLKCKLIVD -> QCFKCEQIMV (in Ref. 2;
AAN05398). {ECO:0000305}.
CONFLICT 61 61 L -> D (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 105 110 PAPPPN -> LAIPPS (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 116 116 V -> A (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 135 135 S -> G (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 141 142 QP -> CL (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 164 164 Y -> H (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 198 198 A -> T (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 219 219 G -> D (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 251 251 K -> R (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 262 267 SSRPTP -> VFPADSMSSETK (in Ref. 2;
AAN05398). {ECO:0000305}.
SEQUENCE 267 AA; 29299 MW; CAB91367AEF48FB7 CRC64;
MSKEKQCRPG PRVPKCSRCR NHSLKTPLKG HKRFCRWKDC HCLKCKLIVD RQRVMAAQVA
LRRQQAQEEE LGICSPEASS GPEVVVKNEA GADCLFSVEG RSGTPAPPPN PNPLSVAGSY
SASSSSPSAA ARVYSEEASD QPLETSYYNF YQPSRYSSYY GNLYNYQQYQ QMPPSDGRLS
GHSMPSQYRM HSFYPGTAYL PQGLGSPVPP YFSLEDNDGA AASFFPSSLT STHDSTLTYR
SISSLVNDGV KAEFESGGQP PSSRPTP


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