Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

E3 ubiquitin-protein ligase BRE1B (BRE1-B) (EC 2.3.2.27) (RING finger protein 40) (RING-type E3 ubiquitin transferase BRE1B) (Syntaxin-1-interacting RING finger protein) (Protein staring)

 BRE1B_RAT               Reviewed;        1002 AA.
Q8CJB9;
20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
20-JUN-2018, entry version 120.
RecName: Full=E3 ubiquitin-protein ligase BRE1B;
Short=BRE1-B;
EC=2.3.2.27 {ECO:0000269|PubMed:12121982};
AltName: Full=RING finger protein 40;
AltName: Full=RING-type E3 ubiquitin transferase BRE1B {ECO:0000305};
AltName: Full=Syntaxin-1-interacting RING finger protein;
Short=Protein staring;
Name=Rnf40; Synonyms=Bre1b;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE FUNCTION, CATALYTIC ACTIVITY,
TISSUE SPECIFICITY, AND POSSIBLE INTERACTION WITH STX1A.
STRAIN=Sprague-Dawley;
PubMed=12121982; DOI=10.1074/jbc.M203300200;
Chin L.-S., Vavalle J.P., Li L.;
"Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1
for degradation.";
J. Biol. Chem. 277:35071-35079(2002).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585 AND SER-586, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase
complex that mediates monoubiquitination of 'Lys-120' of histone
H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic
transcriptional activation and is also prerequisite for histone H3
'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me,
respectively). It thereby plays a central role in histone code and
gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase
complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports
about the cooperation with UBE2E1/UBCH are contradictory. Required
for transcriptional activation of Hox genes.
{ECO:0000250|UniProtKB:O75150}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine. {ECO:0000269|PubMed:12121982}.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Component of the RNF20/40 complex (also known as BRE1
complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies
of RNF40/BRE1B. Interacts with UBE2E1/UBCH6. Interacts with RB1
and WAC (By similarity). May interact with STX1A.
{ECO:0000250|UniProtKB:O75150}.
-!- INTERACTION:
P61265:Stx1b; NbExp=4; IntAct=EBI-6110162, EBI-2255905;
O14933:UBE2L6 (xeno); NbExp=2; IntAct=EBI-6110162, EBI-2129974;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75150}.
-!- TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in brain,
testis, heart, liver and kidney. Weakly expressed in lung, spleen
and skeletal muscle (at protein level).
{ECO:0000269|PubMed:12121982}.
-!- SIMILARITY: Belongs to the BRE1 family. {ECO:0000305}.
-!- CAUTION: Was originally thought to be cytoplasmic and membrane-
associated and to mediate ubiquitination and subsequent
degradation of STX1A. {ECO:0000305|PubMed:12121982}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF352815; AAN16401.1; -; mRNA.
RefSeq; NP_703201.1; NM_153471.1.
UniGene; Rn.162466; -.
ProteinModelPortal; Q8CJB9; -.
SMR; Q8CJB9; -.
IntAct; Q8CJB9; 2.
STRING; 10116.ENSRNOP00000025500; -.
iPTMnet; Q8CJB9; -.
PhosphoSitePlus; Q8CJB9; -.
PaxDb; Q8CJB9; -.
PRIDE; Q8CJB9; -.
Ensembl; ENSRNOT00000025499; ENSRNOP00000025500; ENSRNOG00000018840.
GeneID; 266712; -.
KEGG; rno:266712; -.
UCSC; RGD:628638; rat.
CTD; 9810; -.
RGD; 628638; Rnf40.
eggNOG; KOG0978; Eukaryota.
eggNOG; ENOG410Y5C6; LUCA.
GeneTree; ENSGT00390000002866; -.
HOGENOM; HOG000231526; -.
HOVERGEN; HBG080312; -.
InParanoid; Q8CJB9; -.
KO; K10696; -.
OMA; QRVYSRG; -.
OrthoDB; EOG091G01SA; -.
PhylomeDB; Q8CJB9; -.
TreeFam; TF323183; -.
BRENDA; 2.3.2.B10; 5301.
BRENDA; 6.3.2.19; 5301.
Reactome; R-RNO-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
UniPathway; UPA00143; -.
PRO; PR:Q8CJB9; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000018840; -.
Genevisible; Q8CJB9; RN.
GO; GO:0043679; C:axon terminus; IDA:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0019898; C:extrinsic component of membrane; IDA:RGD.
GO; GO:0033503; C:HULC complex; ISS:UniProtKB.
GO; GO:0043005; C:neuron projection; IDA:RGD.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0044877; F:protein-containing complex binding; IDA:RGD.
GO; GO:0017075; F:syntaxin-1 binding; IPI:RGD.
GO; GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IDA:RGD.
GO; GO:0033523; P:histone H2B ubiquitination; IEA:Ensembl.
GO; GO:0010390; P:histone monoubiquitination; IEA:Ensembl.
GO; GO:1900364; P:negative regulation of mRNA polyadenylation; IEA:Ensembl.
GO; GO:2001168; P:positive regulation of histone H2B ubiquitination; IEA:Ensembl.
GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; IDA:RGD.
GO; GO:1902916; P:positive regulation of protein polyubiquitination; IDA:RGD.
GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:RGD.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR013956; E3_ubiquit_lig_Bre1.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR017907; Znf_RING_CS.
PANTHER; PTHR23163; PTHR23163; 1.
SMART; SM00184; RING; 1.
PROSITE; PS00518; ZF_RING_1; 1.
PROSITE; PS50089; ZF_RING_2; 1.
1: Evidence at protein level;
Acetylation; Chromatin regulator; Coiled coil; Complete proteome;
Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein;
Reference proteome; Transferase; Ubl conjugation;
Ubl conjugation pathway; Zinc; Zinc-finger.
CHAIN 1 1002 E3 ubiquitin-protein ligase BRE1B.
/FTId=PRO_0000055843.
ZN_FING 949 988 RING-type. {ECO:0000255|PROSITE-
ProRule:PRU00175}.
COILED 55 91 {ECO:0000255}.
COILED 190 378 {ECO:0000255}.
COILED 438 526 {ECO:0000255}.
COILED 628 947 {ECO:0000255}.
MOD_RES 20 20 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q3U319}.
MOD_RES 42 42 Phosphoserine.
{ECO:0000250|UniProtKB:Q5VTR2}.
MOD_RES 356 356 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q5VTR2}.
MOD_RES 518 518 N6-acetyllysine.
{ECO:0000250|UniProtKB:Q3U319}.
MOD_RES 585 585 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 586 586 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CROSSLNK 579 579 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:O75150}.
CROSSLNK 580 580 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:O75150}.
SEQUENCE 1002 AA; 113841 MW; EFF371C06B52D231 CRC64;
MSGLSNKRAA GDGGSGPPEK KLNREEKTTT TLIEPIRLGG ISSTEEMDSK VLQFKNKKLA
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLQ CYENQRELSS
SGTEVPGCQE GLTRDVIPRT DPGTSDLREP LPMQFRAPLS EPALAFVVAL GASSCEEVEL
QLQGRMEFSK AAVSRVVEAS DRLQRQVEEL CQRVYSRGDS EAPGEVARAR TRELGRENRR
LQDLATQLQE KHHRISLEYS ELQDKVTSTE TKVLEMETTV EDLQWDIEKL RKREQKLNKH
LAEALEQLNS GYYVSGSSTG FQGGQITLSM QKFEMLNAEL EENQELANSR MAELEKLQAE
LQGAVRTNER LKVALRSLPE EVVRETGEYR MLQAQFSLLY NESLQVKTQL DEARGLLLAS
KNSHLRHIEH MESDELGLQK KLRTEVIQLE DTLAQVRKEY EMLRIEFEQN LAANEQAGPI
NREMRHLISS LQNHNHQLKG DAQRYKRKLR EVQAEIGKLR AQASGSSHCG PNLSHPDDSG
LNALAPGKED SGPGPGGTPD SKKELALVAG ATSVASSVKK EELVSSEDDA QALAPGTQGL
PSRGREPEAR PKRELREREG PSLGPPPAAS TLSRADREKA KAEEARRKES ELLKGLRAEL
KKAQESQKEM KLLLDMYKSA PKEQRDKVQL MAAERKAKAE VDELRSRIRD LEERDRRESK
KIADEDALRR IRQAEEQIEH LQRKLGATKQ EEEALLSEMD VTGQAFEDMQ EQNGRLLQQL
REKDDANFKL MSERIKANQI HKLLREEKDE LGEQVLGLKS QVDAQLLTVQ KLEEKERALQ
GSLGGVEKEL TLRSQALELN KRKAVEAAQL AEDLKVQLEH VQTRLREIQP CLAESRAARE
KESFNLKRAQ EDISRLRRKL EKQRKVEVYA DADEILQEEI KEYKARLTCP CCNTRKKDAV
LTKCFHVFCF ECVRGRYEAR QRKCPKCNAA FGAHDFHRVY IS


Related products :

Catalog number Product name Quantity
18-003-42502 Ubiquitin ligase protein RING2 - EC 6.3.2.-; RING finger protein 2; RING finger protein 1B; RING1b; RING finger protein BAP-1; DinG protein; Huntingtin-interacting protein 2-interacting protein 3; HIP 0.1 mg Protein A
18-003-42501 Ubiquitin ligase protein RING2 - EC 6.3.2.-; RING finger protein 2; RING finger protein 1B; RING1b; RING finger protein BAP-1; DinG protein; Huntingtin-interacting protein 2-interacting protein 3; HIP 0.05 mg Aff Pur
EIAAB45299 E3 ubiquitin-protein ligase UHRF2,Homo sapiens,Human,NIRF,Np95_ICBP90-like RING finger protein,Np95-like RING finger protein,Nuclear protein 97,Nuclear zinc finger protein Np97,RING finger protein 107
EIAAB34367 CARP-2,Caspase regulator CARP2,Caspases-8 and -10-associated RING finger protein 2,E3 ubiquitin-protein ligase rififylin,Fring,FYVE-RING finger protein Sakura,Homo sapiens,Human,RFFL,RING finger and F
EIAAB35549 E3 ubiquitin-protein ligase RLIM,Homo sapiens,Human,LIM domain-interacting RING finger protein,Renal carcinoma antigen NY-REN-43,RING finger LIM domain-binding protein,RING finger protein 12,RLIM,R-LI
EIAAB43947 E3 ubiquitin-protein ligase TRIM63,Homo sapiens,Human,IRF,Iris RING finger protein,MuRF1,MURF1,MuRF-1,Muscle-specific RING finger protein 1,RING finger protein 28,RNF28,SMRZ,Striated muscle RING zinc
EIAAB34857 BAP1,DING,E3 ubiquitin-protein ligase RING2,HIP2-interacting protein 3,HIPI3,Homo sapiens,Human,Huntingtin-interacting protein 2-interacting protein 3,Protein DinG,RING finger protein 1B,RING finger p
EIAAB35550 E3 ubiquitin-protein ligase RLIM,LIM domain-interacting RING finger protein,Mouse,Mus musculus,RING finger LIM domain-binding protein,RING finger protein 12,Rlim,R-LIM,Rnf12
EIAAB35413 E3 ubiquitin-protein ligase RNF138,hNARF,Homo sapiens,HSD4,HSD-4,Human,NARF,Nemo-like kinase-associated RING finger protein,NLK-associated RING finger protein,RING finger protein 138,RNF138
EIAAB35571 CARP-1,Caspase regulator CARP1,Caspases-8 and -10-associated RING finger protein 1,E3 ubiquitin-protein ligase RNF34,FYVE-RING finger protein Momo,Homo sapiens,hRFI,Human,Human RING finger homologous
EIAAB35482 Dorfin,Double ring-finger protein,E3 ubiquitin-protein ligase RNF19A,Gametogenesis-expressed protein GEG-154,Geg-154,Mouse,Mus musculus,RING finger protein 19A,Rnf19,Rnf19a,UBCM4-interacting protein 1
EIAAB24906 Homo sapiens,Human,Makorin RING finger protein pseudogene 4,Makorin RING finger protein pseudogene 5,MKRN4,MKRN4P,MKRNP5,Putative E3 ubiquitin-protein ligase makorin-4,RING finger protein 64,RNF64,Zin
EIAAB45298 E3 ubiquitin-protein ligase UHRF2,Mouse,Mus musculus,NIRF,Nirf,Np95-like ring finger protein,Nuclear protein 97,Nuclear zinc finger protein Np97,Ubiquitin-like PHD and RING finger domain-containing pr
EIAAB35567 HOIL-1-interacting protein,HOIP,Homo sapiens,Human,RING finger protein 31,RNF31,ZIBRA,Zinc in-between-RING-finger ubiquitin-associated domain protein
EIAAB38244 E3 ubiquitin-protein ligase SH3RF1,Homo sapiens,Human,KIAA1494,Plenty of SH3s,POSH,Protein POSH,RING finger protein 142,RNF142,SH3 domain-containing RING finger protein 1,SH3 multiple domains protein
EIAAB38246 Heart protein phosphatase 1-binding protein,HEPP1,Homo sapiens,Human,Putative E3 ubiquitin-protein ligase SH3RF2,RING finger protein 158,RNF158,SH3 domain-containing RING finger protein 2,SH3RF2
EIAAB43998 GERP,Glioblastoma-expressed RING finger protein,Homo sapiens,Human,Probable E3 ubiquitin-protein ligase TRIM8,RING finger protein 27,RNF27,TRIM8,Tripartite motif-containing protein 8
EIAAB34424 Constitutive photomorphogenesis protein 1 homolog,COP1,E3 ubiquitin-protein ligase RFWD2,hCOP1,Homo sapiens,Human,RFWD2,RING finger and WD repeat domain protein 2,RING finger protein 200,RNF200
EIAAB43999 Gerp,Glioblastoma-expressed RING finger protein,Mouse,Mus musculus,Probable E3 ubiquitin-protein ligase TRIM8,RING finger protein 27,Rnf27,Trim8,Tripartite motif-containing protein 8
EIAAB43861 E3 ubiquitin-protein ligase TRIM17,Homo sapiens,Human,RBCC,RING finger protein 16,RNF16,TERF,Testis RING finger protein,TRIM17,Tripartite motif-containing protein 17
EIAAB33374 E3 ubiquitin-protein ligase RNF144B,Homo sapiens,Human,IBR domain-containing protein 2,IBRDC2,p53-inducible RING finger protein,P53RFP,RING finger protein 144B,RNF144B
EIAAB43778 E3 ubiquitin-protein ligase TRAF7,Homo sapiens,Human,RFWD1,RING finger and WD repeat-containing protein 1,RING finger protein 119,RNF119,TNF receptor-associated factor 7,TRAF7
EIAAB07154 Checkpoint with forkhead and RING finger domains protein,CHFR,E3 ubiquitin-protein ligase CHFR,Homo sapiens,Human,RING finger protein 196,RNF196
EIAAB34369 E3 ubiquitin-protein ligase rififylin,FYVE-RING finger protein Sakura,Rat,Rattus norvegicus,Rffl,RING finger and FYVE-like domain-containing protein 1
EIAAB34425 E3 ubiquitin-protein ligase RFWD3,Homo sapiens,Human,RFWD3,RING finger and WD repeat domain-containing protein 3,RING finger protein 201,RNF201


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur