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E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71)

 LIN41_BOVIN             Reviewed;         868 AA.
E1BJS7; F2Y8T8;
28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
16-NOV-2011, sequence version 2.
20-JUN-2018, entry version 49.
RecName: Full=E3 ubiquitin-protein ligase TRIM71;
EC=2.3.2.27;
AltName: Full=Protein lin-41 homolog;
AltName: Full=RING-type E3 ubiquitin transferase TRIM71 {ECO:0000305};
AltName: Full=Tripartite motif-containing protein 71;
Name=TRIM71; Synonyms=LIN41;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hereford;
PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C.,
Puiu D., Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S.,
Marcais G., Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
"A whole-genome assembly of the domestic cow, Bos taurus.";
Genome Biol. 10:R42.01-R42.10(2009).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 476-725.
PubMed=21315162; DOI=10.1016/j.ympev.2011.02.009;
Zhou X., Xu S., Yang Y., Zhou K., Yang G.;
"Phylogenomic analyses and improved resolution of Cetartiodactyla.";
Mol. Phylogenet. Evol. 61:255-264(2011).
-!- FUNCTION: E3 ubiquitin-protein ligase that cooperates with the
microRNAs (miRNAs) machinery and promotes embryonic stem cells
proliferation and maintenance (By similarity). Binds to miRNAs and
associates with AGO2, participating in post-transcriptional
repression of transcripts such as CDKN1A (By similarity). In
addition, participates in post-transcriptional mRNA repression in
a miRNA independent mechanism (By similarity). Facilitates the G1-
S transition to promote rapid embryonic stem cell self-renewal by
repressing CDKN1A expression. Required to maintain proliferation
and prevent premature differentiation of neural progenitor cells
during early neural development: positively regulates FGF
signaling by controlling the stability of SHCBP1 (By similarity).
Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A
hairpin and postranscriptionally modulates MIR29A levels, which
indirectly regulates TET proteins expression (By similarity).
{ECO:0000250|UniProtKB:Q1PSW8, ECO:0000250|UniProtKB:Q2Q1W2}.
-!- CATALYTIC ACTIVITY: S-ubiquitinyl-[E2 ubiquitin-conjugating
enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-
conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor
protein]-L-lysine.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Interacts (via NHL repeats) with AGO2; the interaction
increases in presence of RNA. Interacts with HSP90AA1. Interacts
(via NHL repeats) with MOV10, PABPC1, PUM1, PUM2, STAU2, XRN1 and
XRN2 in an RNA-dependent manner (By similarity). Interacts with
SHCBP1; leading to enhance its stability (By similarity).
{ECO:0000250|UniProtKB:Q1PSW8, ECO:0000250|UniProtKB:Q2Q1W2}.
-!- SUBCELLULAR LOCATION: Cytoplasm, P-body
{ECO:0000250|UniProtKB:Q2Q1W2}.
-!- DOMAIN: The NHL domain, containing the 6 NHL repeats, is necessary
and sufficient to target RNA but not to repress mRNA. The minimal
region needed to execute repression consists of the coiled coil
domain and the Filamin repeat. The RING-type domain is dispensable
for mRNA repression. {ECO:0000250|UniProtKB:Q2Q1W2}.
-!- PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q1PSW8}.
-!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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EMBL; HQ826939; ADZ53892.1; -; Genomic_DNA.
EMBL; DAAA02053578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
SMR; E1BJS7; -.
STRING; 9913.ENSBTAP00000030842; -.
PaxDb; E1BJS7; -.
PRIDE; E1BJS7; -.
Ensembl; ENSBTAT00000030874; ENSBTAP00000030842; ENSBTAG00000022744.
eggNOG; ENOG410ITG8; Eukaryota.
eggNOG; ENOG410XSQC; LUCA.
GeneTree; ENSGT00920000148978; -.
InParanoid; E1BJS7; -.
OMA; FEGALWK; -.
OrthoDB; EOG091G02WU; -.
TreeFam; TF331018; -.
Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
UniPathway; UPA00143; -.
Proteomes; UP000009136; Chromosome 22.
Bgee; ENSBTAG00000022744; -.
GO; GO:0000932; C:P-body; ISS:UniProtKB.
GO; GO:0035198; F:miRNA binding; ISS:UniProtKB.
GO; GO:0030371; F:translation repressor activity; IEA:Ensembl.
GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
GO; GO:0004842; F:ubiquitin-protein transferase activity; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0035278; P:miRNA mediated inhibition of translation; ISS:UniProtKB.
GO; GO:0010586; P:miRNA metabolic process; ISS:UniProtKB.
GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
GO; GO:0021915; P:neural tube development; ISS:UniProtKB.
GO; GO:2000637; P:positive regulation of gene silencing by miRNA; IEA:Ensembl.
GO; GO:0010608; P:posttranscriptional regulation of gene expression; ISS:UniProtKB.
GO; GO:0035196; P:production of miRNAs involved in gene silencing by miRNA; ISS:UniProtKB.
GO; GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.
GO; GO:0060964; P:regulation of gene silencing by miRNA; ISS:UniProtKB.
GO; GO:2000177; P:regulation of neural precursor cell proliferation; ISS:UniProtKB.
GO; GO:0072089; P:stem cell proliferation; ISS:UniProtKB.
CDD; cd00021; BBOX; 2.
Gene3D; 2.120.10.30; -; 2.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
InterPro; IPR017868; Filamin/ABP280_repeat-like.
InterPro; IPR001298; Filamin/ABP280_rpt.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR001258; NHL_repeat.
InterPro; IPR013017; NHL_repeat_subgr.
InterPro; IPR000315; Znf_B-box.
Pfam; PF00630; Filamin; 1.
Pfam; PF01436; NHL; 6.
Pfam; PF00643; zf-B_box; 1.
SMART; SM00336; BBOX; 2.
SMART; SM00557; IG_FLMN; 1.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS50194; FILAMIN_REPEAT; 1.
PROSITE; PS51125; NHL; 6.
PROSITE; PS50119; ZF_BBOX; 1.
3: Inferred from homology;
Acetylation; Coiled coil; Complete proteome; Cytoplasm;
Developmental protein; Metal-binding; Reference proteome; Repeat;
RNA-binding; RNA-mediated gene silencing; Transferase;
Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q2Q1W2}.
CHAIN 2 868 E3 ubiquitin-protein ligase TRIM71.
/FTId=PRO_0000420478.
REPEAT 479 580 Filamin.
REPEAT 593 636 NHL 1.
REPEAT 640 683 NHL 2.
REPEAT 687 730 NHL 3.
REPEAT 734 777 NHL 4.
REPEAT 781 824 NHL 5.
REPEAT 828 868 NHL 6.
ZN_FING 12 89 RING-type.
ZN_FING 191 238 B box-type 1; atypical.
{ECO:0000255|PROSITE-ProRule:PRU00024}.
ZN_FING 273 314 B box-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00024}.
COILED 391 427 {ECO:0000255}.
COMPBIAS 26 42 Ser-rich.
COMPBIAS 140 152 His-rich.
COMPBIAS 160 185 Pro-rich.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:Q2Q1W2}.
SEQUENCE 868 AA; 93192 MW; 35F1D2723A19F4DE CRC64;
MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSGGGGGGPG AAARRLHVLP
CLAFCRPCLE AHRGGAPGEP LKLRCPVCDQ KVVLAEAAGM DARPSSAFLL SNLLDAVVAT
ADEPPPKNGR AGAAAGAGGH GSNHRHHAHH AHPRAAASAP PPPLPPAPPP PAPPRSAPGG
PAGSPSALLL RRPHGCSSCD EGNAASSRCL DCQEHLCDNC VRAHQRVRLT KDHYIERGPP
GPAAAAAAAA AQQLGLGPPF PGAPFSLLSV FPERLGFCQH HDDEVLHLYC DTCSVPICRE
CTVGRHGGHS FVYLQEALQD SRALTIQLLA DAQQGRQAIQ LSIEQAQTVA EQVEMKAKVV
QSEVKAVTAR HKKALEEREC ELLWKVEKIR QVKAKSLYLQ VEKLRQNLNK LESTISAVQQ
VLEEGRALDI LLARDRMLAQ VQELKTVRSL LQPQEDDRVM FTPPDQALYL AIKSFGFVSS
GAFAPLTKAT GDGLKRALQG KVASFTVIGY DHDGEPRLSG GDLMSAVVLG PDGNLFGAEV
SDQQNGTYVV SYRPQLEGEH LVSVTLCNQH IENSPFKVVV KSGRSYVGIG LPGLSFGSEG
DSDGKLCRPW GVSVDKEGYI VVADRSNNRI QVFKPCGAFH HKFGTLGSRP GQFDRPAGVA
CDASRRIVVA DKDNHRIQIF TFEGQFLLKF GEKGTKNGQF NYPWDVAVNS EGKILVSDTR
NHRIQLFGPD GVFLNKYGFE GALWKHFDSP RGVAFNHEGH LVVTDFNNHR LLVIHPDCQS
ARFLGSEGTG NGQFLRPQGV AVDQEGRIIV ADSRNHRVQM FESNGSFLCK FGAQGSGFGQ
MDRPSGIAVT PDGMIVVVDF GNNRILIF


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