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Endothelial transcription factor GATA-2 (GATA-binding protein 2)

 GATA2_RAT               Reviewed;         480 AA.
Q924Y4; Q8VHY4;
29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
12-SEP-2018, entry version 124.
RecName: Full=Endothelial transcription factor GATA-2;
AltName: Full=GATA-binding protein 2;
Name=Gata2 {ECO:0000312|EMBL:AAK51128.1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1] {ECO:0000312|EMBL:AAK51128.1}
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAK51128.1};
Itoh T., Itoh A., Pleasure D.;
Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000305, ECO:0000312|EMBL:AAL57180.1}
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION IN PHAGOCYTOSIS.
STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAL57180.1};
TISSUE=Lung {ECO:0000269|PubMed:12933836};
PubMed=12933836; DOI=10.1128/IAI.71.9.4943-4952.2003;
Lasbury M.E., Tang X., Durant P.J., Lee C.-H.;
"Effect of transcription factor GATA-2 on phagocytic activity of
alveolar macrophages from Pneumocystis carinii-infected hosts.";
Infect. Immun. 71:4943-4952(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart, and Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Transcriptional activator which regulates endothelin-1
gene expression in endothelial cells. Binds to the consensus
sequence 5'-AGATAG-3' (By similarity). Plays an important role in
the regulation of phagocytosis in alveolar macrophages,
particularly during P.carinii infection. {ECO:0000250,
ECO:0000269|PubMed:12933836}.
-!- SUBUNIT: Interacts with BRD3. Interacts with AR and CCAR1.
{ECO:0000250|UniProtKB:O09100, ECO:0000250|UniProtKB:P23769}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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EMBL; AY032734; AAK51128.1; -; mRNA.
EMBL; AF345897; AAL57180.1; -; mRNA.
EMBL; BC061745; AAH61745.1; -; mRNA.
RefSeq; NP_254277.1; NM_033442.1.
RefSeq; XP_017447968.1; XM_017592479.1.
RefSeq; XP_017447969.1; XM_017592480.1.
UniGene; Rn.34322; -.
ProteinModelPortal; Q924Y4; -.
SMR; Q924Y4; -.
BioGrid; 247224; 1.
STRING; 10116.ENSRNOP00000017240; -.
PhosphoSitePlus; Q924Y4; -.
PaxDb; Q924Y4; -.
Ensembl; ENSRNOT00000017240; ENSRNOP00000017240; ENSRNOG00000012347.
GeneID; 25159; -.
KEGG; rno:25159; -.
UCSC; RGD:2664; rat.
CTD; 2624; -.
RGD; 2664; Gata2.
eggNOG; KOG1601; Eukaryota.
eggNOG; COG5641; LUCA.
GeneTree; ENSGT00760000119221; -.
HOGENOM; HOG000047701; -.
HOVERGEN; HBG051705; -.
InParanoid; Q924Y4; -.
KO; K17894; -.
OMA; PRWMAHH; -.
OrthoDB; EOG091G0AUR; -.
PhylomeDB; Q924Y4; -.
TreeFam; TF315391; -.
Reactome; R-RNO-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
Reactome; R-RNO-983231; Factors involved in megakaryocyte development and platelet production.
PRO; PR:Q924Y4; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000012347; Expressed in 9 organ(s), highest expression level in lung.
ExpressionAtlas; Q924Y4; baseline and differential.
Genevisible; Q924Y4; RN.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0005667; C:transcription factor complex; IBA:GO_Central.
GO; GO:0070742; F:C2H2 zinc finger domain binding; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IBA:GO_Central.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001228; F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0021533; P:cell differentiation in hindbrain; IEA:Ensembl.
GO; GO:0001709; P:cell fate determination; IEA:Ensembl.
GO; GO:0048469; P:cell maturation; IEA:Ensembl.
GO; GO:0021954; P:central nervous system neuron development; IEA:Ensembl.
GO; GO:0090102; P:cochlea development; IEP:RGD.
GO; GO:0021902; P:commitment of neuronal cell to specific neuron type in forebrain; IEA:Ensembl.
GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
GO; GO:0001892; P:embryonic placenta development; IEA:Ensembl.
GO; GO:0035854; P:eosinophil fate commitment; IEA:Ensembl.
GO; GO:0097154; P:GABAergic neuron differentiation; IEA:Ensembl.
GO; GO:0048873; P:homeostasis of number of cells within a tissue; IEA:Ensembl.
GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0070345; P:negative regulation of fat cell proliferation; IEA:Ensembl.
GO; GO:0045650; P:negative regulation of macrophage differentiation; IEA:Ensembl.
GO; GO:2000178; P:negative regulation of neural precursor cell proliferation; IEA:Ensembl.
GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IMP:RGD.
GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
GO; GO:1903589; P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IMP:RGD.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0043306; P:positive regulation of mast cell degranulation; IMP:RGD.
GO; GO:0045654; P:positive regulation of megakaryocyte differentiation; IEA:Ensembl.
GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:RGD.
GO; GO:0050766; P:positive regulation of phagocytosis; IDA:UniProtKB.
GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IMP:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:RGD.
GO; GO:0061614; P:pri-miRNA transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:2000977; P:regulation of forebrain neuron differentiation; IEA:Ensembl.
GO; GO:0035065; P:regulation of histone acetylation; IEA:Ensembl.
GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IEA:Ensembl.
GO; GO:0033993; P:response to lipid; IEP:RGD.
GO; GO:0060872; P:semicircular canal development; IEA:Ensembl.
GO; GO:0035019; P:somatic stem cell population maintenance; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IEA:Ensembl.
CDD; cd00202; ZnF_GATA; 2.
Gene3D; 3.30.50.10; -; 2.
InterPro; IPR029522; GATA-2.
InterPro; IPR016374; TF_GATA-2/3.
InterPro; IPR039355; Transcription_factor_GATA.
InterPro; IPR000679; Znf_GATA.
InterPro; IPR013088; Znf_NHR/GATA.
PANTHER; PTHR10071; PTHR10071; 1.
PANTHER; PTHR10071:SF149; PTHR10071:SF149; 1.
Pfam; PF00320; GATA; 2.
PIRSF; PIRSF003027; TF_GATA-1/2/3; 1.
PRINTS; PR00619; GATAZNFINGER.
SMART; SM00401; ZnF_GATA; 2.
PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Isopeptide bond;
Metal-binding; Methylation; Nucleus; Phagocytosis; Phosphoprotein;
Reference proteome; Repeat; Transcription; Transcription regulation;
Ubl conjugation; Zinc; Zinc-finger.
CHAIN 1 480 Endothelial transcription factor GATA-2.
/FTId=PRO_0000083405.
ZN_FING 295 319 GATA-type 1. {ECO:0000255|PROSITE-
ProRule:PRU00094}.
ZN_FING 349 373 GATA-type 2. {ECO:0000255|PROSITE-
ProRule:PRU00094}.
MOD_RES 73 73 Phosphoserine.
{ECO:0000250|UniProtKB:P23769}.
MOD_RES 86 86 Asymmetric dimethylarginine.
{ECO:0000250|UniProtKB:P23769}.
MOD_RES 192 192 Phosphoserine.
{ECO:0000250|UniProtKB:P23769}.
CROSSLNK 389 389 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P23769}.
CONFLICT 347 347 T -> S (in Ref. 2; AAL57180).
{ECO:0000305}.
SEQUENCE 480 AA; 50464 MW; 80FBA84AA4258EAD CRC64;
MEVAPEQPRW MAHPAVLNAQ HPDSHHPGLA HNYMEPAQLL PPDEVDVFFN HLDSQGNPYY
ANPAHARARV SYSPAHARLT GGQMCRPHLL HSPGLPWLDG GKAALSAAAA HHHSPWTVSP
FSKTPLHPSA AGAPGGPLSV YPGAAGGSGG GSGSSVASLT PTAAHSGSHL FGFPPTPPKE
VSPDPSTTGA ASPASPSAGG SVARGEDKDG VKYQVSLSES MKMEGGSPLR PGLAPMGTQP
ATHHPIPTYP SYVPASAHEY GSGLFHPGGF LGGPASSFTP KQRSKARSCS EGRECVNCGA
TATPLWRRDG TGHYLCNACG LYHKMNGQNR PLIKPKRRLS AARRAGTCCA NCQTTTTTLW
RRNANGDPVC NACGLYYKLH NVNRPLTMKK EGIQTRNRKM SSKSKKSKKG AECFEELSKC
MQEKSSPFSA AALAGHMAPV GHLPPFSHSG HILPTPTPIH PSSSLSFGHP HPSSMVTAMG


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