GENTAUR Molecular Products.

 Q6GLD5_XENTR            Unreviewed;       369 AA.
 Q6GLD5;
 19-JUL-2004, integrated into UniProtKB/TrEMBL.
 19-JUL-2004, sequence version 1.
 16-JAN-2019, entry version 117.
 RecName: Full=Dual specificity protein phosphatase {ECO:0000256|PIRNR:PIRNR000939};
          EC=3.1.3.16 {ECO:0000256|PIRNR:PIRNR000939};
          EC=3.1.3.48 {ECO:0000256|PIRNR:PIRNR000939};
 Name=dusp1 {ECO:0000313|EMBL:AAH74564.1,
 ECO:0000313|Ensembl:ENSXETP00000002912,
 ECO:0000313|Xenbase:XB-GENE-975056};
 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
 Silurana.
 NCBI_TaxID=8364 {ECO:0000313|EMBL:AAH74564.1};
 [1] {ECO:0000313|EMBL:AAH74564.1}
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 TISSUE=Embryo {ECO:0000313|EMBL:AAH74564.1};
 NIH - Xenopus Gene Collection (XGC) project;
 Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
 [2] {ECO:0000313|Ensembl:ENSXETP00000002912}
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000002912};
 PubMed=20431018; DOI=10.1126/science.1183670;
 Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
 Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
 Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
 Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
 Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
 Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
 Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
 Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
 Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
 Rokhsar D.S.;
 "The genome of the Western clawed frog Xenopus tropicalis.";
 Science 328:633-636(2010).
 [3] {ECO:0000313|Ensembl:ENSXETP00000002912}
 IDENTIFICATION.
 Ensembl;
 Submitted (JUN-2011) to UniProtKB.
 -!- CATALYTIC ACTIVITY:
     Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-
       [protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-
       COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377,
       ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977;
       EC=3.1.3.16; Evidence={ECO:0000256|PIRNR:PIRNR000939};
 -!- CATALYTIC ACTIVITY:
     Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
       + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
       Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
       ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
       Evidence={ECO:0000256|PIRNR:PIRNR000939};
 -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
     Non-receptor class dual specificity subfamily.
     {ECO:0000256|PIRNR:PIRNR000939, ECO:0000256|SAAS:SAAS00724126}.
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 EMBL; AAMC01116346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 EMBL; BC074564; AAH74564.1; -; mRNA.
 UniGene; Str.10221; -.
 STRING; 8364.ENSXETP00000002912; -.
 Ensembl; ENSXETT00000002912; ENSXETP00000002912; ENSXETG00000027880.
 Xenbase; XB-GENE-975056; dusp1.
 eggNOG; KOG1716; Eukaryota.
 eggNOG; COG2453; LUCA.
 GeneTree; ENSGT00940000159044; -.
 HOVERGEN; HBG007347; -.
 OMA; MVIMEVP; -.
 TreeFam; TF105122; -.
 Reactome; R-XTR-112409; RAF-independent MAPK1/3 activation.
 Reactome; R-XTR-5675221; Negative regulation of MAPK pathway.
 Proteomes; UP000008143; Unassembled WGS sequence.
 Bgee; ENSXETG00000027880; Expressed in 24 organ(s), highest expression level in mesonephros.
 GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
 GO; GO:0005634; C:nucleus; IBA:GO_Central.
 GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IBA:GO_Central.
 GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
 GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:GO_Central.
 GO; GO:0000188; P:inactivation of MAPK activity; IBA:GO_Central.
 CDD; cd00127; DSPc; 1.
 Gene3D; 3.40.250.10; -; 1.
 Gene3D; 3.90.190.10; -; 1.
 InterPro; IPR020417; Atypical_DUSP.
 InterPro; IPR020420; Atypical_DUSP_famB.
 InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
 InterPro; IPR024950; DUSP.
 InterPro; IPR008343; MKP.
 InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
 InterPro; IPR001763; Rhodanese-like_dom.
 InterPro; IPR036873; Rhodanese-like_dom_sf.
 InterPro; IPR016130; Tyr_Pase_AS.
 InterPro; IPR003595; Tyr_Pase_cat.
 InterPro; IPR000387; TYR_PHOSPHATASE_dom.
 InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
 PANTHER; PTHR10159; PTHR10159; 1.
 Pfam; PF00782; DSPc; 1.
 PIRSF; PIRSF000939; MAPK_Ptase; 1.
 PRINTS; PR01908; ADSPHPHTASE.
 PRINTS; PR01910; ADSPHPHTASEB.
 PRINTS; PR01764; MAPKPHPHTASE.
 SMART; SM00195; DSPc; 1.
 SMART; SM00404; PTPc_motif; 1.
 SMART; SM00450; RHOD; 1.
 SUPFAM; SSF52799; SSF52799; 1.
 SUPFAM; SSF52821; SSF52821; 1.
 PROSITE; PS50206; RHODANESE_3; 1.
 PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
 PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
 PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
 2: Evidence at transcript level;
 Complete proteome {ECO:0000313|Proteomes:UP000008143};
 Hydrolase {ECO:0000256|PIRNR:PIRNR000939};
 Protein phosphatase {ECO:0000256|PIRNR:PIRNR000939};
 Reference proteome {ECO:0000313|Proteomes:UP000008143}.
 DOMAIN       21    138       Rhodanese. {ECO:0000259|PROSITE:PS50206}.
 DOMAIN      175    315       Tyrosine-protein phosphatase.
                              {ECO:0000259|PROSITE:PS50054}.
 DOMAIN      240    294       TYR_PHOSPHATASE_2.
                              {ECO:0000259|PROSITE:PS50056}.
 ACT_SITE    260    260       Phosphocysteine intermediate.
                              {ECO:0000256|PIRSR:PIRSR000939-1}.
 SEQUENCE   369 AA;  40336 MW;  9BCEF8597E11728E CRC64;
 MVNMEICAMD CCVLKGLLAE RAHKCLILDC RSFFSFSSSN IIGSSNVRLS TIVKRRAKGS
 MGLEHIVPNE EQRCRLLAGM YEAVVLLDER TSELDMLRKD STMMLAVNAL CRDSRGSSIY
 FLKGGYETFS SQCPEFCNKS SPPVCLSLPL STNNVPGSAD SNCTPCGTPL YDQGGPVEIL
 PFLYLGSAYH ASRKDMLDAL GITALINVSA NCPNHFEGHF QYKSIPVEDS HKADISSWFN
 EAIDFIDSVK NSGGRVFVHC QAGISRSATI CLAYLMRTNR VKLDEAFEFV KQRRSIISPN
 FSFMGQLLQF ESQVLAPSCS AEAGSPTISV LDRGTSTTTV FNFPVSIPVH SGTSSLSYLQ
 NPITTSPSC

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