Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100) (Protein-tyrosine phosphatase non-receptor type 16)

 DUS1_RAT                Reviewed;         367 AA.
Q64623; Q548G6;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
25-OCT-2017, entry version 141.
RecName: Full=Dual specificity protein phosphatase 1;
EC=3.1.3.16;
EC=3.1.3.48;
AltName: Full=Mitogen-activated protein kinase phosphatase 1;
Short=MAP kinase phosphatase 1;
Short=MKP-1;
AltName: Full=Protein-tyrosine phosphatase CL100;
AltName: Full=Protein-tyrosine phosphatase non-receptor type 16;
Name=Dusp1; Synonyms=Cl100, Mkp1, Ptpn16;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Lung;
Muda M., Schlegel W., Arkinstall S.;
"Pathways regulating CL100 gene expression in pituitary cells.";
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Wistar Furth;
PubMed=11423551; DOI=10.1074/jbc.M102326200;
Ryser S., Tortola S., van Haasteren G., Muda M., Li S., Schlegel W.;
"MAP kinase phosphatase-1 gene transcription in rat neuroendocrine
cells is modulated by a calcium-sensitive block to elongation in the
first exon.";
J. Biol. Chem. 276:33319-33327(2001).
[3]
TISSUE SPECIFICITY.
PubMed=8106404;
Kwak S.P., Hakes D.J., Martell K.J., Dixon J.E.;
"Isolation and characterization of a human dual specificity protein-
tyrosine phosphatase gene.";
J. Biol. Chem. 269:3596-3604(1994).
[4]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=15527789; DOI=10.1016/j.febslet.2004.09.083;
Price D.M., Chik C.L., Terriff D., Weller J., Humphries A.,
Carter D.A., Klein D.C., Ho A.K.;
"Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold
nocturnal and norepinephrine-induced changes in the rat pineal
gland.";
FEBS Lett. 577:220-226(2004).
[5]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=19103603; DOI=10.1074/jbc.M808394200;
Bailey M.J., Coon S.L., Carter D.A., Humphries A., Kim J.S., Shi Q.,
Gaildrat P., Morin F., Ganguly S., Hogenesch J.B., Weller J.L.,
Rath M.F., Moller M., Baler R., Sugden D., Rangel Z.G., Munson P.J.,
Klein D.C.;
"Night/day changes in pineal expression of >600 genes: central role of
adrenergic/cAMP signaling.";
J. Biol. Chem. 284:7606-7622(2009).
-!- FUNCTION: Dual specificity phosphatase that dephosphorylates MAP
kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its
activity during the meiotic cell cycle. {ECO:0000250}.
-!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
-!- CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O
= [a protein]-serine/threonine + phosphate.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
-!- TISSUE SPECIFICITY: Brain. High level expression seen in the
cingulate gyrus within the retrospinal cortex, ventral and medial
divisions of the anterior thalamus and the medial geniculate
nucleus. Expressed at moderate levels in the parietal and temporal
cortex. Expressed in the cerebellum. {ECO:0000269|PubMed:15527789,
ECO:0000269|PubMed:19103603, ECO:0000269|PubMed:8106404}.
-!- INDUCTION: Exhibits night/day variations with a 100-fold increased
expression at night in the pineal gland (at protein level). Up-
regulation is due to a large degree to the release of
norepinephrine from nerve terminals in the pineal gland and cAMP
signaling pathway. {ECO:0000269|PubMed:15527789,
ECO:0000269|PubMed:19103603}.
-!- PTM: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and
MAPK3/ERK1 reduces its rate of degradation. {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
Non-receptor class dual specificity subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; X84004; CAA58828.1; -; mRNA.
EMBL; AF357203; AAK55327.1; -; Genomic_DNA.
PIR; S52265; S52265.
RefSeq; NP_446221.2; NM_053769.3.
UniGene; Rn.98260; -.
ProteinModelPortal; Q64623; -.
SMR; Q64623; -.
BioGrid; 250421; 1.
STRING; 10116.ENSRNOP00000005383; -.
PaxDb; Q64623; -.
PRIDE; Q64623; -.
Ensembl; ENSRNOT00000005383; ENSRNOP00000005383; ENSRNOG00000003977.
GeneID; 114856; -.
KEGG; rno:114856; -.
UCSC; RGD:620897; rat.
CTD; 1843; -.
RGD; 620897; Dusp1.
eggNOG; KOG1716; Eukaryota.
eggNOG; COG2453; LUCA.
GeneTree; ENSGT00760000118902; -.
HOGENOM; HOG000294080; -.
HOVERGEN; HBG007347; -.
InParanoid; Q64623; -.
KO; K21278; -.
OMA; MVIMEVP; -.
OrthoDB; EOG091G0249; -.
PhylomeDB; Q64623; -.
TreeFam; TF105122; -.
PRO; PR:Q64623; -.
Proteomes; UP000002494; Chromosome 10.
Bgee; ENSRNOG00000003977; -.
Genevisible; Q64623; RN.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0019838; F:growth factor binding; IPI:RGD.
GO; GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; ISS:UniProtKB.
GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
GO; GO:0008330; F:protein tyrosine/threonine phosphatase activity; IDA:RGD.
GO; GO:0032870; P:cellular response to hormone stimulus; IEP:RGD.
GO; GO:0001706; P:endoderm formation; IBA:GO_Central.
GO; GO:0000188; P:inactivation of MAPK activity; ISS:UniProtKB.
GO; GO:0035556; P:intracellular signal transduction; IDA:RGD.
GO; GO:0071850; P:mitotic cell cycle arrest; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
GO; GO:2000279; P:negative regulation of DNA biosynthetic process; IDA:RGD.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:RGD.
GO; GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.
GO; GO:0043409; P:negative regulation of MAPK cascade; ISS:UniProtKB.
GO; GO:0051447; P:negative regulation of meiotic cell cycle; ISS:UniProtKB.
GO; GO:0035970; P:peptidyl-threonine dephosphorylation; ISS:UniProtKB.
GO; GO:0035335; P:peptidyl-tyrosine dephosphorylation; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0006470; P:protein dephosphorylation; IDA:RGD.
GO; GO:0090266; P:regulation of mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.
GO; GO:0051592; P:response to calcium ion; IEP:RGD.
GO; GO:0051591; P:response to cAMP; IEP:RGD.
GO; GO:0032355; P:response to estradiol; IEP:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
GO; GO:0009416; P:response to light stimulus; IEP:RGD.
GO; GO:0010033; P:response to organic substance; IEP:RGD.
GO; GO:0032526; P:response to retinoic acid; IEP:RGD.
GO; GO:0033574; P:response to testosterone; IEP:RGD.
CDD; cd00127; DSPc; 1.
Gene3D; 3.40.250.10; -; 1.
Gene3D; 3.90.190.10; -; 1.
InterPro; IPR020417; Atypical_DUSP.
InterPro; IPR020420; Atypical_DUSP_famB.
InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
InterPro; IPR024950; DUSP.
InterPro; IPR008343; MKP.
InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
InterPro; IPR001763; Rhodanese-like_dom.
InterPro; IPR036873; Rhodanese-like_dom_sf.
InterPro; IPR016130; Tyr_Pase_AS.
InterPro; IPR003595; Tyr_Pase_cat.
InterPro; IPR000387; TYR_PHOSPHATASE_dom.
InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
PANTHER; PTHR10159; PTHR10159; 1.
Pfam; PF00782; DSPc; 1.
Pfam; PF00581; Rhodanese; 1.
PIRSF; PIRSF000939; MAPK_Ptase; 1.
PRINTS; PR01908; ADSPHPHTASE.
PRINTS; PR01910; ADSPHPHTASEB.
PRINTS; PR01764; MAPKPHPHTASE.
SMART; SM00195; DSPc; 1.
SMART; SM00404; PTPc_motif; 1.
SMART; SM00450; RHOD; 1.
SUPFAM; SSF52799; SSF52799; 1.
SUPFAM; SSF52821; SSF52821; 1.
PROSITE; PS50206; RHODANESE_3; 1.
PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
1: Evidence at protein level;
Cell cycle; Complete proteome; Hydrolase; Nucleus; Phosphoprotein;
Protein phosphatase; Reference proteome.
CHAIN 1 367 Dual specificity protein phosphatase 1.
/FTId=PRO_0000094792.
DOMAIN 20 137 Rhodanese. {ECO:0000255|PROSITE-
ProRule:PRU00173}.
DOMAIN 175 367 Tyrosine-protein phosphatase.
ACT_SITE 258 258 Phosphocysteine intermediate.
{ECO:0000255|PROSITE-ProRule:PRU10044}.
MOD_RES 359 359 Phosphoserine; by MAPK1 and MAPK3.
{ECO:0000250|UniProtKB:P28563}.
MOD_RES 364 364 Phosphoserine; by MAPK1 and MAPK3.
{ECO:0000250|UniProtKB:P28563}.
SEQUENCE 367 AA; 39541 MW; 5112ADF290499139 CRC64;
MVMEVGILDA GGLRALLRER AAQCLLLDCR SFFAFNAGHI VGSVNVRFST IVRRRAKGAM
GLEHIVPNTE LRGRLLAGAY HAVVLLDERS AALDGAKRDG TLALAAGALC REARSTQVFF
LQGGYEAFSA SCPELCSKQS TPMGLSLPLS TSVPDSAESG CSSCSTPLYD QGGPVEILSF
LYLGSAYHAS RKDMLDALGI TALINVSANC PNHFEGHYQY KSIPVEDNHK ADISSWFNEA
IDFIDSIKDA GGRVFVHCQA GISRSATICL AYLMRTNRVK LDEAFEFVKQ RRSIISPNFS
FMGQLLQFES QVLAPHCSAE AGSPAMAVLD RGTSTTTVFN FPVSIPVHPT NSALNYLQSP
ITTSPSC


Related products :

Catalog number Product name Quantity
EIAAB12040 Cl100,Dual specificity protein phosphatase 1,Dusp1,MAP kinase phosphatase 1,Mitogen-activated protein kinase phosphatase 1,Mkp1,MKP-1,Protein-tyrosine phosphatase CL100,Protein-tyrosine phosphatase no
EIAAB12041 CL100,Dual specificity protein phosphatase 1,Dual specificity protein phosphatase hVH1,DUSP1,Homo sapiens,Human,MAP kinase phosphatase 1,Mitogen-activated protein kinase phosphatase 1,MKP1,MKP-1,Prote
EIAAB12057 Dual specificity protein phosphatase 14,DUSP14,Homo sapiens,Human,MAP kinase phosphatase 6,Mitogen-activated protein kinase phosphatase 6,MKP-1-like protein tyrosine phosphatase,MKP6,MKP-6,MKP-L
15-288-22164F Dual specificity protein phosphatase 14 - EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6; MKP-1-like protein tyrosine phosphatase; MKP-L Poly 0.05 mg
15-288-22164F Dual specificity protein phosphatase 14 - EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6; MKP-1-like protein tyrosine phosphatase; MKP-L Poly 0.1 mg
EIAAB12042 3ch134,Dual specificity protein phosphatase 1,Dusp1,MAP kinase phosphatase 1,Mitogen-activated protein kinase phosphatase 1,Mkp1,MKP-1,Mouse,Mus musculus,Protein-tyrosine phosphatase 3CH134,Protein-ty
10-288-22164F Dual specificity protein phosphatase 14 - EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6; MKP-1-like protein tyrosine phosphatase; MKP-L 0.05 mg
10-288-22164F Dual specificity protein phosphatase 14 - EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 6; MAP kinase phosphatase 6; MKP-6; MKP-1-like protein tyrosine phosphatase; MKP-L 0.1 mg
EIAAB12093 Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,DUSP4,Homo sapiens,Human,MAP kinase phosphatase 2,Mitogen-activated protein kinase phosphatase 2,MKP2,MKP-2,VH2
18-461-10232 Dual specificity phosphatase 26 - Low-molecular-mass dual-specificity phosphatase 4; Dual-specificity phosphatase SKRP3; Mitogen-activated protein kinase phosphatase 8; NATA1 protein; CDNA FLJ31142 fi 0.05 ml
18-461-10231 Dual specificity phosphatase 26 - Low-molecular-mass dual-specificity phosphatase 4; Dual-specificity phosphatase SKRP3; Mitogen-activated protein kinase phosphatase 8; NATA1 protein; CDNA FLJ31142 fi 0.05 ml
EIAAB12101 Dual specificity protein phosphatase 6,Dual specificity protein phosphatase PYST1,DUSP6,Homo sapiens,Human,MAP kinase phosphatase 3,Mitogen-activated protein kinase phosphatase 3,MKP3,MKP-3,PYST1
EIAAB12060 Dual specificity protein phosphatase 16,DUSP16,Homo sapiens,Human,KIAA1700,MAP kinase phosphatase 7,Mitogen-activated protein kinase phosphatase 7,MKP7,MKP-7
EIAAB12108 Dual specificity protein phosphatase 9,DUSP9,Homo sapiens,Human,MAP kinase phosphatase 4,Mitogen-activated protein kinase phosphatase 4,MKP4,MKP-4
EIAAB12043 Dual specificity protein phosphatase 10,DUSP10,Homo sapiens,Human,MAP kinase phosphatase 5,Mitogen-activated protein kinase phosphatase 5,MKP5,MKP-5
EIAAB12055 Dual specificity protein phosphatase 14,Dusp14,MAP kinase phosphatase 6,Mitogen-activated protein kinase phosphatase 6,Mkp6,MKP-6,Mouse,Mus musculus
EIAAB12102 Dual specificity protein phosphatase 6,Dusp6,MAP kinase phosphatase 3,Mitogen-activated protein kinase phosphatase 3,Mkp3,MKP-3,Rat,Rattus norvegicus
EIAAB12092 Dual specificity protein phosphatase 4,Dusp4,MAP kinase phosphatase 2,Mitogen-activated protein kinase phosphatase 2,Mkp2,MKP-2,Rat,Rattus norvegicus
EIAAB12100 Dual specificity protein phosphatase 6,Dusp6,MAP kinase phosphatase 3,Mitogen-activated protein kinase phosphatase 3,Mkp3,MKP-3,Mouse,Mus musculus
EIAAB12045 Dual specificity protein phosphatase 10,Dusp10,MAP kinase phosphatase 5,Mitogen-activated protein kinase phosphatase 5,Mkp5,MKP-5,Mouse,Mus musculus
15-288-21509A Dual specificity protein phosphatase 6 - EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3; Dual specificity protein phosphatase PYST1 Polyclona 0.1 mg
15-288-21509A Dual specificity protein phosphatase 6 - EC 3.1.3.48; EC 3.1.3.16; Mitogen-activated protein kinase phosphatase 3; MAP kinase phosphatase 3; MKP-3; Dual specificity protein phosphatase PYST1 Polyclona 0.05 mg
18-461-10240 Dual specificity protein phosphatase 22 - EC 3.1.3.48; EC 3.1.3.16; JNK-stimulatory phosphatase-1; JSP-1; Mitogen-activated protein kinase phosphatase x; LMW-DSP2 Polyclonal 0.05 ml
18-461-10260 Dual specificity protein phosphatase 22 - EC 3.1.3.48; EC 3.1.3.16; JNK-stimulatory phosphatase-1; JSP-1; Mitogen-activated protein kinase phosphatase x; LMW-DSP2 Polyclonal 0.05 ml
18-461-10239 Dual specificity protein phosphatase 22 - EC 3.1.3.48; EC 3.1.3.16; JNK-stimulatory phosphatase-1; JSP-1; Mitogen-activated protein kinase phosphatase x; LMW-DSP2 Polyclonal 0.05 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur