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ELAV-like protein 3 (Hu-antigen C) (HuC) (Paraneoplastic cerebellar degeneration-associated antigen) (Paraneoplastic limbic encephalitis antigen 21)

 ELAV3_HUMAN             Reviewed;         367 AA.
Q14576; Q16135; Q96CL8; Q96QS9;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
27-MAY-2002, sequence version 3.
12-SEP-2018, entry version 158.
RecName: Full=ELAV-like protein 3;
AltName: Full=Hu-antigen C;
Short=HuC;
AltName: Full=Paraneoplastic cerebellar degeneration-associated antigen;
AltName: Full=Paraneoplastic limbic encephalitis antigen 21;
Name=ELAVL3; Synonyms=HUC, PLE21;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
TISSUE=Brain;
Manley T., Furneaux H.M.;
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Zhang B., Yuan J.G., Qiang B.Q.;
"Isolation of HuC cDNA.";
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
TISSUE=Brain;
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [MRNA] OF 9-367 (ISOFORM 2).
TISSUE=Hippocampus;
PubMed=7511893; DOI=10.1006/bbrc.1994.1358;
Sakai K., Gofuku M., Kitagawa Y., Ogasawara T., Hirose G.,
Yamazaki M., Koh C.S., Yanagisawa N., Steinman L.;
"A hippocampal protein associated with paraneoplastic neurologic
syndrome and small cell lung carcinoma.";
Biochem. Biophys. Res. Commun. 199:1200-1208(1994).
[6]
FUNCTION.
PubMed=10710437; DOI=10.1093/nar/28.7.e20;
King P.H.;
"RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3'-
untranslated regions using a novel ELISA-based assay.";
Nucleic Acids Res. 28:E20-E20(2000).
-!- FUNCTION: Binds to AU-rich sequences (AREs) of target mRNAs,
including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By
similarity). May be involved in neuronal differentiation and
maintenance. {ECO:0000250, ECO:0000269|PubMed:10710437}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q14576-1; Sequence=Displayed;
Name=2;
IsoId=Q14576-2; Sequence=VSP_005789;
-!- TISSUE SPECIFICITY: Brain specific.
-!- DOMAIN: RRM 1 and RRM 2 bind cooperatively to AU-rich sequences in
target mRNAs. RRM 3 binds to poly-A mRNA sequences (By
similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the RRM elav family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L26405; AAA58677.1; -; mRNA.
EMBL; AY036909; AAK67714.1; -; mRNA.
EMBL; AC008481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC014144; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; D26158; BAA21838.1; -; mRNA.
CCDS; CCDS32912.1; -. [Q14576-1]
CCDS; CCDS45978.1; -. [Q14576-2]
RefSeq; NP_001411.2; NM_001420.3. [Q14576-1]
RefSeq; NP_115657.2; NM_032281.2. [Q14576-2]
UniGene; Hs.1701; -.
ProteinModelPortal; Q14576; -.
SMR; Q14576; -.
BioGrid; 108310; 11.
IntAct; Q14576; 7.
STRING; 9606.ENSP00000352162; -.
iPTMnet; Q14576; -.
PhosphoSitePlus; Q14576; -.
BioMuta; ELAVL3; -.
DMDM; 21264436; -.
EPD; Q14576; -.
MaxQB; Q14576; -.
PaxDb; Q14576; -.
PeptideAtlas; Q14576; -.
PRIDE; Q14576; -.
ProteomicsDB; 60054; -.
ProteomicsDB; 60055; -. [Q14576-2]
Ensembl; ENST00000359227; ENSP00000352162; ENSG00000196361. [Q14576-1]
Ensembl; ENST00000438662; ENSP00000390878; ENSG00000196361. [Q14576-2]
GeneID; 1995; -.
KEGG; hsa:1995; -.
UCSC; uc002mrx.2; human. [Q14576-1]
CTD; 1995; -.
DisGeNET; 1995; -.
EuPathDB; HostDB:ENSG00000196361.9; -.
GeneCards; ELAVL3; -.
HGNC; HGNC:3314; ELAVL3.
HPA; CAB013066; -.
MIM; 603458; gene.
neXtProt; NX_Q14576; -.
OpenTargets; ENSG00000196361; -.
PharmGKB; PA27742; -.
eggNOG; KOG0145; Eukaryota.
eggNOG; ENOG410XP7S; LUCA.
GeneTree; ENSGT00760000118913; -.
HOGENOM; HOG000231162; -.
HOVERGEN; HBG002295; -.
InParanoid; Q14576; -.
KO; K13208; -.
OMA; YGVKSSP; -.
OrthoDB; EOG091G0G9L; -.
PhylomeDB; Q14576; -.
TreeFam; TF313377; -.
ChiTaRS; ELAVL3; human.
GeneWiki; ELAVL3; -.
GenomeRNAi; 1995; -.
PRO; PR:Q14576; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000196361; Expressed in 221 organ(s), highest expression level in cerebral cortex.
CleanEx; HS_ELAVL3; -.
ExpressionAtlas; Q14576; baseline and differential.
Genevisible; Q14576; HS.
GO; GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
CDD; cd12650; RRM1_Hu; 1.
CDD; cd12655; RRM3_HuC; 1.
Gene3D; 3.30.70.330; -; 3.
InterPro; IPR006548; ELAD_HU_SF.
InterPro; IPR034775; ELAV/Hu_RRM1.
InterPro; IPR034915; HuC_RRM3.
InterPro; IPR002343; Hud_Sxl_RNA.
InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
InterPro; IPR035979; RBD_domain_sf.
InterPro; IPR000504; RRM_dom.
InterPro; IPR003954; RRM_dom_euk.
Pfam; PF00076; RRM_1; 3.
PRINTS; PR00961; HUDSXLRNA.
SMART; SM00360; RRM; 3.
SMART; SM00361; RRM_1; 2.
SUPFAM; SSF54928; SSF54928; 3.
TIGRFAMs; TIGR01661; ELAV_HUD_SF; 1.
PROSITE; PS50102; RRM; 3.
2: Evidence at transcript level;
Alternative splicing; Complete proteome; Developmental protein;
Differentiation; Neurogenesis; Reference proteome; Repeat;
RNA-binding.
CHAIN 1 367 ELAV-like protein 3.
/FTId=PRO_0000081581.
DOMAIN 39 117 RRM 1. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 125 205 RRM 2. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 284 362 RRM 3. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
VAR_SEQ 251 257 Missing (in isoform 2).
{ECO:0000303|PubMed:7511893,
ECO:0000303|Ref.1, ECO:0000303|Ref.2}.
/FTId=VSP_005789.
CONFLICT 20 25 PALPNG -> RPAQR (in Ref. 4; BAA21838).
{ECO:0000305}.
CONFLICT 78 79 QS -> RD (in Ref. 1; AAA58677 and 2;
AAK67714). {ECO:0000305}.
CONFLICT 88 88 S -> P (in Ref. 1; AAA58677 and 2;
AAK67714). {ECO:0000305}.
CONFLICT 195 195 A -> R (in Ref. 4; BAA21838).
{ECO:0000305}.
CONFLICT 248 248 G -> A (in Ref. 4; BAA21838).
{ECO:0000305}.
CONFLICT 282 282 Missing (in Ref. 1; AAA58677 and 4;
BAA21838). {ECO:0000305}.
CONFLICT 295 297 ADE -> PDQ (in Ref. 4; BAA21838).
{ECO:0000305}.
CONFLICT 330 330 V -> M (in Ref. 4; BAA21838).
{ECO:0000305}.
CONFLICT 351 351 G -> A (in Ref. 1; AAA58677).
{ECO:0000305}.
CONFLICT 352 352 E -> Q (in Ref. 4; BAA21838).
{ECO:0000305}.
SEQUENCE 367 AA; 39547 MW; 03FB3BD4D112B326 CRC64;
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILVDQ VTGVSRGVGF IRFDKRIEAE
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK
TSKQHKA


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