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E1B protein, small T-antigen

 A0A220VZ73_ADE07        Unreviewed;       178 AA.
A0A220VZ73;
25-OCT-2017, integrated into UniProtKB/TrEMBL.
25-OCT-2017, sequence version 1.
20-DEC-2017, entry version 3.
RecName: Full=E1B protein, small T-antigen {ECO:0000256|RuleBase:RU364111};
Name=E1B {ECO:0000313|EMBL:ASK85764.1};
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus;
Human mastadenovirus B.
NCBI_TaxID=10519 {ECO:0000313|EMBL:ASK85764.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:ASK85764.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Z9/WH/CHN/2015 complete genome {ECO:0000313|EMBL:ASK85764.1};
PubMed=28225804;
Yang X., Wang Q., Liang B., Wu F., Li H., Liu H., Sheng C., Ma Q.,
Yang C., Xie J., Li P., Jia L., Wang L., Du X., Qiu S., Song H.;
"An outbreak of acute respiratory disease caused by a virus associated
RNA II gene mutation strain of human adenovirus 7 in China, 2015.";
PLoS ONE 12:E0172519-E0172519(2017).
-!- FUNCTION: Putative adenovirus Bcl-2 homolog that inhibits
apoptosis induced by TNF or FAS pathways, as well as p53-mediated
apoptosis. Without E1B 19K function, virus production is
compromised because of premature death of host cell. Interacts
with Bax protein in cell lysates. {ECO:0000256|RuleBase:RU364111}.
-!- SUBCELLULAR LOCATION: Host cell membrane
{ECO:0000256|RuleBase:RU364111}. Host nucleus envelope
{ECO:0000256|RuleBase:RU364111}. Host nucleus lamina
{ECO:0000256|RuleBase:RU364111}.
-!- SIMILARITY: Belongs to the adenoviridae E1B 19 kDa protein family.
{ECO:0000256|RuleBase:RU364111}.
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EMBL; KX897164; ASK85764.1; -; Genomic_DNA.
GO; GO:0044203; C:host cell nuclear lamina; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0005521; F:lamin binding; IEA:UniProtKB-UniRule.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:UniProtKB-UniRule.
GO; GO:0019050; P:suppression by virus of host apoptotic process; IEA:UniProtKB-UniRule.
InterPro; IPR002924; Adenovir_t-Ag_E1B_19kDa.
InterPro; IPR002475; Bcl2-like.
Pfam; PF01691; Adeno_E1B_19K; 1.
PROSITE; PS50062; BCL2_FAMILY; 1.
3: Inferred from homology;
Apoptosis {ECO:0000256|RuleBase:RU364111};
Early protein {ECO:0000256|RuleBase:RU364111};
Host cell membrane {ECO:0000256|RuleBase:RU364111};
Host membrane {ECO:0000256|RuleBase:RU364111};
Host nucleus {ECO:0000256|RuleBase:RU364111};
Host-virus interaction {ECO:0000256|RuleBase:RU364111};
Inhibition of host apoptosis by viral BCL2-like protein
{ECO:0000256|RuleBase:RU364111};
Membrane {ECO:0000256|RuleBase:RU364111};
Modulation of host cell apoptosis by virus
{ECO:0000256|RuleBase:RU364111}.
SEQUENCE 178 AA; 20365 MW; 5C23331EA3DD167E CRC64;
MEVWAILEDL RQTRLLLENA SDGVSGLWRF CFGGDLARLV FRIKQDYSVE FEKLLDDSPG
LFEALNLGHQ AHFKEKVLSV LDFSTPGRTA AAVAFLTFIL DKWIRQTHFS KGYVLDFIAA
ALWRTWKARR MRTILNYWPV QPLGVAGILR HPPTMPAVLQ EEQQEDNPRA GLDPPVEE


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