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Endothelin-1 (ET-1) (Preproendothelin-1) (PPET1) [Cleaved into: Big endothelin-1]

 EDN1_BOVIN              Reviewed;         202 AA.
P17322; Q3T0C1;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
12-SEP-2018, entry version 124.
RecName: Full=Endothelin-1;
Short=ET-1;
AltName: Full=Preproendothelin-1;
Short=PPET1;
Contains:
RecName: Full=Big endothelin-1;
Flags: Precursor;
Name=EDN1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Aorta;
PubMed=2362823; DOI=10.1093/nar/18.12.3658;
Price G.J., Malone L.;
"Cloning and sequencing of a bovine preproendothelin cDNA.";
Nucleic Acids Res. 18:3658-3658(1990).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Pulmonary artery;
PubMed=2198541; DOI=10.1093/nar/18.14.4273;
Elshourbagy N.A., Kmetz P., Sathe G.M.;
"Nucleotide sequence of endothelin cDNA from bovine endothelial
cells.";
Nucleic Acids Res. 18:4273-4273(1990).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Carotid artery;
PubMed=1592477; DOI=10.1161/01.HYP.19.6.753;
Imai T., Hirata Y., Emori T., Yanagisawa M., Masaki T., Marumo F.;
"Induction of endothelin-1 gene by angiotensin and vasopressin in
endothelial cells.";
Hypertension 19:753-757(1992).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor
peptides.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
{ECO:0000305}.
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EMBL; X52740; CAA36954.1; -; mRNA.
EMBL; X52942; CAA37117.1; -; mRNA.
EMBL; S37093; AAB22241.1; -; mRNA.
EMBL; BC102459; AAI02460.1; -; mRNA.
PIR; S10488; S10488.
RefSeq; NP_851353.1; NM_181010.2.
UniGene; Bt.59529; -.
SMR; P17322; -.
STRING; 9913.ENSBTAP00000010649; -.
PaxDb; P17322; -.
PRIDE; P17322; -.
Ensembl; ENSBTAT00000010649; ENSBTAP00000010649; ENSBTAG00000008096.
GeneID; 281137; -.
KEGG; bta:281137; -.
CTD; 1906; -.
VGNC; VGNC:28327; EDN1.
eggNOG; ENOG410IWVG; Eukaryota.
eggNOG; ENOG4111WED; LUCA.
GeneTree; ENSGT00530000063310; -.
HOGENOM; HOG000231110; -.
HOVERGEN; HBG051441; -.
InParanoid; P17322; -.
KO; K16366; -.
OMA; WVNTPEH; -.
OrthoDB; EOG091G0LEL; -.
TreeFam; TF333184; -.
Reactome; R-BTA-375276; Peptide ligand-binding receptors.
Reactome; R-BTA-416476; G alpha (q) signalling events.
Proteomes; UP000009136; Chromosome 23.
Bgee; ENSBTAG00000008096; Expressed in 9 organ(s), highest expression level in lung.
GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005125; F:cytokine activity; IEA:Ensembl.
GO; GO:0031707; F:endothelin A receptor binding; IEA:Ensembl.
GO; GO:0031708; F:endothelin B receptor binding; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; IEA:Ensembl.
GO; GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
GO; GO:0007589; P:body fluid secretion; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
GO; GO:0051216; P:cartilage development; IEA:Ensembl.
GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:Ensembl.
GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0048016; P:inositol phosphate-mediated signaling; IEA:Ensembl.
GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
GO; GO:0032269; P:negative regulation of cellular protein metabolic process; IEA:Ensembl.
GO; GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
GO; GO:0030185; P:nitric oxide transport; IEA:Ensembl.
GO; GO:0030072; P:peptide hormone secretion; IEA:Ensembl.
GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0031583; P:phospholipase D-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0061051; P:positive regulation of cell growth involved in cardiac muscle cell development; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0045793; P:positive regulation of cell size; IEA:Ensembl.
GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; IEA:Ensembl.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
GO; GO:0046887; P:positive regulation of hormone secretion; IEA:Ensembl.
GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IEA:Ensembl.
GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IEA:Ensembl.
GO; GO:0010870; P:positive regulation of receptor biosynthetic process; IEA:Ensembl.
GO; GO:0035815; P:positive regulation of renal sodium excretion; IEA:Ensembl.
GO; GO:0060298; P:positive regulation of sarcomere organization; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0035810; P:positive regulation of urine volume; IEA:Ensembl.
GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
GO; GO:0042313; P:protein kinase C deactivation; IEA:Ensembl.
GO; GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0008217; P:regulation of blood pressure; NAS:AgBase.
GO; GO:0010827; P:regulation of glucose transmembrane transport; IEA:Ensembl.
GO; GO:0006885; P:regulation of pH; IEA:Ensembl.
GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IEA:Ensembl.
GO; GO:0019229; P:regulation of vasoconstriction; NAS:AgBase.
GO; GO:0007585; P:respiratory gaseous exchange; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0043179; P:rhythmic excitation; IEA:Ensembl.
GO; GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl.
InterPro; IPR020475; Endothelin.
InterPro; IPR019764; Endothelin_toxin_CS.
InterPro; IPR001928; Endothln-like_toxin.
Pfam; PF00322; Endothelin; 1.
PRINTS; PR00365; ENDOTHELIN.
SMART; SM00272; END; 2.
PROSITE; PS00270; ENDOTHELIN; 2.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Reference proteome; Secreted; Signal; Vasoactive; Vasoconstrictor.
SIGNAL 1 25 {ECO:0000255}.
PROPEP 26 50 {ECO:0000250|UniProtKB:P22388}.
/FTId=PRO_0000008046.
PEPTIDE 53 91 Big endothelin-1.
{ECO:0000250|UniProtKB:P22388}.
/FTId=PRO_0000436393.
PEPTIDE 53 73 Endothelin-1.
/FTId=PRO_0000008047.
PROPEP 74 202
/FTId=PRO_0000008048.
REGION 110 124 Endothelin-like.
SITE 73 74 Cleavage; by KEL.
{ECO:0000250|UniProtKB:P05305}.
DISULFID 53 67 {ECO:0000250|UniProtKB:P05305}.
DISULFID 55 63 {ECO:0000250|UniProtKB:P05305}.
CONFLICT 132 132 D -> A (in Ref. 2; CAA37117).
{ECO:0000305}.
SEQUENCE 202 AA; 22977 MW; 42EB2AF07C85A5A3 CRC64;
MDYFPMIFAL LFVAFQGAPE AAVLGTELSA GAEDGGEKPA PATPWRPRRS KRCSCSSLMD
KECVYFCHLD IIWVNTPEHV VPYGLGSPSR SKRSLKDFFP TKATVHRKRC QCASQTDKKC
WNFCQAGKEL RDQDSMEKAW NNQKRGKDCS KLGEKCLHQQ LVAGRKTRRL EAISNSIKTS
FRVAKLKAQL YRDKKVIYNR AH


Related products :

Catalog number Product name Quantity
20-272-191636 Endothelin 1 - Mouse monoclonal [1.B.759] to Endothelin 1; Preproendothelin-1; PPET1 Monoclonal 0.05 mg
06-271-83118 Big Endothelin-1 (1-38) Human - Preproendothelin-1; PPET1 0.5 mg
06-271-83118 Big Endothelin-1 (1-38) Human - Preproendothelin-1; PPET1 1 mg
06-271-83198 Endothelin 1 Human Porcine - Preproendothelin-1; PPET1 1 mg
06-271-83198 Endothelin 1 Human Porcine - Preproendothelin-1; PPET1 0.25 mg
E0482p ELISA EDN1,Endothelin-1,ET-1,Pig,PPET1,Preproendothelin-1,Sus scrofa 96T
E0482p ELISA kit EDN1,Endothelin-1,ET-1,Pig,PPET1,Preproendothelin-1,Sus scrofa 96T
U0482p CLIA EDN1,Endothelin-1,ET-1,Pig,PPET1,Preproendothelin-1,Sus scrofa 96T
E0482r ELISA Edn1,Endothelin-1,ET-1,PPET1,Preproendothelin-1,Rat,Rattus norvegicus 96T
E0482m ELISA kit Edn1,Endothelin-1,ET-1,Mouse,Mus musculus,PPET1,Preproendothelin-1 96T
E0482b ELISA kit Bos taurus,Bovine,EDN1,Endothelin-1,ET-1,PPET1,Preproendothelin-1 96T
U0482b CLIA Bos taurus,Bovine,EDN1,Endothelin-1,ET-1,PPET1,Preproendothelin-1 96T
E0482r ELISA kit Edn1,Endothelin-1,ET-1,PPET1,Preproendothelin-1,Rat,Rattus norvegicus 96T
U0482m CLIA Edn1,Endothelin-1,ET-1,Mouse,Mus musculus,PPET1,Preproendothelin-1 96T
U0482r CLIA Edn1,Endothelin-1,ET-1,PPET1,Preproendothelin-1,Rat,Rattus norvegicus 96T
E0482b ELISA Bos taurus,Bovine,EDN1,Endothelin-1,ET-1,PPET1,Preproendothelin-1 96T
E0482m ELISA Edn1,Endothelin-1,ET-1,Mouse,Mus musculus,PPET1,Preproendothelin-1 96T
E0482Rb ELISA kit EDN1,Endothelin-1,ET-1,Oryctolagus cuniculus,PPET1,Preproendothelin-1,Rabbit 96T
E0482h ELISA EDN1,Endothelin-1,Homo sapiens,Human,PPET1,Preproendothelin-1 96T
E0482h ELISA kit EDN1,Endothelin-1,Homo sapiens,Human,PPET1,Preproendothelin-1 96T
U0482h CLIA EDN1,Endothelin-1,Homo sapiens,Human,PPET1,Preproendothelin-1 96T
E0482Rb ELISA EDN1,Endothelin-1,ET-1,Oryctolagus cuniculus,PPET1,Preproendothelin-1,Rabbit 96T
U0482Rb CLIA EDN1,Endothelin-1,ET-1,Oryctolagus cuniculus,PPET1,Preproendothelin-1,Rabbit 96T
E0482c ELISA kit Canis familiaris,Canis lupus familiaris,Dog,EDN1,Endothelin-1,ET-1,PPET1,Preproendothelin-1 96T
U0482c CLIA Canis familiaris,Canis lupus familiaris,Dog,EDN1,Endothelin-1,ET-1,PPET1,Preproendothelin-1 96T


 

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