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Early E1A protein

 Q2KS77_ADE07            Unreviewed;       261 AA.
Q2KS77;
07-MAR-2006, integrated into UniProtKB/TrEMBL.
07-MAR-2006, sequence version 1.
25-APR-2018, entry version 38.
RecName: Full=Early E1A protein {ECO:0000256|PIRNR:PIRNR003669};
Name=E1A {ECO:0000313|EMBL:AAW33380.1};
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7).
Viruses; dsDNA viruses, no RNA stage; Adenoviridae; Mastadenovirus;
Human mastadenovirus B.
NCBI_TaxID=10519 {ECO:0000313|EMBL:AAW33380.1, ECO:0000313|Proteomes:UP000119312};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:AAW33380.1, ECO:0000313|Proteomes:UP000119312}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NHRC 1315 {ECO:0000313|EMBL:AAW33380.1};
PubMed=16481660; DOI=10.1101/gr.4337206;
Lin B., Wang Z., Vora G.J., Thornton J.A., Schnur J.M., Thach D.C.,
Blaney K.M., Ligler A.G., Malanoski A.P., Santiago J., Walter E.A.,
Agan B.K., Metzgar D., Seto D., Daum L.T., Kruzelock R., Rowley R.K.,
Hanson E.H., Tibbetts C., Stenger D.A.;
"Broad-spectrum respiratory tract pathogen identification using
resequencing DNA microarrays.";
Genome Res. 16:527-535(2006).
[2] {ECO:0000313|EMBL:AFV96268.1, ECO:0000313|Proteomes:UP000173062}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CQ1198 {ECO:0000313|EMBL:AFV96268.1};
Ni K., He L.L., Xu Z.F., Peng C.J., Liu E.M.;
"Mutant HAdV-7d2 Strain was Identified from Children with Severe
Respiratory Infection in Southwestern China.";
Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:AFI24563.1, ECO:0000313|Proteomes:UP000169742}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=0901HZ/ShX/CHN/2009 {ECO:0000313|EMBL:AFI24563.1};
PubMed=23409258;
Tang L., An J., Yu P., Xu W.;
"Complete genome sequence of human adenovirus type 7 associated with
fatal infant pneumonia.";
Genome Announc. 1:E00182-12(2013).
[4] {ECO:0000313|EMBL:AHJ81806.1, ECO:0000313|Proteomes:UP000145850}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HAdV B7 XZ2011-93 {ECO:0000313|EMBL:AHJ81806.1};
Tang L., Yang J., Tong J., Zhang L.;
"Genome and bioinformatic analysis of an HAdV-B7 virus in Jiangsu,
China.";
Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:AGZ15319.1, ECO:0000313|Proteomes:UP000120913}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Human/CHN/DG01/2011/7[P7H7F7] {ECO:0000313|EMBL:AGZ15319.1};
PubMed=25482188; DOI=10.1038/srep07365;
Zhao S., Wan C., Ke C., Seto J., Dehghan S., Zou L., Zhou J.,
Cheng Z., Jing S., Zeng Z., Zhang J., Wan X., Wu X., Zhao W., Zhu L.,
Seto D., Zhang Q.;
"Re-emergent Human Adenovirus Genome Type 7d Caused an Acute
Respiratory Disease Outbreak in Southern China After a Twenty-one Year
Absence.";
Sci. Rep. 4:7365-7365(2014).
[6] {ECO:0000313|EMBL:AIY53479.1, ECO:0000313|Proteomes:UP000120727}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC228/JM/CHN/2012 {ECO:0000313|EMBL:AIY53479.1};
PubMed=26338697; DOI=10.1038/srep13617;
Qiu S., Li P., Liu H., Wang Y., Liu N., Li C., Li S., Li M., Jiang Z.,
Sun H., Li Y., Xie J., Yang C., Wang J., Li H., Yi S., Wu Z., Jia L.,
Wang L., Hao R., Sun Y., Huang L., Ma H., Yuan Z., Song H.;
"Whole-genome Sequencing for Tracing the Transmission Link between Two
ARD Outbreaks Caused by a Novel HAdV Serotype 7 Variant, China.";
Sci. Rep. 5:13617-13617(2015).
[7] {ECO:0000313|Proteomes:UP000099968, ECO:0000313|Proteomes:UP000138206, ECO:0000313|Proteomes:UP000143275}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Yu Z., Zhang Q., Fu N.;
"Fatal Pediatric Respiratory Infection Caused by Human Adenovirus
Genotype 7d in Guangzhou, China, 2010-2012.";
Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:ANP91992.1, ECO:0000313|Proteomes:UP000140963}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=19BOVLB/Volgograd/Rus/2014 {ECO:0000313|EMBL:ANP91992.1};
Yatsyshina S.B., Ageeva M.R., Pimkina E.V., Deviatkin A.A.,
Markelov M.L., Dedkov V.G., Safonova M.V.;
"Complete genome sequence of human adenovirus type 7 associated with
fatal adult pneumonia.";
Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:ANI70134.1, ECO:0000313|Proteomes:UP000098519}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 2014012.949 {ECO:0000313|EMBL:ANI70134.1};
PubMed=27191834; DOI=10.3201/eid2206.151898;
Scott M.K., Chommanard C., Lu X., Appelgate D., Grenz L.,
Schneider E., Gerber S.I., Erdman D.D., Thomas A.;
"Human Adenovirus Associated with Severe Respiratory Infection,
Oregon, USA, 2013-2014.";
Emerg. Infect. Dis. 22:1044-1051(2016).
[10] {ECO:0000313|EMBL:AKQ24909.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Human/CHN/GZ6080/2010/7[P7H7F7] {ECO:0000313|EMBL:AKQ25026.1},
Human/CHN/GZ6784/2011/7[P7H7F7] {ECO:0000313|EMBL:AKQ24987.1},
Human/CHN/GZ6965/2011/7[P7H7F7] {ECO:0000313|EMBL:AKQ24948.1},
Human/CHN/GZ7015/2011/7[P7H7F7] {ECO:0000313|EMBL:AKQ24909.1},
Human/CHN/GZ7052/2011/7[P7H7F7] {ECO:0000313|EMBL:AKQ25143.1},
Human/CHN/GZ8546/2012/7[P7H7F7] {ECO:0000313|EMBL:AKQ25104.1}, and
Human/CHN/GZ8987/2012/7[P7H7F7] {ECO:0000313|EMBL:AKQ25065.1};
PubMed=27848998; DOI=.1038/srep37216;
Yu Z., Zeng Z., Zhang J., Pan Y., Chen M., Guo Y., Yu N., Chodosh J.,
Fu N., Che X., Zhang Q.;
"Fatal Community-acquired Pneumonia in Children Caused by Re-emergent
Human Adenovirus 7d Associated with Higher Severity of Illness and
Fatality Rate.";
Sci. Rep. 6:37216-37216(2016).
[11] {ECO:0000313|Proteomes:UP000119758, ECO:0000313|Proteomes:UP000160399}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Yu Z., Zhang Q., Fu N.;
"Fatal Pediatric Respiratory Infection Caused by Human Adenovirus
Genotype 7d in Guangzhou, China, 2010-2012.";
Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
[12] {ECO:0000313|EMBL:ASK85761.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Z9/WH/CHN/2015 complete genome {ECO:0000313|EMBL:ASK85761.1};
PubMed=28225804;
Yang X., Wang Q., Liang B., Wu F., Li H., Liu H., Sheng C., Ma Q.,
Yang C., Xie J., Li P., Jia L., Wang L., Du X., Qiu S., Song H.;
"An outbreak of acute respiratory disease caused by a virus associated
RNA II gene mutation strain of human adenovirus 7 in China, 2015.";
PLoS ONE 12:E0172519-E0172519(2017).
-!- FUNCTION: Plays a role in viral genome replication by driving
entry of quiescent cells into the cell cycle.
{ECO:0000256|PIRNR:PIRNR003669}.
-!- SIMILARITY: Belongs to the adenoviridae E1A protein family.
{ECO:0000256|PIRNR:PIRNR003669}.
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EMBL; AY601634; AAW33380.1; -; Genomic_DNA.
EMBL; JF800905; AFI24563.1; -; Genomic_DNA.
EMBL; JX625134; AFV96268.1; -; Genomic_DNA.
EMBL; KC440171; AGZ15319.1; -; Genomic_DNA.
EMBL; KC857700; AHJ81806.1; -; Genomic_DNA.
EMBL; KJ019884; AIY53479.1; -; Genomic_DNA.
EMBL; KP670855; AKQ24909.1; -; Genomic_DNA.
EMBL; KP670856; AKQ24948.1; -; Genomic_DNA.
EMBL; KP670857; AKQ24987.1; -; Genomic_DNA.
EMBL; KP670858; AKQ25026.1; -; Genomic_DNA.
EMBL; KP670859; AKQ25065.1; -; Genomic_DNA.
EMBL; KP670860; AKQ25104.1; -; Genomic_DNA.
EMBL; KP670861; AKQ25143.1; -; Genomic_DNA.
EMBL; KT963081; ANI70134.1; -; Genomic_DNA.
EMBL; KU361344; ANP91992.1; -; Genomic_DNA.
EMBL; KX897164; ASK85761.1; -; Genomic_DNA.
Proteomes; UP000098519; Genome.
Proteomes; UP000099968; Genome.
Proteomes; UP000119312; Genome.
Proteomes; UP000119758; Genome.
Proteomes; UP000120727; Genome.
Proteomes; UP000120913; Genome.
Proteomes; UP000138206; Genome.
Proteomes; UP000140963; Genome.
Proteomes; UP000143275; Genome.
Proteomes; UP000145850; Genome.
Proteomes; UP000151122; Genome.
Proteomes; UP000160399; Genome.
Proteomes; UP000169742; Genome.
Proteomes; UP000172553; Genome.
Proteomes; UP000173062; Genome.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
GO; GO:0039645; P:modulation by virus of host G1/S transition checkpoint; IEA:UniProtKB-UniRule.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR014410; Aden_E1A.
Pfam; PF02703; Adeno_E1A; 1.
PIRSF; PIRSF003669; Aden_E1A; 1.
3: Inferred from homology;
Activator {ECO:0000256|PIRNR:PIRNR003669};
Complete proteome {ECO:0000313|Proteomes:UP000120727};
Host-virus interaction {ECO:0000256|PIRNR:PIRNR003669};
Reference proteome {ECO:0000313|Proteomes:UP000120727};
Transcription {ECO:0000256|PIRNR:PIRNR003669};
Transcription regulation {ECO:0000256|PIRNR:PIRNR003669};
Viral immunoevasion {ECO:0000256|PIRNR:PIRNR003669}.
SEQUENCE 261 AA; 28457 MW; F9650D2C0B4EA2E7 CRC64;
MRHLRFLPQE IISSETGIEI LEFVVNTLMG DDPEPPVQPF DPPTLHDLYD LEVDGPEDPN
EEAVNGFFTD SMLLAADEGL DINPPPETLV TPGVVVESGR GGKKLPDLGA AEMDLRCYEE
GFPPSDDEDG ETEQSIHTAV NEGVKAASDV FKLDCPELPG HGCKSCEFHR NNTGMKELLC
SLCYMRMHCH FIYSPVSDDE SPSPDSTTSP PEIQAPAPAN VCKPIPVKPK PGKRPAVDKL
EDLLEGGDGP LDLSTRKLPR Q


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