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Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7)

 DMRTD_MOUSE             Reviewed;         370 AA.
Q8CGW9; A6H6T0;
27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
25-OCT-2017, entry version 97.
RecName: Full=Doublesex- and mab-3-related transcription factor C2;
AltName: Full=Doublesex- and mab-3-related transcription factor 7;
Name=Dmrtc2; Synonyms=Dmrt7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=12609607; DOI=10.1016/S1567-133X(02)00071-6;
Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
"Sexually dimorphic expression of multiple doublesex-related genes in
the embryonic mouse gonad.";
Gene Expr. Patterns 3:77-82(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: May be involved in sexual development.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00070}.
-!- TISSUE SPECIFICITY: Expressed in testis. Highly expressed in
ovary.
-!- DEVELOPMENTAL STAGE: Expressed in gonads from E11.5.
-!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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EMBL; AF542046; AAN77233.1; -; mRNA.
EMBL; BC100434; AAI00435.1; -; mRNA.
EMBL; BC138203; AAI38204.1; -; mRNA.
EMBL; BC145988; AAI45989.1; -; mRNA.
CCDS; CCDS20965.1; -.
RefSeq; NP_082008.1; NM_027732.2.
RefSeq; XP_006540422.1; XM_006540359.3.
UniGene; Mm.66855; -.
ProteinModelPortal; Q8CGW9; -.
SMR; Q8CGW9; -.
BioGrid; 214575; 8.
STRING; 10090.ENSMUSP00000011493; -.
PhosphoSitePlus; Q8CGW9; -.
PaxDb; Q8CGW9; -.
PRIDE; Q8CGW9; -.
Ensembl; ENSMUST00000011493; ENSMUSP00000011493; ENSMUSG00000011349.
GeneID; 71241; -.
KEGG; mmu:71241; -.
UCSC; uc009fqp.2; mouse.
CTD; 63946; -.
MGI; MGI:1918491; Dmrtc2.
eggNOG; KOG3815; Eukaryota.
eggNOG; ENOG410XSK9; LUCA.
GeneTree; ENSGT00550000074486; -.
HOGENOM; HOG000231505; -.
HOVERGEN; HBG081447; -.
InParanoid; Q8CGW9; -.
KO; K19493; -.
OMA; ISRSPTC; -.
OrthoDB; EOG091G0K2L; -.
PhylomeDB; Q8CGW9; -.
TreeFam; TF340713; -.
PRO; PR:Q8CGW9; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000011349; -.
Genevisible; Q8CGW9; MM.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0001741; C:XY body; IDA:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0007141; P:male meiosis I; IMP:MGI.
GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; IMP:MGI.
GO; GO:1900114; P:positive regulation of histone H3-K9 trimethylation; IMP:MGI.
GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
GO; GO:0007290; P:spermatid nucleus elongation; IMP:MGI.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 4.10.1040.10; -; 1.
InterPro; IPR001275; DM_DNA-bd.
InterPro; IPR036407; DM_DNA-bd_sf.
InterPro; IPR031577; DMRT-C1/C2_C.
InterPro; IPR026607; DMRT/dsx/mab-3.
PANTHER; PTHR12322; PTHR12322; 1.
Pfam; PF00751; DM; 1.
Pfam; PF15791; DMRT-like; 1.
SMART; SM00301; DM; 1.
SUPFAM; SSF82927; SSF82927; 1.
PROSITE; PS40000; DM_1; 1.
PROSITE; PS50809; DM_2; 1.
2: Evidence at transcript level;
Complete proteome; Differentiation; DNA-binding; Metal-binding;
Nucleus; Reference proteome; Sexual differentiation; Transcription;
Transcription regulation; Zinc.
CHAIN 1 370 Doublesex- and mab-3-related
transcription factor C2.
/FTId=PRO_0000244107.
DNA_BIND 42 89 DM. {ECO:0000255|PROSITE-
ProRule:PRU00070}.
COMPBIAS 123 352 Pro-rich.
SEQUENCE 370 AA; 39095 MW; F4DFCB23C94C8A6C CRC64;
MDPSETAALH HCSADSSPAD EARVPQSTEL IPRRPVSRSP TCARCRNHGV TAHLKGHKRL
CLFQACECHK CVLILERRRV MAAQVALRRQ QEAQLKRHLA QGLMKGATPL KAPLRVKKGA
IRPGIPSGKE NIAPQPQSPH GAVPLVLTPP GKENYGPLLL SRPPEALPLP WTPVPPGPWG
PGHWLPPGLS MPPPVVCRLL CQEPAVPLHP FPGFDPGTSL RLPTHGTLPT CPGSRSVLTA
PLSGEPQGPP NLPHTCSTLI LQSCGTPDSL LLQPQAPGAS CLAWTSGPSE RQLQREAAEA
LVGLKDSSQA PRLTPSVPPN PAWISLLHPC GPPAPPGGRG FQPVGPPLRP SPGSSVSLHI
GRLGSISLLS


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