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E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (IER 2.9/ER2.6) (P135 protein) (RING-type E3 ubiquitin transferase ICP0)

 ICP0_BHV1J              Reviewed;         676 AA.
P29128;
01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
01-DEC-1992, sequence version 1.
30-AUG-2017, entry version 87.
RecName: Full=E3 ubiquitin-protein ligase ICP0;
EC=2.3.2.27;
AltName: Full=IER 2.9/ER2.6;
AltName: Full=P135 protein;
AltName: Full=RING-type E3 ubiquitin transferase ICP0 {ECO:0000305};
Name=BICP0;
Bovine herpesvirus 1.1 (strain Jura) (BoHV-1) (Infectious bovine
rhinotracheitis virus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=31518;
NCBI_TaxID=9913; Bos taurus (Bovine).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1313901;
Wirth U.V., Fraefel C., Vogt B., Vlcek C., Paces V., Schwyzer M.;
"Immediate-early RNA 2.9 and early RNA 2.6 of bovine herpesvirus 1 are
3' coterminal and encode a putative zinc finger transactivator
protein.";
J. Virol. 66:2763-2772(1992).
[2]
FUNCTION IN IMMUNE EVASION.
PubMed=20106921; DOI=10.1128/JVI.02544-09;
Everett R.D., Boutell C., McNair C., Grant L., Orr A.;
"Comparison of the biological and biochemical activities of several
members of the alphaherpesvirus ICP0 family of proteins.";
J. Virol. 84:3476-3487(2010).
-!- FUNCTION: Evades nuclear antiviral defenses triggered by dsDNA
viruses. Acts during the initial stages of lytic infection and the
reactivation of latent viral genome. Prevents the antiviral effect
of nuclear bodies by degrading host PML and SP100.
{ECO:0000269|PubMed:20106921}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine.
-!- INTERACTION:
Q13547:HDAC1 (xeno); NbExp=2; IntAct=EBI-11292028, EBI-301834;
Q92985:IRF7 (xeno); NbExp=5; IntAct=EBI-11292028, EBI-968267;
-!- DOMAIN: The strongly acidic region might serve as a
transcriptional activation domain.
-!- PTM: Auto-ubiquitinated. {ECO:0000250}.
-!- PTM: Transactivation activity is possibly regulated through
phosphorylation by casein kinase II.
-!- SIMILARITY: Belongs to the simplexviruses ICp0 family.
{ECO:0000305}.
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EMBL; M84465; AAA46062.1; -; Genomic_DNA.
EMBL; AJ004801; CAA06138.1; -; Genomic_DNA.
PIR; B38209; EDBE23.
RefSeq; NP_045363.1; NC_001847.1.
ProteinModelPortal; P29128; -.
SMR; P29128; -.
IntAct; P29128; 4.
GeneID; 1487364; -.
KEGG; vg:1487364; -.
GO; GO:0042025; C:host cell nucleus; IMP:AgBase.
GO; GO:0075341; C:host cell PML body; IMP:AgBase.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO; GO:0075342; P:disruption by symbiont of host cell PML body; IDA:UniProtKB.
GO; GO:1990214; P:negative regulation by symbiont of host protein levels; IMP:AgBase.
GO; GO:1990219; P:positive regulation by symbiont of host protein levels; IDA:AgBase.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0046774; P:suppression by virus of host intracellular interferon activity; IMP:AgBase.
GO; GO:0039557; P:suppression by virus of host IRF7 activity; IMP:AgBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR017907; Znf_RING_CS.
Pfam; PF13639; zf-RING_2; 1.
SMART; SM00184; RING; 1.
PROSITE; PS00518; ZF_RING_1; 1.
PROSITE; PS50089; ZF_RING_2; 1.
1: Evidence at protein level;
Activator; DNA-binding; Early protein; Host-virus interaction;
Inhibition of host innate immune response by virus;
Inhibition of host IRF3 by virus;
Inhibition of host mitotic exit by virus;
Inhibition of host RLR pathway by virus; Metal-binding;
Modulation of host cell cycle by virus;
Modulation of host ubiquitin pathway by viral E3 ligase;
Modulation of host ubiquitin pathway by virus; Phosphoprotein;
Repressor; Transcription; Transcription regulation; Transferase;
Ubl conjugation; Ubl conjugation pathway; Viral immunoevasion; Zinc;
Zinc-finger.
CHAIN 1 676 E3 ubiquitin-protein ligase ICP0.
/FTId=PRO_0000056356.
ZN_FING 13 52 RING-type. {ECO:0000255|PROSITE-
ProRule:PRU00175}.
COMPBIAS 104 160 Ala-rich.
COMPBIAS 284 331 Asp/Glu-rich (acidic).
COMPBIAS 462 466 Poly-Arg.
COMPBIAS 522 526 Poly-Ala.
COMPBIAS 529 533 Poly-Ala.
SEQUENCE 676 AA; 67879 MW; 11B06BA4E5C4EB71 CRC64;
MAPPAAAPEL GSCCICLDAI TGAARALPCL HAFCLACIRR WLEGRPTCPL CKAPVQSLIH
SVASDECFEE IPVGGGPGAD GALEPDAAVI WGEDYDAGPI DLTAADGEAS GAGGEAGAAD
GSEAGGGAGG AEEAGEARGA GAGRAAGAAG GRAGRGADAA QEFIDRVARG PRLPLLPNTP
EHGPGAPYLR RVVEWVEGAL VGSFAVTARE LAAMTDYVMA MLAECGFDDD GLADAMEPLI
GEDDAPAFVR SLLFVAARCV TVGPSHLIPQ QSAPPGGRGV VFLDTSDSDS EGSEDDSWSE
SEESSSGLST SDLTAIDDTE TEPETDAEVE SRRTRGASGA ARARRPAERQ YVSTRGRQTP
AVQPAPRSLA RRPCGRAAAV SAPPSSRSRG GRRDPRLPAA PRAAPAAQAR ACSPEPREEG
RGAGLGVAAG ETAGWGAGSE EGRGERRARL LGEAGPPRVQ ARRRRRTELD RAPTPAPAPA
PAPAPISTVI DLTANAPARP ADPAPAAAPG PASAGAQIGT PAAAAAVTAA AAAPSVARSS
APSPAVTAAA TSTAAAISTR APTPSPAGRA PAADPRRAGA PALAGAARAE VGRNGNPGRE
RRPASAMARG DLDPGPESSA QKRRRTEMEV AAWVRESLLG TPRRSSAALA PQPGGRQGPS
LAGLLGRCSG GSAWRQ


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