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Endonuclease V (EC 3.1.21.7) (Deoxyinosine 3'endonuclease) (Deoxyribonuclease V) (DNase V)

 NFI_PYRAB               Reviewed;         194 AA.
Q9UYX5; G8ZHI8;
07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
28-FEB-2018, entry version 89.
RecName: Full=Endonuclease V {ECO:0000255|HAMAP-Rule:MF_00801};
EC=3.1.21.7 {ECO:0000255|HAMAP-Rule:MF_00801};
AltName: Full=Deoxyinosine 3'endonuclease {ECO:0000255|HAMAP-Rule:MF_00801};
AltName: Full=Deoxyribonuclease V {ECO:0000255|HAMAP-Rule:MF_00801};
Short=DNase V {ECO:0000255|HAMAP-Rule:MF_00801};
Name=nfi {ECO:0000255|HAMAP-Rule:MF_00801};
OrderedLocusNames=PYRAB13820; ORFNames=PAB0916;
Pyrococcus abyssi (strain GE5 / Orsay).
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
Pyrococcus.
NCBI_TaxID=272844;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=GE5 / Orsay;
PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C.,
Van der Oost J., Weissenbach J., Zivanovic Y., Forterre P.;
"An integrated analysis of the genome of the hyperthermophilic
archaeon Pyrococcus abyssi.";
Mol. Microbiol. 47:1495-1512(2003).
[2]
GENOME REANNOTATION.
STRAIN=GE5 / Orsay;
PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
Gao J., Wang J.;
"Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5
and Pyrococcus furiosus DSM 3638.";
Curr. Microbiol. 64:118-129(2012).
-!- FUNCTION: DNA repair enzyme involved in the repair of deaminated
bases. Selectively cleaves double-stranded DNA at the second
phosphodiester bond 3' to a deoxyinosine leaving behind the intact
lesion on the nicked DNA. {ECO:0000255|HAMAP-Rule:MF_00801}.
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage at apurinic or
apyrimidinic sites to products with a 5'-phosphate.
{ECO:0000255|HAMAP-Rule:MF_00801}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_00801};
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00801}.
-!- SIMILARITY: Belongs to the endonuclease V family.
{ECO:0000255|HAMAP-Rule:MF_00801}.
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EMBL; AJ248287; CAB50287.1; -; Genomic_DNA.
EMBL; HE613800; CCE70825.1; -; Genomic_DNA.
PIR; B75049; B75049.
RefSeq; WP_010868497.1; NC_000868.1.
ProteinModelPortal; Q9UYX5; -.
STRING; 272844.PAB0916; -.
EnsemblBacteria; CAB50287; CAB50287; PAB0916.
GeneID; 1496771; -.
KEGG; pab:PAB0916; -.
PATRIC; fig|272844.11.peg.1469; -.
eggNOG; arCOG00929; Archaea.
eggNOG; COG1515; LUCA.
HOGENOM; HOG000229135; -.
KO; K05982; -.
OMA; VKVGKYY; -.
OrthoDB; POG093Z0CUB; -.
BioCyc; PABY272844:G1GT8-1519-MONOMER; -.
Proteomes; UP000000810; Chromosome.
Proteomes; UP000009139; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0043737; F:deoxyribonuclease V activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
CDD; cd06559; Endonuclease_V; 1.
HAMAP; MF_00801; Endonuclease_5; 1.
InterPro; IPR007581; Endonuclease-V.
PANTHER; PTHR28511; PTHR28511; 2.
Pfam; PF04493; Endonuclease_5; 1.
3: Inferred from homology;
Complete proteome; Cytoplasm; DNA damage; DNA repair; Endonuclease;
Hydrolase; Magnesium; Metal-binding; Nuclease.
CHAIN 1 194 Endonuclease V.
/FTId=PRO_0000159689.
METAL 31 31 Magnesium. {ECO:0000255|HAMAP-
Rule:MF_00801}.
METAL 95 95 Magnesium. {ECO:0000255|HAMAP-
Rule:MF_00801}.
SITE 67 67 Interaction with target DNA.
{ECO:0000255|HAMAP-Rule:MF_00801}.
SEQUENCE 194 AA; 21523 MW; 22979780CF46B312 CRC64;
MLEKIAEVQK KLSKRIVEKE VRMVSKIAAV DVSYKGNKAR VALVICSFPD CKVLKTKVLE
TEVSFPYIPT FFFLRETRPI LLVTKGEEFD VLIVEGHGKA HPRKYGLASH IGLILGKPTI
GVAKKLLRGT PENSYRKVGK AYVSVGNMIT LKDAVRIIEK LLDGGYPKPL KLADKLSKGK
ISEDENTLPS DKTS


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