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Early growth response protein 1 (EGR-1) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor Zif268) (Zinc finger protein Krox-24)

 EGR1_MOUSE              Reviewed;         533 AA.
P08046; Q61777;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 2.
12-SEP-2018, entry version 183.
RecName: Full=Early growth response protein 1;
Short=EGR-1;
AltName: Full=Nerve growth factor-induced protein A {ECO:0000303|PubMed:1740423};
Short=NGFI-A {ECO:0000303|PubMed:1740423};
AltName: Full=Transcription factor Zif268 {ECO:0000303|PubMed:2028256};
AltName: Full=Zinc finger protein Krox-24 {ECO:0000303|PubMed:2511075};
Name=Egr1; Synonyms=Egr-1, Krox-24 {ECO:0000303|PubMed:2511075};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3127059; DOI=10.1016/0092-8674(88)90485-0;
Sukhatme V.P., Cao X., Chang L.C., Tsai-Morris C.-H., Stamenkovich D.,
Ferreira P.C.P., Cohen D.R., Edwards S.A., Shows T.B., Curran T.,
le Beau M.M., Adamson E.D.;
"A zinc finger-encoding gene coregulated with c-fos during growth and
differentiation, and after cellular depolarization.";
Cell 53:37-43(1988).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3141919; DOI=10.1073/pnas.85.21.7857;
Christy B.A., Lau L.F., Nathans D.;
"A gene activated in mouse 3T3 cells by serum growth factors encodes a
protein with 'zinc finger' sequences.";
Proc. Natl. Acad. Sci. U.S.A. 85:7857-7861(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2511075; DOI=10.1016/0378-1119(89)90296-5;
Janssen-Timmen U., Lemaire P., Mattei M.-G., Revelant O., Charnay P.;
"Structure, chromosome mapping and regulation of the mouse zinc-finger
gene Krox-24; evidence for a common regulatory pathway for immediate-
early serum-response genes.";
Gene 80:325-336(1989).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 50-533, AND INDUCTION BY GROWTH FACTORS.
PubMed=3133658; DOI=10.1073/pnas.85.13.4691;
Lemaire P., Revelant O., Bravo R., Charnay P.;
"Two mouse genes encoding potential transcription factors with
identical DNA-binding domains are activated by growth factors in
cultured cells.";
Proc. Natl. Acad. Sci. U.S.A. 85:4691-4695(1988).
[5]
MUTAGENESIS OF ZINC-FINGERS, AND DOMAIN.
PubMed=1740423;
Wilson T.E., Day M.L., Pexton T., Padgett K.A., Johnston M.,
Milbrandt J.;
"In vivo mutational analysis of the NGFI-A zinc fingers.";
J. Biol. Chem. 267:3718-3724(1992).
[6]
FUNCTION, SUBCELLULAR LOCATION, AND DOMAIN.
PubMed=8336701; DOI=10.1128/MCB.13.8.4556;
Gashler A.L., Swaminathan S., Sukhatme V.P.;
"A novel repression module, an extensive activation domain, and a
bipartite nuclear localization signal defined in the immediate-early
transcription factor Egr-1.";
Mol. Cell. Biol. 13:4556-4571(1993).
[7]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=8703054; DOI=10.1126/science.273.5279.1219;
Lee S.L., Sadovsky Y., Swirnoff A.H., Polish J.A., Goda P.,
Gavrilina G., Milbrandt J.;
"Luteinizing hormone deficiency and female infertility in mice lacking
the transcription factor NGFI-A (Egr-1).";
Science 273:1219-1221(1996).
[8]
DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR
LOCATION, AND INDUCTION BY ISCHEMIA.
PubMed=11100120; DOI=10.1038/82168;
Yan S.F., Fujita T., Lu J., Okada K., Shan Zou Y., Mackman N.,
Pinsky D.J., Stern D.M.;
"Egr-1, a master switch coordinating upregulation of divergent gene
families underlying ischemic stress.";
Nat. Med. 6:1355-1361(2000).
[9]
DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY
PARTIAL HEPATECTOMY.
PubMed=15265859; DOI=10.1074/jbc.M407969200;
Liao Y., Shikapwashya O.N., Shteyer E., Dieckgraefe B.K., Hruz P.W.,
Rudnick D.A.;
"Delayed hepatocellular mitotic progression and impaired liver
regeneration in early growth response-1-deficient mice.";
J. Biol. Chem. 279:43107-43116(2004).
[10]
DISRUPTION PHENOTYPE, FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15958557; DOI=10.1158/0008-5472.CAN-04-3742;
Krones-Herzig A., Mittal S., Yule K., Liang H., English C., Urcis R.,
Soni T., Adamson E.D., Mercola D.;
"Early growth response 1 acts as a tumor suppressor in vivo and in
vitro via regulation of p53.";
Cancer Res. 65:5133-5143(2005).
[11] {ECO:0000244|PDB:1ZAA}
X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 332-418 IN COMPLEX WITH ZINC
AND TARGET DNA, DOMAIN, AND FUNCTION.
PubMed=2028256; DOI=10.1126/science.2028256;
Pavletich N.P., Pabo C.O.;
"Zinc finger-DNA recognition: crystal structure of a Zif268-DNA
complex at 2.1 A.";
Science 252:809-817(1991).
[12] {ECO:0000244|PDB:1AAY}
X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 333-421 IN COMPLEX WITH ZINC
AND TARGET DNA, DOMAIN, AND FUNCTION.
PubMed=8939742; DOI=10.1016/S0969-2126(96)00125-6;
Elrod-Erickson M., Rould M.A., Nekludova L., Pabo C.O.;
"Zif268 protein-DNA complex refined at 1.6 A: a model system for
understanding zinc finger-DNA interactions.";
Structure 4:1171-1180(1996).
-!- FUNCTION: Transcriptional regulator (PubMed:8336701,
PubMed:8703054, PubMed:15958557). Recognizes and binds to the DNA
sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of
target genes (PubMed:8703054, PubMed:15958557, PubMed:2028256,
PubMed:8939742). Binds double-stranded target DNA, irrespective of
the cytosine methylation status (By similarity). Regulates the
transcription of numerous target genes, and thereby plays an
important role in regulating the response to growth factors, DNA
damage, and ischemia (PubMed:11100120, PubMed:15958557). Plays a
role in the regulation of cell survival, proliferation and cell
death (PubMed:15265859, PubMed:15958557). Activates expression of
p53/TP53 and TGFB1, and thereby helps prevent tumor formation
(PubMed:15958557). Required for normal progress through mitosis
and normal proliferation of hepatocytes after partial hepatectomy
(PubMed:15265859). Mediates responses to ischemia and hypoxia;
regulates the expression of proteins such as IL1B and CXCL2 that
are involved in inflammatory processes and development of tissue
damage after ischemia (PubMed:11100120). Regulates biosynthesis of
luteinizing hormone (LHB) in the pituitary (PubMed:8703054).
{ECO:0000250|UniProtKB:P18146, ECO:0000269|PubMed:11100120,
ECO:0000269|PubMed:15265859, ECO:0000269|PubMed:15958557,
ECO:0000269|PubMed:2028256, ECO:0000269|PubMed:8336701,
ECO:0000269|PubMed:8703054, ECO:0000269|PubMed:8939742,
ECO:0000305}.
-!- SUBUNIT: Interacts with SNAI1 and SP1 upon 12-O-
tetradecanoylphorbol-13-acetate (TPA) induction.
{ECO:0000250|UniProtKB:P18146}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11100120,
ECO:0000269|PubMed:15958557, ECO:0000269|PubMed:8336701}.
Cytoplasm {ECO:0000250|UniProtKB:P18146}.
-!- TISSUE SPECIFICITY: Detected in lung vasculature and in
mononuclear phagocytes (PubMed:11100120). Detected in liver (at
protein level) (PubMed:15265859). Detected in lung vasculature and
in mononuclear phagocytes (PubMed:11100120).
{ECO:0000269|PubMed:11100120, ECO:0000269|PubMed:15265859}.
-!- INDUCTION: By growth factors (PubMed:3133658). Up-regulated in
lung vasculature in response to reperfusion after ischemia
(PubMed:11100120). Up-regulated in liver in response to partial
hepatectomy (PubMed:15265859). {ECO:0000269|PubMed:11100120,
ECO:0000269|PubMed:15265859, ECO:0000269|PubMed:3133658}.
-!- DOMAIN: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3'
via its C2H2-type zinc fingers (PubMed:1740423, PubMed:8336701,
PubMed:2028256, PubMed:8939742). The first, most N-terminal zinc
finger binds to the 3'-GCG motif, the middle zinc finger interacts
with the central TGG motif, and the C-terminal zinc finger binds
to the 5'-GCG motif (PubMed:2028256, PubMed:8939742). Binds
double-stranded target DNA, irrespective of the cytosine
methylation status. Has reduced affinity for target DNA where the
cytosines have been oxidized to 5-hydroxymethylcytosine. Does not
bind target DNA where the cytosines have been oxidized to 5-
formylcytosine or 5-carboxylcytosine (By similarity).
{ECO:0000250|UniProtKB:P18146, ECO:0000269|PubMed:1740423,
ECO:0000269|PubMed:2028256, ECO:0000269|PubMed:8939742}.
-!- DISRUPTION PHENOTYPE: Mice appear grossly normal, but females are
anestrous and infertile with an uterus weight that is roughly 30%
of that of wild-type. Ovaries contain normal numbers of follicles,
but lack corpora lutea. Serum progesterone levels are strongly
reduced; estradiol levels are normal. The level of luteinizing
hormone (LHB) in the pituitary is strongly reduced in males and
not detectable in females (PubMed:8703054). Responses to ischemia
and hypoxia are blunted, leading to reduced tissue damage in
response to ischemia and increased survival (PubMed:11100120).
Liver regeneration is impaired after partial hepatectomy, due to
impaired mitotic progress and reduced proliferation of hepatocytes
(PubMed:15265859). Untreated mutant mice do not display an
increased tendency to develop tumors, but develop tumors earlier
than wild-type when treated first with a tumor initiator, and then
with a tumor promoter (PubMed:15958557).
{ECO:0000269|PubMed:11100120, ECO:0000269|PubMed:15265859,
ECO:0000269|PubMed:15958557, ECO:0000269|PubMed:8703054}.
-!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
family. {ECO:0000305}.
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EMBL; M20157; AAA37544.1; -; mRNA.
EMBL; M22326; AAA40416.1; -; mRNA.
EMBL; M28845; AAB00468.1; -; Genomic_DNA.
EMBL; M28844; AAB00468.1; JOINED; Genomic_DNA.
EMBL; M19643; AAA39382.1; -; mRNA.
CCDS; CCDS29136.1; -.
PIR; JS0304; JS0304.
RefSeq; NP_031939.1; NM_007913.5.
UniGene; Mm.181959; -.
PDB; 1A1F; X-ray; 2.10 A; A=333-421.
PDB; 1A1G; X-ray; 1.90 A; A=333-421.
PDB; 1A1H; X-ray; 1.60 A; A=333-421.
PDB; 1A1I; X-ray; 1.60 A; A=333-421.
PDB; 1A1J; X-ray; 2.00 A; A=333-421.
PDB; 1A1K; X-ray; 1.90 A; A=333-421.
PDB; 1A1L; X-ray; 2.30 A; A=333-421.
PDB; 1AAY; X-ray; 1.60 A; A=333-421.
PDB; 1F2I; X-ray; 2.35 A; G/H/I/J/K/L=334-389.
PDB; 1G2D; X-ray; 2.20 A; C/F=333-421.
PDB; 1G2F; X-ray; 2.00 A; C/F=333-421.
PDB; 1JK1; X-ray; 1.90 A; A=333-421.
PDB; 1JK2; X-ray; 1.65 A; A=333-421.
PDB; 1LLM; X-ray; 1.50 A; C/D=364-412.
PDB; 1P47; X-ray; 2.20 A; A/B=333-419.
PDB; 1ZAA; X-ray; 2.10 A; C=332-418.
PDBsum; 1A1F; -.
PDBsum; 1A1G; -.
PDBsum; 1A1H; -.
PDBsum; 1A1I; -.
PDBsum; 1A1J; -.
PDBsum; 1A1K; -.
PDBsum; 1A1L; -.
PDBsum; 1AAY; -.
PDBsum; 1F2I; -.
PDBsum; 1G2D; -.
PDBsum; 1G2F; -.
PDBsum; 1JK1; -.
PDBsum; 1JK2; -.
PDBsum; 1LLM; -.
PDBsum; 1P47; -.
PDBsum; 1ZAA; -.
ProteinModelPortal; P08046; -.
SMR; P08046; -.
BioGrid; 199404; 7.
STRING; 10090.ENSMUSP00000069616; -.
iPTMnet; P08046; -.
PhosphoSitePlus; P08046; -.
PaxDb; P08046; -.
PRIDE; P08046; -.
Ensembl; ENSMUST00000064795; ENSMUSP00000069616; ENSMUSG00000038418.
Ensembl; ENSMUST00000165033; ENSMUSP00000126931; ENSMUSG00000038418.
GeneID; 13653; -.
KEGG; mmu:13653; -.
UCSC; uc008elt.1; mouse.
CTD; 1958; -.
MGI; MGI:95295; Egr1.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00550000074455; -.
HOGENOM; HOG000036856; -.
HOVERGEN; HBG003909; -.
InParanoid; P08046; -.
KO; K09203; -.
OMA; FATQTGS; -.
OrthoDB; EOG091G06VX; -.
PhylomeDB; P08046; -.
TreeFam; TF318980; -.
ChiTaRS; Egr1; mouse.
EvolutionaryTrace; P08046; -.
PRO; PR:P08046; -.
Proteomes; UP000000589; Chromosome 18.
Bgee; ENSMUSG00000038418; Expressed in 340 organ(s), highest expression level in cumulus cell.
CleanEx; MM_EGR1; -.
ExpressionAtlas; P08046; baseline and differential.
Genevisible; P08046; MM.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:UniProtKB.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:UniProtKB.
GO; GO:0035035; F:histone acetyltransferase binding; ISO:MGI.
GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0000982; F:transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:BHF-UCL.
GO; GO:0008134; F:transcription factor binding; ISO:MGI.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IMP:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
GO; GO:0071480; P:cellular response to gamma radiation; IMP:BHF-UCL.
GO; GO:0071504; P:cellular response to heparin; ISS:UniProtKB.
GO; GO:0098759; P:cellular response to interleukin-8; ISS:UniProtKB.
GO; GO:0071506; P:cellular response to mycophenolic acid; ISS:UniProtKB.
GO; GO:0071310; P:cellular response to organic substance; IDA:MGI.
GO; GO:0044849; P:estrous cycle; IMP:UniProtKB.
GO; GO:0072110; P:glomerular mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0070498; P:interleukin-1-mediated signaling pathway; ISO:MGI.
GO; GO:0007611; P:learning or memory; ISO:MGI.
GO; GO:0007616; P:long-term memory; ISO:MGI.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IMP:BHF-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0010942; P:positive regulation of cell death; ISO:MGI.
GO; GO:0045080; P:positive regulation of chemokine biosynthetic process; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
GO; GO:0072303; P:positive regulation of glomerular metanephric mesangial cell proliferation; ISS:UniProtKB.
GO; GO:0046886; P:positive regulation of hormone biosynthetic process; IMP:UniProtKB.
GO; GO:0050725; P:positive regulation of interleukin-1 beta biosynthetic process; IMP:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISO:MGI.
GO; GO:1901216; P:positive regulation of neuron death; ISO:MGI.
GO; GO:0014911; P:positive regulation of smooth muscle cell migration; ISO:MGI.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:1902949; P:positive regulation of tau-protein kinase activity; ISO:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; IMP:MGI.
GO; GO:0048169; P:regulation of long-term neuronal synaptic plasticity; ISO:MGI.
GO; GO:2000182; P:regulation of progesterone biosynthetic process; IMP:UniProtKB.
GO; GO:0033233; P:regulation of protein sumoylation; ISO:MGI.
GO; GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; IDA:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:MGI.
GO; GO:0009749; P:response to glucose; IDA:UniProtKB.
GO; GO:0001666; P:response to hypoxia; IMP:UniProtKB.
GO; GO:0032868; P:response to insulin; IDA:UniProtKB.
GO; GO:0002931; P:response to ischemia; IMP:UniProtKB.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0030217; P:T cell differentiation; IMP:MGI.
GO; GO:0006366; P:transcription by RNA polymerase II; ISO:MGI.
InterPro; IPR021849; EGR.
InterPro; IPR021839; EGR1_C.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF11914; DUF3432; 1.
Pfam; PF11928; DUF3446; 1.
SMART; SM00355; ZnF_C2H2; 3.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
1: Evidence at protein level;
3D-structure; Activator; Complete proteome; Cytoplasm; DNA-binding;
Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
Transcription; Transcription regulation; Ubl conjugation; Zinc;
Zinc-finger.
CHAIN 1 533 Early growth response protein 1.
/FTId=PRO_0000047110.
ZN_FING 336 360 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 366 388 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 394 416 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
COMPBIAS 57 81 Gly/Ser-rich.
SITE 334 334 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 345 345 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 349 349 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 355 355 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 373 373 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 377 377 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 401 401 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 405 405 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
SITE 411 411 Interaction with DNA.
{ECO:0000244|PDB:1AAY,
ECO:0000244|PDB:1ZAA,
ECO:0000269|PubMed:2028256,
ECO:0000269|PubMed:8939742}.
CROSSLNK 303 303 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P18146}.
CONFLICT 76 76 S -> T (in Ref. 3; AAB00468 and 4;
AAA39382). {ECO:0000305}.
CONFLICT 80 80 S -> T (in Ref. 3; AAB00468 and 4;
AAA39382). {ECO:0000305}.
STRAND 335 337 {ECO:0000244|PDB:1P47}.
STRAND 340 342 {ECO:0000244|PDB:1A1H}.
STRAND 346 349 {ECO:0000244|PDB:1A1H}.
HELIX 350 361 {ECO:0000244|PDB:1A1H}.
TURN 369 371 {ECO:0000244|PDB:1LLM}.
STRAND 374 376 {ECO:0000244|PDB:1LLM}.
HELIX 378 389 {ECO:0000244|PDB:1LLM}.
TURN 397 399 {ECO:0000244|PDB:1LLM}.
STRAND 402 405 {ECO:0000244|PDB:1LLM}.
HELIX 406 412 {ECO:0000244|PDB:1LLM}.
HELIX 414 417 {ECO:0000244|PDB:1A1H}.
SEQUENCE 533 AA; 56590 MW; 36E3935767CEAA0F CRC64;
MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGTPEGSGG
NSSSSTSSGG GGGGGSNSGS SAFNPQGEPS EQPYEHLTTE SFSDIALNNE KAMVETSYPS
QTTRLPPITY TGRFSLEPAP NSGNTLWPEP LFSLVSGLVS MTNPPTSSSS APSPAASSSS
SASQSPPLSC AVPSNDSSPI YSAAPTFPTP NTDIFPEPQS QAFPGSAGTA LQYPPPAYPA
TKGGFQVPMI PDYLFPQQQG DLSLGTPDQK PFQGLENRTQ QPSLTPLSTI KAFATQSGSQ
DLKALNTTYQ SQLIKPSRMR KYPNRPSKTP PHERPYACPV ESCDRRFSRS DELTRHIRIH
TGQKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDICG RKFARSDERK RHTKIHLRQK
DKKADKSVVA SPAASSLSSY PSPVATSYPS PATTSFPSPV PTSYSSPGSS TYPSPAHSGF
PSPSVATTFA SVPPAFPTQV SSFPSAGVSS SFSTSTGLSD MTATFSPRTI EIC


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E0416m ELISA kit Early growth response protein 1,Egr1,EGR-1,Egr-1,Krox-24,Mouse,Mus musculus,Nerve growth factor-induced protein A,NGFI-A,Transcription factor Zif268,Zinc finger protein Krox-24 96T
U0416m CLIA Early growth response protein 1,Egr1,EGR-1,Egr-1,Krox-24,Mouse,Mus musculus,Nerve growth factor-induced protein A,NGFI-A,Transcription factor Zif268,Zinc finger protein Krox-24 96T
E0416m ELISA Early growth response protein 1,Egr1,EGR-1,Egr-1,Krox-24,Mouse,Mus musculus,Nerve growth factor-induced protein A,NGFI-A,Transcription factor Zif268,Zinc finger protein Krox-24 96T
18-003-42165 Early growth response protein 1 - EGR-1; Krox-24 protein; Transcription factor Zif268; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Zinc finger protein 225; AT225 Polycl 0.05 mg Aff Pur
E0416r ELISA kit Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
U0416r CLIA Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
E0416r ELISA Early growth response protein 1,Egr1,EGR-1,Nerve growth factor-induced protein A,NGFI-A,Rat,Rattus norvegicus,Transcription factor Zif268,Zinc finger protein Krox-24 96T
U0416h CLIA AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protein 96T
E0416h ELISA kit AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger p 96T
E0416h ELISA AT225,Early growth response protein 1,EGR1,EGR-1,Homo sapiens,Human,KROX24,Nerve growth factor-induced protein A,NGFI-A,Transcription factor ETR103,Transcription factor Zif268,Zinc finger protei 96T
28-572 Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger 0.1 mg
27-526 Early Growth Response Protein 1 (EGR1, Krox-24 protein, nerve growth factor-induced protein A, Transcription factor ETR103, Zinc finger protein 225) belongs to the EGR family of C2H2-type zinc-finger 0.05 mg
EIAAB12630 Early growth response protein 4,Early response protein NGFI-C,Egr4,EGR-4,Egr-4,Nerve growth factor-induced protein C,Ngfic,NGFI-C,Rat,Rattus norvegicus
28-787 The nerve growth factor-induced clone C (NGFI-C_EGR4) gene is a zinc-finger transcription factor that is rapidly induced by nerve growth factor in rat pheochromocytoma PC12 cells and by seizure in bra 0.05 mg
EIAAB12624 Early growth response protein 2,Egr2,EGR-2,Egr-2,Krox-20,Mouse,Mus musculus,Zfp-25,Zinc finger protein Krox-20
EIAAB12623 Early growth response protein 2,Egr2,EGR-2,Egr-2,Krox20,Krox-20,Rat,Rattus norvegicus,Zinc finger protein Krox-20
EIAAB12625 AT591,Early growth response protein 2,EGR2,EGR-2,Homo sapiens,Human,KROX20,Zinc finger protein Krox-20
18-003-43783 Krueppel-like factor 11 - Transforming growth factor-beta-inducible early growth response protein 2; TGFB-inducible early growth response protein 2; TIEG-2 Polyclonal 0.1 mg Protein A
U0688h CLIA EGR-alpha,Homo sapiens,Human,KLF10,Krueppel-like factor 10,TGFB-inducible early growth response protein 1,TIEG,TIEG1,TIEG-1,Transforming growth factor-beta-inducible early growth response protein 96T
E0688r ELISA Cpg20,Klf10,Krueppel-like factor 10,Rat,Rattus norvegicus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transforming growth factor-beta-inducible early growth response protein 96T
U0688r CLIA Cpg20,Klf10,Krueppel-like factor 10,Rat,Rattus norvegicus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transforming growth factor-beta-inducible early growth response protein 96T
E0688h ELISA EGR-alpha,Homo sapiens,Human,KLF10,Krueppel-like factor 10,TGFB-inducible early growth response protein 1,TIEG,TIEG1,TIEG-1,Transforming growth factor-beta-inducible early growth response protei 96T
E0688h ELISA kit EGR-alpha,Homo sapiens,Human,KLF10,Krueppel-like factor 10,TGFB-inducible early growth response protein 1,TIEG,TIEG1,TIEG-1,Transforming growth factor-beta-inducible early growth response p 96T
E0688r ELISA kit Cpg20,Klf10,Krueppel-like factor 10,Rat,Rattus norvegicus,TGFB-inducible early growth response protein 1,Tieg,Tieg1,TIEG-1,Transforming growth factor-beta-inducible early growth response pr 96T
EIAAB39974 Cl-4,Delayed-early protein HRS,Hrs,Insulin-induced growth response protein CL-4,Pre-mRNA-splicing factor SRP40,Rat,Rattus norvegicus,Serine_arginine-rich splicing factor 5,Sfrs5,Splicing factor, argin


 

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