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Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase)

 A0A161YCR9_9CELL        Unreviewed;       262 AA.
A0A161YCR9;
06-JUL-2016, integrated into UniProtKB/TrEMBL.
06-JUL-2016, sequence version 1.
25-OCT-2017, entry version 8.
RecName: Full=Endonuclease III {ECO:0000256|HAMAP-Rule:MF_00942};
EC=4.2.99.18 {ECO:0000256|HAMAP-Rule:MF_00942};
AltName: Full=DNA-(apurinic or apyrimidinic site) lyase {ECO:0000256|HAMAP-Rule:MF_00942};
Name=pdg {ECO:0000313|EMBL:KZM33398.1};
Synonyms=nth {ECO:0000256|HAMAP-Rule:MF_00942};
ORFNames=OJAG_37160 {ECO:0000313|EMBL:KZM33398.1};
Oerskovia enterophila.
Bacteria; Actinobacteria; Micrococcales; Cellulomonadaceae; Oerskovia.
NCBI_TaxID=43678 {ECO:0000313|EMBL:KZM33398.1, ECO:0000313|Proteomes:UP000076447};
[1] {ECO:0000313|EMBL:KZM33398.1, ECO:0000313|Proteomes:UP000076447}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VJag {ECO:0000313|EMBL:KZM33398.1,
ECO:0000313|Proteomes:UP000076447};
Poehlein A., Jag V., Bengelsdorf F., Duerre P., Daniel R.;
"Genome sequence of Oerskovia enterophila VJag, an agar and cellulose
degrading bacterium.";
Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: DNA repair enzyme that has both DNA N-glycosylase
activity and AP-lyase activity. The DNA N-glycosylase activity
releases various damaged pyrimidines from DNA by cleaving the N-
glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The
AP-lyase activity cleaves the phosphodiester bond 3' to the AP
site by a beta-elimination, leaving a 3'-terminal unsaturated
sugar and a product with a terminal 5'-phosphate.
{ECO:0000256|HAMAP-Rule:MF_00942}.
-!- CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or
apyrimidinic site in DNA is broken by a beta-elimination reaction,
leaving a 3'-terminal unsaturated sugar and a product with a
terminal 5'-phosphate. {ECO:0000256|HAMAP-Rule:MF_00942}.
-!- COFACTOR:
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
Evidence={ECO:0000256|HAMAP-Rule:MF_00942};
Note=Binds 1 [4Fe-4S] cluster. {ECO:0000256|HAMAP-Rule:MF_00942};
-!- SIMILARITY: Belongs to the Nth/MutY family. {ECO:0000256|HAMAP-
Rule:MF_00942}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KZM33398.1}.
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EMBL; LRIE01000085; KZM33398.1; -; Genomic_DNA.
EnsemblBacteria; KZM33398; KZM33398; OJAG_37160.
PATRIC; fig|43678.3.peg.3883; -.
Proteomes; UP000076447; Unassembled WGS sequence.
GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-UniRule.
GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) lyase activity; IEA:UniProtKB-EC.
GO; GO:0140080; F:class III/IV DNA-(apurinic or apyrimidinic site) lyase activity; IEA:UniProtKB-EC.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
GO; GO:0019104; F:DNA N-glycosylase activity; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006284; P:base-excision repair; IEA:InterPro.
CDD; cd00056; ENDO3c; 1.
Gene3D; 1.10.1670.10; -; 1.
HAMAP; MF_00942; Nth; 1.
InterPro; IPR011257; DNA_glycosylase.
InterPro; IPR004036; Endonuclease-III-like_CS2.
InterPro; IPR003651; Endonuclease3_FeS-loop_motif.
InterPro; IPR004035; Endouclease-III_FeS-bd_BS.
InterPro; IPR003265; HhH-GPD_domain.
InterPro; IPR000445; HhH_motif.
InterPro; IPR023170; HTH_base_excis_C.
InterPro; IPR005759; Nth.
Pfam; PF00633; HHH; 1.
Pfam; PF00730; HhH-GPD; 1.
SMART; SM00478; ENDO3c; 1.
SMART; SM00525; FES; 1.
SUPFAM; SSF48150; SSF48150; 1.
TIGRFAMs; TIGR01083; nth; 1.
PROSITE; PS00764; ENDONUCLEASE_III_1; 1.
PROSITE; PS01155; ENDONUCLEASE_III_2; 1.
3: Inferred from homology;
4Fe-4S {ECO:0000256|HAMAP-Rule:MF_00942};
Complete proteome {ECO:0000313|Proteomes:UP000076447};
DNA damage {ECO:0000256|HAMAP-Rule:MF_00942};
DNA repair {ECO:0000256|HAMAP-Rule:MF_00942};
DNA-binding {ECO:0000256|HAMAP-Rule:MF_00942};
Glycosidase {ECO:0000256|HAMAP-Rule:MF_00942};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_00942};
Iron {ECO:0000256|HAMAP-Rule:MF_00942};
Iron-sulfur {ECO:0000256|HAMAP-Rule:MF_00942};
Lyase {ECO:0000256|HAMAP-Rule:MF_00942, ECO:0000313|EMBL:KZM33398.1};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00942}.
DOMAIN 77 224 ENDO3c. {ECO:0000259|SMART:SM00478}.
METAL 226 226 Iron-sulfur (4Fe-4S). {ECO:0000256|HAMAP-
Rule:MF_00942}.
METAL 233 233 Iron-sulfur (4Fe-4S). {ECO:0000256|HAMAP-
Rule:MF_00942}.
METAL 236 236 Iron-sulfur (4Fe-4S). {ECO:0000256|HAMAP-
Rule:MF_00942}.
METAL 242 242 Iron-sulfur (4Fe-4S). {ECO:0000256|HAMAP-
Rule:MF_00942}.
SEQUENCE 262 AA; 28455 MW; 11C4B366DAC35376 CRC64;
MGPSRLPNVT SSGGTSRPAP SPSPARPQAP AGPSAESRLA LVRRARRTNR ELAETYPDAR
CELDFTTPLE LLIATVLSAQ TTDKRVNLTT PELFSRYPDA AAYAAADRLD LEDVLRPLGF
FRAKAQAVIG IGQALVERYG GQVPKKLDDL VTLPGVGRKT ANVVLGNAFG VPGLTVDTHF
GRLVRRLEWT SEEDPVKVET EVGELIEKRE WTMLSHRLIF HGRRVCFSRR PACGACTISH
LCPSFGIGET DPVVAATLVK TD


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