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ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)

 ELK4_MOUSE              Reviewed;         430 AA.
P41158; A6H693;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
28-MAR-2018, entry version 132.
RecName: Full=ETS domain-containing protein Elk-4;
AltName: Full=Serum response factor accessory protein 1;
Short=SAP-1;
Short=SRF accessory protein 1;
Name=Elk4; Synonyms=Sap1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
PubMed=7958835; DOI=10.1101/gad.8.13.1502;
Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.;
"Net, a new ets transcription factor that is activated by Ras.";
Genes Dev. 8:1502-1513(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Involved in both transcriptional activation and
repression. Interaction with SIRT7 leads to recruitment and
stabilization of SIRT7 at promoters, followed by deacetylation of
histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription
repression. Forms a ternary complex with the serum response factor
(SRF). Requires DNA-bound SRF for ternary complex formation and
makes extensive DNA contacts to the 5'side of SRF, but does not
bind DNA autonomously (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with SIRT7. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Lung and liver.
-!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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EMBL; Z36885; CAA85358.1; -; mRNA.
EMBL; CH466520; EDL39692.1; -; Genomic_DNA.
EMBL; BC144844; AAI44845.1; -; mRNA.
EMBL; BC145795; AAI45796.1; -; mRNA.
CCDS; CCDS35704.1; -.
PIR; I48755; I48755.
RefSeq; NP_031949.2; NM_007923.2.
RefSeq; XP_006529189.1; XM_006529126.3.
RefSeq; XP_006529190.1; XM_006529127.3.
RefSeq; XP_006529191.1; XM_006529128.3.
RefSeq; XP_006529192.1; XM_006529129.3.
RefSeq; XP_006529193.1; XM_006529130.3.
UniGene; Mm.254233; -.
UniGene; Mm.482266; -.
ProteinModelPortal; P41158; -.
SMR; P41158; -.
STRING; 10090.ENSMUSP00000027696; -.
iPTMnet; P41158; -.
PhosphoSitePlus; P41158; -.
EPD; P41158; -.
MaxQB; P41158; -.
PaxDb; P41158; -.
PRIDE; P41158; -.
Ensembl; ENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436.
Ensembl; ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436.
GeneID; 13714; -.
KEGG; mmu:13714; -.
UCSC; uc007cob.1; mouse.
CTD; 2005; -.
MGI; MGI:102853; Elk4.
eggNOG; KOG3806; Eukaryota.
eggNOG; ENOG410Z0ZF; LUCA.
GeneTree; ENSGT00760000118907; -.
HOGENOM; HOG000237332; -.
HOVERGEN; HBG004344; -.
InParanoid; P41158; -.
KO; K04376; -.
OMA; ICWTSNN; -.
OrthoDB; EOG091G0COO; -.
TreeFam; TF317732; -.
PRO; PR:P41158; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026436; -.
CleanEx; MM_ELK4; -.
ExpressionAtlas; P41158; baseline and differential.
Genevisible; P41158; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0070932; P:histone H3 deacetylation; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR000418; Ets_dom.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00178; Ets; 1.
PRINTS; PR00454; ETSDOMAIN.
SMART; SM00413; ETS; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00345; ETS_DOMAIN_1; 1.
PROSITE; PS00346; ETS_DOMAIN_2; 1.
PROSITE; PS50061; ETS_DOMAIN_3; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 430 ETS domain-containing protein Elk-4.
/FTId=PRO_0000204100.
DNA_BIND 5 85 ETS. {ECO:0000255|PROSITE-
ProRule:PRU00237}.
CROSSLNK 166 166 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P28324}.
CONFLICT 99 99 G -> A (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 206 206 F -> C (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 228 228 S -> F (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 307 307 P -> A (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 340 340 L -> S (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 395 395 T -> M (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 409 409 F -> L (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 415 415 D -> E (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 419 419 T -> L (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 426 426 D -> R (in Ref. 1; CAA85358).
{ECO:0000305}.
SEQUENCE 430 AA; 46826 MW; 76CF28AB7627AB5F CRC64;
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN KPNMNYDKLS
RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR IEGDCEALNS IETSSSKDVE
YGGKERPPQP GAKTSSRNDY IHSGLYSSFT LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ
EPTPSVIKFV TTPAKKPPIE PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI
SILATTFNPT PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA SLTPALFSQT
PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP SVLNSHGPFT LSGLDGPSTP
GPFSPDLQKT


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