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Endonuclease G

 G1PPS8_MYOLU            Unreviewed;       294 AA.
G1PPS8;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
30-AUG-2017, entry version 33.
SubName: Full=Endonuclease G {ECO:0000313|Ensembl:ENSMLUP00000013031};
Name=ENDOG {ECO:0000313|Ensembl:ENSMLUP00000013031};
Myotis lucifugus (Little brown bat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
Vespertilionidae; Myotis.
NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013031, ECO:0000313|Proteomes:UP000001074};
[1] {ECO:0000313|Ensembl:ENSMLUP00000013031, ECO:0000313|Proteomes:UP000001074}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29
mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSMLUP00000013031}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSMLUP00000013031}.
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EMBL; AAPE02046837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_006103214.1; XM_006103152.2.
STRING; 59463.ENSMLUP00000013031; -.
Ensembl; ENSMLUT00000014326; ENSMLUP00000013031; ENSMLUG00000014319.
GeneID; 102427586; -.
CTD; 2021; -.
eggNOG; KOG3721; Eukaryota.
eggNOG; COG1864; LUCA.
GeneTree; ENSGT00530000063772; -.
InParanoid; G1PPS8; -.
OMA; VPHWVFE; -.
OrthoDB; EOG091G0BHG; -.
TreeFam; TF105386; -.
Proteomes; UP000001074; Unassembled WGS sequence.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:InterPro.
GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO; GO:0006309; P:apoptotic DNA fragmentation; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
InterPro; IPR018524; DNA/RNA_endonuclease_AS.
InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
InterPro; IPR020821; Extracellular_endonuc_su_A.
Pfam; PF01223; Endonuclease_NS; 1.
SMART; SM00892; Endonuclease_NS; 1.
SMART; SM00477; NUC; 1.
PROSITE; PS01070; NUCLEASE_NON_SPEC; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001074};
Reference proteome {ECO:0000313|Proteomes:UP000001074};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 19 {ECO:0000256|SAM:SignalP}.
CHAIN 20 294 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003417363.
DOMAIN 74 282 Endonuclease_NS.
{ECO:0000259|SMART:SM00892}.
DOMAIN 75 282 NUC. {ECO:0000259|SMART:SM00477}.
SEQUENCE 294 AA; 32282 MW; 8CC98EBEA823A74B CRC64;
MRALRAALTL ALGAGLGAAA EGWRRRRADA RPAPGLLGRL PVLPVAAAAE LPVVPAGPGE
LAKYGLPGLA QLKSRESYVL CYDPRTRCAL WVVEQLRPER LRGDGDRRSC DFREDDSVHA
YHRATNADYR GSGFDRGHLA AAANHRWSQK AMDDTFYLSN IAPQVPHLNQ KAWNNLEKYS
RSLTRTYQNV YVCTGPLFLP KTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAAGGQIE
LRSYVMPNAP VDEAIPLERF LVPIESIERA SGLLFVPNIL ARAGSLKAIT AGSK


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