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Endothelial cell-specific chemotaxis regulator (Apoptosis regulator through modulating IAP expression) (ARIA) (Endothelial cell-specific molecule 2)

 ECSCR_HUMAN             Reviewed;         205 AA.
Q19T08; B4E3H7; C3RSF2;
03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
11-JUL-2006, sequence version 1.
28-FEB-2018, entry version 70.
RecName: Full=Endothelial cell-specific chemotaxis regulator;
AltName: Full=Apoptosis regulator through modulating IAP expression;
Short=ARIA;
AltName: Full=Endothelial cell-specific molecule 2;
Flags: Precursor;
Name=ECSCR; Synonyms=ECSM2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, GLYCOSYLATION, INTERACTION WITH
FLNA, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
TISSUE=Umbilical vein endothelial cell;
PubMed=18556573; DOI=10.1161/ATVBAHA.108.162511;
Armstrong L.-J., Heath V.L., Sanderson S., Kaur S., Beesley J.F.J.,
Herbert J.M.J., Legg J.A., Poulsom R., Bicknell R.;
"ECSM2, an endothelial specific filamin a binding protein that
mediates chemotaxis.";
Arterioscler. Thromb. Vasc. Biol. 28:1640-1646(2008).
[2]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR
LOCATION, AND INTERACTION WITH PSMA7.
PubMed=19416853; DOI=10.1073/pnas.0806780106;
Ikeda K., Nakano R., Uraoka M., Nakagawa Y., Koide M., Katsume A.,
Minamino K., Yamada E., Yamada H., Quertermous T., Matsubara H.;
"Identification of ARIA regulating endothelial apoptosis and
angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-
2.";
Proc. Natl. Acad. Sci. U.S.A. 106:8227-8232(2009).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Uterus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Regulates endothelial chemotaxis and tube formation. Has
a role in angiogenesis and apoptosis via modulation of the actin
cytoskeleton and facilitation of proteasomal degradation of the
apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
{ECO:0000269|PubMed:18556573, ECO:0000269|PubMed:19416853}.
-!- SUBUNIT: Interacts with FLNA. Interacts with the 20S proteasome
subunit PSMA7. {ECO:0000269|PubMed:18556573,
ECO:0000269|PubMed:19416853}.
-!- INTERACTION:
O14818:PSMA7; NbExp=3; IntAct=EBI-15778214, EBI-603272;
P60484-1:PTEN; NbExp=4; IntAct=EBI-15778214, EBI-15722967;
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein. Cytoplasm.
-!- TISSUE SPECIFICITY: Highest expression in endothelial cells. Also
detected in vascular smooth muscle, macrophages, lymphocytes, and
mast cells. {ECO:0000269|PubMed:18556573,
ECO:0000269|PubMed:19416853}.
-!- PTM: May be heavily O-glycosylated. {ECO:0000269|PubMed:18556573}.
-!- SIMILARITY: Belongs to the ECSCR family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; DQ462572; ABE73209.1; -; mRNA.
EMBL; EU025066; ABW05062.1; -; mRNA.
EMBL; AK304726; BAG65489.1; -; mRNA.
EMBL; BC146912; AAI46913.1; -; mRNA.
EMBL; BC146913; AAI46914.1; -; mRNA.
CCDS; CCDS75317.1; -.
RefSeq; NP_001071161.1; NM_001077693.3.
RefSeq; NP_001280668.1; NM_001293739.1.
UniGene; Hs.483538; -.
UniGene; Hs.570903; -.
ProteinModelPortal; Q19T08; -.
BioGrid; 567392; 12.
DIP; DIP-60344N; -.
IntAct; Q19T08; 3.
iPTMnet; Q19T08; -.
PhosphoSitePlus; Q19T08; -.
DMDM; 121940639; -.
PaxDb; Q19T08; -.
PeptideAtlas; Q19T08; -.
PRIDE; Q19T08; -.
Ensembl; ENST00000618155; ENSP00000479243; ENSG00000249751.
GeneID; 641700; -.
KEGG; hsa:641700; -.
UCSC; uc032vne.2; human.
CTD; 641700; -.
DisGeNET; 641700; -.
EuPathDB; HostDB:ENSG00000249751.3; -.
GeneCards; ECSCR; -.
HGNC; HGNC:35454; ECSCR.
neXtProt; NX_Q19T08; -.
OpenTargets; ENSG00000249751; -.
PharmGKB; PA164718891; -.
eggNOG; ENOG410J4RP; Eukaryota.
eggNOG; ENOG410Z78P; LUCA.
GeneTree; ENSGT00400000023549; -.
InParanoid; Q19T08; -.
OMA; LQGHHSQ; -.
OrthoDB; EOG091G1786; -.
PhylomeDB; Q19T08; -.
ChiTaRS; ECSCR; human.
GenomeRNAi; 641700; -.
PRO; PR:Q19T08; -.
Proteomes; UP000005640; Chromosome 5.
Bgee; ENSG00000249751; -.
Genevisible; Q19T08; HS.
GO; GO:0005829; C:cytosol; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
GO; GO:0016525; P:negative regulation of angiogenesis; IMP:MGI.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IMP:MGI.
GO; GO:1901800; P:positive regulation of proteasomal protein catabolic process; IMP:MGI.
InterPro; IPR026247; ECSCR.
PANTHER; PTHR28602; PTHR28602; 1.
Pfam; PF15820; ECSCR; 1.
PRINTS; PR02069; ECCREGULATOR.
1: Evidence at protein level;
Angiogenesis; Apoptosis; Cell membrane; Chemotaxis; Complete proteome;
Cytoplasm; Developmental protein; Differentiation; Glycoprotein;
Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 24 {ECO:0000255}.
CHAIN 25 205 Endothelial cell-specific chemotaxis
regulator.
/FTId=PRO_0000365017.
TOPO_DOM 25 124 Extracellular. {ECO:0000255}.
TRANSMEM 125 145 Helical. {ECO:0000255}.
TOPO_DOM 146 205 Cytoplasmic. {ECO:0000255}.
COMPBIAS 135 138 Poly-Val.
MOD_RES 198 198 Phosphoserine.
{ECO:0000250|UniProtKB:Q3TZW0}.
CONFLICT 69 69 T -> I (in Ref. 3; BAG65489).
{ECO:0000305}.
SEQUENCE 205 AA; 21295 MW; 7CB22DEF4B6ADCAD CRC64;
MGTAGAMQLC WVILGFLLFR GHNSQPTMTQ TSSSQGGLGG LSLTTEPVSS NPGYIPSSEA
NRPSHLSSTG TPGAGVPSSG RDGGTSRDTF QTVPPNSTTM SLSMREDATI LPSPTSETVL
TVAAFGVISF IVILVVVVII LVGVVSLRFK CRKSKESEDP QKPGSSGLSE SCSTANGEKD
SITLISMKNI NMNNGKQSLS AEKVL


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