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Endothelial transcription factor GATA-2

 G3HIC9_CRIGR            Unreviewed;       480 AA.
G3HIC9;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
20-JUN-2018, entry version 35.
SubName: Full=Endothelial transcription factor GATA-2 {ECO:0000313|EMBL:EGW09469.1};
ORFNames=I79_010389 {ECO:0000313|EMBL:EGW09469.1};
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09469.1, ECO:0000313|Proteomes:UP000001075};
[1] {ECO:0000313|Proteomes:UP000001075}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
PubMed=21804562; DOI=10.1038/nbt.1932;
Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
Quake S.R., Famili I., Palsson B.O., Wang J.;
"The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
line.";
Nat. Biotechnol. 29:735-741(2011).
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EMBL; JH000402; EGW09469.1; -; Genomic_DNA.
RefSeq; XP_007642349.1; XM_007644159.1.
PRIDE; G3HIC9; -.
GeneID; 100762331; -.
CTD; 2624; -.
InParanoid; G3HIC9; -.
Proteomes; UP000001075; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008134; F:transcription factor binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IEA:Ensembl.
GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0035854; P:eosinophil fate commitment; IEA:Ensembl.
GO; GO:0097154; P:GABAergic neuron differentiation; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0070345; P:negative regulation of fat cell proliferation; IEA:Ensembl.
GO; GO:0045650; P:negative regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Ensembl.
GO; GO:0061614; P:pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000977; P:regulation of forebrain neuron differentiation; IEA:Ensembl.
GO; GO:0035065; P:regulation of histone acetylation; IEA:Ensembl.
GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IEA:Ensembl.
GO; GO:0060872; P:semicircular canal development; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IEA:Ensembl.
Gene3D; 3.30.50.10; -; 2.
InterPro; IPR029522; GATA-2.
InterPro; IPR016374; TF_GATA-2/3.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
Pfam; PF00320; GATA; 2.
PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
PRINTS; PR00619; GATAZNFINGER.
SMART; SM00401; ZnF_GATA; 2.
PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000001075};
Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00094,
ECO:0000256|SAAS:SAAS01008217};
Reference proteome {ECO:0000313|Proteomes:UP000001075};
Zinc {ECO:0000256|PROSITE-ProRule:PRU00094,
ECO:0000256|SAAS:SAAS01008217};
Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00094,
ECO:0000256|SAAS:SAAS01008217}.
DOMAIN 289 343 GATA-type. {ECO:0000259|PROSITE:PS50114}.
DOMAIN 343 396 GATA-type. {ECO:0000259|PROSITE:PS50114}.
SEQUENCE 480 AA; 50296 MW; 43B9C5E49AD8A48C CRC64;
MEVAPEQPRG RPPPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGGSVASLT PTAAHSGSHL FGFPPTPPKE
VSPDPSTTGA ASPASSSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLATMGTQP
ATHHPIPTYP SYVPASAHDY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC
MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG


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