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ELH [Cleaved into: Beta-bag cell peptide (Beta-BCP); Gamma-delta-bag cell peptide; Gamma-bag cell peptide (Gamma-BCP); Delta-bag cell peptide; Delta-bag cell peptide(1-36); Alpha-bag cell peptide (Alpha-BCP); Alpha-bag cell peptide(1-8); Alpha-bag cell peptide(1-7); Epsilon-bag cell peptide; Epsilon-bag cell peptide(4-19); Egg-laying hormone (ELH); Egg-laying hormone(1-29); Egg-laying hormone(1-14); Egg-laying hormone(15-36); Egg-laying hormone(30-36); Acidic peptide; Acidic peptide(1-20); Acidic peptide(7-27); Acidic peptide(8-27); Acidic peptide(9-27); Acidic peptide(9-26); Acidic peptide(9-20)]

 ELH1_APLCA              Reviewed;         271 AA.
P01362; Q24868; Q99261; Q99264; Q99265; Q99266; Q99267;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 2.
10-MAY-2017, entry version 68.
RecName: Full=ELH;
Contains:
RecName: Full=Beta-bag cell peptide;
Short=Beta-BCP;
Contains:
RecName: Full=Gamma-delta-bag cell peptide;
Contains:
RecName: Full=Gamma-bag cell peptide;
Short=Gamma-BCP;
Contains:
RecName: Full=Delta-bag cell peptide;
Contains:
RecName: Full=Delta-bag cell peptide(1-36);
Contains:
RecName: Full=Alpha-bag cell peptide;
Short=Alpha-BCP;
Contains:
RecName: Full=Alpha-bag cell peptide(1-8);
Contains:
RecName: Full=Alpha-bag cell peptide(1-7);
Contains:
RecName: Full=Epsilon-bag cell peptide;
Contains:
RecName: Full=Epsilon-bag cell peptide(4-19);
Contains:
RecName: Full=Egg-laying hormone;
Short=ELH;
Contains:
RecName: Full=Egg-laying hormone(1-29);
Contains:
RecName: Full=Egg-laying hormone(1-14);
Contains:
RecName: Full=Egg-laying hormone(15-36);
Contains:
RecName: Full=Egg-laying hormone(30-36);
Contains:
RecName: Full=Acidic peptide;
Contains:
RecName: Full=Acidic peptide(1-20);
Contains:
RecName: Full=Acidic peptide(7-27);
Contains:
RecName: Full=Acidic peptide(8-27);
Contains:
RecName: Full=Acidic peptide(9-27);
Contains:
RecName: Full=Acidic peptide(9-26);
Contains:
RecName: Full=Acidic peptide(9-20);
Flags: Precursor;
Aplysia californica (California sea hare).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Heterobranchia; Euthyneura; Euopisthobranchia; Aplysiomorpha;
Aplysioidea; Aplysiidae; Aplysia.
NCBI_TaxID=6500;
[1]
NUCLEOTIDE SEQUENCE (ISOFORM 1).
PubMed=6687446; DOI=10.1016/0092-8674(83)90492-0;
Scheller R.H., Jackson J.F., McAllister L.B., Rothman B.S., Mayeri E.,
Axel R.;
"A single gene encodes multiple neuropeptides mediating a stereotyped
behavior.";
Cell 32:7-22(1983).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), AND
VARIANTS MET-26; ALA-43; TYR-62; GLU-63; GLN-64; LEU-75; ILE-119;
GLU-140; ALA-143; GLU-165 AND PRO-236.
TISSUE=Abdominal ganglion, and Atrial gland;
PubMed=4020422;
Mahon A.C., Nambu J.R., Taussig R., Shyamala M., Roach A.,
Scheller R.H.;
"Structure and expression of the egg-laying hormone gene family in
Aplysia.";
J. Neurosci. 5:1872-1880(1985).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Ring ganglion;
PubMed=3708345; DOI=10.1016/0006-8993(86)90809-7;
Shyamala M., Nambu J.R., Scheller R.H.;
"Expression of the egg-laying hormone gene family in the head ganglia
of Aplysia.";
Brain Res. 371:49-57(1986).
[4]
PROTEIN SEQUENCE OF 150-158.
PubMed=16593372; DOI=10.1073/pnas.80.18.5753;
Rothman B.S., Mayeri E., Brown R.O., Yuan P.-M., Shively J.E.;
"Primary structure and neuronal effects of alpha-bag cell peptide, a
second candidate neurotransmitter encoded by a single gene in bag cell
neurons of Aplysia.";
Proc. Natl. Acad. Sci. U.S.A. 80:5753-5757(1983).
[5]
PROTEIN SEQUENCE OF 206-241.
TISSUE=Bag cell;
PubMed=293751; DOI=10.1073/pnas.76.12.6656;
Chiu A.Y., Hunkapiller M.W., Heller E., Stuart D.K., Hood L.E.,
Strumwasser F.;
"Purification and primary structure of the neuropeptide egg-laying
hormone of Aplysia californica.";
Proc. Natl. Acad. Sci. U.S.A. 76:6656-6660(1979).
[6]
PROTEOLYTIC PROCESSING.
PubMed=3549995;
Newcomb R., Scheller R.H.;
"Proteolytic processing of the Aplysia egg-laying hormone and R3-14
neuropeptide precursors.";
J. Neurosci. 7:854-863(1987).
[7]
PROTEOLYTIC PROCESSING, AMIDATION AT LYS-241, AND MASS SPECTROMETRY.
PubMed=9520477; DOI=10.1073/pnas.95.7.3972;
Garden R.W., Shippy S.A., Li L., Moroz T.P., Sweedler J.V.;
"Proteolytic processing of the Aplysia egg-laying hormone
prohormone.";
Proc. Natl. Acad. Sci. U.S.A. 95:3972-3977(1998).
-!- FUNCTION: ELH acts as a neurotransmitter locally, upon neurons of
the abdominal ganglion and as a hormone by diffusing into the
circulating hemolymph and modulating the activity of other organs.
It specifically causes contraction of smooth muscle in the
ovotestis and expulsion of the egg string.
-!- FUNCTION: Alpha-BCP decreases the activity of a cluster of neurons
in the left upper quadrant of the abdominal ganglion.
-!- FUNCTION: Beta-BCP specifically excites 2 neurons, L1 and R1, in
the abdominal ganglion.
-!- SUBCELLULAR LOCATION: Secreted.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P01362-1; Sequence=Displayed;
Name=2;
IsoId=P01362-2; Sequence=VSP_025432, VSP_025433;
-!- TISSUE SPECIFICITY: Bag cell neurons.
-!- MASS SPECTROMETRY: Mass=7346.17; Method=MALDI; Range=29-95;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=728.39; Method=MALDI; Range=96-100;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=706.36; Method=MALDI; Range=103-107;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=5410.11; Method=MALDI; Range=103-148;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=4024.98; Method=MALDI; Range=110-145;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=4409.16; Method=MALDI; Range=110-148;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=922.51; Method=MALDI; Range=150-156;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=1009.55; Method=MALDI; Range=150-157;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=1122.64; Method=MALDI; Range=150-158;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=1862.75; Method=MALDI; Range=185-203;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=1563.81; Method=MALDI; Range=188-203;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=1574.86; Method=MALDI; Range=206-219;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=3461.0; Method=MALDI; Range=206-234;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2826.64; Method=MALDI; Range=220-241;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=941.51; Method=MALDI; Range=235-241;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2304.20; Method=MALDI; Range=245-265;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2961.31; Method=MALDI; Range=245-271;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=1559.80; Method=MALDI; Range=253-265;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2100.14; Method=MALDI; Range=253-270;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2215.20; Method=MALDI; Range=253-271;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2316.24; Method=MALDI; Range=252-271;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=2429.32; Method=MALDI; Range=251-271;
Evidence={ECO:0000269|PubMed:9520477};
-!- MASS SPECTROMETRY: Mass=4385.15; Method=MALDI; Range=206-241;
Evidence={ECO:0000269|PubMed:9520477};
-!- SIMILARITY: Belongs to the molluscan ELH family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; M29345; AAA27747.1; -; Genomic_DNA.
EMBL; M29347; AAA27748.1; -; mRNA.
EMBL; M29346; AAA27749.1; -; mRNA.
EMBL; M29348; AAA62575.1; -; mRNA.
EMBL; M29349; AAA62576.1; -; mRNA.
EMBL; M25886; AAA62580.1; -; mRNA.
PIR; A90833; ONGAPA.
RefSeq; NP_001191670.1; NM_001204741.1.
UniGene; Acl.5072; -.
SMR; P01362; -.
GeneID; 100533533; -.
CTD; 100533533; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR003424; ELH.
Pfam; PF02323; ELH; 1.
1: Evidence at protein level;
Alternative splicing; Amidation; Cleavage on pair of basic residues;
Direct protein sequencing; Hormone; Neuropeptide; Secreted; Signal.
SIGNAL 1 28
PROPEP 29 95
/FTId=PRO_0000001813.
PEPTIDE 96 100 Beta-bag cell peptide.
/FTId=PRO_0000001814.
PEPTIDE 103 148 Gamma-delta-bag cell peptide.
/FTId=PRO_0000287290.
PEPTIDE 103 107 Gamma-bag cell peptide.
/FTId=PRO_0000001815.
PEPTIDE 110 148 Delta-bag cell peptide.
/FTId=PRO_0000001816.
PEPTIDE 110 145 Delta-bag cell peptide(1-36).
/FTId=PRO_0000287291.
PEPTIDE 150 158 Alpha-bag cell peptide.
/FTId=PRO_0000001817.
PEPTIDE 150 157 Alpha-bag cell peptide(1-8).
/FTId=PRO_0000287292.
PEPTIDE 150 156 Alpha-bag cell peptide(1-7).
/FTId=PRO_0000287293.
PROPEP 162 184
/FTId=PRO_0000001818.
PEPTIDE 185 203 Epsilon-bag cell peptide.
/FTId=PRO_0000287294.
PEPTIDE 188 203 Epsilon-bag cell peptide(4-19).
/FTId=PRO_0000287295.
PEPTIDE 206 241 Egg-laying hormone.
/FTId=PRO_0000001819.
PEPTIDE 206 234 Egg-laying hormone(1-29).
/FTId=PRO_0000287296.
PEPTIDE 206 219 Egg-laying hormone(1-14).
/FTId=PRO_0000287297.
PEPTIDE 220 241 Egg-laying hormone(15-36).
/FTId=PRO_0000287298.
PEPTIDE 235 241 Egg-laying hormone(30-36).
/FTId=PRO_0000287299.
PEPTIDE 245 271 Acidic peptide.
/FTId=PRO_0000001820.
PEPTIDE 245 265 Acidic peptide(1-20).
/FTId=PRO_0000287300.
PEPTIDE 251 271 Acidic peptide(7-27).
/FTId=PRO_0000287301.
PEPTIDE 252 271 Acidic peptide(8-27).
/FTId=PRO_0000287302.
PEPTIDE 253 271 Acidic peptide(9-27).
/FTId=PRO_0000287303.
PEPTIDE 253 270 Acidic peptide(9-26).
/FTId=PRO_0000287304.
PEPTIDE 253 265 Acidic peptide(9-20).
/FTId=PRO_0000287305.
MOD_RES 241 241 Lysine amide.
{ECO:0000269|PubMed:9520477}.
VAR_SEQ 23 83 Missing (in isoform 2).
{ECO:0000303|PubMed:4020422}.
/FTId=VSP_025432.
VAR_SEQ 84 84 D -> H (in isoform 2).
{ECO:0000303|PubMed:4020422}.
/FTId=VSP_025433.
VARIANT 26 26 S -> M. {ECO:0000269|PubMed:4020422}.
VARIANT 43 43 V -> A. {ECO:0000269|PubMed:4020422}.
VARIANT 62 62 S -> Y. {ECO:0000269|PubMed:4020422}.
VARIANT 63 63 G -> E. {ECO:0000269|PubMed:4020422}.
VARIANT 64 64 E -> Q. {ECO:0000269|PubMed:4020422}.
VARIANT 75 75 F -> L. {ECO:0000269|PubMed:4020422}.
VARIANT 119 119 F -> I. {ECO:0000269|PubMed:4020422}.
VARIANT 140 140 D -> E. {ECO:0000269|PubMed:4020422}.
VARIANT 143 143 V -> A. {ECO:0000269|PubMed:4020422}.
VARIANT 165 165 G -> E. {ECO:0000269|PubMed:4020422}.
VARIANT 236 236 Q -> P. {ECO:0000269|PubMed:4020422}.
CONFLICT 3 3 R -> C (in Ref. 3; AAA62580).
{ECO:0000305}.
SEQUENCE 271 AA; 30827 MW; FB2F1EBE3B9113A6 CRC64;
MKRPNNRPTN TMSLILCLTL SSLCVSSQSA SVHGKNFATN RAVKSSSPFV VLSPDDNVVS
MSGENGYRSA LREAFDKSSR DYDDNGEDVF SNEKRRLRFH KRRLRFDRRD QDEGNFRRFP
TNAVSMSADE NSPFDLSNED GAVYQRDLRA PRLRFYSLRK RAAGGMEQSE GQNPETESHS
RRKRSVLTPS LSSLGESLES GISKRISINQ DLKAITDMLL TEQIRERQRY LADLRQRLLE
KGKRSSGVSL LTSNKDEEQR ELLKAISNLL D


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