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EPH receptor B3

 H0XNQ5_OTOGA            Unreviewed;      1004 AA.
H0XNQ5;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
18-JUL-2018, entry version 53.
SubName: Full=EPH receptor B3 {ECO:0000313|Ensembl:ENSOGAP00000017746};
Name=EPHB3 {ECO:0000313|Ensembl:ENSOGAP00000017746};
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini;
Lorisiformes; Galagidae; Otolemur.
NCBI_TaxID=30611 {ECO:0000313|Ensembl:ENSOGAP00000017746, ECO:0000313|Proteomes:UP000005225};
[1] {ECO:0000313|Ensembl:ENSOGAP00000017746}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
The Broad Institute Genome Sequencing Platform;
Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K., Jaffe D.B.,
Gnerre S., MacCallum I., Przybylski D., Ribeiro F.J., Burton J.N.,
Walker B.J., Sharpe T., Hall G.;
"Version 3 of the genome sequence of Otolemur garnettii (Bushbaby).";
Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSOGAP00000017746}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a
[protein]-L-tyrosine phosphate. {ECO:0000256|SAAS:SAAS00701269}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
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EMBL; AAQR03181458; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003802920.1; XM_003802872.2.
STRING; 30611.ENSOGAP00000017746; -.
Ensembl; ENSOGAT00000033819; ENSOGAP00000017746; ENSOGAG00000032936.
GeneID; 100948490; -.
CTD; 2049; -.
eggNOG; KOG0196; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00760000118975; -.
InParanoid; H0XNQ5; -.
OMA; ELAWTAH; -.
OrthoDB; EOG091G00W0; -.
TreeFam; TF315608; -.
Proteomes; UP000005225; Unassembled WGS sequence.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008046; F:axon guidance receptor activity; IEA:Ensembl.
GO; GO:0005003; F:ephrin receptor activity; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0007413; P:axonal fasciculation; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0021952; P:central nervous system projection neuron axonogenesis; IEA:Ensembl.
GO; GO:0022038; P:corpus callosum development; IEA:Ensembl.
GO; GO:0060997; P:dendritic spine morphogenesis; IEA:Ensembl.
GO; GO:0048546; P:digestive tract morphogenesis; IEA:Ensembl.
GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
GO; GO:0022407; P:regulation of cell-cell adhesion; IEA:Ensembl.
GO; GO:0043087; P:regulation of GTPase activity; IEA:Ensembl.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IEA:Ensembl.
GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd10478; EphR_LBD_B3; 1.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.120.260; -; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR027936; Eph_TM.
InterPro; IPR034245; EphB3_rcpt_lig-bd.
InterPro; IPR001090; Ephrin_rcpt_lig-bd_dom.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR008979; Galactose-bd-like_sf.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001660; SAM.
InterPro; IPR013761; SAM/pointed_sf.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016257; Tyr_kinase_ephrin_rcpt.
InterPro; IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam; PF14575; EphA2_TM; 1.
Pfam; PF01404; Ephrin_lbd; 1.
Pfam; PF07699; Ephrin_rec_like; 1.
Pfam; PF00041; fn3; 2.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00536; SAM_1; 1.
PIRSF; PIRSF000666; TyrPK_ephrin_receptor; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00615; EPH_lbd; 1.
SMART; SM01411; Ephrin_rec_like; 1.
SMART; SM00060; FN3; 2.
SMART; SM00454; SAM; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF47769; SSF47769; 1.
SUPFAM; SSF49265; SSF49265; 1.
SUPFAM; SSF49785; SSF49785; 1.
SUPFAM; SSF56112; SSF56112; 1.
SUPFAM; SSF57184; SSF57184; 2.
PROSITE; PS51550; EPH_LBD; 1.
PROSITE; PS50853; FN3; 2.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PROSITE; PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PROSITE; PS50105; SAM_DOMAIN; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRSR:PIRSR000666-2,
ECO:0000256|SAAS:SAAS00708816};
Complete proteome {ECO:0000313|Proteomes:UP000005225};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000666-2,
ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000005225};
Repeat {ECO:0000256|SAAS:SAAS01054641};
Signal {ECO:0000256|SAM:SignalP};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
SIGNAL 1 40 {ECO:0000256|SAM:SignalP}.
CHAIN 41 1004 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003545927.
TRANSMEM 565 588 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 42 220 Eph LBD. {ECO:0000259|PROSITE:PS51550}.
DOMAIN 342 457 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 458 551 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 639 902 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DOMAIN 931 995 SAM. {ECO:0000259|PROSITE:PS50105}.
NP_BIND 645 653 ATP. {ECO:0000256|PIRSR:PIRSR000666-2}.
ACT_SITE 764 764 Proton acceptor.
{ECO:0000256|PIRSR:PIRSR000666-1}.
BINDING 671 671 ATP. {ECO:0000256|PIRSR:PIRSR000666-2}.
SEQUENCE 1004 AA; 110968 MW; 91405E365B1E50E6 CRC64;
MARARPPPPP PPPGLLPLLP PLLLPPLLLL PLLLPIGCRA LEETLMDTKW VTSELAWTAH
PESGWEEVSG YDEAMNPIRT YQVCNVRESS QNNWLRTGFI WRRDVQRVYV ELKFTVRDCN
SIPNIPGSCK ETFNLFYYEA DSDVASASSP FWMENPYVKV DTIAPDESFS RLDAGRVNTK
VRSFGPLSKA GFYLAFQDQG ACMSLISVRA FYKKCASTTA GFALFPETLT GAEPTSLVIA
PGTCIPNAVE VSVPLKLYCN GDGEWMVPVG ACTCATGHEP AAKESQCRPC PPGSYKAKQG
EGPCLPCPPN SRTTSPAASI CTCHNNFYRA DSDSADSACT TVPSPPRGVI SNVNETSLIL
EWSEPRDLGG RDDLLYNVIC KKCHGGPGAG GPSTCSRCDD NVEFVPRQLG LTERRVHISH
LLAHTRYTFE VQAVNGVSGK SPLPPRYAAV NITTNQAAPS EVPTLRLHSS SGSSLTLSWA
PPERPNGVIL DYEMKYFEKS EGIASTVTSQ KNSVQLDGLR PDARYVVQVR ARTVAGYGQY
SRPAEFETTS ERGSGAQQLQ EQLPLIVGSA TAGLVFVVAI VVIAIVCLRK QRHGSDSEYT
EKLQQYIAPG MKVYIDPFTY EDPNEAVREF AKEIDVSCVK IEEVIGAGEF GEVCRGRLKQ
PGRREVFVAI KTLKVGYTER QRRDFLSEAS IMGQFDHPNI IRLEGVVTKS RPVMILTEFM
ENCALDSFLR LNDGQFTVIQ LVGMLRGIAA GMKYLSEMNY VHRDLAARNI LVNSNLVCKV
SDFGLSRFLE DDPSDPTYTS SLGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY
GERPYWDMSN QDVINAVEQD YRLPPPMDCP TALHQLMLDC WVRDRNLRPK FSQIVNTLDK
LIRNAASLKV IASAQSGMSQ PLLDRTVPDY TTFTTVGDWL DAIKMGRYKE SFVSAGFASF
DLVAQMTAED LLRIGVTLAG HQKKILSSIQ DMRLQMNQTL PVQV


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