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Egg-laying defective protein 27

 EGL27_CAEEL             Reviewed;        1129 AA.
Q09228; J7RNK9; Q09229; Q86LT4; Q8MQF3; Q9XYD0;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
27-MAY-2002, sequence version 2.
22-NOV-2017, entry version 136.
RecName: Full=Egg-laying defective protein 27;
Name=egl-27; ORFNames=C04A2.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR
LOCATION, AND DEVELOPMENTAL STAGE.
STRAIN=Bristol N2;
PubMed=9927605;
Herman M.A., Ch'ng Q., Hettenbach S.M., Ratliff T.M., Kenyon C.,
Herman R.K.;
"EGL-27 is similar to a metastasis-associated factor and controls cell
polarity and cell migration in C. elegans.";
Development 126:1055-1064(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), FUNCTION, SUBCELLULAR
LOCATION, AND DEVELOPMENTAL STAGE.
STRAIN=Bristol N2;
PubMed=10226007;
Solari F., Bateman A., Ahringer J.;
"The Caenorhabditis elegans genes egl-27 and egr-1 are similar to
MTA1, a member of a chromatin regulatory complex, and are redundantly
required for embryonic patterning.";
Development 126:2483-2494(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE
SPLICING.
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[4]
FUNCTION, INTERACTION WITH CEH-6; SEM-4 AND SOX-2, SUBCELLULAR
LOCATION, DEVELOPMENTAL STAGE, DOMAIN, AND DISRUPTION PHENOTYPE.
PubMed=22493276; DOI=10.1073/pnas.1117031109;
Kagias K., Ahier A., Fischer N., Jarriault S.;
"Members of the NODE (Nanog and Oct4-associated deacetylase) complex
and SOX-2 promote the initiation of a natural cellular reprogramming
event in vivo.";
Proc. Natl. Acad. Sci. U.S.A. 109:6596-6601(2012).
[5]
FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND
DISRUPTION PHENOTYPE.
PubMed=23271974; DOI=10.1371/journal.pgen.1003108;
Xu X., Kim S.K.;
"The GATA transcription factor egl-27 delays aging by promoting stress
resistance in Caenorhabditis elegans.";
PLoS Genet. 8:E1003108-E1003108(2012).
[6]
INTERACTION WITH WDR-5.1.
PubMed=25124442; DOI=10.1126/science.1255885;
Zuryn S., Ahier A., Portoso M., White E.R., Morin M.C., Margueron R.,
Jarriault S.;
"Sequential histone-modifying activities determine the robustness of
transdifferentiation.";
Science 345:826-829(2014).
-!- FUNCTION: Transcription factor which promotes stress survival and
delays aging. Required for normal T-cell polarity, for correct
migration of QL neuroblast descendants and other cells, for
embryonic patterning and for the embryonic expression of hlh-8.
Also required for the transdifferentiation of the Y rectal
epithelial cell to the PDA motor neuron during larval development.
{ECO:0000269|PubMed:10226007, ECO:0000269|PubMed:22493276,
ECO:0000269|PubMed:23271974, ECO:0000269|PubMed:9927605}.
-!- SUBUNIT: Interacts with ceh-6, sem-4 and sox-2 (PubMed:22493276).
Interacts with wdr-5.1 (PubMed:25124442).
{ECO:0000269|PubMed:22493276, ECO:0000269|PubMed:25124442}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624,
ECO:0000269|PubMed:10226007, ECO:0000269|PubMed:22493276,
ECO:0000269|PubMed:9927605}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=a;
IsoId=Q09228-1; Sequence=Displayed;
Name=b;
IsoId=Q09228-2; Sequence=VSP_047939, VSP_001608;
Name=c;
IsoId=Q09228-3; Sequence=VSP_019864, VSP_001609;
Note=No experimental confirmation available.;
Name=d;
IsoId=Q09228-4; Sequence=VSP_047940, VSP_001608;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Expression detected in anterior intestine and
head region. {ECO:0000269|PubMed:23271974}.
-!- DEVELOPMENTAL STAGE: Expression detected from the 50-cell stage of
embryogenesis through to adulthood. In the adult, expression
increases two-fold between day 4 and day 14.
{ECO:0000269|PubMed:10226007, ECO:0000269|PubMed:22493276,
ECO:0000269|PubMed:23271974, ECO:0000269|PubMed:9927605}.
-!- INDUCTION: By starvation, heat stress, oxidative stress, and UV
stress. {ECO:0000269|PubMed:23271974}.
-!- DOMAIN: The SANT domain and GATA-type zinc finger are required for
conversion of the Y rectal cell to the PDA neuron.
{ECO:0000269|PubMed:22493276}.
-!- DISRUPTION PHENOTYPE: Shortened lifespan and reduced survival in
response to heat stress. Impaired differentiation of the Y rectal
cell to the PDA neuron with the Y cell remaining undifferentiated
in its original rectal location. {ECO:0000269|PubMed:22493276,
ECO:0000269|PubMed:23271974}.
-----------------------------------------------------------------------
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EMBL; AF096618; AAD27790.1; -; mRNA.
EMBL; FO080320; CCD62843.1; -; Genomic_DNA.
EMBL; FO080320; CCD62844.2; -; Genomic_DNA.
EMBL; FO080320; CCD62845.1; -; Genomic_DNA.
EMBL; FO080320; CCM09405.1; -; Genomic_DNA.
PIR; T43674; T43674.
RefSeq; NP_001021911.2; NM_001026740.4. [Q09228-2]
RefSeq; NP_001021912.1; NM_001026741.2. [Q09228-3]
RefSeq; NP_001263660.1; NM_001276731.1. [Q09228-4]
RefSeq; NP_741012.1; NM_171011.3. [Q09228-1]
UniGene; Cel.17167; -.
ProteinModelPortal; Q09228; -.
BioGrid; 39459; 12.
DIP; DIP-61372N; -.
IntAct; Q09228; 7.
MINT; MINT-1115071; -.
STRING; 6239.C04A2.3a; -.
iPTMnet; Q09228; -.
EPD; Q09228; -.
PaxDb; Q09228; -.
PeptideAtlas; Q09228; -.
EnsemblMetazoa; C04A2.3a; C04A2.3a; WBGene00001194. [Q09228-1]
GeneID; 174121; -.
KEGG; cel:CELE_C04A2.3; -.
UCSC; C04A2.3a; c. elegans. [Q09228-1]
CTD; 174121; -.
WormBase; C04A2.3a; CE31287; WBGene00001194; egl-27. [Q09228-1]
WormBase; C04A2.3b; CE47754; WBGene00001194; egl-27. [Q09228-2]
WormBase; C04A2.3c; CE33268; WBGene00001194; egl-27. [Q09228-3]
WormBase; C04A2.3d; CE47784; WBGene00001194; egl-27. [Q09228-4]
eggNOG; KOG2133; Eukaryota.
eggNOG; ENOG410ZIND; LUCA.
GeneTree; ENSGT00580000081398; -.
HOGENOM; HOG000019369; -.
InParanoid; Q09228; -.
KO; K05628; -.
OMA; DWHHANG; -.
OrthoDB; EOG091G0O1H; -.
PRO; PR:Q09228; -.
Proteomes; UP000001940; Chromosome II.
Bgee; WBGene00001194; -.
ExpressionAtlas; Q09228; baseline and differential.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0016581; C:NuRD complex; ISS:WormBase.
GO; GO:0003682; F:chromatin binding; IDA:WormBase.
GO; GO:0019899; F:enzyme binding; IPI:WormBase.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IPI:WormBase.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0010171; P:body morphogenesis; IMP:WormBase.
GO; GO:0007155; P:cell adhesion; IMP:WormBase.
GO; GO:0001708; P:cell fate specification; IMP:WormBase.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0008544; P:epidermis development; IMP:WormBase.
GO; GO:0007163; P:establishment or maintenance of cell polarity; IMP:UniProtKB.
GO; GO:0031581; P:hemidesmosome assembly; IGI:WormBase.
GO; GO:0007498; P:mesoderm development; IMP:WormBase.
GO; GO:0002119; P:nematode larval development; IMP:WormBase.
GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
GO; GO:0018991; P:oviposition; IMP:WormBase.
GO; GO:0009786; P:regulation of asymmetric cell division; IMP:WormBase.
GO; GO:0030334; P:regulation of cell migration; IMP:UniProtKB.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:WormBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0060290; P:transdifferentiation; IMP:WormBase.
GO; GO:0016055; P:Wnt signaling pathway; IMP:WormBase.
Gene3D; 3.30.50.10; -; 1.
InterPro; IPR001025; BAH_dom.
InterPro; IPR000949; ELM2_dom.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001005; SANT/Myb.
InterPro; IPR017884; SANT_dom.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
Pfam; PF01426; BAH; 1.
Pfam; PF01448; ELM2; 1.
Pfam; PF00320; GATA; 1.
SMART; SM00439; BAH; 1.
SMART; SM01189; ELM2; 1.
SMART; SM00717; SANT; 1.
SMART; SM00401; ZnF_GATA; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS51038; BAH; 1.
PROSITE; PS51156; ELM2; 1.
PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PROSITE; PS51293; SANT; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Developmental protein;
DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
Transcription; Transcription regulation; Zinc; Zinc-finger.
CHAIN 1 1129 Egg-laying defective protein 27.
/FTId=PRO_0000083511.
DOMAIN 87 223 BAH. {ECO:0000255|PROSITE-
ProRule:PRU00370}.
DOMAIN 224 327 ELM2. {ECO:0000255|PROSITE-
ProRule:PRU00512}.
DOMAIN 332 384 SANT. {ECO:0000255|PROSITE-
ProRule:PRU00624}.
ZN_FING 439 485 GATA-type; atypical.
{ECO:0000255|PROSITE-ProRule:PRU00094}.
COMPBIAS 615 619 Poly-Asp.
COMPBIAS 777 1111 Gln-rich.
COMPBIAS 948 1055 Ala-rich.
VAR_SEQ 1 515 Missing (in isoform c). {ECO:0000305}.
/FTId=VSP_019864.
VAR_SEQ 1 238 Missing (in isoform d). {ECO:0000305}.
/FTId=VSP_047940.
VAR_SEQ 1 141 Missing (in isoform b).
{ECO:0000303|PubMed:10226007}.
/FTId=VSP_047939.
VAR_SEQ 294 296 Missing (in isoform b and isoform d).
{ECO:0000303|PubMed:10226007}.
/FTId=VSP_001608.
VAR_SEQ 886 887 Missing (in isoform c). {ECO:0000305}.
/FTId=VSP_001609.
CONFLICT 671 671 P -> L (in Ref. 1; AAD27790).
{ECO:0000305}.
SEQUENCE 1129 AA; 128359 MW; 6E0F88BBC0AF43E8 CRC64;
MSRFDSQCSS EDVNKEDECV PSSSEDSQDG VSSPMENDDE PEFSQKHYDI EPCYYSLTGK
SDRNCRGIVY RYRQDSDLKG FQSHDGTLYR LRDSVFVEVS QNEPYVIAAI CGFKYTKRDH
VVVKLTRYFR ADDIPEISLN LMKQERAELE INPHLCPQSL NRELFNSELQ ITQPVSCLRG
KCIVEYVKDV RHARTVADFS LDNDTFFFCL HYNQDSTKLA STHYAIRVGT SFQATLPPMA
ECSVGDDSDR DELLYRPNSI ESGEEEDYIK LARCYRTYTL SGNHMLDSQK NARSLQVSDL
LMDEAIIQLH RSGYKIDDAL SELNANDIIL TTDVDNMTQD DAKKFAKGIK QLGKNFSRIH
RELLPHHSRE QLVSYYYLWK KTPEATKPKQ AARRVNPTSI KRPTKEKVKA SRPTSTEYLD
FDSASESDVE NNGPSGRACH HCYGAESKDW HHANGLLLCT DCRLHYKKYG QLRQIANRPS
QVPACLFKRS NSDEEESGVR TRAGKKEQRR RTPSSMSETP DRRSPSTVSN GAPNLTAEET
PTKKLNGSVK RAPKRPLHNG VINNVEKSNS SEEPASPTTP PPTLTNGLTN GHGPESSTPN
GETISKRMKV EPSYDDDDDE EEGKMTIDEG DDDPMPVLNG FKKEESVEEI KLELNGTIKK
ENGVETDPTT PTCSMEAENE VCETPAVVSV EIRDETNGET NSDLKDDENV EPDSPEDTFE
LGSNVEFETK NAMFVRSIVR SCGPRCARTD LIFKIKVGGV WEKSIKEKEE RKKVHLQNQR
IQDSEKVAIQ QNQIKKEQQQ SQPTPQQIHQ QQAQQNAQHL QQLQQAVMLG HLPPEVLRQM
MPPQFGVDPT AILMQQMMAG QQSQGVNAAF QHQMALQQQL EAHQVQFQLM MAHQHQQKMI
AEQQQQQRHA AAQQLREREQ REQRERERER QHQQQAQQAL HQQQQQHAAA AANQLNPAMM
QMMALMANSA ASQQDIARLM EMAAQQQQQQ QQAAQAQAQR DQERERRERE AREREAARER
EREQAAREAA ARDQAAREHA QAVQAAAAAA QQAQALTPDM QHMHLLQQLM LNPALMMQLQ
QAQAQQQQQQ PQVTNPLQML QHGMAAQSAN QAEMMRRIHP EPAMRPQHQ


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