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Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type)

 EDNRB_RAT               Reviewed;         442 AA.
P21451;
01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 2.
07-NOV-2018, entry version 141.
RecName: Full=Endothelin receptor type B {ECO:0000305};
Short=ET-B;
Short=ET-BR;
AltName: Full=Endothelin receptor non-selective type;
Flags: Precursor;
Name=Ednrb {ECO:0000312|RGD:2536};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=1312429; DOI=10.1210/endo.130.4.1312429;
Hori S., Komatsu Y., Shigemoto R., Mizuno N., Nakanishi S.;
"Distinct tissue distribution and cellular localization of two
messenger ribonucleic acids encoding different subtypes of rat
endothelin receptors.";
Endocrinology 130:1885-1895(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
PubMed=2175397; DOI=10.1038/348732a0;
Sakurai T., Yanagisawa M., Takuwa Y., Miyazaki H., Kimura S., Goto K.,
Masaki T.;
"Cloning of a cDNA encoding a non-isopeptide-selective subtype of the
endothelin receptor.";
Nature 348:732-735(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
PubMed=8371713;
Cheng H.F., Su Y.M., Yeh J.R., Chang K.J.;
"Alternative transcript of the nonselective-type endothelin receptor
from rat brain.";
Mol. Pharmacol. 44:533-538(1993).
-!- FUNCTION: Non-specific receptor for endothelin 1, 2, and 3.
Mediates its action by association with G proteins that activate a
phosphatidylinositol-calcium second messenger system.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P24530}; Multi-pass membrane protein.
Note=internalized after activation by endothelins.
{ECO:0000250|UniProtKB:P24530}.
-!- TISSUE SPECIFICITY: Widely distributed in cell types of a variety
of tissues.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Endothelin receptor subfamily. EDNRB sub-subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; X57764; CAA40916.1; -; mRNA.
EMBL; S65355; AAB28172.1; -; mRNA.
PIR; S13425; S13425.
RefSeq; NP_059029.1; NM_017333.1.
RefSeq; XP_006252493.1; XM_006252431.3.
RefSeq; XP_017455275.1; XM_017599786.1.
UniGene; Rn.11412; -.
ProteinModelPortal; P21451; -.
SMR; P21451; -.
STRING; 10116.ENSRNOP00000014747; -.
BindingDB; P21451; -.
ChEMBL; CHEMBL4631; -.
GuidetoPHARMACOLOGY; 220; -.
PhosphoSitePlus; P21451; -.
PaxDb; P21451; -.
PRIDE; P21451; -.
Ensembl; ENSRNOT00000014747; ENSRNOP00000014747; ENSRNOG00000010997.
GeneID; 50672; -.
KEGG; rno:50672; -.
UCSC; RGD:2536; rat.
CTD; 1910; -.
RGD; 2536; Ednrb.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00760000119177; -.
HOVERGEN; HBG051443; -.
InParanoid; P21451; -.
KO; K04198; -.
OMA; CCWCQSK; -.
OrthoDB; EOG091G0CJV; -.
PhylomeDB; P21451; -.
Reactome; R-RNO-375276; Peptide ligand-binding receptors.
Reactome; R-RNO-416476; G alpha (q) signalling events.
PRO; PR:P21451; -.
Proteomes; UP000002494; Chromosome 15.
Bgee; ENSRNOG00000010997; Expressed in 10 organ(s), highest expression level in lung.
Genevisible; P21451; RN.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; IDA:RGD.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0031965; C:nuclear membrane; IDA:RGD.
GO; GO:0005886; C:plasma membrane; IDA:RGD.
GO; GO:0004962; F:endothelin receptor activity; IDA:RGD.
GO; GO:0004930; F:G protein-coupled receptor activity; TAS:RGD.
GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
GO; GO:0038023; F:signaling receptor activity; TAS:RGD.
GO; GO:0031702; F:type 1 angiotensin receptor binding; IPI:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0019934; P:cGMP-mediated signaling; IMP:RGD.
GO; GO:0048484; P:enteric nervous system development; IGI:RGD.
GO; GO:0035645; P:enteric smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0042045; P:epithelial fluid transport; IMP:RGD.
GO; GO:0048246; P:macrophage chemotaxis; IEA:Ensembl.
GO; GO:0030318; P:melanocyte differentiation; IDA:RGD.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.
GO; GO:0032269; P:negative regulation of cellular protein metabolic process; IEA:Ensembl.
GO; GO:0014043; P:negative regulation of neuron maturation; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0001755; P:neural crest cell migration; IEA:Ensembl.
GO; GO:0007422; P:peripheral nervous system development; IEA:Ensembl.
GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; IMP:RGD.
GO; GO:0043473; P:pigmentation; IMP:RGD.
GO; GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
GO; GO:0060406; P:positive regulation of penile erection; IMP:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IMP:RGD.
GO; GO:0035810; P:positive regulation of urine volume; IMP:RGD.
GO; GO:0007497; P:posterior midgut development; IEA:Ensembl.
GO; GO:0008217; P:regulation of blood pressure; IMP:RGD.
GO; GO:0050678; P:regulation of epithelial cell proliferation; IMP:RGD.
GO; GO:0031620; P:regulation of fever generation; IMP:RGD.
GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
GO; GO:0051930; P:regulation of sensory perception of pain; IMP:RGD.
GO; GO:1990839; P:response to endothelin; IMP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IMP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0048265; P:response to pain; IMP:RGD.
GO; GO:0019233; P:sensory perception of pain; IMP:RGD.
GO; GO:0042310; P:vasoconstriction; IMP:RGD.
GO; GO:0042311; P:vasodilation; IMP:RGD.
GO; GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl.
InterPro; IPR000499; Endthln_rcpt.
InterPro; IPR001112; ETB_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00571; ENDOTHELINBR.
PRINTS; PR00366; ENDOTHELINR.
PRINTS; PR00237; GPCRRHODOPSN.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Disulfide bond;
G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane;
Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal;
Transducer; Transmembrane; Transmembrane helix.
SIGNAL 1 26 {ECO:0000255}.
CHAIN 27 442 Endothelin receptor type B.
/FTId=PRO_0000012733.
TOPO_DOM 27 101 Extracellular. {ECO:0000255}.
TRANSMEM 102 126 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 127 137 Cytoplasmic. {ECO:0000255}.
TRANSMEM 138 163 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 164 175 Extracellular. {ECO:0000255}.
TRANSMEM 176 197 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 198 218 Cytoplasmic. {ECO:0000255}.
TRANSMEM 219 243 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 244 271 Extracellular. {ECO:0000255}.
TRANSMEM 272 296 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 297 324 Cytoplasmic. {ECO:0000255}.
TRANSMEM 325 350 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 351 362 Extracellular. {ECO:0000255}.
TRANSMEM 363 389 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 390 442 Cytoplasmic. {ECO:0000255}.
MOD_RES 305 305 Phosphoserine.
{ECO:0000250|UniProtKB:P28088}.
MOD_RES 419 419 Phosphoserine.
{ECO:0000250|UniProtKB:P28088}.
MOD_RES 439 439 Phosphotyrosine.
{ECO:0000250|UniProtKB:P28088}.
MOD_RES 440 440 Phosphoserine.
{ECO:0000250|UniProtKB:P28088}.
MOD_RES 441 441 Phosphoserine.
{ECO:0000250|UniProtKB:P28088}.
MOD_RES 442 442 Phosphoserine.
{ECO:0000250|UniProtKB:P28088}.
LIPID 402 402 S-palmitoyl cysteine. {ECO:0000255}.
LIPID 403 403 S-palmitoyl cysteine. {ECO:0000255}.
LIPID 405 405 S-palmitoyl cysteine. {ECO:0000255}.
CARBOHYD 60 60 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 97 97 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 174 255 {ECO:0000255|PROSITE-ProRule:PRU00521}.
CONFLICT 66 69 SSAP -> FRT (in Ref. 2; CAA40916).
{ECO:0000305}.
SEQUENCE 442 AA; 49455 MW; BDA628D78E8071CB CRC64;
MQSSASRCGR ALVALLLACG LLGVWGEKRG FPPAQATPSL LGTKEVMTPP TKTSWTRGSN
SSLMRSSAPA EVTKGGRVAG VPPRSFPPPC QRKIEINKTF KYINTIVSCL VFVLGIIGNS
TLLRIIYKNK CMRNGPNILI ASLALGDLLH IIIDIPINAY KLLAGDWPFG AEMCKLVPFI
QKASVGITVL SLCALSIDRY RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF
DVITSDYKGK PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA IFYTLMTCEM
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY DQSNPQRCEL
LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC LCCWCQTFEE KQSLEEKQSC
LKFKANDHGY DNFRSSNKYS SS


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