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Early growth response protein 1 (EGR-1) (Zinc finger protein ZENK) (Fragment)

 EGR1_SERCA              Reviewed;          59 AA.
O73694;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
25-OCT-2017, entry version 87.
RecName: Full=Early growth response protein 1;
Short=EGR-1;
AltName: Full=Zinc finger protein ZENK {ECO:0000303|PubMed:9501495};
Flags: Fragment;
Name=EGR1; Synonyms=ZENK {ECO:0000303|PubMed:9501495};
Serinus canaria (Island canary) (Fringilla canaria).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea;
Fringillidae; Carduelinae; Serinus.
NCBI_TaxID=9135;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9501495; DOI=10.1093/oxfordjournals.molbev.a025925;
Long K.D., Salbaum J.M.;
"Evolutionary conservation of the immediate-early gene ZENK.";
Mol. Biol. Evol. 15:284-292(1998).
-!- FUNCTION: Transcriptional regulator. Recognizes and binds to the
DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region
of target genes (By similarity). Binds double-stranded target DNA,
irrespective of the cytosine methylation status (By similarity).
Regulates the transcription of numerous target genes, and thereby
plays an important role in regulating the response to growth
factors, DNA damage, and ischemia. Plays a role in the regulation
of cell survival, proliferation and cell death. Mediates responses
to ischemia and hypoxia; regulates the expression of proteins that
are involved in inflammatory processes (By similarity).
{ECO:0000250|UniProtKB:P08046, ECO:0000250|UniProtKB:P18146}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P18146}.
Cytoplasm {ECO:0000250|UniProtKB:P18146}.
-!- DOMAIN: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3'
via its C2H2-type zinc fingers. The first, most N-terminal zinc
finger binds to the 3'-GCG motif, the middle zinc finger interacts
with the central TGG motif, and the C-terminal zinc finger binds
to the 5'-GCG motif. Binds double-stranded target DNA,
irrespective of the cytosine methylation status. Has reduced
affinity for target DNA where the cytosines have been oxidized to
5-hydroxymethylcytosine. Does not bind target DNA where the
cytosines have been oxidized to 5-formylcytosine or 5-
carboxylcytosine. {ECO:0000250|UniProtKB:P18146}.
-!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
family. {ECO:0000305}.
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EMBL; AF026085; AAC12269.1; -; Genomic_DNA.
ProteinModelPortal; O73694; -.
SMR; O73694; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; ISA:AgBase.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; ISA:AgBase.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:UniProtKB.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:UniProtKB.
GO; GO:0035035; F:histone acetyltransferase binding; ISA:AgBase.
GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; ISA:AgBase.
GO; GO:0043565; F:sequence-specific DNA binding; ISA:AgBase.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; ISA:AgBase.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISA:AgBase.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0098759; P:cellular response to interleukin-8; ISS:AgBase.
GO; GO:0070498; P:interleukin-1-mediated signaling pathway; ISA:AgBase.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISA:AgBase.
GO; GO:0033233; P:regulation of protein sumoylation; ISA:AgBase.
GO; GO:0006366; P:transcription from RNA polymerase II promoter; ISA:AgBase.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
SMART; SM00355; ZnF_C2H2; 2.
SUPFAM; SSF57667; SSF57667; 1.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
3: Inferred from homology;
Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN <1 >59 Early growth response protein 1.
/FTId=PRO_0000047115.
ZN_FING <1 18 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 24 46 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 52 >59 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
SITE 3 3 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 7 7 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 13 13 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 31 31 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 35 35 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 59 59 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
NON_TER 1 1
NON_TER 59 59
SEQUENCE 59 AA; 7030 MW; 50471C038B24AF2C CRC64;
CDRRFSRSDE LTRHIRIHTG QKPFQCRICM RNFSRSDHLT THIRTHTGEK PFACDICGR


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