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Endonuclease G

 Q3UN47_MOUSE            Unreviewed;       294 AA.
Q3UN47;
11-OCT-2005, integrated into UniProtKB/TrEMBL.
11-OCT-2005, sequence version 1.
22-NOV-2017, entry version 106.
SubName: Full=Endonuclease G {ECO:0000313|EMBL:EDL08440.1};
Name=Endog {ECO:0000313|EMBL:EDL08440.1, ECO:0000313|MGI:MGI:1261433};
ORFNames=mCG_18295 {ECO:0000313|EMBL:EDL08440.1};
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE25900.1};
[1] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
Carninci P., Hayashizaki Y.;
"High-efficiency full-length cDNA cloning.";
Methods Enzymol. 303:19-44(1999).
[2] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
PubMed=11042159; DOI=10.1101/gr.145100;
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
"Normalization and subtraction of cap-trapper-selected cDNAs to
prepare full-length cDNA libraries for rapid discovery of new genes.";
Genome Res. 10:1617-1630(2000).
[3] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
PubMed=11076861; DOI=10.1101/gr.152600;
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
"RIKEN integrated sequence analysis (RISA) system--384-format
sequencing pipeline with 384 multicapillary sequencer.";
Genome Res. 10:1757-1771(2000).
[4] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
PubMed=11217851; DOI=10.1038/35055500;
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
"Functional annotation of a full-length mouse cDNA collection.";
Nature 409:685-690(2001).
[5] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
PubMed=12466851; DOI=10.1038/nature01266;
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
"Analysis of the mouse transcriptome based on functional annotation of
60,770 full-length cDNAs.";
Nature 420:563-573(2002).
[6] {ECO:0000313|EMBL:EDL08440.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL08440.1};
PubMed=12040188; DOI=10.1126/science.1069193;
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
"A comparison of whole-genome shotgun-derived mouse chromosome 16 and
the human genome.";
Science 296:1661-1671(2002).
[7] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
Muramatsu M., Hayashizaki Y.;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
The FANTOM Consortium;
Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
"The Transcriptional Landscape of the Mammalian Genome.";
Science 309:1559-1563(2005).
[9] {ECO:0000313|EMBL:BAE25900.1}
NUCLEOTIDE SEQUENCE.
STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE25900.1};
TISSUE=Diencephalon {ECO:0000313|EMBL:BAE25900.1};
PubMed=16141073; DOI=10.1126/science.1112009;
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
"Antisense Transcription in the Mammalian Transcriptome.";
Science 309:1564-1566(2005).
[10] {ECO:0000313|EMBL:EDL08440.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Mixed {ECO:0000313|EMBL:EDL08440.1};
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[11] {ECO:0000213|PubMed:21183079}
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-----------------------------------------------------------------------
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EMBL; AK144459; BAE25900.1; -; mRNA.
EMBL; CH466542; EDL08440.1; -; Genomic_DNA.
RefSeq; NP_031957.1; NM_007931.1.
UniGene; Mm.474473; -.
SMR; Q3UN47; -.
MaxQB; Q3UN47; -.
GeneID; 13804; -.
KEGG; mmu:13804; -.
CTD; 2021; -.
MGI; MGI:1261433; Endog.
eggNOG; KOG3721; Eukaryota.
eggNOG; COG1864; LUCA.
HOVERGEN; HBG002851; -.
KO; K01173; -.
OMA; VPHWVFE; -.
OrthoDB; EOG091G0BHG; -.
ChiTaRS; Endog; mouse.
Bgee; ENSMUSG00000015337; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0043204; C:perikaryon; IEA:Ensembl.
GO; GO:0004536; F:deoxyribonuclease activity; IEA:Ensembl.
GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:InterPro.
GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0006309; P:apoptotic DNA fragmentation; IEA:Ensembl.
GO; GO:0071277; P:cellular response to calcium ion; IEA:Ensembl.
GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0036475; P:neuron death in response to oxidative stress; IEA:Ensembl.
GO; GO:1902512; P:positive regulation of apoptotic DNA fragmentation; IEA:Ensembl.
GO; GO:1901300; P:positive regulation of hydrogen peroxide-mediated programmed cell death; IEA:Ensembl.
GO; GO:0046677; P:response to antibiotic; IEA:Ensembl.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
GO; GO:0034612; P:response to tumor necrosis factor; IEA:Ensembl.
InterPro; IPR018524; DNA/RNA_endonuclease_AS.
InterPro; IPR001604; DNA/RNA_non-sp_Endonuclease.
InterPro; IPR020821; Extracellular_endonuc_su_A.
Pfam; PF01223; Endonuclease_NS; 1.
SMART; SM00892; Endonuclease_NS; 1.
SMART; SM00477; NUC; 1.
PROSITE; PS01070; NUCLEASE_NON_SPEC; 1.
1: Evidence at protein level;
Endonuclease {ECO:0000313|EMBL:EDL08440.1};
Hydrolase {ECO:0000313|EMBL:EDL08440.1};
Nuclease {ECO:0000313|EMBL:EDL08440.1};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 19 {ECO:0000256|SAM:SignalP}.
CHAIN 20 294 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5011098873.
DOMAIN 74 282 Endonuclease_NS.
{ECO:0000259|SMART:SM00892}.
DOMAIN 75 282 NUC. {ECO:0000259|SMART:SM00477}.
SEQUENCE 294 AA; 32191 MW; 9F01FB1BC28B95D3 CRC64;
MRALRAGLTL ALGAGLGAAA EHWRRREGKA PGLLGRVPLL PVVAADLPAL PGGPAGGTGE
LAKYGLPGVA QLRSRESYVL SYDPRTRGAL WVLEQLRPER LRGDGDRSAC DFREDDSVHA
YHRATNADYR GSGFDRGHLA AAANHRWSQR AMDDTFYLSN VAPQVPHLNQ NAWNNLERYS
RSLTRTYQNV YVCTGPLFLP RTEADGKSYV KYQVIGKNHV AVPTHFFKVL ILEAAGGQIE
LRSYVMPNAP VDETIPLERF LVPIESIERA SGLLFVPNIL ARAGNLKAIT AGSK


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