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Elongation factor 1-alpha (EF-1-alpha) (50 kDa actin-binding protein) (ABP-50)

 EF1A1_DICDI             Reviewed;         453 AA.
P0CT31; P18624; Q55E03;
16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
16-OCT-2013, sequence version 1.
31-JAN-2018, entry version 36.
RecName: Full=Elongation factor 1-alpha;
Short=EF-1-alpha;
AltName: Full=50 kDa actin-binding protein;
AltName: Full=ABP-50;
Name=eef1a1; Synonyms=efaa1, efaAI; ORFNames=DDB_G0269134;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliaceae;
Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, AND INTERACTION
WITH ACTIN.
STRAIN=AX3;
PubMed=2215665; DOI=10.1038/347494a0;
Yang F., Demma M., Warren V., Dharmawardhane S., Condeelis J.;
"Identification of an actin-binding protein from Dictyostelium as
elongation factor 1a.";
Nature 347:494-496(1990).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
STRAIN=AX2;
PubMed=16926386; DOI=10.1074/mcp.M600113-MCP200;
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
Soldati T.;
"Proteomics fingerprinting of phagosome maturation and evidence for
the role of a Galpha during uptake.";
Mol. Cell. Proteomics 5:2228-2243(2006).
-!- FUNCTION: This protein promotes the GTP-dependent binding of
aminoacyl-tRNA to the A-site of ribosomes during protein
biosynthesis. It is also an abundant actin filament bundling
protein.
-!- SUBUNIT: Binds to actin.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X55973; CAA39443.1; -; mRNA.
EMBL; AAFI02000005; EAL71917.1; -; Genomic_DNA.
PIR; S11665; S11665.
RefSeq; XP_645839.1; XM_640747.1.
RefSeq; XP_645978.1; XM_640886.1.
ProteinModelPortal; P0CT31; -.
SMR; P0CT31; -.
STRING; 44689.DDB0191135; -.
PaxDb; P0CT31; -.
PRIDE; P0CT31; -.
EnsemblProtists; EAL71917; EAL71917; DDB_G0269134.
GeneID; 8616783; -.
GeneID; 8616922; -.
KEGG; ddi:DDB_G0269134; -.
KEGG; ddi:DDB_G0269136; -.
dictyBase; DDB_G0269134; efaAI.
eggNOG; KOG0052; Eukaryota.
eggNOG; COG5256; LUCA.
KO; K03231; -.
OMA; WYKGWTK; -.
PhylomeDB; P0CT31; -.
Reactome; R-DDI-156842; Eukaryotic Translation Elongation.
Reactome; R-DDI-3371511; HSF1 activation.
Reactome; R-DDI-6798695; Neutrophil degranulation.
Reactome; R-DDI-8876725; Protein methylation.
PRO; PR:P0CT31; -.
Proteomes; UP000002195; Chromosome 1.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0005938; C:cell cortex; IDA:dictyBase.
GO; GO:0005829; C:cytosol; IDA:dictyBase.
GO; GO:0030175; C:filopodium; IDA:dictyBase.
GO; GO:0030027; C:lamellipodium; IDA:dictyBase.
GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
GO; GO:0031143; C:pseudopodium; IDA:dictyBase.
GO; GO:0051015; F:actin filament binding; IDA:dictyBase.
GO; GO:0003785; F:actin monomer binding; IDA:dictyBase.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
GO; GO:0003746; F:translation elongation factor activity; IDA:dictyBase.
GO; GO:0051017; P:actin filament bundle assembly; IDA:dictyBase.
GO; GO:0010446; P:response to alkaline pH; IDA:dictyBase.
GO; GO:0009617; P:response to bacterium; HEP:dictyBase.
GO; GO:0000302; P:response to reactive oxygen species; IEP:dictyBase.
GO; GO:0006412; P:translation; IDA:dictyBase.
GO; GO:0006414; P:translational elongation; IDA:dictyBase.
HAMAP; MF_00118_A; EF_Tu_A; 1.
InterPro; IPR004161; EFTu-like_2.
InterPro; IPR031157; G_TR_CS.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005225; Small_GTP-bd_dom.
InterPro; IPR000795; TF_GTP-bd_dom.
InterPro; IPR009000; Transl_B-barrel_sf.
InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
InterPro; IPR004539; Transl_elong_EF1A_euk/arc.
InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
Pfam; PF00009; GTP_EFTU; 1.
Pfam; PF03144; GTP_EFTU_D2; 1.
Pfam; PF03143; GTP_EFTU_D3; 1.
PRINTS; PR00315; ELONGATNFCT.
SUPFAM; SSF50447; SSF50447; 1.
SUPFAM; SSF50465; SSF50465; 1.
SUPFAM; SSF52540; SSF52540; 1.
TIGRFAMs; TIGR00483; EF-1_alpha; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS00301; G_TR_1; 1.
PROSITE; PS51722; G_TR_2; 1.
1: Evidence at protein level;
Actin-binding; Complete proteome; Cytoplasm;
Direct protein sequencing; Elongation factor; GTP-binding;
Nucleotide-binding; Protein biosynthesis; Reference proteome.
CHAIN 1 453 Elongation factor 1-alpha.
/FTId=PRO_0000090919.
DOMAIN 5 230 tr-type G.
NP_BIND 14 21 GTP. {ECO:0000250}.
NP_BIND 91 95 GTP. {ECO:0000250}.
NP_BIND 153 156 GTP. {ECO:0000250}.
REGION 14 21 G1. {ECO:0000250}.
REGION 70 74 G2. {ECO:0000250}.
REGION 91 94 G3. {ECO:0000250}.
REGION 153 156 G4. {ECO:0000250}.
REGION 194 196 G5. {ECO:0000250}.
CONFLICT 1 3 MGK -> MEFPES (in Ref. 1; CAA39443).
{ECO:0000305}.
SEQUENCE 453 AA; 49662 MW; 5D608E4B722CE003 CRC64;
MGKEKTHINI VVIGHVDAGK STTTGHLIYK CGGIDKRVIE KYEKEASEMG KQSFKYAWVM
DKLKAERERG ITIDIALWKF ETSKYYFTII DAPGHRDFIK NMITGTSQAD CAVLVIASPT
GEFEAGIAKN GQTREHALLA YTLGVKQMIV AINKMDEKST NYSQARYDEI VKEVSSFIKK
IGYNPEKVAF VPISGWNGDN MLERSDKMEW YKGPTLLEAL DAIVEPKRPH DKPLRIPLQD
VYKIGGIGTV PVGRVETGII KPGMVVTFAP AGLSTEVKSV EMHHEQLPEA RPGDNVGFNV
KNVSVKEIKR GMVAGDSKND PPQETEKFVA QVIVLNHPGQ IHAGYSPVLD CHTAHIACKF
TEIVDKVDRR TGAVVAKEGT AAVVLKNGDA AMVELTPSRP MCVESFTEYP PLGRFAVRDM
RQTVAVGVIK STVKKAPGKA GDKKGAAAPS KKK


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