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Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase Elovl6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Fatty acid elongase 2) (rELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6)

 ELOV6_RAT               Reviewed;         267 AA.
Q920L6;
03-APR-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
23-MAY-2018, entry version 96.
RecName: Full=Elongation of very long chain fatty acids protein 6 {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000305};
EC=2.3.1.199 {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:12005057};
AltName: Full=3-keto acyl-CoA synthase Elovl6 {ECO:0000255|HAMAP-Rule:MF_03206};
AltName: Full=ELOVL fatty acid elongase 6 {ECO:0000255|HAMAP-Rule:MF_03206};
Short=ELOVL FA elongase 6 {ECO:0000255|HAMAP-Rule:MF_03206};
AltName: Full=Fatty acid elongase 2;
Short=rELO2;
AltName: Full=Fatty acyl-CoA elongase;
AltName: Full=Long-chain fatty-acyl elongase;
AltName: Full=Very long chain 3-ketoacyl-CoA synthase 6 {ECO:0000255|HAMAP-Rule:MF_03206};
AltName: Full=Very long chain 3-oxoacyl-CoA synthase 6 {ECO:0000255|HAMAP-Rule:MF_03206};
Name=Elovl6 {ECO:0000255|HAMAP-Rule:MF_03206}; Synonyms=Face, Lce;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, PATHWAY, AND
TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley; TISSUE=Liver;
PubMed=12005057; DOI=10.1271/bbb.66.613;
Inagaki K., Aki T., Fukuda Y., Kawamoto S., Shigeta S., Ono K.,
Suzuki O.;
"Identification and expression of a rat fatty acid elongase involved
in the biosynthesis of C18 fatty acids.";
Biosci. Biotechnol. Biochem. 66:613-621(2002).
-!- FUNCTION: Catalyzes the first and rate-limiting reaction of the
four that constitute the long-chain fatty acids elongation cycle.
This endoplasmic reticulum-bound enzymatic process, allows the
addition of 2 carbons to the chain of long- and very long-chain
fatty acids/VLCFAs per cycle. Condensing enzyme that elongates
fatty acids with 12, 14 and 16 carbons with higher activity toward
C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long
chain fatty acids and, to a lesser extent, C18:0 and those with
low desaturation degree. May participate in the production of
saturated and monounsaturated VLCFAs of different chain lengths
that are involved in multiple biological processes as precursors
of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-
Rule:MF_03206, ECO:0000269|PubMed:12005057}.
-!- CATALYTIC ACTIVITY: A very-long-chain acyl-CoA + malonyl-CoA = CoA
+ a very-long-chain 3-oxoacyl-CoA + CO(2). {ECO:0000255|HAMAP-
Rule:MF_03206, ECO:0000269|PubMed:12005057}.
-!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
{ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:12005057}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000255|HAMAP-Rule:MF_03206}; Multi-pass membrane protein
{ECO:0000255|HAMAP-Rule:MF_03206}.
-!- TISSUE SPECIFICITY: Expressed in liver and barely in brain.
{ECO:0000269|PubMed:12005057}.
-!- PTM: N-Glycosylated. {ECO:0000255|HAMAP-Rule:MF_03206}.
-!- SIMILARITY: Belongs to the ELO family. ELOVL6 subfamily.
{ECO:0000255|HAMAP-Rule:MF_03206}.
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EMBL; AB071986; BAB69888.1; -; mRNA.
RefSeq; NP_599210.1; NM_134383.2.
RefSeq; XP_008759707.1; XM_008761485.1.
RefSeq; XP_017452388.1; XM_017596899.1.
UniGene; Rn.46942; -.
STRING; 10116.ENSRNOP00000067070; -.
SwissLipids; SLP:000000453; -.
PaxDb; Q920L6; -.
Ensembl; ENSRNOT00000014155; ENSRNOP00000014155; ENSRNOG00000010468.
Ensembl; ENSRNOT00000071270; ENSRNOP00000067070; ENSRNOG00000048949.
GeneID; 102549542; -.
GeneID; 171402; -.
KEGG; rno:102549542; -.
KEGG; rno:171402; -.
UCSC; RGD:620585; rat.
CTD; 79071; -.
RGD; 620585; Elovl6.
eggNOG; KOG3072; Eukaryota.
eggNOG; ENOG410Z3FZ; LUCA.
GeneTree; ENSGT00760000119122; -.
HOGENOM; HOG000038943; -.
HOVERGEN; HBG099423; -.
InParanoid; Q920L6; -.
KO; K10203; -.
OMA; EYEFERQ; -.
OrthoDB; EOG091G0EKU; -.
PhylomeDB; Q920L6; -.
TreeFam; TF106467; -.
Reactome; R-RNO-75876; Synthesis of very long-chain fatty acyl-CoAs.
UniPathway; UPA00094; -.
PRO; PR:Q920L6; -.
Proteomes; UP000002494; Chromosome 2.
Bgee; ENSRNOG00000010468; -.
Genevisible; Q920L6; RN.
GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
GO; GO:0102336; F:3-oxo-arachidoyl-CoA synthase activity; IEA:UniProtKB-EC.
GO; GO:0102337; F:3-oxo-cerotoyl-CoA synthase activity; IEA:UniProtKB-EC.
GO; GO:0102338; F:3-oxo-lignoceronyl-CoA synthase activity; IEA:UniProtKB-EC.
GO; GO:0009922; F:fatty acid elongase activity; IDA:UniProtKB.
GO; GO:0102756; F:very-long-chain 3-ketoacyl-CoA synthase activity; IEA:UniProtKB-EC.
GO; GO:0034625; P:fatty acid elongation, monounsaturated fatty acid; IDA:UniProtKB.
GO; GO:0034626; P:fatty acid elongation, polyunsaturated fatty acid; IBA:GO_Central.
GO; GO:0019367; P:fatty acid elongation, saturated fatty acid; IDA:UniProtKB.
GO; GO:0042759; P:long-chain fatty acid biosynthetic process; ISS:UniProtKB.
GO; GO:0030148; P:sphingolipid biosynthetic process; IBA:GO_Central.
GO; GO:0042761; P:very long-chain fatty acid biosynthetic process; IBA:GO_Central.
HAMAP; MF_03206; VLCF_elongase_6; 1.
InterPro; IPR030457; ELO_CS.
InterPro; IPR002076; ELO_fam.
InterPro; IPR033675; ELOVL6.
PANTHER; PTHR11157; PTHR11157; 1.
PANTHER; PTHR11157:SF42; PTHR11157:SF42; 1.
Pfam; PF01151; ELO; 1.
PROSITE; PS01188; ELO; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis;
Fatty acid metabolism; Glycoprotein; Lipid biosynthesis;
Lipid metabolism; Membrane; Reference proteome; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1 267 Elongation of very long chain fatty acids
protein 6.
/FTId=PRO_0000282847.
TRANSMEM 34 51 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
TRANSMEM 70 90 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
TRANSMEM 111 131 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
TRANSMEM 136 156 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
TRANSMEM 159 179 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
TRANSMEM 197 217 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
TRANSMEM 234 254 Helical. {ECO:0000255|HAMAP-
Rule:MF_03206}.
CARBOHYD 2 2 N-linked (GlcNAc...) asparagine.
{ECO:0000255|HAMAP-Rule:MF_03206}.
SEQUENCE 267 AA; 31624 MW; 4026C9CB33ED0743 CRC64;
MNMSVLTLQE YEFEKQFNEN EAIQWMQENW KKSFLFSALY AAFIFGGRHL MNKRAKFELR
KPLVLWSLTL AVFSIFGALR TGAYMLYILM TKGLKQSVCD QSFYNGPVSK FWAYAFVLSK
APELGDTIFI ILRKQKLIFL HWYHHITVLL YSWYSYKDMV AGGGWFMTMN YGVHAVMYSY
YALRAAGFRV SRKFAMFITL SQITQMLMGC VINYLVFNWM QHDNDQCYSH FQNIFWSSLM
YLSYLLLFCH FFFEAYIGKV KKATKAE


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