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E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)

 HECW1_HUMAN             Reviewed;        1606 AA.
Q76N89; A7E2X0; A8MYS3; B4DH42; O15036; Q9HCC7;
20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
10-FEB-2009, sequence version 3.
12-SEP-2018, entry version 131.
RecName: Full=E3 ubiquitin-protein ligase HECW1;
EC=2.3.2.26;
AltName: Full=HECT, C2 and WW domain-containing protein 1;
AltName: Full=HECT-type E3 ubiquitin transferase HECW1;
AltName: Full=NEDD4-like E3 ubiquitin-protein ligase 1;
Short=hNEDL1;
Name=HECW1; Synonyms=KIAA0322, NEDL1;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=9205841; DOI=10.1093/dnares/4.2.141;
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N.,
Tanaka A., Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. VII.
The complete sequences of 100 new cDNA clones from brain which can
code for large proteins in vitro.";
DNA Res. 4:141-150(1997).
[2]
SEQUENCE REVISION.
PubMed=12168954; DOI=10.1093/dnares/9.3.99;
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual
curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Brain;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=12853948; DOI=10.1038/nature01782;
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
Waterston R.H., Wilson R.K.;
"The DNA sequence of human chromosome 7.";
Nature 424:157-164(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 22-1606 (ISOFORM 1), FUNCTION,
INTERACTION WITH DVL1; SSR3 AND SOD1, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=14684739; DOI=10.1074/jbc.M312389200;
Miyazaki K., Fujita T., Ozaki T., Kato C., Kurose Y., Sakamoto M.,
Kato S., Goto T., Itoyama Y., Aoki M., Nakagawara A.;
"NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1,
targets mutant superoxide dismutase-1.";
J. Biol. Chem. 279:11327-11335(2004).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21406692; DOI=10.1126/scisignal.2001570;
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J.,
Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V.,
Blagoev B.;
"System-wide temporal characterization of the proteome and
phosphoproteome of human embryonic stem cell differentiation.";
Sci. Signal. 4:RS3-RS3(2011).
-!- FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination
and subsequent degradation of DVL1. Also targets the mutant SOD1
protein involved in familial amyotrophic lateral sclerosis (FALS).
Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that
lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Interacts with DVL1 and SSR3. Also interacts with mutant
SOD1. {ECO:0000269|PubMed:14684739}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14684739}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q76N89-1; Sequence=Displayed;
Name=2;
IsoId=Q76N89-2; Sequence=VSP_054642;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Predominantly expressed in neurons of adult
and fetal brain. Weakly expressed in the kidney.
{ECO:0000269|PubMed:14684739}.
-!- SEQUENCE CAUTION:
Sequence=BAA20780.2; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AB002320; BAA20780.2; ALT_INIT; mRNA.
EMBL; AK294918; BAG58003.1; -; mRNA.
EMBL; AC004455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC004692; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC005537; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC006365; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC011738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC151227; AAI51228.1; -; mRNA.
EMBL; AB048365; BAB13352.1; -; mRNA.
CCDS; CCDS5469.2; -. [Q76N89-1]
CCDS; CCDS69286.1; -. [Q76N89-2]
RefSeq; NP_001273988.1; NM_001287059.1. [Q76N89-2]
RefSeq; NP_055867.3; NM_015052.4. [Q76N89-1]
RefSeq; XP_016867375.1; XM_017011886.1. [Q76N89-1]
RefSeq; XP_016867378.1; XM_017011889.1. [Q76N89-2]
UniGene; Hs.164453; -.
PDB; 3L4H; X-ray; 1.80 A; A=948-1056.
PDBsum; 3L4H; -.
ProteinModelPortal; Q76N89; -.
SMR; Q76N89; -.
BioGrid; 116705; 23.
IntAct; Q76N89; 7.
MINT; Q76N89; -.
STRING; 9606.ENSP00000379228; -.
iPTMnet; Q76N89; -.
PhosphoSitePlus; Q76N89; -.
BioMuta; HECW1; -.
DMDM; 223590222; -.
MaxQB; Q76N89; -.
PaxDb; Q76N89; -.
PeptideAtlas; Q76N89; -.
PRIDE; Q76N89; -.
ProteomicsDB; 68692; -.
Ensembl; ENST00000395891; ENSP00000379228; ENSG00000002746. [Q76N89-1]
Ensembl; ENST00000453890; ENSP00000407774; ENSG00000002746. [Q76N89-2]
GeneID; 23072; -.
KEGG; hsa:23072; -.
UCSC; uc003tid.2; human. [Q76N89-1]
CTD; 23072; -.
DisGeNET; 23072; -.
EuPathDB; HostDB:ENSG00000002746.14; -.
GeneCards; HECW1; -.
H-InvDB; HIX0022191; -.
H-InvDB; HIX0033890; -.
HGNC; HGNC:22195; HECW1.
HPA; HPA007203; -.
HPA; HPA007593; -.
HPA; HPA007609; -.
MIM; 610384; gene.
neXtProt; NX_Q76N89; -.
OpenTargets; ENSG00000002746; -.
PharmGKB; PA134964191; -.
eggNOG; KOG0940; Eukaryota.
eggNOG; COG5021; LUCA.
GeneTree; ENSGT00760000118966; -.
HOGENOM; HOG000069940; -.
HOVERGEN; HBG057414; -.
InParanoid; Q76N89; -.
KO; K12167; -.
OMA; THYIRIH; -.
OrthoDB; EOG091G0A54; -.
PhylomeDB; Q76N89; -.
TreeFam; TF313938; -.
BRENDA; 2.3.2.B9; 2681.
BRENDA; 6.3.2.19; 2681.
Reactome; R-HSA-4641258; Degradation of DVL.
SignaLink; Q76N89; -.
UniPathway; UPA00143; -.
ChiTaRS; HECW1; human.
EvolutionaryTrace; Q76N89; -.
GenomeRNAi; 23072; -.
PRO; PR:Q76N89; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000002746; Expressed in 122 organ(s), highest expression level in middle temporal gyrus.
CleanEx; HS_HECW1; -.
ExpressionAtlas; Q76N89; baseline and differential.
Genevisible; Q76N89; HS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
CDD; cd08691; C2_NEDL1-like; 1.
CDD; cd00078; HECTc; 1.
CDD; cd00201; WW; 2.
Gene3D; 2.60.40.150; -; 1.
InterPro; IPR000008; C2_dom.
InterPro; IPR035892; C2_domain_sf.
InterPro; IPR037795; C2_HECW.
InterPro; IPR000569; HECT_dom.
InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
InterPro; IPR032348; HECW_N.
InterPro; IPR001202; WW_dom.
InterPro; IPR036020; WW_dom_sf.
Pfam; PF00168; C2; 1.
Pfam; PF00632; HECT; 1.
Pfam; PF16562; HECW_N; 1.
Pfam; PF00397; WW; 1.
SMART; SM00239; C2; 1.
SMART; SM00119; HECTc; 1.
SMART; SM00456; WW; 2.
SUPFAM; SSF51045; SSF51045; 2.
SUPFAM; SSF56204; SSF56204; 1.
PROSITE; PS50004; C2; 1.
PROSITE; PS50237; HECT; 1.
PROSITE; PS01159; WW_DOMAIN_1; 2.
PROSITE; PS50020; WW_DOMAIN_2; 2.
1: Evidence at protein level;
3D-structure; Alternative splicing; Coiled coil; Complete proteome;
Cytoplasm; Phosphoprotein; Reference proteome; Repeat; Transferase;
Ubl conjugation pathway.
CHAIN 1 1606 E3 ubiquitin-protein ligase HECW1.
/FTId=PRO_0000277665.
DOMAIN 192 302 C2. {ECO:0000255|PROSITE-
ProRule:PRU00041}.
DOMAIN 829 862 WW 1. {ECO:0000255|PROSITE-
ProRule:PRU00224}.
DOMAIN 1018 1051 WW 2. {ECO:0000255|PROSITE-
ProRule:PRU00224}.
DOMAIN 1271 1606 HECT. {ECO:0000255|PROSITE-
ProRule:PRU00104}.
COILED 870 901 {ECO:0000255}.
COMPBIAS 456 519 Glu-rich.
COMPBIAS 670 707 Cys-rich.
ACT_SITE 1574 1574 Glycyl thioester intermediate.
{ECO:0000255|PROSITE-ProRule:PRU00104}.
MOD_RES 874 874 Phosphoserine.
{ECO:0000250|UniProtKB:Q8K4P8}.
MOD_RES 937 937 Phosphoserine.
{ECO:0000250|UniProtKB:Q8K4P8}.
MOD_RES 939 939 Phosphoserine.
{ECO:0000250|UniProtKB:Q8K4P8}.
VAR_SEQ 800 834 GECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPN -> D
(in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_054642.
CONFLICT 404 404 G -> R (in Ref. 1; BAA20780, 4; AAI51228
and 5; BAB13352). {ECO:0000305}.
HELIX 953 958 {ECO:0000244|PDB:3L4H}.
HELIX 963 968 {ECO:0000244|PDB:3L4H}.
HELIX 971 979 {ECO:0000244|PDB:3L4H}.
HELIX 982 992 {ECO:0000244|PDB:3L4H}.
HELIX 995 1000 {ECO:0000244|PDB:3L4H}.
HELIX 1004 1011 {ECO:0000244|PDB:3L4H}.
STRAND 1024 1028 {ECO:0000244|PDB:3L4H}.
STRAND 1034 1038 {ECO:0000244|PDB:3L4H}.
TURN 1039 1042 {ECO:0000244|PDB:3L4H}.
STRAND 1043 1047 {ECO:0000244|PDB:3L4H}.
SEQUENCE 1606 AA; 179554 MW; 22AE698F16276E98 CRC64;
MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV
LSENFLDYKN RGVNGSHRGQ IIWKIDASSY FVEPETKICF KYYHGVSGAL RATTPSVTVK
NSAAPIFKSI GADETVQGQG SRRLISFSLS DFQAMGLKKG MFFNPDPYLK ISIQPGKHSI
FPALPHHGQE RRSKIIGNTV NPIWQAEQFS FVSLPTDVLE IEVKDKFAKS RPIIKRFLGK
LSMPVQRLLE RHAIGDRVVS YTLGRRLPTD HVSGQLQFRF EITSSIHPDD EEISLSTEPE
SAQIQDSPMN NLMESGSGEP RSEAPESSES WKPEQLGEGS VPDGPGNQSI ELSRPAEEAA
VITEAGDQGM VSVGPEGAGE LLAQVQKDIQ PAPSAEELAE QLDLGEEASA LLLEDGEAPA
STKEEPLEEE ATTQSRAGRE EEEKEQEEEG DVSTLEQGEG RLQLRASVKR KSRPCSLPVS
ELETVIASAC GDPETPRTHY IRIHTLLHSM PSAQGGSAAE EEDGAEEEST LKDSSEKDGL
SEVDTVAADP SALEEDREEP EGATPGTAHP GHSGGHFPSL ANGAAQDGDT HPSTGSESDS
SPRQGGDHSC EGCDASCCSP SCYSSSCYST SCYSSSCYSA SCYSPSCYNG NRFASHTRFS
SVDSAKISES TVFSSQDDEE EENSAFESVP DSMQSPELDP ESTNGAGPWQ DELAAPSGHV
ERSPEGLESP VAGPSNRREG ECPILHNSQP VSQLPSLRPE HHHYPTIDEP LPPNWEARID
SHGRVFYVDH VNRTTTWQRP TAAATPDGMR RSGSIQQMEQ LNRRYQNIQR TIATERSEED
SGSQSCEQAP AGGGGGGGSD SEAESSQSSL DLRREGSLSP VNSQKITLLL QSPAVKFITN
PEFFTVLHAN YSAYRVFTSS TCLKHMILKV RRDARNFERY QHNRDLVNFI NMFADTRLEL
PRGWEIKTDQ QGKSFFVDHN SRATTFIDPR IPLQNGRLPN HLTHRQHLQR LRSYSAGEAS
EVSRNRGASL LARPGHSLVA AIRSQHQHES LPLAYNDKIV AFLRQPNIFE MLQERQPSLA
RNHTLREKIH YIRTEGNHGL EKLSCDADLV ILLSLFEEEI MSYVPLQAAF HPGYSFSPRC
SPCSSPQNSP GLQRASARAP SPYRRDFEAK LRNFYRKLEA KGFGQGPGKI KLIIRRDHLL
EGTFNQVMAY SRKELQRNKL YVTFVGEEGL DYSGPSREFF FLLSQELFNP YYGLFEYSAN
DTYTVQISPM SAFVENHLEW FRFSGRILGL ALIHQYLLDA FFTRPFYKAL LRLPCDLSDL
EYLDEEFHQS LQWMKDNNIT DILDLTFTVN EEVFGQVTER ELKSGGANTQ VTEKNKKEYI
ERMVKWRVER GVVQQTEALV RGFYEVVDSR LVSVFDAREL ELVIAGTAEI DLNDWRNNTE
YRGGYHDGHL VIRWFWAAVE RFNNEQRLRL LQFVTGTSSV PYEGFAALRG SNGLRRFCIE
KWGKITSLPR AHTCFNRLDL PPYPSYSMLY EKLLTAVEET STFGLE


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