Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Embigin

 EMB_RAT                 Reviewed;         328 AA.
O88775;
01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
05-DEC-2018, entry version 112.
RecName: Full=Embigin;
Flags: Precursor;
Name=Emb; Synonyms=Gp70;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=Sprague-Dawley; TISSUE=Prostate;
PubMed=9438341;
DOI=10.1002/(SICI)1520-6408(1997)21:4<268::AID-DVG4>3.0.CO;2-5;
Guenette R., Sridhar S., Herley M., Mooibroek M., Wong P.,
Tenniswood M.;
"Embigin, a developmentally expressed member of the immunoglobulin
super family, is also expressed during regression of prostate and
mammary gland.";
Dev. Genet. 21:268-278(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 121-135, INTERACTION WITH SLC16A1, GLYCOSYLATION,
TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
PubMed=9169423; DOI=10.1074/jbc.272.23.14624;
Poole R.C., Halestrap A.P.;
"Interaction of the erythrocyte lactate transporter (monocarboxylate
transporter 1) with an integral 70-kDa membrane glycoprotein of the
immunoglobulin superfamily.";
J. Biol. Chem. 272:14624-14628(1997).
[4]
PROTEIN SEQUENCE OF 142-151; 165-179 AND 240-252, AND IDENTIFICATION
BY MASS SPECTROMETRY.
STRAIN=Sprague-Dawley; TISSUE=Brain;
Lubec G., Kang S.U., Lubec S.;
Submitted (SEP-2007) to UniProtKB.
[5]
INTERACTION WITH SLC16A7.
PubMed=15917240; DOI=10.1074/jbc.M411950200;
Wilson M.C., Meredith D., Fox J.E., Manoharan C., Davies A.J.,
Halestrap A.P.;
"Basigin (CD147) is the target for organomercurial inhibition of
monocarboxylate transporter isoforms 1 and 4: the ancillary protein
for the insensitive MCT2 is EMBIGIN (gp70).";
J. Biol. Chem. 280:27213-27221(2005).
[6]
INDUCTION.
PubMed=19164284; DOI=10.1074/jbc.M809491200;
Lain E., Carnejac S., Escher P., Wilson M.C., Lomo T., Gajendran N.,
Brenner H.R.;
"A novel role for embigin to promote sprouting of motor nerve
terminals at the neuromuscular junction.";
J. Biol. Chem. 284:8930-8939(2009).
[7]
FUNCTION, INTERACTION WITH SLC16A1, SUBCELLULAR LOCATION, AND
TOPOLOGY.
PubMed=19473976; DOI=10.1074/jbc.M109.014217;
Wilson M.C., Meredith D., Bunnun C., Sessions R.B., Halestrap A.P.;
"Studies on the DIDS-binding site of monocarboxylate transporter 1
suggest a homology model of the open conformation and a plausible
translocation cycle.";
J. Biol. Chem. 284:20011-20021(2009).
[8]
INTERACTION WITH SLC16A7, AND FUNCTION.
PubMed=20695846; DOI=10.1042/BJ20100890;
Ovens M.J., Manoharan C., Wilson M.C., Murray C.M., Halestrap A.P.;
"The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858
is modulated by the associated ancillary protein.";
Biochem. J. 431:217-225(2010).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Plays a role in the outgrowth of motoneurons and in the
formation of neuromuscular junctions. Following muscle
denervation, promotes nerve terminal sprouting and the formation
of additional acetylcholine receptor clusters at synaptic sites
without affecting terminal Schwann cell number or morphology.
Delays the retraction of terminal sprouts following re-innervation
of denervated endplates (By similarity). Plays a role in targeting
the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell
membrane. {ECO:0000250, ECO:0000269|PubMed:19473976,
ECO:0000269|PubMed:20695846}.
-!- SUBUNIT: Interacts with SLC16A1 and SLC16A7.
{ECO:0000269|PubMed:15917240, ECO:0000269|PubMed:19473976,
ECO:0000269|PubMed:20695846, ECO:0000269|PubMed:9169423}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20695846,
ECO:0000269|PubMed:9169423}; Single-pass type I membrane protein
{ECO:0000305|PubMed:19473976, ECO:0000305|PubMed:9169423}. Cell
junction, synapse {ECO:0000250|UniProtKB:P21995}. Note=Localizes
to the neuromuscular junctions. {ECO:0000250|UniProtKB:P21995}.
-!- TISSUE SPECIFICITY: Detected in prostate, mammary gland and
erythrocytes (at protein level). Detected in testis, brain,
prostate, heart, kidney, liver, mammary gland and lung.
{ECO:0000269|PubMed:9169423, ECO:0000269|PubMed:9438341}.
-!- INDUCTION: Regulated by muscle activity. Strongly up-regulated
after muscle denervation, including that of soleus muscle.
Expression is significantly increased 3 days after denervation and
reaches a maximum, about 130-fold increase, after 5 days.
{ECO:0000269|PubMed:19164284}.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:9169423}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AJ009698; CAA08796.1; -; mRNA.
EMBL; BC061846; AAH61846.1; -; mRNA.
RefSeq; NP_446171.1; NM_053719.1.
UniGene; Rn.16221; -.
ProteinModelPortal; O88775; -.
STRING; 10116.ENSRNOP00000015306; -.
iPTMnet; O88775; -.
PhosphoSitePlus; O88775; -.
PaxDb; O88775; -.
PRIDE; O88775; -.
GeneID; 114511; -.
KEGG; rno:114511; -.
CTD; 133418; -.
RGD; 621067; Emb.
eggNOG; ENOG410IVBC; Eukaryota.
eggNOG; ENOG41120A3; LUCA.
HOGENOM; HOG000082417; -.
HOVERGEN; HBG051471; -.
InParanoid; O88775; -.
PhylomeDB; O88775; -.
TreeFam; TF326759; -.
PRO; PR:O88775; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0030424; C:axon; IBA:GO_Central.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
GO; GO:0007411; P:axon guidance; IBA:GO_Central.
GO; GO:0007155; P:cell adhesion; IDA:RGD.
GO; GO:0070593; P:dendrite self-avoidance; IBA:GO_Central.
GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
GO; GO:0035879; P:plasma membrane lactate transport; IDA:RGD.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR027114; Embigin.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
PANTHER; PTHR10075:SF4; PTHR10075:SF4; 1.
SMART; SM00409; IG; 2.
SUPFAM; SSF48726; SSF48726; 2.
PROSITE; PS50835; IG_LIKE; 2.
1: Evidence at protein level;
Cell junction; Cell membrane; Complete proteome;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome;
Repeat; Signal; Synapse; Transmembrane; Transmembrane helix.
SIGNAL 1 33 {ECO:0000255}.
CHAIN 34 328 Embigin.
/FTId=PRO_0000014751.
TOPO_DOM 34 264 Extracellular. {ECO:0000255}.
TRANSMEM 265 285 Helical. {ECO:0000255}.
TOPO_DOM 286 328 Cytoplasmic. {ECO:0000255}.
DOMAIN 67 160 Ig-like 1.
DOMAIN 159 254 Ig-like 2.
MOD_RES 310 310 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CARBOHYD 55 55 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 75 75 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 100 100 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 117 117 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 189 189 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 196 196 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 214 214 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 219 219 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 88 144 {ECO:0000255|PROSITE-ProRule:PRU00114}.
DISULFID 180 238 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 328 AA; 37005 MW; C749A847ACE374B1 CRC64;
MRSHTGLRAL VAPGCSLLLL YLLAATRPDR AVGDPADSAF TSLPVREEMM AKYANLSLET
YNISLTEQTR VSEQNITLER PSHLELECTF TATEDVMSMN VTWKKDDALL ETTDGFNTTK
MGDTLYSQYR FTVFNSKQMG KYSCFLGEEL RGTFNIRVPK VHGKNKPLIT YVGDSTVLKC
ECQNCLPLNW TWYMSNGTAQ VPIDVHVNDK FDINGSYANE TKLKVKHLLE EDGGSYWCRA
AFPLGESEEH IKLVVLSFMV PLKPFLAIIA EVILLVAIIL LCEVYTQKKK NDPDDGKEFE
QIEQLKSDDS NGIENNVPRY RKTDSGDQ


Related products :

Catalog number Product name Quantity
EMD EMB Gene embigin
orb96657 Embigin antibody 50 ug
orb96656 Embigin antibody 50 ug
orb94800 Embigin antibody 50 ug
orb94799 Embigin antibody 50 ug
CSB-EL007631RA Rat Embigin(EMB) ELISA kit 96T
E7746h Human Embigin ELISA Kit 96T
CSB-EL007631HU Human Embigin(EMB) ELISA kit 96T
CSB-EL007631MO Mouse Embigin(EMB) ELISA kit 96T
QY-E04948 Human Embigin(EMB)ELISA Kit 96T
201-12-3700 Human Embigin(EMB)ELISA Kit 96T
UT-E04948 Human Embigin (EMB) ELISA Kit 96T
UB-E04948 Human Embigin(EMB)ELISA Kit 96T
EIAAB12892 Emb,Embigin,Rat,Rattus norvegicus
CSB-EL007631RA Rat Embigin(EMB) ELISA kit SpeciesRat 96T
E1290h Mouse ELISA Kit FOR Embigin 96T
12-5839-80 Anti-Mouse Embigin PE 25 ug
12-5839-82 Anti-Mouse Embigin PE 100 ug
'AP31142PU-N Embigin IgG antibody Ab host: Rabbit 50 Вµl
'AP21779PU-N Embigin antibody Ab host: Rabbit 0.1 mg
14-5839-81 Anti-Mouse Embigin Purified 50 ug
14-5839-85 Anti-Mouse Embigin Purified 500 ug
GTX121953 Embigin Rabbit antibody Ab Aff - Purified 0.1 ml
GTX121952 Embigin Rabbit IgG antibody Ab Purified 0.1 ml
AP21779PU-N Embigin Rabbit antibody Ab Purified 0.1 mg


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur | Gentaur





GENTAUR Ltd.
Unicorn House, Station Cl
Hertfordshire, Potters Bar EN6 1TL
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017
RIB 30004 00187 00010092253 10
BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG
IBAN FR76 3000 4001 8700 0100 9225 310
france@gentaur.com | Gentaur | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: +49 0241 40 08 90 86, +49 0241 95 78 94 78, +49 0241 40 08 90 86
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur | Gentaur