Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Doublesex- and mab-3-related transcription factor 3

 DMRT3_MOUSE             Reviewed;         476 AA.
Q80WT2; Q8CGX1;
20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
01-MAR-2004, sequence version 2.
12-SEP-2018, entry version 98.
RecName: Full=Doublesex- and mab-3-related transcription factor 3;
Name=Dmrt3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryo;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
DEVELOPMENTAL STAGE.
PubMed=12609607; DOI=10.1016/S1567-133X(02)00071-6;
Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
"Sexually dimorphic expression of multiple doublesex-related genes in
the embryonic mouse gonad.";
Gene Expr. Patterns 3:77-82(2003).
[4]
FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
PubMed=22932389; DOI=10.1038/nature11399;
Andersson L.S., Larhammar M., Memic F., Wootz H., Schwochow D.,
Rubin C.-J., Patra K., Arnason T., Wellbring L., Hjalm G., Imsland F.,
Petersen J.L., McCue M.E., Mickelson J.R., Cothran G., Ahituv N.,
Roepstorff L., Mikko S., Vallstedt A., Lindgren G., Andersson L.,
Kullander K.;
"Mutations in DMRT3 affect locomotion in horses and spinal circuit
function in mice.";
Nature 488:642-646(2012).
-!- FUNCTION: Probable transcription factor that plays a role in
configuring the spinal circuits controlling stride in vertebrates.
Involved in neuronal specification within specific subdivision of
spinal cord neurons and in the development of a coordinated
locomotor network controlling limb movements. May regulate
transcription during sexual development.
{ECO:0000269|PubMed:22932389}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00070}.
-!- TISSUE SPECIFICITY: Expressed in the ventral spinal cord, in a
restrical population of neurons migrating ventrically in the
developing spinal cord at E11.5. {ECO:0000269|PubMed:22932389}.
-!- DEVELOPMENTAL STAGE: Expressed at E14.5 in testis, kidney and
bladder. Expression drops at E13.5 in female gonads and is not
detected at E15.5 while it is expressed by Sertoli cells in
testis. {ECO:0000269|PubMed:12609607}.
-!- DISRUPTION PHENOTYPE: Significantly increase of stride length and
extension movements in all limbs. Mice have major difficulties
running at higher velocities. In water, mice spend less time
swimming and showed frequent twitching limb movements.
{ECO:0000269|PubMed:22932389}.
-!- MISCELLANEOUS: DMRT3 is a marker for a subset of spinal cord
neurons (dI6).
-!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Protein Spotlight; Note=A gait on the wildside
- Issue 154 of November 2013;
URL="https://web.expasy.org/spotlight/back_issues/154/";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF541936; AAN77230.1; -; mRNA.
EMBL; BC052041; AAH52041.2; -; mRNA.
CCDS; CCDS29718.1; -.
RefSeq; NP_796334.2; NM_177360.3.
RefSeq; XP_006527129.1; XM_006527066.3.
UniGene; Mm.62785; -.
ProteinModelPortal; Q80WT2; -.
SMR; Q80WT2; -.
iPTMnet; Q80WT2; -.
PhosphoSitePlus; Q80WT2; -.
PaxDb; Q80WT2; -.
PRIDE; Q80WT2; -.
Ensembl; ENSMUST00000048935; ENSMUSP00000046812; ENSMUSG00000042372.
GeneID; 240590; -.
KEGG; mmu:240590; -.
UCSC; uc008hbk.2; mouse.
CTD; 58524; -.
MGI; MGI:2449470; Dmrt3.
eggNOG; KOG3815; Eukaryota.
eggNOG; ENOG410XSK9; LUCA.
GeneTree; ENSGT00550000074486; -.
HOGENOM; HOG000112230; -.
HOVERGEN; HBG080568; -.
InParanoid; Q80WT2; -.
KO; K19490; -.
OMA; SNGHLFE; -.
OrthoDB; EOG091G08TD; -.
PhylomeDB; Q80WT2; -.
TreeFam; TF317837; -.
PRO; PR:Q80WT2; -.
Proteomes; UP000000589; Chromosome 19.
Bgee; ENSMUSG00000042372; Expressed in 60 organ(s), highest expression level in lacrimal gland.
Genevisible; Q80WT2; MM.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; IPI:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0007628; P:adult walking behavior; IMP:MGI.
GO; GO:0046661; P:male sex differentiation; IMP:MGI.
GO; GO:0042487; P:regulation of odontogenesis of dentin-containing tooth; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0019226; P:transmission of nerve impulse; IMP:MGI.
GO; GO:0021521; P:ventral spinal cord interneuron specification; IMP:MGI.
Gene3D; 4.10.1040.10; -; 1.
InterPro; IPR001275; DM_DNA-bd.
InterPro; IPR036407; DM_DNA-bd_sf.
InterPro; IPR005173; DMA.
InterPro; IPR026607; DMRT/dsx/mab-3.
InterPro; IPR009060; UBA-like_sf.
PANTHER; PTHR12322; PTHR12322; 1.
Pfam; PF00751; DM; 1.
Pfam; PF03474; DMA; 1.
SMART; SM00301; DM; 1.
SUPFAM; SSF46934; SSF46934; 1.
SUPFAM; SSF82927; SSF82927; 1.
PROSITE; PS40000; DM_1; 1.
PROSITE; PS50809; DM_2; 1.
2: Evidence at transcript level;
Complete proteome; Developmental protein; Differentiation;
DNA-binding; Metal-binding; Nucleus; Reference proteome;
Sexual differentiation; Transcription; Transcription regulation; Zinc.
CHAIN 1 476 Doublesex- and mab-3-related
transcription factor 3.
/FTId=PRO_0000277795.
DNA_BIND 29 76 DM. {ECO:0000255|PROSITE-
ProRule:PRU00070}.
CONFLICT 93 93 A -> D (in Ref. 1; AAN77230).
{ECO:0000305}.
CONFLICT 301 301 A -> T (in Ref. 1; AAN77230).
{ECO:0000305}.
CONFLICT 361 361 P -> H (in Ref. 1; AAN77230).
{ECO:0000305}.
SEQUENCE 476 AA; 51518 MW; 7FC6A4ED5DAE62A1 CRC64;
MNGYGSPYLY MGGPVSQPPR APLQRTPKCA RCRNHGVLSW LKGHKRYCRF KDCTCEKCIL
IIERQRVMAA QVALRRQQAN ESLESLIPDS LRALPGPPPP GDAAATAATA SQSSPASQAS
QPPAPPRPTA ELAAAAALRW VAEPQPGTLP AQLAKPDLTE ERVGDSSSTD NTAEAFSDKD
TDQRSSPDVV KSKNCFTPES PEIVSVDEGG YAVQKNGGNP ESCPDSPKYH AEQSHLLIEG
PSGTVSLPFS LKANRPPLEV LKKIFPNQKP TVLELILKGC GGDLVSAVEV LLSSRSSAAG
AERTAEESLV LPSSGHIFEH TLGSYPISSS KWSVGSAFRV PDTLRFSADS SNVVPNPLAV
PLQHPFPQPP RYPLMLRNTL ARNQSSPFLP NDVTLWNTMT LQQQYQLRSQ YVSPFPSNST
SVFRSSPVLS SRTTEDPRIS IPDDGCPIVT KQSIYTEDDY DERSDSSDSR ILNTSS


Related products :

Catalog number Product name Quantity
EIAAB11489 DMRT5,DMRTA2,Doublesex- and mab-3-related transcription factor 5,Doublesex- and mab-3-related transcription factor A2,Homo sapiens,Human
EIAAB11483 Dmrt8.1,Dmrtc1,Dmrtc1a,Doublesex- and mab-3-related transcription factor 8.1,Doublesex- and mab-3-related transcription factor C1,Mouse,Mus musculus
EIAAB11491 Bos taurus,Bovine,DMRT5,DMRTA2,Doublesex- and mab-3-related transcription factor 5,Doublesex- and mab-3-related transcription factor A2
EIAAB11488 Dmrt7,Dmrtc2,Doublesex- and mab-3-related transcription factor 7,Doublesex- and mab-3-related transcription factor C2,Mouse,Mus musculus
EIAAB11481 Dmrt6,Dmrtb1,Doublesex- and mab-3-related transcription factor 6,Doublesex- and mab-3-related transcription factor B1,Mouse,Mus musculus
EIAAB11490 Dmrt5,Dmrta2,Doublesex- and mab-3-related transcription factor 5,Doublesex- and mab-3-related transcription factor A2,Mouse,Mus musculus
EIAAB11480 Dmrt4,Dmrta1,Doublesex- and mab-3-related transcription factor 4,Doublesex- and mab-3-related transcription factor A1,Mouse,Mus musculus
18-003-43164 Doublesex- and mab-3-related transcription factor C2 - Doublesex- and mab-3-related transcription factor 7 Polyclonal 0.05 mg Aff Pur
18-003-43331 Doublesex- and mab-3-related transcription factor A1 - Doublesex- and mab-3-related transcription factor 4 Polyclonal 0.05 mg Aff Pur
EIAAB11476 DMRT2,Doublesex- and mab-3-related transcription factor 2,Doublesex-like 2 protein,DSXL2,DSXL-2,Homo sapiens,Human
DMRT1_PIG Pig ELISA Kit FOR Doublesex- and mab-3-related transcription factor 1 96T
DMRTD_BOVIN Bovine ELISA Kit FOR Doublesex- and mab-3-related transcription factor C2 96T
DMRTA2 DMRT3 Gene doublesex and mab-3 related transcription factor 3
E1313m Human ELISA Kit FOR Doublesex- and mab-3-related transcription factor A1 96T
DMRTA1 DMRT2 Gene doublesex and mab-3 related transcription factor 2
CSB-EL006975RA Rat Doublesex- and mab-3-related transcription factor C1(DMRTC1) ELISA kit 96T
DMTA2_HUMAN Human ELISA Kit FOR Doublesex- and mab-3-related transcription factor A2 96T
DMRT3 DMRT1 Gene doublesex and mab-3 related transcription factor 1
DMRTA_MOUSE Mouse ELISA Kit FOR Doublesex- and mab-3-related transcription factor A1 96T
DMRT3_HUMAN Human ELISA Kit FOR Doublesex- and mab-3-related transcription factor 3 96T
EIAAB11472 DMRT1,Doublesex- and mab-3-related transcription factor 1,Pig,Sus scrofa
DMRT1_MOUSE Mouse ELISA Kit FOR Doublesex- and mab-3-related transcription factor 1 96T
CSB-EL006969PI Pig Doublesex- and mab-3-related transcription factor 1(DMRT1) ELISA kit SpeciesPig 96T
GWB-998B1F Anti- DMRT2 (doublesex and mab-3 related transcription factor 2) Antibody
CSB-EL006975RA Rat Doublesex- and mab-3-related transcription factor C1(DMRTC1) ELISA kit SpeciesRat 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur