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Ectonucleoside triphosphate diphosphohydrolase 6 (NTPDase 6) (EC 3.6.1.6) (CD39 antigen-like 2)

 ENTP6_RAT               Reviewed;         455 AA.
Q9ER31;
29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
22-NOV-2017, entry version 114.
RecName: Full=Ectonucleoside triphosphate diphosphohydrolase 6;
Short=NTPDase 6;
EC=3.6.1.6;
AltName: Full=CD39 antigen-like 2;
Name=Entpd6; Synonyms=Cd39l2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND
CHARACTERIZATION.
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=11042118; DOI=10.1042/bj3510639;
Braun N., Fengler S., Ebeling C., Servos J., Zimmermann H.;
"Sequencing, functional expression and characterization of rat
NTPDase6, a nucleoside diphosphatase and novel member of the ecto-
nucleoside triphosphate diphosphohydrolase family.";
Biochem. J. 351:639-647(2000).
-!- FUNCTION: Might support glycosylation reactions in the Golgi
apparatus and, when released from cells, might catalyze the
hydrolysis of extracellular nucleotides. Hydrolyzes preferentially
nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are
hydrolyzed only to a minor extent, there is no hydrolysis of
nucleoside 5'-monophosphates. The order of activity with different
substrates is GDP > IDP >> UDP = CDP >> ADP.
-!- CATALYTIC ACTIVITY: A nucleoside diphosphate + H(2)O = a
nucleoside phosphate + phosphate.
-!- COFACTOR:
Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
-!- SUBCELLULAR LOCATION: Golgi apparatus membrane
{ECO:0000269|PubMed:11042118}; Single-pass type II membrane
protein {ECO:0000269|PubMed:11042118}. Secreted
{ECO:0000269|PubMed:11042118}. Note=But also occurs in a soluble
extracellular form.
-!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family. {ECO:0000305}.
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EMBL; AJ277748; CAC16598.1; -; mRNA.
RefSeq; NP_445950.1; NM_053498.1.
RefSeq; XP_006235280.1; XM_006235218.3.
UniGene; Rn.27017; -.
ProteinModelPortal; Q9ER31; -.
SMR; Q9ER31; -.
STRING; 10116.ENSRNOP00000009946; -.
PaxDb; Q9ER31; -.
PRIDE; Q9ER31; -.
Ensembl; ENSRNOT00000009946; ENSRNOP00000009946; ENSRNOG00000007427.
GeneID; 85260; -.
KEGG; rno:85260; -.
UCSC; RGD:619725; rat.
CTD; 955; -.
RGD; 619725; Entpd6.
eggNOG; KOG1385; Eukaryota.
eggNOG; COG5371; LUCA.
GeneTree; ENSGT00510000046675; -.
HOGENOM; HOG000220904; -.
HOVERGEN; HBG018208; -.
InParanoid; Q9ER31; -.
KO; K01511; -.
OMA; DNVETSW; -.
OrthoDB; EOG091G06ET; -.
PhylomeDB; Q9ER31; -.
TreeFam; TF315029; -.
Reactome; R-RNO-8850843; Phosphate bond hydrolysis by NTPDase proteins.
PRO; PR:Q9ER31; -.
Proteomes; UP000002494; Chromosome 3.
Bgee; ENSRNOG00000007427; -.
Genevisible; Q9ER31; RN.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0070062; C:extracellular exosome; ISO:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0005794; C:Golgi apparatus; IDA:RGD.
GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0008894; F:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity; IDA:RGD.
GO; GO:0017110; F:nucleoside-diphosphatase activity; IDA:RGD.
GO; GO:0017111; F:nucleoside-triphosphatase activity; IDA:RGD.
GO; GO:0045134; F:uridine-diphosphatase activity; IEA:UniProtKB-EC.
GO; GO:0051592; P:response to calcium ion; IDA:RGD.
GO; GO:0032026; P:response to magnesium ion; IDA:RGD.
InterPro; IPR000407; GDA1_CD39_NTPase.
PANTHER; PTHR11782; PTHR11782; 1.
Pfam; PF01150; GDA1_CD39; 1.
PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
1: Evidence at protein level;
Calcium; Complete proteome; Disulfide bond; Glycoprotein;
Golgi apparatus; Hydrolase; Magnesium; Membrane; Reference proteome;
Secreted; Signal-anchor; Transmembrane; Transmembrane helix.
CHAIN 1 455 Ectonucleoside triphosphate
diphosphohydrolase 6.
/FTId=PRO_0000209914.
TOPO_DOM 1 12 Cytoplasmic. {ECO:0000255}.
TRANSMEM 13 32 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 33 455 Lumenal. {ECO:0000255}.
ACT_SITE 196 196 Proton acceptor. {ECO:0000250}.
CARBOHYD 192 192 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 256 256 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 297 327 {ECO:0000250}.
DISULFID 387 401 {ECO:0000250}.
SEQUENCE 455 AA; 49899 MW; 19A22E8BAEF0F77B CRC64;
MRKIPNHGTL RMTKVAYPLG LCVGLFIYVA YIKWHRASAA QAFFTIAGAA SGVRWTQQAF
SSPDSATRGH EVFYGIMFDA GSTGTRIHVF QFARPPGETP TLTHETFKAL KPGLSAYADD
VEKSAQGIQE LLNVAKQHIP YDFWKATPLV LKATAGLRLL PGEKAQKLLQ KVKEVFKASP
FLVGDDCVSI MNGTDEGVSA WITVNFLTGS LKTPGSSSVG MLDLGGGSTQ ITFLPRVEGT
LQASPPGHLT ALQMFNRTFK LYSYSYLGLG LMSARLAILG GVEGKPAEDD KELVSPCLSP
RFRGKWEHAE VTYRISGQKA VGLYELCASR VSEVLRNKVH RTEEAQHVDF YAFSYYYDLA
ASFGLIDAEK GGSLVVGDFE IAAKYVCRTL ETQPPSSPFA CMDLTYISLL LHEFGFPGDK
VLKLARKIDN VETSWALGAI FHYIDSLKRQ KVPAL


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