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E3 ubiquitin-protein ligase Mdm2

 M3XEK9_FELCA            Unreviewed;       491 AA.
M3XEK9;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
25-APR-2018, entry version 45.
RecName: Full=E3 ubiquitin-protein ligase Mdm2 {ECO:0000256|PIRNR:PIRNR006748};
EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR006748};
Name=MDM2 {ECO:0000313|Ensembl:ENSFCAP00000025067};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000025067, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000025067, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025067,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000025067, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025067,
ECO:0000313|Proteomes:UP000011712};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000025067}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000025067};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
[4] {ECO:0000313|Ensembl:ENSFCAP00000028676}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000028676};
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine. {ECO:0000256|PIRNR:PIRNR006748}.
-!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
{ECO:0000256|PIRNR:PIRNR006748}. Cytoplasm
{ECO:0000256|PIRNR:PIRNR006748}. Nucleus, nucleolus
{ECO:0000256|PIRNR:PIRNR006748}.
-!- SIMILARITY: Belongs to the MDM2/MDM4 family.
{ECO:0000256|PIRNR:PIRNR006748}.
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EMBL; AANG03354492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG03354493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG03354494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AANG03354495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_006933941.1; XM_006933879.3.
RefSeq; XP_006933942.1; XM_006933880.3.
RefSeq; XP_006933943.1; XM_006933881.3.
Ensembl; ENSFCAT00000029807; ENSFCAP00000025067; ENSFCAG00000024456.
Ensembl; ENSFCAT00000039184; ENSFCAP00000028676; ENSFCAG00000024456.
GeneID; 493939; -.
CTD; 4193; -.
eggNOG; ENOG410IGXG; Eukaryota.
eggNOG; ENOG41125MP; LUCA.
GeneTree; ENSGT00530000063539; -.
OMA; GELPCKL; -.
OrthoDB; EOG091G0FYK; -.
Proteomes; UP000011712; Chromosome B4.
Bgee; ENSFCAG00000024456; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
GO; GO:0071157; P:negative regulation of cell cycle arrest; IEA:InterPro.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
Gene3D; 1.10.245.10; -; 1.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR028340; Mdm2.
InterPro; IPR015459; MDM2_E3_ligase.
InterPro; IPR016495; p53_neg-reg_MDM_2/4.
InterPro; IPR036885; SWIB_MDM2_dom_sf.
InterPro; IPR003121; SWIB_MDM2_domain.
InterPro; IPR001876; Znf_RanBP2.
InterPro; IPR036443; Znf_RanBP2_sf.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
PANTHER; PTHR13844:SF15; PTHR13844:SF15; 1.
Pfam; PF02201; SWIB; 1.
Pfam; PF00641; zf-RanBP; 1.
PIRSF; PIRSF500700; MDM2; 1.
PIRSF; PIRSF006748; p53_MDM_2/4; 1.
SUPFAM; SSF47592; SSF47592; 2.
SUPFAM; SSF90209; SSF90209; 1.
PROSITE; PS01358; ZF_RANBP2_1; 1.
PROSITE; PS50199; ZF_RANBP2_2; 1.
PROSITE; PS50089; ZF_RING_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Cytoplasm {ECO:0000256|PIRNR:PIRNR006748};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00322,
ECO:0000256|SAAS:SAAS00581830};
Nucleus {ECO:0000256|PIRNR:PIRNR006748};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Transferase {ECO:0000256|PIRNR:PIRNR006748};
Ubl conjugation pathway {ECO:0000256|PIRNR:PIRNR006748};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00322,
ECO:0000256|SAAS:SAAS00581830};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00322,
ECO:0000256|SAAS:SAAS00581830}.
DOMAIN 299 328 RanBP2-type.
{ECO:0000259|PROSITE:PS50199}.
DOMAIN 438 479 RING-type. {ECO:0000259|PROSITE:PS50089}.
SEQUENCE 491 AA; 55405 MW; F42915D638FFB93A CRC64;
MCNTNMSVST DGAVSTSQMP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVIFYLGQY
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQHEPSDSGT
SVSENRCHLE GGSDQKDPVQ ELQEEKPSSS DLVSRPSTSS RRRTISETEE HSDELPGERQ
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYRVTV YQAGESDTDS FEEDPEISLA
DYWKCTSCNE MNPPLPPHCN RCWALRENWL PEDKGKDKGK MPEKAKVENS TQVEEGFDVP
DCKKTTVNDS RESCAEENDD KITQASQSQE SEDYSQPSTS NSIIHSSQED VKEFEREETQ
DKEEIVEPSF PHNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ
PIQMIVLTYF P


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