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Doublesex- and mab-3-related transcription factor DM-W (W-linked doublesex- and mab-3-related transcription factor) (xDM-W)

 DMW_XENLA               Reviewed;         194 AA.
B0I1G7;
18-APR-2012, integrated into UniProtKB/Swiss-Prot.
18-MAR-2008, sequence version 1.
28-MAR-2018, entry version 41.
RecName: Full=Doublesex- and mab-3-related transcription factor DM-W;
AltName: Full=W-linked doublesex- and mab-3-related transcription factor;
Short=xDM-W;
Name=dm-w;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND
DEVELOPMENTAL STAGE.
TISSUE=Gonad;
PubMed=18268317; DOI=10.1073/pnas.0712244105;
Yoshimoto S., Okada E., Umemoto H., Tamura K., Uno Y.,
Nishida-Umehara C., Matsuda Y., Takamatsu N., Shiba T., Ito M.;
"A W-linked DM-domain gene, DM-W, participates in primary ovary
development in Xenopus laevis.";
Proc. Natl. Acad. Sci. U.S.A. 105:2469-2474(2008).
[2]
FUNCTION, DNA-BINDING, AND TISSUE SPECIFICITY.
PubMed=20573695; DOI=10.1242/dev.048751;
Yoshimoto S., Ikeda N., Izutsu Y., Shiba T., Takamatsu N., Ito M.;
"Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual
dimorphism of Xenopus laevis: implications of a ZZ/ZW-type sex-
determining system.";
Development 137:2519-2526(2010).
-!- FUNCTION: Transcription factor that plays a key role in female sex
determination and primary ovary development. Acts as a sex-
determining protein by antagonizing the transcriptional activity
of male-determination protein dmrt1-a, acting as a dominant-
negative type protein. {ECO:0000269|PubMed:18268317,
ECO:0000269|PubMed:20573695}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00070}.
-!- TISSUE SPECIFICITY: Expressed exclusively in the primordial gonads
of ZW tadpoles. Specifically expressed in the somatic cells
surrounding primordial germ cells in a ZW gonad at stage 50 during
sex determination (at protein level).
{ECO:0000269|PubMed:18268317, ECO:0000269|PubMed:20573695}.
-!- DEVELOPMENTAL STAGE: Barely detectable at stage 52 in the ZW
gonads. {ECO:0000269|PubMed:18268317}.
-!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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EMBL; AB259777; BAG06159.1; -; mRNA.
RefSeq; NP_001108314.1; NM_001114842.1.
UniGene; Xl.84199; -.
ProteinModelPortal; B0I1G7; -.
SMR; B0I1G7; -.
GeneID; 100137717; -.
KEGG; xla:100137717; -.
CTD; 100137717; -.
KO; K19488; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0000987; F:proximal promoter sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0008585; P:female gonad development; IMP:UniProtKB.
GO; GO:0030237; P:female sex determination; IMP:UniProtKB.
GO; GO:0046660; P:female sex differentiation; IMP:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 4.10.1040.10; -; 1.
InterPro; IPR001275; DM_DNA-bd.
InterPro; IPR036407; DM_DNA-bd_sf.
InterPro; IPR026607; DMRT/dsx/mab-3.
InterPro; IPR022114; DMRT1-like.
PANTHER; PTHR12322; PTHR12322; 1.
Pfam; PF00751; DM; 1.
Pfam; PF12374; Dmrt1; 1.
SMART; SM00301; DM; 1.
SUPFAM; SSF82927; SSF82927; 1.
PROSITE; PS40000; DM_1; 1.
PROSITE; PS50809; DM_2; 1.
1: Evidence at protein level;
Developmental protein; Differentiation; DNA-binding; Metal-binding;
Nucleus; Sexual differentiation; Transcription;
Transcription regulation; Zinc.
CHAIN 1 194 Doublesex- and mab-3-related
transcription factor DM-W.
/FTId=PRO_0000416902.
DNA_BIND 28 75 DM. {ECO:0000255|PROSITE-
ProRule:PRU00070}.
SEQUENCE 194 AA; 21489 MW; 9670979EA2FD889C CRC64;
MQNNEEPYNT GQYPSGPHGK KSPRLHKCAR CRNHGYATPL KGHKRFCIWR DCQCQKCSLI
TERQRVIAAQ VALQRQQAQE EELGIYHPIP LPIAAVIKRE HGGSSSQLML ESSSTQTTST
PTSAEWIKEE EVAKPAAGLF APPPSSEEMG MTLAAVGAAD AATQTDQPGH LFNMMSAMIQ
QLMDMSWELQ QGWI


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