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Endothelial PAS domain protein 1/hypoxia-inducible factor-2 alpha

 Q9XTA4_BOVIN            Unreviewed;       870 AA.
Q9XTA4;
01-NOV-1999, integrated into UniProtKB/TrEMBL.
01-NOV-1999, sequence version 1.
18-JUL-2018, entry version 124.
SubName: Full=Endothelial PAS domain protein 1/hypoxia-inducible factor-2 alpha {ECO:0000313|EMBL:BAA78676.1};
Name=EPAS1/HIF2 alpha {ECO:0000313|EMBL:BAA78676.1};
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913 {ECO:0000313|EMBL:BAA78676.1};
[1] {ECO:0000313|EMBL:BAA78676.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Arterial {ECO:0000313|EMBL:BAA78676.1};
PubMed=10320777; DOI=10.1016/S0167-4781(99)00048-2;
Hara S., Kobayashi C., Imura N.;
"Molecular cloning of cDNAs encoding hypoxia-inducible factor (HIF)-
1alpha and -2alpha of bovine arterial endothelial cells.";
Biochim. Biophys. Acta 1445:237-243(1999).
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00895706}.
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EMBL; AB018399; BAA78676.1; -; mRNA.
RefSeq; NP_777150.1; NM_174725.2.
UniGene; Bt.45570; -.
ProteinModelPortal; Q9XTA4; -.
GeneID; 282711; -.
KEGG; bta:282711; -.
CTD; 2034; -.
eggNOG; KOG3558; Eukaryota.
eggNOG; ENOG410YK57; LUCA.
HOVERGEN; HBG060456; -.
KO; K09095; -.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0003700; F:DNA binding transcription factor activity; IEA:InterPro.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
CDD; cd00083; HLH; 1.
CDD; cd00130; PAS; 2.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR014887; HIF-1_TAD_C.
InterPro; IPR021537; HIF_alpha_subunit.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR001067; Nuc_translocat.
InterPro; IPR001610; PAC.
InterPro; IPR000014; PAS.
InterPro; IPR035965; PAS-like_dom_sf.
InterPro; IPR013767; PAS_fold.
Pfam; PF11413; HIF-1; 1.
Pfam; PF08778; HIF-1a_CTAD; 1.
Pfam; PF00989; PAS; 1.
PRINTS; PR00785; NCTRNSLOCATR.
SMART; SM00353; HLH; 1.
SMART; SM00086; PAC; 1.
SMART; SM00091; PAS; 2.
SUPFAM; SSF47459; SSF47459; 1.
SUPFAM; SSF55785; SSF55785; 2.
TIGRFAMs; TIGR00229; sensory_box; 2.
PROSITE; PS50888; BHLH; 1.
PROSITE; PS50112; PAS; 2.
2: Evidence at transcript level;
Nucleus {ECO:0000256|SAAS:SAAS00896251};
Repeat {ECO:0000256|SAAS:SAAS01052434};
Transcription {ECO:0000256|SAAS:SAAS00896243};
Transcription regulation {ECO:0000256|SAAS:SAAS00896243}.
DOMAIN 14 67 BHLH. {ECO:0000259|PROSITE:PS50888}.
DOMAIN 92 147 PAS. {ECO:0000259|PROSITE:PS50112}.
DOMAIN 249 300 PAS. {ECO:0000259|PROSITE:PS50112}.
MOD_RES 405 405 4-hydroxyproline.
{ECO:0000256|PIRSR:PIRSR621537-50}.
MOD_RES 530 530 4-hydroxyproline.
{ECO:0000256|PIRSR:PIRSR621537-50}.
MOD_RES 847 847 (3S)-3-hydroxyasparagine.
{ECO:0000256|PIRSR:PIRSR621537-50}.
SEQUENCE 870 AA; 96169 MW; FEC602E6012D7712 CRC64;
MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA
ISFLRTHKLL SSVCSENESE ADADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG
LTQVELTGHS IFDFTHPCDH EEIRENLSLK NGSGFGKKSK DMSTERDFFM RMKCTVTNRG
RTVNLKSATW KVLHCTGQVK VYNNCPPHSS LCGCKEPLLS CLIIMCEPIQ HPSHMDIPLD
SKTFLSRHSM DMKFTYCDDR ITELVGYHPE ELLGRSAYEF YHALDSENMT KSHQNLCTKG
QVVSGQYRML AKHGGYVWLE TQGTVIYNPR NLQPQCIMCV NYVLSEIEKN DVVFSMDQTE
SLFKPHLLTM NSIFDNSGKV AVSEKSNFLF TKLKEEPEEL AQLAPTAGDT IISLDFGTPN
FEESSAYGKG ILPPGQQWTG EVKSHGTHSE AGSLPAFTVP QAAALGNSTP SASSSSSCST
PSSPGDYYTS LDDNLKIEAI EKLFAMDTEA KDQCGTQTDF NELDLETLAP YIPMDGEDFQ
LSPICPEESL LPETPQSAPQ HCFSTMSNIF QPLAPMASHS TFLLDKYQQQ LESKKTEPEQ
RRVSFAFFDG GSRVSLLQCC GQTYTPLSSM GGISNTQWPP DPPLQLGPTK WPGEDRHAEA
VGAAPLGLPP ATPHLAMLKK RSAKGFGPQG PDVMSPAMIA LSNKLKLKRQ LEYEEQAFQD
MSGGDPPGSG TSHLMWKRMK SLRGGGTCSL MPDKLPNANV PNDEFIQNPV RGRSQPLRHL
SPPQPPSATS PGEPTKSGFP AQCYAPQYQD YSLPAAHKMS GMASRLLGPS FEPYLLPELT
RYDCEVNVPV PGTSTLLQGG DLLRALDQAT


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