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Early growth response protein 1 (EGR-1) (Zinc finger protein Krox-24)

 EGR1_DANRE              Reviewed;         511 AA.
P26632;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 2.
10-MAY-2017, entry version 125.
RecName: Full=Early growth response protein 1;
Short=EGR-1;
AltName: Full=Zinc finger protein Krox-24;
Name=egr1; Synonyms=krox24;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
PubMed=7945937; DOI=10.1089/dna.1994.13.1047;
Drummond I.A., Rohwer-Nutter P., Sukhatme V.P.;
"The zebrafish egr1 gene encodes a highly conserved, zinc-finger
transcriptional regulator.";
DNA Cell Biol. 13:1047-1055(1994).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 315-376.
PubMed=1930167; DOI=10.1016/0006-291X(91)91702-E;
Lanfear J., Jowett T., Holland P.W.;
"Cloning of fish zinc-finger genes related to Krox-20 and Krox-24.";
Biochem. Biophys. Res. Commun. 179:1220-1224(1991).
-!- FUNCTION: Transcriptional regulator (PubMed:7945937). Recognizes
and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the
promoter region of target genes (By similarity). Binds double-
stranded target DNA, irrespective of the cytosine methylation
status (By similarity). Regulates the transcription of numerous
target genes, and thereby plays an important role in regulating
the response to growth factors, DNA damage, and ischemia. Plays a
role in the regulation of cell survival, proliferation and cell
death. Mediates responses to ischemia and hypoxia; regulates the
expression of proteins that are involved in inflammatory processes
(By similarity). {ECO:0000250|UniProtKB:P08046,
ECO:0000250|UniProtKB:P18146, ECO:0000269|PubMed:7945937}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P18146}.
Cytoplasm {ECO:0000250|UniProtKB:P18146}.
-!- TISSUE SPECIFICITY: Detected in muscle and brain.
{ECO:0000269|PubMed:7945937}.
-!- DOMAIN: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3'
via its C2H2-type zinc fingers. The first, most N-terminal zinc
finger binds to the 3'-GCG motif, the middle zinc finger interacts
with the central TGG motif, and the C-terminal zinc finger binds
to the 5'-GCG motif. Binds double-stranded target DNA,
irrespective of the cytosine methylation status. Has reduced
affinity for target DNA where the cytosines have been oxidized to
5-hydroxymethylcytosine. Does not bind target DNA where the
cytosines have been oxidized to 5-formylcytosine or 5-
carboxylcytosine. {ECO:0000250|UniProtKB:P18146}.
-!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
family. {ECO:0000305}.
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EMBL; U12895; AAA63651.1; -; Genomic_DNA.
EMBL; M81109; AAA50035.1; -; Genomic_DNA.
PIR; I50114; I50114.
PIR; PQ0233; PQ0233.
RefSeq; NP_571323.1; NM_131248.1.
UniGene; Dr.144146; -.
ProteinModelPortal; P26632; -.
STRING; 7955.ENSDARP00000054459; -.
PaxDb; P26632; -.
Ensembl; ENSDART00000054460; ENSDARP00000054459; ENSDARG00000037421.
GeneID; 30498; -.
KEGG; dre:30498; -.
CTD; 1958; -.
ZFIN; ZDB-GENE-980526-320; egr1.
eggNOG; KOG1721; Eukaryota.
eggNOG; COG5048; LUCA.
GeneTree; ENSGT00550000074455; -.
HOGENOM; HOG000036856; -.
HOVERGEN; HBG003909; -.
InParanoid; P26632; -.
KO; K09203; -.
OMA; FATQTGS; -.
OrthoDB; EOG091G06VX; -.
PhylomeDB; P26632; -.
TreeFam; TF318980; -.
PRO; PR:P26632; -.
Proteomes; UP000000437; Chromosome 14.
Bgee; ENSDARG00000037421; -.
ExpressionAtlas; P26632; baseline and differential.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:UniProtKB.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:UniProtKB.
GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0043010; P:camera-type eye development; IMP:ZFIN.
GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IMP:ZFIN.
GO; GO:0048703; P:embryonic viscerocranium morphogenesis; IMP:ZFIN.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR021839; DUF3432.
InterPro; IPR021849; DUF3446.
InterPro; IPR013087; Znf_C2H2_type.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
Pfam; PF11914; DUF3432; 1.
Pfam; PF11928; DUF3446; 1.
SMART; SM00355; ZnF_C2H2; 3.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
2: Evidence at transcript level;
Activator; Complete proteome; Cytoplasm; DNA-binding; Metal-binding;
Nucleus; Reference proteome; Repeat; Transcription;
Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 511 Early growth response protein 1.
/FTId=PRO_0000047116.
ZN_FING 311 335 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 341 363 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 369 391 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
COMPBIAS 146 152 Poly-Ser.
COMPBIAS 155 165 Poly-Ser.
SITE 309 309 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 320 320 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 324 324 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 330 330 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 348 348 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 352 352 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 376 376 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 380 380 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 386 386 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
CONFLICT 317 317 T -> S (in Ref. 2; AAA50035).
{ECO:0000305}.
CONFLICT 320 320 R -> S (in Ref. 2; AAA50035).
{ECO:0000305}.
CONFLICT 351 351 S -> R (in Ref. 2; AAA50035).
{ECO:0000305}.
CONFLICT 372 372 E -> D (in Ref. 2; AAA50035).
{ECO:0000305}.
SEQUENCE 511 AA; 55140 MW; 411C31E6F4AA10BF CRC64;
MAAAKTEMLL PALQISDPLS FPHSPTDNYP KLEEMIMLNS AGTPFLNATA PEGAVFGSGE
PGEQFDHLAG DTLSEISMEK PLSDQTYSTQ RLPPISYTGR FTLEPATNCS NSLWAEPLFS
LVSGLVGINP PPASIPSSTS QATHPSSSST SSIPSSSSSS TSSASLSCSV HQSEPNPIYS
AAPTYSSASP DIFPESGPNF STTVGTSLQY SSSTYPSAKT CNPSFSVPMI PDYLFTQQQS
EISLVPPDQK PIQTQAGQQP ALTPLHTIKA FATQTGSQDL KSVYQSQLIK PSRMRKYPNR
PSKTPPHERP YACPVETCDR RFSRSDELTR HIRIHTGQKP FQCRICMRNF SRSDHLTTHI
RTHTGEKPFA CEICGRKFAR SDERKRHTKI HMRQKDKKAE KGATAAVQSS VSNISISASS
PVSSYPSPIT SYPSPVSSFP SPVNSCYSSP VHTSYPSPSI ATTYPSATST FQTQVATSFP
TSVASNIYSS PVTTPLPDMQ SALSPRTADI C


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