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Early growth response protein 1-A (EGR-1-A) (Xegr-1)

 EGR1A_XENLA             Reviewed;         497 AA.
Q6GQH4; Q9I831;
13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
19-JUL-2004, sequence version 1.
20-JUN-2018, entry version 68.
RecName: Full=Early growth response protein 1-A;
Short=EGR-1-A;
Short=Xegr-1 {ECO:0000303|PubMed:9687509};
Name=egr1-a; Synonyms=egr1;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1] {ECO:0000305, ECO:0000312|EMBL:AAF66986.1}
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
AND INDUCTION.
PubMed=9687509; DOI=10.1093/emboj/17.15.4414;
Panitz F., Krain B., Hollemann T., Nordheim A., Pieler T.;
"The Spemann organizer-expressed zinc finger gene Xegr-1 responds to
the MAP kinase/Ets-SRF signal transduction pathway.";
EMBO J. 17:4414-4425(1998).
[2] {ECO:0000312|EMBL:AAH72770.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Spleen {ECO:0000312|EMBL:AAH72770.1};
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000305}
INDUCTION.
PubMed=10610029;
Krain B., Nordheim A.;
"Artefactual gene induction during preparation of Xenopus laevis
animal cap explants.";
Int. J. Dev. Biol. 43:563-566(1999).
[4] {ECO:0000305}
INDUCTION.
PubMed=10096064; DOI=10.1016/S0925-4773(98)00194-4;
Chen Y., Hollemann T., Grunz H., Pieler T.;
"Characterization of the Ets-type protein ER81 in Xenopus embryos.";
Mech. Dev. 80:67-76(1999).
[5] {ECO:0000305}
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=10781937; DOI=10.1016/S0925-4773(00)00260-4;
Saka Y., Tada M., Smith J.C.;
"A screen for targets of the Xenopus T-box gene Xbra.";
Mech. Dev. 93:27-39(2000).
-!- FUNCTION: Transcriptional regulator. Recognizes and binds to the
DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region
of target genes (By similarity). Binds double-stranded target DNA,
irrespective of the cytosine methylation status (By similarity).
Regulates the transcription of numerous target genes, and thereby
plays an important role in regulating the response to growth
factors, DNA damage, and ischemia. Plays a role in the regulation
of cell survival, proliferation and cell death. Mediates responses
to ischemia and hypoxia; regulates the expression of proteins that
are involved in inflammatory processes (By similarity).
{ECO:0000250|UniProtKB:P08046, ECO:0000250|UniProtKB:P18146}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P18146}.
Cytoplasm {ECO:0000250|UniProtKB:P18146}.
-!- TISSUE SPECIFICITY: Expressed in the presumptive mesoderm. In
blastula embryos, expressed in the dorsal marginal zone, and at
the onset of gastrulation expression is specific to the Spemann
organizer. As gastrulation proceeds, expressed in a ring around
the yolk plug. This expression is maintained in advanced
gastrulae, with weak expression also extending into the dorsal
midline. By the neurula stage, expression is excluded from the
notochord. In late tailbud stages, expressed in two spots in the
anterior forebrain, which are connected via a bridge of cells that
also show expression. {ECO:0000269|PubMed:10781937,
ECO:0000269|PubMed:9687509}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Expressed at a low level maternally, with expression strongly
increasing with the onset of gastrulation, then decreasing again
in later stages of embryonic development with expression
undetectable during neurulation. Expressed in adults.
{ECO:0000269|PubMed:9687509}.
-!- INDUCTION: By dorsalizing and ventralizing growth factors during
mesoderm induction. Responds to the FGF-induced MAPK/Ets-serum
response factor (srf-elk1)-signaling pathway. Induced by activin
and bmp4 acting indirectly via an FGF-signaling pathway. Induced
in response to wound-induced activation of the MAPK pathway.
Induced by both t/bra and foxa4/pintallavis alone, with maximal
activation requiring both transcription factors. Induction by
t/bra is indirect and probably occurs via the FGF-signaling
pathway, whereas induction by foxa4/pintallavis may be direct.
{ECO:0000269|PubMed:10096064, ECO:0000269|PubMed:10610029,
ECO:0000269|PubMed:10781937, ECO:0000269|PubMed:9687509}.
-!- DOMAIN: Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3'
via its C2H2-type zinc fingers. The first, most N-terminal zinc
finger binds to the 3'-GCG motif, the middle zinc finger interacts
with the central TGG motif, and the C-terminal zinc finger binds
to the 5'-GCG motif. Binds double-stranded target DNA,
irrespective of the cytosine methylation status. Has reduced
affinity for target DNA where the cytosines have been oxidized to
5-hydroxymethylcytosine. Does not bind target DNA where the
cytosines have been oxidized to 5-formylcytosine or 5-
carboxylcytosine. {ECO:0000250|UniProtKB:P18146}.
-!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
family. {ECO:0000255}.
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EMBL; AF250345; AAF66986.1; -; mRNA.
EMBL; BC072770; AAH72770.1; -; mRNA.
RefSeq; NP_001083862.1; NM_001090393.1.
UniGene; Xl.637; -.
ProteinModelPortal; Q6GQH4; -.
SMR; Q6GQH4; -.
GeneID; 399162; -.
KEGG; xla:399162; -.
CTD; 399162; -.
Xenbase; XB-GENE-853419; egr1.
KO; K09203; -.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0003700; F:DNA binding transcription factor activity; ISS:UniProtKB.
GO; GO:0010385; F:double-stranded methylated DNA binding; ISS:UniProtKB.
GO; GO:0044729; F:hemi-methylated DNA-binding; ISS:UniProtKB.
GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR021849; EGR.
InterPro; IPR021839; EGR1_C.
InterPro; IPR036236; Znf_C2H2_sf.
InterPro; IPR013087; Znf_C2H2_type.
Pfam; PF11914; DUF3432; 1.
Pfam; PF11928; DUF3446; 1.
SMART; SM00355; ZnF_C2H2; 3.
SUPFAM; SSF57667; SSF57667; 2.
PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
2: Evidence at transcript level;
Activator; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Repeat;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 497 Early growth response protein 1-A.
/FTId=PRO_0000386427.
ZN_FING 306 330 C2H2-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 336 358 C2H2-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
ZN_FING 364 386 C2H2-type 3. {ECO:0000255|PROSITE-
ProRule:PRU00042}.
COMPBIAS 139 186 Ser-rich. {ECO:0000255}.
COMPBIAS 401 490 Ser-rich. {ECO:0000255}.
SITE 304 304 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 315 315 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 319 319 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 325 325 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 343 343 Interaction with DNA.
{ECO:0000250|UniProtKB:P08046}.
SITE 347 347 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 371 371 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 375 375 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
SITE 381 381 Interaction with DNA.
{ECO:0000250|UniProtKB:P18146}.
CONFLICT 447 447 A -> G (in Ref. 1; AAF66986).
{ECO:0000305}.
CONFLICT 497 497 C -> W (in Ref. 1; AAF66986).
{ECO:0000305}.
SEQUENCE 497 AA; 54142 MW; 794C1446864E53EB CRC64;
MAVAKTEMLV SPLQISDPFS SFPHSPTMDN YPKLEEMMLL NAGGPQFLGA SVPDGSGFNS
TVEGAEQFDH LTADAFSEMS LSSEKALVES SYANQTTRLP SLTYTGRFSL EPATNSSNTL
WPEPLFSLVS GLVGMANISP SSAPSSSPSS SSSSSSSQSP PLSCSVQSND SSPIYSAAPT
FPNSSSEIFP DHSPQPFQNA SIPYPPPAYP VSKTTFQVPM IPDYLFPQQQ GDVSLVSADQ
KPFQAMESRT QQPSLTPLST IKAYATHTSQ DLKTINSTYQ SQIIKPSRMR KYPNRPSKTP
PHERPYGCPV ESCDRRFSRS DELTRHIRIH TGQKPFQCRI CMRNFSRSDH LTTHIRTHTG
EKPFACDICG RKFARSDERK RHTKIHLRQK DKKADKATPV SVASPVSSYS PSASTSYPSP
VPTSYSSPVS SSYPSPVHSS FPSPTTAVTY PSVTSTFQTH GITSFPSSIM TNAFSSPMSS
ALSDMSLTYS PRTIEIC


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