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E1A binding protein p300

 H2QLS0_PANTR            Unreviewed;      2175 AA.
H2QLS0;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 2.
12-SEP-2018, entry version 49.
SubName: Full=E1A binding protein p300 {ECO:0000313|Ensembl:ENSPTRP00000024841};
Name=EP300 {ECO:0000313|Ensembl:ENSPTRP00000024841,
ECO:0000313|VGNC:VGNC:5978};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000024841, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000024841, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164055; DOI=10.1038/nature02564;
Watanabe H., Fujiyama A., Hattori M., Taylor T.D., Toyoda A.,
Kuroki Y., Noguchi H., BenKahla A., Lehrach H., Sudbrak R., Kube M.,
Taenzer S., Galgoczy P., Platzer M., Scharfe M., Nordsiek G.,
Bloecker H., Hellmann I., Khaitovich P., Paabo S., Reinhardt R.,
Zheng H.-J., Zhang X.-L., Zhu G.-F., Wang B.-F., Fu G., Ren S.-X.,
Zhao G.-P., Chen Z., Lee Y.-S., Cheong J.-E., Choi S.-H., Wu K.-M.,
Liu T.-T., Hsiao K.-J., Tsai S.-F., Kim C.-G., Oota S., Kitano T.,
Kohara Y., Saitou N., Park H.-S., Wang S.-Y., Yaspo M.-L., Sakaki Y.;
"DNA sequence and comparative analysis of chimpanzee chromosome 22.";
Nature 429:382-388(2004).
[2] {ECO:0000313|Ensembl:ENSPTRP00000024841, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[3] {ECO:0000313|Ensembl:ENSPTRP00000024841}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
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EMBL; AACZ04068013; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9598.ENSPTRP00000024841; -.
PaxDb; H2QLS0; -.
Ensembl; ENSPTRT00000026944; ENSPTRP00000024841; ENSPTRG00000014418.
VGNC; VGNC:5978; EP300.
eggNOG; KOG1778; Eukaryota.
eggNOG; COG5076; LUCA.
GeneTree; ENSGT00920000148952; -.
InParanoid; H2QLS0; -.
OMA; GQVSNPP; -.
OrthoDB; EOG091G0L04; -.
TreeFam; TF101097; -.
Proteomes; UP000002277; Chromosome 22.
Bgee; ENSPTRG00000014418; Expressed in 6 organ(s), highest expression level in cerebellum.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0000123; C:histone acetyltransferase complex; IEA:Ensembl.
GO; GO:0005667; C:transcription factor complex; IEA:Ensembl.
GO; GO:0050681; F:androgen receptor binding; IEA:Ensembl.
GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
GO; GO:0031490; F:chromatin DNA binding; IEA:Ensembl.
GO; GO:0003684; F:damaged DNA binding; IEA:Ensembl.
GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-UniRule.
GO; GO:0140069; F:histone butyryltransferase activity; IEA:Ensembl.
GO; GO:0140068; F:histone crotonyltransferase activity; IEA:Ensembl.
GO; GO:0004468; F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; IEA:Ensembl.
GO; GO:0002039; F:p53 binding; IEA:Ensembl.
GO; GO:0097157; F:pre-mRNA intronic binding; IEA:Ensembl.
GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
GO; GO:0061920; F:protein propionyltransferase activity; IEA:Ensembl.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0097677; F:STAT family protein binding; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO; GO:0030183; P:B cell differentiation; IEA:Ensembl.
GO; GO:0034644; P:cellular response to UV; IEA:Ensembl.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0043969; P:histone H2B acetylation; IEA:Ensembl.
GO; GO:0043967; P:histone H4 acetylation; IEA:Ensembl.
GO; GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0010742; P:macrophage derived foam cell differentiation; IEA:Ensembl.
GO; GO:0035855; P:megakaryocyte development; IEA:Ensembl.
GO; GO:0018076; P:N-terminal peptidyl-lysine acetylation; IEA:Ensembl.
GO; GO:0032460; P:negative regulation of protein oligomerization; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0140067; P:peptidyl-lysine butyrylation; IEA:Ensembl.
GO; GO:0140066; P:peptidyl-lysine crotonylation; IEA:Ensembl.
GO; GO:0061921; P:peptidyl-lysine propionylation; IEA:Ensembl.
GO; GO:0030220; P:platelet formation; IEA:Ensembl.
GO; GO:0043923; P:positive regulation by host of viral transcription; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0045815; P:positive regulation of gene expression, epigenetic; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO; GO:0032092; P:positive regulation of protein binding; IEA:Ensembl.
GO; GO:0006990; P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response; IEA:Ensembl.
GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0060765; P:regulation of androgen receptor signaling pathway; IEA:Ensembl.
GO; GO:0090043; P:regulation of tubulin deacetylation; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
CDD; cd15802; RING_CBP-p300; 1.
Gene3D; 1.10.1630.10; -; 1.
Gene3D; 1.20.1020.10; -; 2.
Gene3D; 1.20.920.10; -; 1.
Gene3D; 2.10.110.40; -; 1.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR001487; Bromodomain.
InterPro; IPR036427; Bromodomain-like_sf.
InterPro; IPR018359; Bromodomain_CS.
InterPro; IPR031162; CBP_P300_HAT.
InterPro; IPR013178; Histone_AcTrfase_Rtt109/CBP.
InterPro; IPR003101; KIX_dom.
InterPro; IPR036529; KIX_dom_sf.
InterPro; IPR009110; Nuc_rcpt_coact.
InterPro; IPR014744; Nuc_rcpt_coact_CREBbp.
InterPro; IPR037073; Nuc_rcpt_coact_CREBbp_sf.
InterPro; IPR010303; RING_CBP-p300.
InterPro; IPR038547; RING_CBP-p300_sf.
InterPro; IPR035898; TAZ_dom_sf.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR000197; Znf_TAZ.
InterPro; IPR000433; Znf_ZZ.
Pfam; PF00439; Bromodomain; 1.
Pfam; PF09030; Creb_binding; 1.
Pfam; PF06001; DUF902; 1.
Pfam; PF08214; HAT_KAT11; 1.
Pfam; PF02172; KIX; 1.
Pfam; PF02135; zf-TAZ; 2.
Pfam; PF00569; ZZ; 1.
PRINTS; PR00503; BROMODOMAIN.
SMART; SM00297; BROMO; 1.
SMART; SM01250; KAT11; 1.
SMART; SM00551; ZnF_TAZ; 2.
SMART; SM00291; ZnF_ZZ; 1.
SUPFAM; SSF47040; SSF47040; 1.
SUPFAM; SSF47370; SSF47370; 1.
SUPFAM; SSF57933; SSF57933; 2.
SUPFAM; SSF69125; SSF69125; 1.
PROSITE; PS00633; BROMODOMAIN_1; 1.
PROSITE; PS50014; BROMODOMAIN_2; 1.
PROSITE; PS51727; CBP_P300_HAT; 1.
PROSITE; PS50952; KIX; 1.
PROSITE; PS50134; ZF_TAZ; 2.
PROSITE; PS01357; ZF_ZZ_1; 1.
PROSITE; PS50135; ZF_ZZ_2; 1.
4: Predicted;
Acyltransferase {ECO:0000256|PROSITE-ProRule:PRU01065};
Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035,
ECO:0000256|SAAS:SAAS00979529}; Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00203,
ECO:0000256|SAAS:SAAS00594509};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Transferase {ECO:0000256|PROSITE-ProRule:PRU01065};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00203,
ECO:0000256|SAAS:SAAS00594509};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00203,
ECO:0000256|SAAS:SAAS00594509}.
DOMAIN 95 181 TAZ-type. {ECO:0000259|PROSITE:PS50134}.
DOMAIN 330 409 KIX. {ECO:0000259|PROSITE:PS50952}.
DOMAIN 831 903 Bromo. {ECO:0000259|PROSITE:PS50014}.
DOMAIN 1051 1427 CBP/p300-type HAT.
{ECO:0000259|PROSITE:PS51727}.
DOMAIN 1428 1471 ZZ-type. {ECO:0000259|PROSITE:PS50135}.
DOMAIN 1492 1573 TAZ-type. {ECO:0000259|PROSITE:PS50134}.
ZN_FING 95 181 TAZ-type. {ECO:0000256|PROSITE-
ProRule:PRU00203}.
ZN_FING 1492 1573 TAZ-type. {ECO:0000256|PROSITE-
ProRule:PRU00203}.
REGION 1162 1164 Acetyl-CoA binding. {ECO:0000256|PROSITE-
ProRule:PRU01065}.
REGION 1174 1175 Acetyl-CoA binding. {ECO:0000256|PROSITE-
ProRule:PRU01065}.
COILED 773 793 {ECO:0000256|SAM:Coils}.
COILED 1277 1304 {ECO:0000256|SAM:Coils}.
BINDING 1221 1221 Acetyl-CoA; via carbonyl oxygen.
{ECO:0000256|PROSITE-ProRule:PRU01065}.
BINDING 1226 1226 Acetyl-CoA. {ECO:0000256|PROSITE-
ProRule:PRU01065}.
BINDING 1230 1230 Acetyl-CoA. {ECO:0000256|PROSITE-
ProRule:PRU01065}.
SEQUENCE 2175 AA; 239992 MW; 5D7C8DE18CED04E4 CRC64;
RQSFVLVMGM MNNPNPYGSP YTQNPGQQIG ASGLGLQIQT KTVLSNNLSP FAMDKKAVPG
GGMPNMGQQP APQVQQPGLV TPVAQGMGSG AHTADPEKRK LIQQQLVLLL HAHKCQRREQ
ANGEVRQCNL PHCRTMKNVL NHMTHCQSGK SCQVAHCASS RQIISHWKNC TRHDCPVCLP
LKNAGDKRNQ QPILTGAPVG LGNPSSLGVG QQSAPNLSTV SQIDPSSIER AYAALGLPYQ
VNQMPTQPQV QAKNQQNQQP GQSPQGMRPM SNMSASPMGV NGGVGVQTPS LLSDSMLHSA
INSQNPMMSE NASVPSLGPM PTAAQPSTTG IRKQWHEDIT QDLRNHLVHK LVQAIFPTPD
PAALKDRRME NLVAYARKVE GDMYESANNR AEYYHLLAEK IYKIQKELEE KRRTRLQKQN
MLPNAAGMVP VSMNPGPNMG QPQPGMTSNG PLPDPSMIRG SVPNQMMPRI TPQSGLNQFG
QMSMAQPPIV PRQTPPLQHH GQLAQPGALN PPMGYGPRMQ QPSNQGQFLP QTQFPSQGMN
VTNIPLAPSS GQAPVSQAQM SSSSCPVNSP IMPPGSQGSH IHCPQLPQPA LHQNSPSPVP
SRTPTPHHTP PSIGAQQPPA TTIPAPVPTP PAMPPGPQSQ ALHPPPRQTP TPPTTQLPQQ
VQPSLPAAPS ADQPQQQPRS QQSTAASVPT PTAPLLPPQP ATPLSQPAVS IEGQVSNPPS
TSSTEVNSQA IPEKQPSQEV KMEAKMEVDQ PEPADTQPED ISESKVEDCK MESTETEERS
TELKTEIKEE EDQPSTSATQ SSPAPGQSKK KIFKPEELRQ ALMPTLEALY RQDPESLPFR
QPVDPQLLGI PDYFDIVKSP MDLSTIKRKL DTGQYQEPWQ YVDDIWLMFN NAWLYNRKTS
RVYKYCSKLS EVFEQEIDPV MQSLGYCCGR KLEFSPQTLC CYGKQLCTIP RDATYYSYQN
RYHFCEKCFN EIQGESVSLG DDPSQPQTTI NKEQFSKRKN DTLDPELFVE CTECGRKMHQ
ICVLHHEIIW PAGFVCDGCL KKSARTRKEN KFSAKRLPST RLGTFLENRV NDFLRRQNHP
ESGEVTVRVV HASDKTVEVK PGMKARFVDS GEMAESFPYR TKALFAFEEI DGVDLCFFGM
HVQEYGSDCP PPNQRRVYIS YLDSVHFFRP KCLRTAVYHE ILIGYLEYVK KLGYTTGHIW
ACPPSEGDDY IFHCHPPDQK IPKPKRLQEW YKKMLDKAVS ERIVHDYKDI FKQATEDRLT
SAKELPYFEG DFWPNVLEES IKELEQEEEE RKREENTSNE STDVTKGDSK NAKKKNNKKT
SKNKSSLSRG NKKKPGMPNV SNDLSQKLYA TMEKHKEVFF VIRLIAGPAA NSLPPIVDPD
PLIPCDLMDG RDAFLTLARD KHLEFSSLRR AQWSTMCMLV ELHTQSQDRF VYTCNECKHH
VETRWHCTVC EDYDLCITCY NTKNHDHKME KLGLGLDDES NNQQAAATQS PGDSRRLSIQ
RCIQSLVHAC QCRNANCSLP SCQKMKRVVQ HTKGCKRKTN GGCPICKQLI ALCCYHAKHC
QENKCPVPFC LNIKQKLRQQ QLQHRLQQAQ MLRRRMASMQ RTGVVGQQQG LPSPTPATPT
TPTGQQPTTP QTPQPTSQPQ PTPPNSMPPY LPRTQAAGPV SQGKAAGQVT PPTPPQTAQP
PLPGPPPAAV EMAMQIQRAA ETQRQMAHVQ IFQRPIQHQM PPMTPMAPMG MNPPPMTRGP
SGHLEPGMGP TGMQQQPPWS QGGLPQPQQL QSGMPRPAMM SVAQHGQPLN MAPQPGLGQV
GVSPLKPGTV SQQALQNLLR TLRSPSSPLQ QQQVLSILHA NPQLLAAFIK QRAAKYANSN
PQPIPGQPGM PQGQPGLQPP TMPGQQGVHS NPAMQNMNPM QAGVQRAGLP QQQPQQQLQP
PMGGMSPQAQ QMNMNHNTMP SQFRDILRRQ QMMQQQQQQG AGPGIGPGMA NHNQFQQPQG
VGYPPQQQQR MQHHMQQGNM GQIGQLPQAL GAEAGASLQA YQQRLLQQQM GSPVQPNPMS
PQQHMLPNQA QSPHLQGQQI PNSLSNQVRS PQPVPSPRPQ SQPPHSSPSP RMQPQPSPHH
VSPQTSSPHP GLVAAQANPM EQGHFASPDQ NSMLSQLASN PGMANLHGAS ATDLGLSTDN
SDLNSNLSQS TLDIH


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