Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Endoplasmic reticulum membrane sensor NFE2L1 (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) [Cleaved into: Transcription factor NRF1]

 NF2L1_CHICK             Reviewed;         772 AA.
Q5ZL67;
01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
23-MAY-2018, entry version 103.
RecName: Full=Endoplasmic reticulum membrane sensor NFE2L1 {ECO:0000305};
AltName: Full=Nuclear factor erythroid 2-related factor 1 {ECO:0000250|UniProtKB:Q14494};
Short=NF-E2-related factor 1 {ECO:0000250|UniProtKB:Q14494};
Short=NFE2-related factor 1 {ECO:0000250|UniProtKB:Q14494};
AltName: Full=Nuclear factor, erythroid derived 2, like 1 {ECO:0000250|UniProtKB:Q14494};
Contains:
RecName: Full=Transcription factor NRF1 {ECO:0000250|UniProtKB:Q14494};
Name=NFE2L1 {ECO:0000250|UniProtKB:Q14494};
Synonyms=NRF1 {ECO:0000250|UniProtKB:Q14494};
ORFNames=RCJMB04_7g14 {ECO:0000303|PubMed:15642098};
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=CB; TISSUE=Bursa of Fabricius;
PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J.,
Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M.,
Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.;
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
function analysis.";
Genome Biol. 6:R6.1-R6.9(2005).
-!- FUNCTION: Endoplasmic reticulum membrane sensor NFE2L1:
Endoplasmic reticulum membrane sensor that translocates into the
nucleus in response to various stresses to act as a transcription
factor (By similarity). Constitutes a precursor of the
transcription factor NRF1 (By similarity). Able to detect various
cellular stresses, such as cholesterol excess, oxidative stress or
proteasome inhibition (By similarity). In response to stress, it
is released from the endoplasmic reticulum membrane following
cleavage and translocates into the nucleus to form the
transcription factor NRF1 (By similarity). Acts as a key sensor of
cholesterol excess: in excess cholesterol conditions, the
endoplasmic reticulum membrane form of the protein directly binds
cholesterol via its CRAC motif, preventing cleavage and release of
the transcription factor NRF1, thereby allowing expression of
genes promoting cholesterol removal (By similarity). Involved in
proteasome homeostasis: in response to proteasome inhibition, it
is released from the endoplasmic reticulum membrane, translocates
to the nucleus and activates expression of genes encoding
proteasome subunits (By similarity).
{ECO:0000250|UniProtKB:Q14494, ECO:0000250|UniProtKB:Q61985}.
-!- FUNCTION: Transcription factor NRF1: CNC-type bZIP family
transcription factor that translocates to the nucleus and
regulates expression of target genes in response to various
stresses. Heterodimerizes with small-Maf proteins (MAFF, MAFG or
MAFK) and binds DNA motifs including the antioxidant response
elements (AREs), which regulate expression of genes involved in
oxidative stress response. Activates or represses expression of
target genes, depending on the context (By similarity). Plays a
key role in cholesterol homeostasis by acting as a sensor of
cholesterol excess: in low cholesterol conditions, translocates
into the nucleus and represses expression of genes involved in
defense against cholesterol excess (By similarity). In excess
cholesterol conditions, the endoplasmic reticulum membrane form of
the protein directly binds cholesterol via its CRAC motif,
preventing cleavage and release of the transcription factor NRF1,
thereby allowing expression of genes promoting cholesterol removal
(By similarity). Critical for redox balance in response to
oxidative stress: acts by binding the AREs motifs on promoters and
mediating activation of oxidative stress response genes (By
similarity). Involved in proteasome homeostasis: in response to
proteasome inhibition, mediates the 'bounce-back' of proteasome
subunits by translocating into the nucleus and activating
expression of genes encoding proteasome subunits (By similarity).
{ECO:0000250|UniProtKB:Q14494, ECO:0000250|UniProtKB:Q61985}.
-!- SUBUNIT: Transcription factor NRF1: Interacts (via the bZIP
domain) with small MAF protein (MAFF, MAFG or MAFK); required for
binding to antioxidant response elements (AREs) on DNA.
{ECO:0000250|UniProtKB:Q14494}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane sensor
NFE2L1: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:Q14494}; Single-pass type II membrane
protein {ECO:0000250|UniProtKB:Q14494}. Endoplasmic reticulum
membrane {ECO:0000250|UniProtKB:Q14494}; Single-pass type III
membrane protein {ECO:0000250|UniProtKB:Q14494}. Note=In normal
conditions, probably has a single-pass type II membrane protein
topology, with the DNA-binding domain facing the endoplasmic
reticulum lumen. Following cellular stress, it is rapidly and
efficiently retrotranslocated to the cytosolic side of the
membrane, a process dependent on p97/VCP, to have a single-pass
type III membrane protein topology with the major part of the
protein facing the cytosol. Retrotranslocated proteins are
normally rapidly degraded by the proteasome and active species do
not accumulate. However, retrotranslocated protein NFE2L1 escapes
degradation and is cleaved at Leu-104, releasing the protein from
the endoplasmic reticulum membrane and forming the transcription
factor NRF1 that translocates into the nucleus.
{ECO:0000250|UniProtKB:Q14494}.
-!- SUBCELLULAR LOCATION: Transcription factor NRF1: Nucleus
{ECO:0000250|UniProtKB:Q14494, ECO:0000255|PROSITE-
ProRule:PRU00978}. Note=Translocates into the nucleus following
cleavage of Endoplasmic reticulum membrane sensor NFE2L1.
{ECO:0000250|UniProtKB:Q14494}.
-!- DOMAIN: The cholesterol recognition/amino acid consensus (CRAC)
region directly binds cholesterol, as well as campesterol and 27-
hydroxycholesterol. Has much lower affinity for epicholesterol.
{ECO:0000250|UniProtKB:Q61985}.
-!- PTM: Endoplasmic reticulum membrane sensor NFE2L1: Cleaved at Leu-
104 following retrotranslocation, releasing the protein from the
endoplasmic reticulum membrane and forming the transcription
factor NRF1 that translocates into the nucleus.
{ECO:0000250|UniProtKB:Q14494}.
-!- SIMILARITY: Belongs to the bZIP family. CNC subfamily.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AJ719867; CAG31526.1; -; mRNA.
RefSeq; NP_001025927.1; NM_001030756.1.
UniGene; Gga.31932; -.
ProteinModelPortal; Q5ZL67; -.
SMR; Q5ZL67; -.
STRING; 9031.ENSGALP00000019444; -.
PaxDb; Q5ZL67; -.
Ensembl; ENSGALT00000069198; ENSGALP00000050038; ENSGALG00000011937.
Ensembl; ENSGALT00000078057; ENSGALP00000051255; ENSGALG00000011937.
GeneID; 417987; -.
KEGG; gga:417987; -.
CTD; 4779; -.
eggNOG; KOG3863; Eukaryota.
eggNOG; ENOG410ZGMS; LUCA.
GeneTree; ENSGT00910000144085; -.
HOGENOM; HOG000234410; -.
HOVERGEN; HBG052609; -.
InParanoid; Q5ZL67; -.
KO; K09040; -.
OrthoDB; EOG091G02EB; -.
PhylomeDB; Q5ZL67; -.
PRO; PR:Q5ZL67; -.
Proteomes; UP000000539; Chromosome 27.
Bgee; ENSGALG00000011937; -.
ExpressionAtlas; Q5ZL67; baseline and differential.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISS:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0015485; F:cholesterol binding; ISS:UniProtKB.
GO; GO:0003700; F:DNA binding transcription factor activity; IBA:GO_Central.
GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0001078; F:transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0045454; P:cell redox homeostasis; ISS:UniProtKB.
GO; GO:0071397; P:cellular response to cholesterol; ISS:UniProtKB.
GO; GO:0034599; P:cellular response to oxidative stress; ISS:UniProtKB.
GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
GO; GO:0055088; P:lipid homeostasis; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0097201; P:negative regulation of transcription from RNA polymerase II promoter in response to stress; ISS:UniProtKB.
GO; GO:0036003; P:positive regulation of transcription from RNA polymerase II promoter in response to stress; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:1901329; P:regulation of odontoblast differentiation; ISS:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR004827; bZIP.
InterPro; IPR004826; bZIP_Maf.
InterPro; IPR029847; Nrf1_NFE2L1.
InterPro; IPR008917; TF_DNA-bd_sf.
PANTHER; PTHR24411:SF31; PTHR24411:SF31; 1.
Pfam; PF03131; bZIP_Maf; 1.
SMART; SM00338; BRLZ; 1.
SUPFAM; SSF47454; SSF47454; 1.
PROSITE; PS50217; BZIP; 1.
PROSITE; PS00036; BZIP_BASIC; 1.
2: Evidence at transcript level;
Activator; Cholesterol metabolism; Complete proteome; DNA-binding;
Endoplasmic reticulum; Glycoprotein; Lipid metabolism; Lipid-binding;
Membrane; Nucleus; Reference proteome; Repressor; Signal-anchor;
Steroid metabolism; Sterol metabolism; Transcription;
Transcription regulation; Transmembrane; Transmembrane helix.
CHAIN 1 772 Endoplasmic reticulum membrane sensor
NFE2L1.
/FTId=PRO_0000341948.
CHAIN 104 772 Transcription factor NRF1.
{ECO:0000250|UniProtKB:Q14494}.
/FTId=PRO_0000443106.
TRANSMEM 7 24 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
DOMAIN 654 717 bZIP. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 191 199 Cholesterol recognition/amino acid
consensus (CRAC) region.
{ECO:0000250|UniProtKB:Q61985}.
REGION 656 675 Basic motif. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
REGION 682 696 Leucine-zipper. {ECO:0000255|PROSITE-
ProRule:PRU00978}.
MOTIF 761 768 Nuclear localization signal.
{ECO:0000255}.
COMPBIAS 477 530 Ser-rich.
SITE 103 104 Cleavage. {ECO:0000250|UniProtKB:Q14494}.
CARBOHYD 332 332 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 340 340 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 362 362 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 402 402 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 407 407 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 414 414 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 425 425 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 429 429 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 574 574 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
SEQUENCE 772 AA; 85186 MW; 56387649E95BEDF0 CRC64;
MLSLKKYFTE GLIQFTILLS LIGVRVDVDT YLNSQLPPLR EIILGQSSAY TQTQFHNLRN
TLDGYGIHPK SVDLDYYFTA RRLLNQVRAL DRFQVPTTEV SAWLVHRDPD GSVSGTQPSA
GIALENSGGL QDGTGPDGAV RESGAEQGFG EELEDLGAVA APVNGDLTKE DIDLIDILWR
QDIDLGAGRE IFDYSHRQKE SEVDKELSDG RERGDGWRSA GGQVTNRNLL VDGETGESFP
AQVPGVEDQT ALSLEECLRL LEATFPFGEN SEFPAADVST LSEAVPSESR PAGIQSSLLS
PLLPETESPF DLEQQWQDLM SIMEMQAMEV NNTTAETLYN GTSGDLLTSN YNLAPNTPIN
QNVSLHQASL GSCSQDFSLF SSEIESPSMG GSSALLQLAP DNSTGLNTTF SSTNFSGIFF
PPQLNSTVNE TAGPELPDPL GGLLDEAMLD EISLMDLAIE EGFNPVQASQ LEEEFDSDSG
LSLDSGHSPA SLSSSEASSS SSSSSSSSSS SSSSSSSFSE EGAVGYSSDS ENVDFEEAEG
AVGYQPEYSK FCRMSYQDPS QLHYLPYLEH VGHNHTYNMA PGTLDPEEPK LPSVGKKSSK
EKPSEFLDKQ MSRDEHRARA MKIPFTNDKI INLPVEEFNE LLSKYQLSEA QLSLIRDIRR
RGKNKMAAQN CRKRKLDTIL NLERDVEDLQ RDKSKLLREK VEFLKSIRQM KQKVQNLYQE
VFGRLRDENG QPYSPNQYAL QYASDGSVIL IPRTLADQQA RRQERKQKDR RK


Related products :

Catalog number Product name Quantity
EIAAB27022 HBZ17,Homo sapiens,Human,Locus control region-factor 1,NFE2L1,NF-E2-related factor 1,NFE2-related factor 1,NRF1,Nuclear factor erythroid 2-related factor 1,Nuclear factor, erythroid derived 2, like 1,
EIAAB27021 Bos taurus,Bovine,NFE2L1,NF-E2-related factor 1,NFE2-related factor 1,NRF1,Nuclear factor erythroid 2-related factor 1,Nuclear factor, erythroid derived 2, like 1
EIAAB27020 Mouse,Mus musculus,Nfe2l1,NF-E2-related factor 1,NFE2-related factor 1,Nrf1,Nuclear factor erythroid 2-related factor 1,Nuclear factor, erythroid derived 2, like 1
EIAAB27019 Chicken,Gallus gallus,NFE2L1,NF-E2-related factor 1,NFE2-related factor 1,NRF1,Nuclear factor erythroid 2-related factor 1,Nuclear factor, erythroid derived 2, like 1,RCJMB04_7g14
EIAAB27026 HEBP1,Homo sapiens,Human,NFE2L2,NF-E2-related factor 2,NFE2-related factor 2,NRF2,Nuclear factor erythroid 2-related factor 2,Nuclear factor, erythroid derived 2, like 2
EIAAB27028 Homo sapiens,Human,NFE2L3,NF-E2-related factor 3,NFE2-related factor 3,NRF3,Nuclear factor erythroid 2-related factor 3,Nuclear factor, erythroid derived 2, like 3
EIAAB27025 Bos taurus,Bovine,NFE2L2,NF-E2-related factor 2,NFE2-related factor 2,NRF2,Nuclear factor erythroid 2-related factor 2,Nuclear factor, erythroid derived 2, like 2
EIAAB27027 Mouse,Mus musculus,Nfe2l3,NF-E2-related factor 3,NFE2-related factor 3,Nrf3,Nuclear factor erythroid 2-related factor 3,Nuclear factor, erythroid derived 2, like 3
EIAAB27023 Nfe2l2,NF-E2-related factor 2,NFE2-related factor 2,Nrf2,Nuclear factor erythroid 2-related factor 2,Nuclear factor, erythroid derived 2, like 2,Rat,Rattus norvegicus
EIAAB27024 Mouse,Mus musculus,Nfe2l2,NF-E2-related factor 2,NFE2-related factor 2,Nrf2,Nrf-2,Nuclear factor erythroid 2-related factor 2,Nuclear factor, erythroid derived 2, like 2
18-003-43244 Nuclear factor erythroid 2-related factor 2 - NF-E2-related factor 2; NFE2-related factor 2; Nuclear factor. erythroid derived 2. like 2; HEBP1 Polyclonal 0.1 mg Protein A
CSB-EL015751BO Bovine Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit 96T
CSB-EL015751HU Human Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit 96T
CSB-EL015751CH Chicken Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit 96T
CSB-EL015751MO Mouse Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit 96T
CSB-EL015751HU Human Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit SpeciesHuman 96T
CSB-EL015751BO Bovine Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit SpeciesBovine 96T
CSB-EL015751MO Mouse Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit SpeciesMouse 96T
CSB-EL015751CH Chicken Nuclear factor erythroid 2-related factor 1(NFE2L1) ELISA kit SpeciesChicken 96T
NF2L1_MOUSE ELISA Kit FOR Nuclear factor erythroid 2-related factor 1; organism: Mouse; gene name: Nfe2l1 96T
EIAAB27050 Leucine zipper protein NF-E2,Mouse,Mus musculus,Nfe2,Nuclear factor, erythroid-derived 2 45 kDa subunit,p45 NF-E2,Transcription factor NF-E2 45 kDa subunit
EIAAB27049 Bos taurus,Bovine,Leucine zipper protein NF-E2,NFE2,Nuclear factor, erythroid-derived 2 45 kDa subunit,p45 NF-E2,Transcription factor NF-E2 45 kDa subunit
EIAAB27047 Leucine zipper protein NF-E2,Nfe2,Nuclear factor, erythroid-derived 2 45 kDa subunit,p45 NF-E2,Rat,Rattus norvegicus,Transcription factor NF-E2 45 kDa subunit
EIAAB27048 Homo sapiens,Human,Leucine zipper protein NF-E2,NFE2,Nuclear factor, erythroid-derived 2 45 kDa subunit,p45 NF-E2,Transcription factor NF-E2 45 kDa subunit
E3244Hu Human Nuclear factor erythroid 2-related factor 2,NRF2 ELISA kit 48T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur