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Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)

 EPAS1_HUMAN             Reviewed;         870 AA.
Q99814; Q86VA2; Q99630;
15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
03-JUL-2003, sequence version 3.
18-JUL-2018, entry version 198.
RecName: Full=Endothelial PAS domain-containing protein 1;
Short=EPAS-1;
AltName: Full=Basic-helix-loop-helix-PAS protein MOP2;
AltName: Full=Class E basic helix-loop-helix protein 73;
Short=bHLHe73;
AltName: Full=HIF-1-alpha-like factor;
Short=HLF;
AltName: Full=Hypoxia-inducible factor 2-alpha;
Short=HIF-2-alpha;
Short=HIF2-alpha;
AltName: Full=Member of PAS protein 2;
AltName: Full=PAS domain-containing protein 2;
Name=EPAS1; Synonyms=BHLHE73, HIF2A, MOP2, PASD2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9000051; DOI=10.1101/gad.11.1.72;
Tian H., McKnight S.L., Russell D.W.;
"Endothelial PAS domain protein 1 (EPAS1), a transcription factor
selectively expressed in endothelial cells.";
Genes Dev. 11:72-82(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Hepatoma;
PubMed=9079689; DOI=10.1074/jbc.272.13.8581;
Hogenesch J.B., Chan W.K., Jackiw V.H., Brown R.C., Gu Y.-Z.,
Pray-Grant M., Perdew G.H., Bradfield C.A.;
"Characterization of a subset of the basic-helix-loop-helix-PAS
superfamily that interacts with components of the dioxin signaling
pathway.";
J. Biol. Chem. 272:8581-8593(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TRANSACTIVATION DOMAINS NTAD AND CTAD, INTERACTION WITH APEX, AND
MUTAGENESIS OF CYS-844.
PubMed=10202154; DOI=10.1093/emboj/18.7.1905;
Ema M., Hirota K., Mimura J., Abe H., Yodoi J., Sogawa K.,
Poellinger L., Fujii-Kuriyama Y.;
"Molecular mechanisms of transcription activation by HLF and HIF1alpha
in response to hypoxia: their stabilization and redox signal-induced
interaction with CBP/p300.";
EMBO J. 18:1905-1914(1999).
[5]
INTERACTION WITH EGLN1 AND VHL, VARIANT ECYT4 LEU-534, AND
CHARACTERIZATION OF VARIANTS ECYT4 LEU-534; VAL-535 AND ARG-537.
PubMed=19208626; DOI=10.1074/jbc.M808737200;
Furlow P.W., Percy M.J., Sutherland S., Bierl C., McMullin M.F.,
Master S.R., Lappin T.R., Lee F.S.;
"Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical
role for residues C-terminal to the hydroxylacceptor proline.";
J. Biol. Chem. 284:9050-9058(2009).
[6] {ECO:0000244|PDB:2A24}
STRUCTURE BY NMR OF 356-470 IN COMPLEX WITH ARNT, AND INTERACTION WITH
ARNT.
PubMed=16181639; DOI=10.1016/j.jmb.2005.08.043;
Card P.B., Erbel P.J., Gardner K.H.;
"Structural basis of ARNT PAS-B dimerization: use of a common beta-
sheet interface for hetero- and homodimerization.";
J. Mol. Biol. 353:664-677(2005).
[7]
VARIANTS ECYT4 VAL-535 AND ARG-537.
PubMed=18378852; DOI=10.1182/blood-2008-02-137703;
Percy M.J., Beer P.A., Campbell G., Dekker A.W., Green A.R.,
Oscier D., Rainey M.G., van Wijk R., Wood M., Lappin T.R.,
McMullin M.F., Lee F.S.;
"Novel exon 12 mutations in the HIF2A gene associated with
erythrocytosis.";
Blood 111:5400-5402(2008).
[8]
VARIANT ECYT4 TRP-537, IDENTIFICATION BY MASS SPECTROMETRY, AND
CHARACTERIZATION OF VARIANT ECYT4 TRP-537.
PubMed=18184961; DOI=10.1056/NEJMoa073123;
Percy M.J., Furlow P.W., Lucas G.S., Li X., Lappin T.R.,
McMullin M.F., Lee F.S.;
"A gain-of-function mutation in the HIF2A gene in familial
erythrocytosis.";
N. Engl. J. Med. 358:162-168(2008).
[9]
VARIANTS ECYT4 THR-535 AND LEU-540, AND CHARACTERIZATION OF VARIANT
ECYT4 LEU-540.
PubMed=22367913; DOI=10.1002/ajh.23123;
Percy M.J., Chung Y.J., Harrison C., Mercieca J., Hoffbrand A.V.,
Dinardo C.L., Santos P.C., Fonseca G.H., Gualandro S.F., Pereira A.C.,
Lappin T.R., McMullin M.F., Lee F.S.;
"Two new mutations in the HIF2A gene associated with erythrocytosis.";
Am. J. Hematol. 87:439-442(2012).
-!- FUNCTION: Transcription factor involved in the induction of oxygen
regulated genes. Heterodimerizes with ARNT; heterodimer binds to
core DNA sequence 5'-TACGTG-3' within the hypoxia response element
(HRE) of target gene promoters (By similarity). Regulates the
vascular endothelial growth factor (VEGF) expression and seems to
be implicated in the development of blood vessels and the tubular
system of lung. May also play a role in the formation of the
endothelium that gives rise to the blood brain barrier. Potent
activator of the Tie-2 tyrosine kinase expression. Activation
requires recruitment of transcriptional coactivators such as
CREBBP and probably EP300. Interaction with redox regulatory
protein APEX seems to activate CTAD (By similarity). {ECO:0000250,
ECO:0000250|UniProtKB:P97481}.
-!- SUBUNIT: Interacts with HIF3A (By similarity). Efficient DNA
binding requires dimerization with another bHLH protein.
Heterodimerizes with ARNT; heterodimer binds to core DNA sequence
5'-TACGTG-3' within the hypoxia response element (HRE) of target
gene promoters (PubMed:16181639). Interacts with CREBBP (By
similarity). Interacts with EGLN1. Interacts with VHL
(PubMed:19208626). {ECO:0000250|UniProtKB:P97481,
ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:16181639,
ECO:0000269|PubMed:19208626}.
-!- INTERACTION:
P27540:ARNT; NbExp=6; IntAct=EBI-447470, EBI-80809;
Q96RK4:BBS4; NbExp=2; IntAct=EBI-447470, EBI-1805814;
Q9GZT9:EGLN1; NbExp=2; IntAct=EBI-447470, EBI-1174818;
P60228:EIF3E; NbExp=10; IntAct=EBI-447470, EBI-347740;
O60573:EIF4E2; NbExp=2; IntAct=EBI-447470, EBI-398610;
P09467:FBP1; NbExp=4; IntAct=EBI-447470, EBI-712740;
P61244:MAX; NbExp=2; IntAct=EBI-447470, EBI-751711;
Q9BWF3-1:RBM4; NbExp=6; IntAct=EBI-447470, EBI-15621561;
P84022:SMAD3; NbExp=2; IntAct=EBI-447470, EBI-347161;
P08047:SP1; NbExp=2; IntAct=EBI-447470, EBI-298336;
P40818:USP8; NbExp=2; IntAct=EBI-447470, EBI-1050865;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97481,
ECO:0000255|PROSITE-ProRule:PRU00981}. Nucleus speckle
{ECO:0000250|UniProtKB:P97481}. Note=Colocalizes with HIF3A in the
nucleus and speckles. {ECO:0000250|UniProtKB:P97481}.
-!- TISSUE SPECIFICITY: Expressed in most tissues, with highest levels
in placenta, lung and heart. Selectively expressed in endothelial
cells.
-!- PTM: In normoxia, is probably hydroxylated on Pro-405 and Pro-531
by EGLN1/PHD1, EGLN2/PHD2 and/or EGLN3/PHD3. The hydroxylated
prolines promote interaction with VHL, initiating rapid
ubiquitination and subsequent proteasomal degradation. Under
hypoxia, proline hydroxylation is impaired and ubiquitination is
attenuated, resulting in stabilization (By similarity).
{ECO:0000250}.
-!- PTM: In normoxia, is hydroxylated on Asn-847 by HIF1AN thus
probably abrogating interaction with CREBBP and EP300 and
preventing transcriptional activation. {ECO:0000250}.
-!- PTM: Phosphorylated on multiple sites in the CTAD. {ECO:0000250}.
-!- PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of
asparagine is (S) stereospecific within HIF CTAD domains.
{ECO:0000250}.
-!- DISEASE: Erythrocytosis, familial, 4 (ECYT4) [MIM:611783]: An
autosomal dominant disorder characterized by increased serum red
blood cell mass, elevated serum hemoglobin and hematocrit, and
normal platelet and leukocyte counts.
{ECO:0000269|PubMed:18184961, ECO:0000269|PubMed:18378852,
ECO:0000269|PubMed:19208626, ECO:0000269|PubMed:22367913}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
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EMBL; U81984; AAB41495.1; -; mRNA.
EMBL; U51626; AAC51212.1; -; mRNA.
EMBL; BC051338; AAH51338.1; -; mRNA.
CCDS; CCDS1825.1; -.
RefSeq; NP_001421.2; NM_001430.4.
UniGene; Hs.468410; -.
PDB; 1P97; NMR; -; A=240-350.
PDB; 2A24; NMR; -; A=242-348.
PDB; 3F1N; X-ray; 1.48 A; A=239-350.
PDB; 3F1O; X-ray; 1.60 A; A=239-350.
PDB; 3F1P; X-ray; 1.17 A; A=239-350.
PDB; 3H7W; X-ray; 1.65 A; A=239-350.
PDB; 3H82; X-ray; 1.50 A; A=239-350.
PDB; 4GHI; X-ray; 1.50 A; A=239-350.
PDB; 4GS9; X-ray; 1.72 A; A=239-350.
PDB; 4PKY; X-ray; 3.20 A; G=239-350.
PDB; 4XT2; X-ray; 1.70 A; A/C=239-350.
PDB; 5KIZ; NMR; -; A=239-349.
PDB; 5TBM; X-ray; 1.85 A; A=239-348.
PDB; 5UFP; X-ray; 1.90 A; A=239-348.
PDBsum; 1P97; -.
PDBsum; 2A24; -.
PDBsum; 3F1N; -.
PDBsum; 3F1O; -.
PDBsum; 3F1P; -.
PDBsum; 3H7W; -.
PDBsum; 3H82; -.
PDBsum; 4GHI; -.
PDBsum; 4GS9; -.
PDBsum; 4PKY; -.
PDBsum; 4XT2; -.
PDBsum; 5KIZ; -.
PDBsum; 5TBM; -.
PDBsum; 5UFP; -.
ProteinModelPortal; Q99814; -.
SMR; Q99814; -.
BioGrid; 108348; 110.
CORUM; Q99814; -.
DIP; DIP-32857N; -.
ELM; Q99814; -.
IntAct; Q99814; 38.
MINT; Q99814; -.
STRING; 9606.ENSP00000263734; -.
BindingDB; Q99814; -.
ChEMBL; CHEMBL1744522; -.
iPTMnet; Q99814; -.
PhosphoSitePlus; Q99814; -.
BioMuta; EPAS1; -.
DMDM; 32470617; -.
MaxQB; Q99814; -.
PaxDb; Q99814; -.
PeptideAtlas; Q99814; -.
PRIDE; Q99814; -.
ProteomicsDB; 78489; -.
Ensembl; ENST00000263734; ENSP00000263734; ENSG00000116016.
GeneID; 2034; -.
KEGG; hsa:2034; -.
UCSC; uc002ruv.3; human.
CTD; 2034; -.
DisGeNET; 2034; -.
EuPathDB; HostDB:ENSG00000116016.13; -.
GeneCards; EPAS1; -.
HGNC; HGNC:3374; EPAS1.
HPA; HPA031200; -.
HPA; HPA069697; -.
MalaCards; EPAS1; -.
MIM; 603349; gene.
MIM; 611783; phenotype.
neXtProt; NX_Q99814; -.
OpenTargets; ENSG00000116016; -.
Orphanet; 247511; Autosomal dominant secondary polycythemia.
Orphanet; 324299; Multiple paragangliomas associated with polycythemia.
Orphanet; 276624; Sporadic pheochromocytoma.
Orphanet; 276627; Sporadic secreting paraganglioma.
PharmGKB; PA27809; -.
eggNOG; KOG3558; Eukaryota.
eggNOG; ENOG410YK57; LUCA.
GeneTree; ENSGT00760000118788; -.
HOGENOM; HOG000234306; -.
HOVERGEN; HBG060456; -.
InParanoid; Q99814; -.
KO; K09095; -.
OMA; DFQLSPI; -.
OrthoDB; EOG091G0486; -.
PhylomeDB; Q99814; -.
TreeFam; TF317772; -.
Reactome; R-HSA-1234158; Regulation of gene expression by Hypoxia-inducible Factor.
Reactome; R-HSA-1234162; Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha.
Reactome; R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
Reactome; R-HSA-452723; Transcriptional regulation of pluripotent stem cells.
Reactome; R-HSA-8849473; PTK6 Expression.
Reactome; R-HSA-8951664; Neddylation.
SignaLink; Q99814; -.
SIGNOR; Q99814; -.
ChiTaRS; EPAS1; human.
EvolutionaryTrace; Q99814; -.
GeneWiki; EPAS1; -.
GenomeRNAi; 2034; -.
PRO; PR:Q99814; -.
Proteomes; UP000005640; Chromosome 2.
Bgee; ENSG00000116016; -.
CleanEx; HS_EPAS1; -.
ExpressionAtlas; Q99814; baseline and differential.
Genevisible; Q99814; HS.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0005667; C:transcription factor complex; IDA:MGI.
GO; GO:0003677; F:DNA binding; IGI:MGI.
GO; GO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0001974; P:blood vessel remodeling; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0055072; P:iron ion homeostasis; IEA:Ensembl.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
GO; GO:0048625; P:myoblast fate commitment; ISS:BHF-UCL.
GO; GO:0042415; P:norepinephrine metabolic process; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
GO; GO:0043687; P:post-translational protein modification; TAS:Reactome.
GO; GO:0002027; P:regulation of heart rate; IEA:Ensembl.
GO; GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome.
GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IDA:MGI.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
GO; GO:0006366; P:transcription by RNA polymerase II; TAS:ProtInc.
GO; GO:0007601; P:visual perception; IEA:Ensembl.
CDD; cd00083; HLH; 1.
CDD; cd00130; PAS; 2.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR014887; HIF-1_TAD_C.
InterPro; IPR021537; HIF_alpha_subunit.
InterPro; IPR036638; HLH_DNA-bd_sf.
InterPro; IPR001067; Nuc_translocat.
InterPro; IPR001610; PAC.
InterPro; IPR000014; PAS.
InterPro; IPR035965; PAS-like_dom_sf.
InterPro; IPR013767; PAS_fold.
InterPro; IPR013655; PAS_fold_3.
Pfam; PF11413; HIF-1; 1.
Pfam; PF08778; HIF-1a_CTAD; 1.
Pfam; PF00989; PAS; 1.
Pfam; PF08447; PAS_3; 1.
PRINTS; PR00785; NCTRNSLOCATR.
SMART; SM00353; HLH; 1.
SMART; SM00086; PAC; 1.
SMART; SM00091; PAS; 2.
SUPFAM; SSF47459; SSF47459; 1.
SUPFAM; SSF55785; SSF55785; 2.
TIGRFAMs; TIGR00229; sensory_box; 2.
PROSITE; PS50888; BHLH; 1.
PROSITE; PS50112; PAS; 2.
1: Evidence at protein level;
3D-structure; Activator; Angiogenesis; Complete proteome;
Congenital erythrocytosis; Developmental protein; Differentiation;
Disease mutation; DNA-binding; Hydroxylation; Nucleus; Phosphoprotein;
Polymorphism; Reference proteome; Repeat; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 870 Endothelial PAS domain-containing protein
1.
/FTId=PRO_0000127419.
DOMAIN 14 67 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
DOMAIN 84 154 PAS 1. {ECO:0000255|PROSITE-
ProRule:PRU00140}.
DOMAIN 230 300 PAS 2. {ECO:0000255|PROSITE-
ProRule:PRU00140}.
DOMAIN 304 347 PAC.
REGION 26 53 DNA-binding.
{ECO:0000250|UniProtKB:P97481}.
REGION 171 192 Required for heterodimer formation with
ARNT. {ECO:0000250|UniProtKB:P97481}.
REGION 496 542 NTAD.
REGION 830 870 CTAD.
COMPBIAS 474 480 Poly-Ser.
MOD_RES 405 405 4-hydroxyproline. {ECO:0000250}.
MOD_RES 531 531 4-hydroxyproline. {ECO:0000250}.
MOD_RES 840 840 Phosphothreonine.
{ECO:0000250|UniProtKB:P97481}.
MOD_RES 847 847 (3S)-3-hydroxyasparagine. {ECO:0000250}.
VARIANT 534 534 P -> L (in ECYT4; impairs interaction
with EGLN1 and VHL).
{ECO:0000269|PubMed:19208626}.
/FTId=VAR_067358.
VARIANT 535 535 M -> T (in ECYT4).
{ECO:0000269|PubMed:22367913}.
/FTId=VAR_067359.
VARIANT 535 535 M -> V (in ECYT4; impairs interaction
with EGLN1; dbSNP:rs137853037).
{ECO:0000269|PubMed:18378852,
ECO:0000269|PubMed:19208626}.
/FTId=VAR_067360.
VARIANT 537 537 G -> R (in ECYT4; impairs interaction
with EGLN1 and VHL; dbSNP:rs137853036).
{ECO:0000269|PubMed:18378852,
ECO:0000269|PubMed:19208626}.
/FTId=VAR_067361.
VARIANT 537 537 G -> W (in ECYT4; gain of function;
affects hydroxylation;
dbSNP:rs137853036).
{ECO:0000269|PubMed:18184961}.
/FTId=VAR_042443.
VARIANT 540 540 F -> L (in ECYT4; affects the interaction
with EGLN1 and VHL).
{ECO:0000269|PubMed:22367913}.
/FTId=VAR_067362.
VARIANT 766 766 T -> P (in dbSNP:rs59901247).
/FTId=VAR_061261.
VARIANT 785 785 P -> T (in dbSNP:rs61518065).
/FTId=VAR_061262.
MUTAGEN 844 844 C->S: Abolishes hypoxia-inducible
transcriptional activation of ctaD.
{ECO:0000269|PubMed:10202154}.
CONFLICT 60 60 A -> E (in Ref. 1; AAB41495).
{ECO:0000305}.
CONFLICT 539 539 D -> G (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 601 601 H -> R (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 693 693 D -> N (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 716 716 E -> K (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 722 722 L -> P (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 765 765 F -> L (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 769 769 P -> S (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 844 844 C -> R (in Ref. 2; AAC51212).
{ECO:0000305}.
CONFLICT 847 847 N -> K (in Ref. 2; AAC51212).
{ECO:0000305}.
HELIX 240 242 {ECO:0000244|PDB:3F1P}.
STRAND 243 248 {ECO:0000244|PDB:3F1P}.
TURN 250 252 {ECO:0000244|PDB:2A24}.
STRAND 253 257 {ECO:0000244|PDB:3F1P}.
HELIX 260 265 {ECO:0000244|PDB:3F1P}.
HELIX 269 272 {ECO:0000244|PDB:3F1P}.
HELIX 277 280 {ECO:0000244|PDB:3F1P}.
HELIX 283 285 {ECO:0000244|PDB:3F1P}.
HELIX 286 299 {ECO:0000244|PDB:3F1P}.
STRAND 300 303 {ECO:0000244|PDB:3F1P}.
STRAND 307 310 {ECO:0000244|PDB:3F1P}.
STRAND 314 327 {ECO:0000244|PDB:3F1P}.
TURN 329 331 {ECO:0000244|PDB:3F1P}.
STRAND 334 343 {ECO:0000244|PDB:3F1P}.
SEQUENCE 870 AA; 96459 MW; 4838989598234FC1 CRC64;
MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA
ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG
LTQVELTGHS IFDFTHPCDH EEIRENLSLK NGSGFGKKSK DMSTERDFFM RMKCTVTNRG
RTVNLKSATW KVLHCTGQVK VYNNCPPHNS LCGYKEPLLS CLIIMCEPIQ HPSHMDIPLD
SKTFLSRHSM DMKFTYCDDR ITELIGYHPE ELLGRSAYEF YHALDSENMT KSHQNLCTKG
QVVSGQYRML AKHGGYVWLE TQGTVIYNPR NLQPQCIMCV NYVLSEIEKN DVVFSMDQTE
SLFKPHLMAM NSIFDSSGKG AVSEKSNFLF TKLKEEPEEL AQLAPTPGDA IISLDFGNQN
FEESSAYGKA ILPPSQPWAT ELRSHSTQSE AGSLPAFTVP QAAAPGSTTP SATSSSSSCS
TPNSPEDYYT SLDNDLKIEV IEKLFAMDTE AKDQCSTQTD FNELDLETLA PYIPMDGEDF
QLSPICPEER LLAENPQSTP QHCFSAMTNI FQPLAPVAPH SPFLLDKFQQ QLESKKTEPE
HRPMSSIFFD AGSKASLPPC CGQASTPLSS MGGRSNTQWP PDPPLHFGPT KWAVGDQRTE
FLGAAPLGPP VSPPHVSTFK TRSAKGFGAR GPDVLSPAMV ALSNKLKLKR QLEYEEQAFQ
DLSGGDPPGG STSHLMWKRM KNLRGGSCPL MPDKPLSANV PNDKFTQNPM RGLGHPLRHL
PLPQPPSAIS PGENSKSRFP PQCYATQYQD YSLSSAHKVS GMASRLLGPS FESYLLPELT
RYDCEVNVPV LGSSTLLQGG DLLRALDQAT


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U2004h CLIA Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF-2-alph 96T
U2004h CLIA kit Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF-2 96T
E2004h ELISA Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF-2-alp 96T
E2004h ELISA kit Basic-helix-loop-helix-PAS protein MOP2,bHLHe73,BHLHE73,Class E basic helix-loop-helix protein 73,Endothelial PAS domain-containing protein 1,EPAS1,EPAS-1,HIF-1-alpha-like factor,HIF2A,HIF- 96T
18-272-195931 HIF2 alpha - Rabbit polyclonal to HIF2 alpha; EPAS-1; Member of PAS protein 2; Basic-helix-loop-helix-PAS protein MOP2; Hypoxia-inducible factor 2 alpha; HIF-2 alpha; HIF2 alpha; HIF-1 alpha-like fact 0.2 ml
U0798h CLIA ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,BHLHE78,Class E basic helix-loop-helix protein 78,HIF1A,HIF-1-alpha,HIF1-alpha,Homo sapiens,Human,Hypoxia-inducible factor 96T
E0798h ELISA ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,BHLHE78,Class E basic helix-loop-helix protein 78,HIF1A,HIF-1-alpha,HIF1-alpha,Homo sapiens,Human,Hypoxia-inducible facto 96T
E0798h ELISA kit ARNT-interacting protein,Basic-helix-loop-helix-PAS protein MOP1,bHLHe78,BHLHE78,Class E basic helix-loop-helix protein 78,HIF1A,HIF-1-alpha,HIF1-alpha,Homo sapiens,Human,Hypoxia-inducible 96T
EIAAB37697 Basic helix-loop-helix transcription factor scleraxis,bHLHa41,BHLHA41,bHLHa48,Class A basic helix-loop-helix protein 41,Class A basic helix-loop-helix protein 48,Homo sapiens,Human,SCX,SCXA
EIAAB27612 Basic-helix-loop-helix-PAS protein MOP5,bHLHe11,BHLHE11,Class E basic helix-loop-helix protein 11,Homo sapiens,Human,Member of PAS protein 5,MOP5,Neuronal PAS domain-containing protein 1,Neuronal PAS1
EIAAB27618 Basic-helix-loop-helix-PAS protein MOP6,bHLHe12,BHLHE12,Class E basic helix-loop-helix protein 12,Homo sapiens,Human,Member of PAS protein 6,MOP6,Neuronal PAS domain-containing protein 3,Neuronal PAS3
EIAAB27615 Basic-helix-loop-helix-PAS protein MOP4,bHLHe9,BHLHE9,Class E basic helix-loop-helix protein 9,Homo sapiens,Human,Member of PAS protein 4,MOP4,Neuronal PAS domain-containing protein 2,Neuronal PAS2,NP
EIAAB28826 bHLHb1,BHLHB1,bHLHe19,BHLHE19,Class B basic helix-loop-helix protein 1,Class E basic helix-loop-helix protein 19,Homo sapiens,Human,OLIG2,Oligo2,Oligodendrocyte transcription factor 2,PRKCBP2,Protein
EIAAB28828 bHLHb7,BHLHB7,bHLHe20,BHLHE20,Class B basic helix-loop-helix protein 7,Class E basic helix-loop-helix protein 20,Homo sapiens,Human,OLIG3,Oligo3,Oligodendrocyte transcription factor 3
EIAAB28821 bHLHb6,BHLHB6,bHLHe21,BHLHE21,Class B basic helix-loop-helix protein 6,Class E basic helix-loop-helix protein 21,Homo sapiens,Human,OLIG1,Oligo1,Oligodendrocyte transcription factor 1
E0255h ELISA kit ATH1,ATOH1,bHLHa14,BHLHA14,Class A basic helix-loop-helix protein 14,hATH1,Helix-loop-helix protein hATH-1,Homo sapiens,Human,Protein atonal homolog 1 96T
E0255h ELISA ATH1,ATOH1,bHLHa14,BHLHA14,Class A basic helix-loop-helix protein 14,hATH1,Helix-loop-helix protein hATH-1,Homo sapiens,Human,Protein atonal homolog 1 96T
U0255h CLIA ATH1,ATOH1,bHLHa14,BHLHA14,Class A basic helix-loop-helix protein 14,hATH1,Helix-loop-helix protein hATH-1,Homo sapiens,Human,Protein atonal homolog 1 96T
EIAAB14718 Basic helix-loop-helix protein N-twist,bHLHa31,BHLHA31,Class A basic helix-loop-helix protein 31,Fer3-like protein,FERD3L,Homo sapiens,Human,NATO3,Nephew of atonal 3,Neuronal twist,NTWIST
EIAAB27132 bHLHa6,BHLHA6,Class A basic helix-loop-helix protein 6,Homo sapiens,Human,NeuroD3,NEUROD3,NEUROG1,Neurogenic basic-helix-loop-helix protein,Neurogenic differentiation factor 3,Neurogenin-1,NGN,NGN1,NG
E1384088 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit
201-20-2528 HIF1A{hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)}rabbit.pAb 0.2ml
HIF3A HIF1A Gene hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
E1381863 Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) ELISA Kit 1
CSB-EL010351HO Horse hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A) ELISA kit 96T


 

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