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ELH type 1 [Cleaved into: Alpha-bag cell peptide (Alpha-BCP); Beta-bag cell peptide (Beta-BCP); Gamma-bag cell peptide (Gamma-BCP); Egg-laying hormone (ELH); Acidic peptide]

 ELH1_APLPA              Reviewed;         263 AA.
P17685;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
10-MAY-2017, entry version 55.
RecName: Full=ELH type 1;
Contains:
RecName: Full=Alpha-bag cell peptide;
Short=Alpha-BCP;
Contains:
RecName: Full=Beta-bag cell peptide;
Short=Beta-BCP;
Contains:
RecName: Full=Gamma-bag cell peptide;
Short=Gamma-BCP;
Contains:
RecName: Full=Egg-laying hormone;
Short=ELH;
Contains:
RecName: Full=Acidic peptide;
Flags: Precursor;
Name=ELH1;
Aplysia parvula (Little sea hare).
Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
Heterobranchia; Euthyneura; Euopisthobranchia; Aplysiomorpha;
Aplysioidea; Aplysiidae; Aplysia.
NCBI_TaxID=6503;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3734873;
Nambu J.R., Scheller R.H.;
"Egg-laying hormone genes of Aplysia: evolution of the ELH gene
family.";
J. Neurosci. 6:2026-2036(1986).
-!- FUNCTION: ELH acts as a neurotransmitter locally, upon neurons of
the abdominal ganglion and as a hormone by diffusing into the
circulating hemolymph and modulating the activity of other organs.
It specifically causes contraction of smooth muscle in the
ovotestis and expulsion of the egg string.
-!- FUNCTION: Alpha-BCP decreases the activity of a cluster of neurons
in the left upper quadrant of the abdominal ganglion.
-!- FUNCTION: Beta-BCP specifically excites 2 neurons, L1 and R1, in
the abdominal ganglion.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Bag cell neurons.
-!- SIMILARITY: Belongs to the molluscan ELH family. {ECO:0000305}.
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EMBL; M30048; AAA27765.1; -; Genomic_DNA.
PIR; A26147; A26147.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
GO; GO:0007275; P:multicellular organism development; IEA:InterPro.
GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR003424; ELH.
Pfam; PF02323; ELH; 1.
2: Evidence at transcript level;
Amidation; Cleavage on pair of basic residues; Hormone; Neuropeptide;
Secreted; Signal.
SIGNAL 1 29 {ECO:0000250}.
PROPEP 30 85 {ECO:0000250}.
/FTId=PRO_0000001821.
PEPTIDE 88 92 Beta-bag cell peptide.
/FTId=PRO_0000001822.
PEPTIDE 95 99 Gamma-bag cell peptide.
/FTId=PRO_0000001823.
PROPEP 102 140 {ECO:0000250}.
/FTId=PRO_0000001824.
PEPTIDE 142 150 Alpha-bag cell peptide.
/FTId=PRO_0000001825.
PROPEP 154 195 {ECO:0000250}.
/FTId=PRO_0000001826.
PEPTIDE 198 233 Egg-laying hormone.
/FTId=PRO_0000001827.
PEPTIDE 237 263 Acidic peptide.
/FTId=PRO_0000001828.
MOD_RES 233 233 Lysine amide. {ECO:0000250}.
SEQUENCE 263 AA; 29676 MW; E0C69F9E3E5FFF29 CRC64;
MGRPSYRSAA AISLLMCLIL SALCASSESA VVHGSSFATE RAVKSSPYLV LSPADEMVGM
STANEAFDKS PSYYDDDDDD FVKNEKRRLR FHKRRIRFNK RPQEVSGLKP VMMSRASASA
DENSLFDLYN TDGAMYQRDL RAPRLRFYSL RKRAAGDEDK SEENNPETES HSRRKRSALT
PSIRSLRSSL ESGIAKRISI NQDLKAIADM LIVEQKQERE KYLADLRQRL LNKGKRSSEV
ALAASDKGDE ERELLNTLSN LLE


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