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E3 ubiquitin-protein ligase (EC 2.3.2.26)

 A0A0L0P779_9ASCO        Unreviewed;       780 AA.
A0A0L0P779;
11-NOV-2015, integrated into UniProtKB/TrEMBL.
11-NOV-2015, sequence version 1.
22-NOV-2017, entry version 18.
RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|PIRNR:PIRNR001569};
EC=2.3.2.26 {ECO:0000256|PIRNR:PIRNR001569};
ORFNames=QG37_01233 {ECO:0000313|EMBL:KNE01886.1};
[Candida] auris.
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Metschnikowiaceae; Clavispora;
Clavispora/Candida clade.
NCBI_TaxID=498019 {ECO:0000313|EMBL:KNE01886.1, ECO:0000313|Proteomes:UP000037122};
[1] {ECO:0000313|Proteomes:UP000037122}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=6684 {ECO:0000313|Proteomes:UP000037122};
PubMed=26346253; DOI=10.1186/s12864-015-1863-z;
Chatterjee S., Alampalli S.V., Nageshan R.K., Chettiar S.T., Joshi S.,
Tatu U.S.;
"Draft genome of a commonly misdiagnosed multidrug resistant pathogen
Candida auris.";
BMC Genomics 16:686-686(2015).
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine. {ECO:0000256|PIRNR:PIRNR001569,
ECO:0000256|SAAS:SAAS00628607}.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000256|PIRNR:PIRNR001569}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KNE01886.1}.
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EMBL; LGST01000008; KNE01886.1; -; Genomic_DNA.
RefSeq; XP_018171609.1; XM_018310771.1.
EnsemblFungi; KNE01886; KNE01886; QG37_01233.
GeneID; 28875035; -.
KEGG; caur:QG37_01233; -.
KO; K10591; -.
UniPathway; UPA00143; -.
Proteomes; UP000037122; Unassembled WGS sequence.
GO; GO:0005934; C:cellular bud tip; IEA:EnsemblFungi.
GO; GO:0010008; C:endosome membrane; IEA:EnsemblFungi.
GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IEA:EnsemblFungi.
GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
GO; GO:0000151; C:ubiquitin ligase complex; IEA:EnsemblFungi.
GO; GO:0035091; F:phosphatidylinositol binding; IEA:EnsemblFungi.
GO; GO:0043130; F:ubiquitin binding; IEA:EnsemblFungi.
GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:EnsemblFungi.
GO; GO:0034644; P:cellular response to UV; IEA:EnsemblFungi.
GO; GO:0006333; P:chromatin assembly or disassembly; IEA:EnsemblFungi.
GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IEA:EnsemblFungi.
GO; GO:0072671; P:mitochondria-associated ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
GO; GO:0007005; P:mitochondrion organization; IEA:EnsemblFungi.
GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:EnsemblFungi.
GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:EnsemblFungi.
GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IEA:EnsemblFungi.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:EnsemblFungi.
GO; GO:0051865; P:protein autoubiquitination; IEA:EnsemblFungi.
GO; GO:0006513; P:protein monoubiquitination; IEA:EnsemblFungi.
GO; GO:0000209; P:protein polyubiquitination; IEA:EnsemblFungi.
GO; GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
GO; GO:0032956; P:regulation of actin cytoskeleton organization; IEA:EnsemblFungi.
GO; GO:0010794; P:regulation of dolichol biosynthetic process; IEA:EnsemblFungi.
GO; GO:0032443; P:regulation of ergosterol biosynthetic process; IEA:EnsemblFungi.
GO; GO:0031384; P:regulation of initiation of mating projection growth; IEA:EnsemblFungi.
GO; GO:0010793; P:regulation of mRNA export from nucleus; IEA:EnsemblFungi.
GO; GO:0010796; P:regulation of multivesicular body size; IEA:EnsemblFungi.
GO; GO:0006808; P:regulation of nitrogen utilization; IEA:EnsemblFungi.
GO; GO:0019220; P:regulation of phosphate metabolic process; IEA:EnsemblFungi.
GO; GO:2000203; P:regulation of ribosomal large subunit export from nucleus; IEA:EnsemblFungi.
GO; GO:2000232; P:regulation of rRNA processing; IEA:EnsemblFungi.
GO; GO:2000238; P:regulation of tRNA export from nucleus; IEA:EnsemblFungi.
GO; GO:2000235; P:regulation of tRNA processing; IEA:EnsemblFungi.
GO; GO:0010795; P:regulation of ubiquinone biosynthetic process; IEA:EnsemblFungi.
GO; GO:0042493; P:response to drug; IEA:EnsemblFungi.
GO; GO:0034517; P:ribophagy; IEA:EnsemblFungi.
GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:EnsemblFungi.
GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:EnsemblFungi.
CDD; cd00078; HECTc; 1.
CDD; cd00201; WW; 3.
Gene3D; 2.60.40.150; -; 1.
InterPro; IPR000008; C2_dom.
InterPro; IPR035892; C2_domain_sf.
InterPro; IPR024928; E3_ub_ligase_SMURF1.
InterPro; IPR000569; HECT_dom.
InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
InterPro; IPR001202; WW_dom.
InterPro; IPR036020; WW_dom_sf.
Pfam; PF00168; C2; 1.
Pfam; PF00632; HECT; 1.
Pfam; PF00397; WW; 3.
PIRSF; PIRSF001569; E3_ub_ligase_SMURF1; 2.
SMART; SM00239; C2; 1.
SMART; SM00119; HECTc; 1.
SMART; SM00456; WW; 3.
SUPFAM; SSF49562; SSF49562; 1.
SUPFAM; SSF51045; SSF51045; 3.
SUPFAM; SSF56204; SSF56204; 1.
PROSITE; PS50004; C2; 1.
PROSITE; PS50237; HECT; 1.
PROSITE; PS01159; WW_DOMAIN_1; 3.
PROSITE; PS50020; WW_DOMAIN_2; 3.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000037122};
Reference proteome {ECO:0000313|Proteomes:UP000037122};
Transferase {ECO:0000256|PIRNR:PIRNR001569,
ECO:0000256|SAAS:SAAS00628615};
Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR001569,
ECO:0000256|PROSITE-ProRule:PRU00104, ECO:0000256|SAAS:SAAS00593691}.
DOMAIN 1 87 C2. {ECO:0000259|PROSITE:PS50004}.
DOMAIN 191 224 WW. {ECO:0000259|PROSITE:PS50020}.
DOMAIN 303 336 WW. {ECO:0000259|PROSITE:PS50020}.
DOMAIN 358 391 WW. {ECO:0000259|PROSITE:PS50020}.
DOMAIN 447 780 HECT. {ECO:0000259|PROSITE:PS50237}.
ACT_SITE 748 748 Glycyl thioester intermediate.
{ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}.
SEQUENCE 780 AA; 88720 MW; A129EE95D0B8728F CRC64;
MTTKVNVKVV AAESLYKRDV FRQPDPFAVI TVDGAQTITT KTAKRTLNPY WNESFLLNAL
EDSILAIQVF DQRKFKKKDQ GFLGVVNVRV GDVIDLSLPA SEETITRDLK KSNENLAVSG
RVIIVLSHNS NASSSNGSVA APAQGTSSSA RASNPAPVAS NSAAAAANAA ATNNGGELFT
KQYSSFEDQY GRLPPGWERR TDNFGRTYYV DHNSRTTTWE RPTLDQSETE RGQQRENTTE
AERRQHRGRT LPGETPLSPT LGASSSTSNN GNVTVNSTGA NTPVSPAAAV SMAATGGTTR
GLGELPTGWE QRFTNEGRPY FVDHNTRTTT WVDPRRQQYI RTFGPNTTIQ QQPVSQLGPL
PSGWEMRLTN TARVYFVDHN TKTTTWDDPR LPSSLDQNVP QYKRDFRRKV IYFRSQPALR
ILPGQCHIKV RRDHIFEDSY QEIMRQTPED LKKRLMIKFD GEEGLDYGGV SREFFFLLSH
DMFNPFYCLF EYSSHDNYTL QINPNSGINP EHLNYFKFIG RVVGLGVFHR RFLDAFFVGA
LYKMMLRKKV CLQDMEGVDA EFFRSLQWIC DNDITNVLDL TFSAEDDKFG EIVEVDLKPN
GRNIEVTEEN KHEYVELISE WKIHKRIELQ FQAFIDGFNE LIPHELVNVF DERELELLIG
GLAEIDVEDW KKHTDYRGYQ ETDQVIQWFW QCIKEWDSEQ KARLLQFTTG TSRIPVNGFK
DLQGSDGPRR FTIEKAGEPN QLPKSHTCFN RVDLPPYTSY ESMKQKLTLA VEETVGFGQE


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