Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Endothelin-1 receptor (Endothelin receptor type A) (ET-A) (ETA-R) (hET-AR)

 EDNRA_HUMAN             Reviewed;         427 AA.
P25101; B2R723; B4E2V6; B7Z9G6; D3DP03; E7ER36; O43441; Q16432;
Q16433; Q8TBH2;
01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
01-MAY-1992, sequence version 1.
20-JUN-2018, entry version 188.
RecName: Full=Endothelin-1 receptor {ECO:0000305};
AltName: Full=Endothelin receptor type A {ECO:0000312|HGNC:HGNC:3179};
Short=ET-A;
Short=ETA-R;
Short=hET-AR;
Flags: Precursor;
Name=EDNRA {ECO:0000312|HGNC:HGNC:3179}; Synonyms=ETA, ETRA;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Placenta;
PubMed=1719979; DOI=10.1016/S0006-291X(05)81332-4;
Adachi M., Yang Y.Y., Furuichi Y., Miyamoto C.;
"Cloning and characterization of cDNA encoding human A-type endothelin
receptor.";
Biochem. Biophys. Res. Commun. 180:1265-1272(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Placenta;
PubMed=1659806; DOI=10.1016/S0006-291X(05)81399-3;
Cyr C., Huebner K., Druck T., Kris R.;
"Cloning and chromosomal localization of a human endothelin ETA
receptor.";
Biochem. Biophys. Res. Commun. 181:184-190(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=1652463; DOI=10.1016/0014-5793(91)80007-P;
Hosoda K., Nakao K., Arai H., Suga S., Ogawa Y., Mukoyama M.,
Shirakami G., Saito Y., Nakanishi S., Imura H.;
"Cloning and expression of human endothelin-1 receptor cDNA.";
FEBS Lett. 287:23-26(1991).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=1291713;
Arai H., Nakao K., Hosoda K., Ogawa Y., Nakagawa O., Komatsu Y.,
Imura H.;
"Molecular cloning of human endothelin receptors and their expression
in vascular endothelial cells and smooth muscle cells.";
Jpn. Circ. J. 56:1303-1307(1992).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=8440682;
Elshourbagy N.A., Korman D.R., Wu H.L., Sylvester D.R., Lee J.A.,
Nuthalaganti P., Bergsma D.J., Kumar C.S., Nambi P.;
"Molecular characterization and regulation of the human endothelin
receptors.";
J. Biol. Chem. 268:3873-3879(1993).
[6]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
PubMed=1326535;
Hosoda K., Nakao K., Tamura N., Arai H., Ogawa Y., Suga S.,
Nakanishi S., Imura H.;
"Organization, structure, chromosomal assignment, and expression of
the gene encoding the human endothelin-A receptor.";
J. Biol. Chem. 267:18797-18804(1992).
[7]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
TISSUE=Placenta;
PubMed=1415318;
Hayzer D.J., Rose P.M., Lynch J.S., Webb M.L., Kienzle B.K., Liu E.C.,
Bogosian E.A., Brinson E., Runge M.S.;
"Cloning and expression of a human endothelin receptor: subtype A.";
Am. J. Med. Sci. 304:231-238(1992).
[8]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3 AND 4), AND TISSUE
SPECIFICITY.
TISSUE=Lung;
PubMed=8611157; DOI=10.1042/bj3130795;
Miyamoto Y., Yoshimasa T., Arai H., Takaya K., Ogawa Y., Itoh H.,
Nakao K.;
"Alternative RNA splicing of the human endothelin-A receptor generates
multiple transcripts.";
Biochem. J. 313:795-801(1996).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Placenta;
Warren C.N., Aronstam R.S., Sharma S.V.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NIEHS SNPs program;
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[11]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5).
TISSUE=Cerebellum, Testis, and Trachea;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[12]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15815621; DOI=10.1038/nature03466;
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2
and 4.";
Nature 434:724-731(2005).
[13]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[14]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[15]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-140 (ISOFORMS 1/2/3/4).
PubMed=8427579; DOI=10.1006/bbrc.1993.1052;
Yang H., Tabuchi H., Furuichi Y., Miyamoto C.;
"Molecular characterization of the 5'-flanking region of human genomic
ETA gene.";
Biochem. Biophys. Res. Commun. 190:332-339(1993).
[16]
NUCLEOTIDE SEQUENCE [MRNA] OF 52-427 (ISOFORM 2), AND TISSUE
SPECIFICITY.
TISSUE=Placenta;
PubMed=9284755; DOI=10.1210/jcem.82.9.4209;
Bourgeois C., Robert B., Rebourcet R., Mondon F., Mignot T.-M.,
Duc-Goiran P., Ferre F.;
"Endothelin-1 and ETA receptor expression in vascular smooth muscle
cells from human placenta: a new ETA receptor messenger ribonucleic
acid is generated by alternative splicing of exon 3.";
J. Clin. Endocrinol. Metab. 82:3116-3123(1997).
[17]
INTERACTION WITH HDAC7 AND KAT5.
PubMed=11262386; DOI=10.1074/jbc.C000909200;
Lee H.-J., Chun M., Kandror K.V.;
"Tip60 and HDAC7 interact with the endothelin receptor a and may be
involved in downstream signaling.";
J. Biol. Chem. 276:16597-16600(2001).
[18]
INVOLVEMENT IN MFDA, AND VARIANTS MFDA PHE-129 AND LYS-303.
PubMed=25772936; DOI=10.1016/j.ajhg.2015.01.015;
Gordon C.T., Weaver K.N., Zechi-Ceide R.M., Madsen E.C., Tavares A.L.,
Oufadem M., Kurihara Y., Adameyko I., Picard A., Breton S.,
Pierrot S., Biosse-Duplan M., Voisin N., Masson C., Bole-Feysot C.,
Nitschke P., Delrue M.A., Lacombe D., Guion-Almeida M.L., Moura P.P.,
Garib D.G., Munnich A., Ernfors P., Hufnagel R.B., Hopkin R.J.,
Kurihara H., Saal H.M., Weaver D.D., Katsanis N., Lyonnet S.,
Golzio C., Clouthier D.E., Amiel J.;
"Mutations in the endothelin receptor type A cause mandibulofacial
dysostosis with alopecia.";
Am. J. Hum. Genet. 96:519-531(2015).
[19]
VARIANT [LARGE SCALE ANALYSIS] LEU-136.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Receptor for endothelin-1. Mediates its action by
association with G proteins that activate a phosphatidylinositol-
calcium second messenger system. The rank order of binding
affinities for ET-A is: ET1 > ET2 >> ET3.
-!- SUBUNIT: Interacts with HDAC7 and KAT5.
{ECO:0000269|PubMed:11262386}.
-!- INTERACTION:
P49407:ARRB1; NbExp=3; IntAct=EBI-6624559, EBI-743313;
P32121:ARRB2; NbExp=2; IntAct=EBI-6624559, EBI-714559;
P05305:EDN1; NbExp=2; IntAct=EBI-6624559, EBI-715181;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=1;
IsoId=P25101-1; Sequence=Displayed;
Name=2; Synonyms=Delta-3;
IsoId=P25101-2; Sequence=VSP_011059, VSP_011060;
Name=3; Synonyms=Delta-4;
IsoId=P25101-3; Sequence=VSP_011062, VSP_011063;
Name=4; Synonyms=Delta-3,4;
IsoId=P25101-4; Sequence=VSP_011061;
Name=5;
IsoId=P25101-5; Sequence=VSP_045578;
Note=No experimental confirmation available.;
-!- TISSUE SPECIFICITY: Isoform 1, isoform 3 and isoform 4 are
expressed in a variety of tissues, with highest levels in the
aorta and cerebellum, followed by lung, atrium and cerebral
cortex, lower levels in the placenta, kidney, adrenal gland,
duodenum, colon, ventricle and liver but no expression in
umbilical vein endothelial cells. Within the placenta, isoform 1,
isoform 2, isoform 3 and isoform 4 are expressed in the villi and
stem villi vessels. {ECO:0000269|PubMed:8611157,
ECO:0000269|PubMed:9284755}.
-!- DISEASE: Mandibulofacial dysostosis with alopecia (MFDA)
[MIM:616367]: A form of mandibulofacial dysostosis, a disorder
characterized by malar and mandibular hypoplasia, typically
associated with abnormalities of the ears and eyelids. MFDA
features include maxillary dysmorphism with dysplastic zygomatic
arch, hypoplastic mandible, scalp alopecia, scant eyebrows and
eyelashes, severe hypoplasia or aplasia of eyelids, small cupped
dysplastic ears, conductive hearing loss, cleft palate, dental
anomalies, micrognathia, and limited jaw mobility.
{ECO:0000269|PubMed:25772936}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Endothelin receptor subfamily. EDNRA sub-subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/ednra/";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; S63938; AAB20278.1; -; mRNA.
EMBL; S67127; AAB20407.1; -; mRNA.
EMBL; X61950; CAA43953.1; -; mRNA.
EMBL; D90348; BAA14359.1; -; mRNA.
EMBL; S57498; AAB25530.2; -; mRNA.
EMBL; L06622; AAA58447.1; -; mRNA.
EMBL; D11151; BAA01920.1; -; Genomic_DNA.
EMBL; S45956; AAB23644.1; -; mRNA.
EMBL; S81539; AAB36325.1; -; mRNA.
EMBL; S81542; AAB36326.1; -; mRNA.
EMBL; S81545; AAB36327.1; -; mRNA.
EMBL; AY275462; AAP32294.1; -; mRNA.
EMBL; AY422989; AAQ87880.1; -; Genomic_DNA.
EMBL; AK304451; BAG65268.1; -; mRNA.
EMBL; AK312812; BAG35670.1; -; mRNA.
EMBL; AK315931; BAH14302.1; -; mRNA.
EMBL; AC093908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471056; EAX05019.1; -; Genomic_DNA.
EMBL; CH471056; EAX05021.1; -; Genomic_DNA.
EMBL; BC022511; AAH22511.1; -; mRNA.
EMBL; S55772; AAB25212.1; -; Genomic_DNA.
EMBL; AF014826; AAB94859.1; -; mRNA.
CCDS; CCDS3769.1; -. [P25101-1]
CCDS; CCDS54810.1; -. [P25101-4]
PIR; A44158; A44158.
RefSeq; NP_001159527.1; NM_001166055.1. [P25101-4]
RefSeq; NP_001243212.1; NM_001256283.1.
RefSeq; NP_001948.1; NM_001957.3. [P25101-1]
UniGene; Hs.183713; -.
ProteinModelPortal; P25101; -.
SMR; P25101; -.
BioGrid; 108231; 21.
DIP; DIP-48718N; -.
IntAct; P25101; 4.
STRING; 9606.ENSP00000315011; -.
ChEMBL; CHEMBL252; -.
DrugBank; DB00945; Acetylsalicylic acid.
DrugBank; DB05367; Actelion-1.
DrugBank; DB06403; Ambrisentan.
DrugBank; DB00559; Bosentan.
DrugBank; DB04883; Darusentan.
DrugBank; DB08932; Macitentan.
DrugBank; DB05206; PS433540.
DrugBank; DB06268; Sitaxentan.
DrugBank; DB05290; SPP 301.
GuidetoPHARMACOLOGY; 219; -.
iPTMnet; P25101; -.
PhosphoSitePlus; P25101; -.
SwissPalm; P25101; -.
BioMuta; EDNRA; -.
DMDM; 119606; -.
PaxDb; P25101; -.
PeptideAtlas; P25101; -.
PRIDE; P25101; -.
ProteomicsDB; 54256; -.
ProteomicsDB; 54257; -. [P25101-2]
ProteomicsDB; 54258; -. [P25101-3]
ProteomicsDB; 54259; -. [P25101-4]
DNASU; 1909; -.
Ensembl; ENST00000324300; ENSP00000315011; ENSG00000151617. [P25101-1]
Ensembl; ENST00000358556; ENSP00000351359; ENSG00000151617. [P25101-4]
Ensembl; ENST00000506066; ENSP00000425281; ENSG00000151617. [P25101-4]
Ensembl; ENST00000510697; ENSP00000427259; ENSG00000151617. [P25101-3]
Ensembl; ENST00000511804; ENSP00000425354; ENSG00000151617. [P25101-5]
GeneID; 1909; -.
KEGG; hsa:1909; -.
UCSC; uc003iky.4; human. [P25101-1]
CTD; 1909; -.
DisGeNET; 1909; -.
EuPathDB; HostDB:ENSG00000151617.15; -.
GeneCards; EDNRA; -.
HGNC; HGNC:3179; EDNRA.
HPA; CAB018957; -.
HPA; HPA013774; -.
MalaCards; EDNRA; -.
MIM; 131243; gene.
MIM; 616367; phenotype.
neXtProt; NX_P25101; -.
OpenTargets; ENSG00000151617; -.
PharmGKB; PA27617; -.
eggNOG; KOG3656; Eukaryota.
eggNOG; ENOG410XRW9; LUCA.
GeneTree; ENSGT00760000119177; -.
HOGENOM; HOG000169267; -.
HOVERGEN; HBG051443; -.
InParanoid; P25101; -.
KO; K04197; -.
OMA; NNHNTER; -.
OrthoDB; EOG091G0CJV; -.
PhylomeDB; P25101; -.
TreeFam; TF331292; -.
Reactome; R-HSA-375276; Peptide ligand-binding receptors.
Reactome; R-HSA-416476; G alpha (q) signalling events.
SIGNOR; P25101; -.
GeneWiki; Endothelin_receptor_type_A; -.
GenomeRNAi; 1909; -.
PRO; PR:P25101; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000151617; -.
CleanEx; HS_EDNRA; -.
Genevisible; P25101; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0004962; F:endothelin receptor activity; NAS:UniProtKB.
GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.
GO; GO:0007190; P:activation of adenylate cyclase activity; TAS:ProtInc.
GO; GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.
GO; GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Ensembl.
GO; GO:0014824; P:artery smooth muscle contraction; IMP:BHF-UCL.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
GO; GO:0048484; P:enteric nervous system development; IEA:InterPro.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:1904659; P:glucose transmembrane transport; ISS:UniProtKB.
GO; GO:0060322; P:head development; IEA:Ensembl.
GO; GO:0007507; P:heart development; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; TAS:ProtInc.
GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
GO; GO:0010827; P:regulation of glucose transmembrane transport; IEA:Ensembl.
GO; GO:0007585; P:respiratory gaseous exchange; ISS:UniProtKB.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0006939; P:smooth muscle contraction; TAS:ProtInc.
GO; GO:0042310; P:vasoconstriction; IMP:BHF-UCL.
InterPro; IPR000499; Endthln_rcpt.
InterPro; IPR002175; ETA_rcpt.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00570; ENDOTHELINAR.
PRINTS; PR00366; ENDOTHELINR.
PRINTS; PR00237; GPCRRHODOPSN.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
Alternative splicing; Cell membrane; Complete proteome;
Disease mutation; Disulfide bond; G-protein coupled receptor;
Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Receptor;
Reference proteome; Signal; Transducer; Transmembrane;
Transmembrane helix.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 427 Endothelin-1 receptor.
/FTId=PRO_0000012721.
TOPO_DOM 21 80 Extracellular. {ECO:0000255}.
TRANSMEM 81 102 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 103 112 Cytoplasmic. {ECO:0000255}.
TRANSMEM 113 132 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 133 159 Extracellular. {ECO:0000255}.
TRANSMEM 160 181 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 182 205 Cytoplasmic. {ECO:0000255}.
TRANSMEM 206 229 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 230 256 Extracellular. {ECO:0000255}.
TRANSMEM 257 278 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 279 306 Cytoplasmic. {ECO:0000255}.
TRANSMEM 307 328 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 329 347 Extracellular. {ECO:0000255}.
TRANSMEM 348 372 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 373 427 Cytoplasmic. {ECO:0000255}.
MOD_RES 425 425 Phosphoserine.
{ECO:0000250|UniProtKB:P28088}.
CARBOHYD 29 29 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 62 62 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 158 239 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VAR_SEQ 1 225 Missing (in isoform 5).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_045578.
VAR_SEQ 141 249 Missing (in isoform 4).
{ECO:0000303|PubMed:8611157}.
/FTId=VSP_011061.
VAR_SEQ 141 161 LLAGRWPFDHNDFGVFLCKLF -> VQSSCLLESCSGNWDS
FGNCH (in isoform 2).
{ECO:0000303|PubMed:9284755}.
/FTId=VSP_011059.
VAR_SEQ 162 427 Missing (in isoform 2).
{ECO:0000303|PubMed:9284755}.
/FTId=VSP_011060.
VAR_SEQ 183 187 RYRAV -> SSTKM (in isoform 3).
{ECO:0000303|PubMed:8611157}.
/FTId=VSP_011062.
VAR_SEQ 188 427 Missing (in isoform 3).
{ECO:0000303|PubMed:8611157}.
/FTId=VSP_011063.
VARIANT 129 129 Y -> F (in MFDA; dbSNP:rs786205230).
{ECO:0000269|PubMed:25772936}.
/FTId=VAR_073788.
VARIANT 136 136 I -> L (in a breast cancer sample;
somatic mutation).
{ECO:0000269|PubMed:16959974}.
/FTId=VAR_035758.
VARIANT 303 303 E -> K (in MFDA; dbSNP:rs876657388).
{ECO:0000269|PubMed:25772936}.
/FTId=VAR_073789.
CONFLICT 110 110 C -> Y (in Ref. 7; AAB23644).
{ECO:0000305}.
CONFLICT 115 115 P -> H (in Ref. 14; AAH22511).
{ECO:0000305}.
CONFLICT 207 207 V -> A (in Ref. 5; AAA58447).
{ECO:0000305}.
CONFLICT 232 232 R -> K (in Ref. 11; BAH14302).
{ECO:0000305}.
CONFLICT 234 234 E -> G (in Ref. 5; AAA58447).
{ECO:0000305}.
CONFLICT 280 280 C -> G (in Ref. 5; AAA58447).
{ECO:0000305}.
CONFLICT 300 300 Q -> H (in Ref. 11; BAG65268).
{ECO:0000305}.
CONFLICT 322 322 L -> V (in Ref. 14; AAH22511).
{ECO:0000305}.
CONFLICT 345 345 S -> G (in Ref. 11; BAG65268).
{ECO:0000305}.
CONFLICT 409 409 N -> D (in Ref. 14; AAH22511).
{ECO:0000305}.
SEQUENCE 427 AA; 48722 MW; 207272D4A231404F CRC64;
METLCLRASF WLALVGCVIS DNPERYSTNL SNHVDDFTTF RGTELSFLVT THQPTNLVLP
SNGSMHNYCP QQTKITSAFK YINTVISCTI FIVGMVGNAT LLRIIYQNKC MRNGPNALIA
SLALGDLIYV VIDLPINVFK LLAGRWPFDH NDFGVFLCKL FPFLQKSSVG ITVLNLCALS
VDRYRAVASW SRVQGIGIPL VTAIEIVSIW ILSFILAIPE AIGFVMVPFE YRGEQHKTCM
LNATSKFMEF YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYNEMDKNR CELLSFLLLM DYIGINLATM
NSCINPIALY FVSKKFKNCF QSCLCCCCYQ SKSLMTSVPM NGTSIQWKNH DQNNHNTDRS
SHKDSMN


Related products :

Catalog number Product name Quantity
AER002/1 Endothelin Receptor B, ET_B, Nonselective Type Endothelin Receptor, Ednrb, ETB, ETRB, 298_314, Rabbit anti_Rat; WB_IH 50 µl.
EIAAB12453 EDNRB,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR,ETRB,Homo sapiens,Human
EIAAB12452 EDNRB,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR,Oryctolagus cuniculus,Rabbit
EIAAB12454 Ednrb,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR,Rat,Rattus norvegicus
EIAAB12451 Ednrb,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR,Mouse,Mus musculus
EIAAB12449 Bos taurus,Bovine,EDNRB,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR
EIAAB12448 EDNRB,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR,Pig,Sus scrofa
18-461-10791 Endothelin B receptor - ET-B; Endothelin receptor Non-selective type Polyclonal 0.05 ml
18-461-10793 Endothelin B receptor - ET-B; Endothelin receptor Non-selective type Polyclonal 0.05 ml
18-461-10577 Endothelin B receptor - ET-B; Endothelin receptor Non-selective type Polyclonal 0.05 ml
18-461-10790 Endothelin B receptor - ET-B; Endothelin receptor Non-selective type Polyclonal 0.05 ml
18-461-10674 Probable G-protein coupled receptor 37 - Endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; PAELR Polyclonal 0.05 ml
18-461-10353 Probable G-protein coupled receptor 37 - Endothelin B receptor-like protein 1; ETBR-LP-1; Parkin-associated endothelin receptor-like receptor; PAELR Polyclonal 0.05 ml
SCH-AAR43 SHEEP ANTI RAT ENDOTHELIN B RECEPTOR (C_TERMINAL), Product Type Polyclonal Antibody, Specificity ENDOTHELIN B RECEPTOR, Target Species Rat, Host Sheep, Format Purified, Isotypes Polyclonal IgG, 0.1 mg
AAR43 SHEEP ANTI RAT ENDOTHELIN B RECEPTOR (C_TERMINAL), Product Type Polyclonal Antibody, Specificity ENDOTHELIN B RECEPTOR, Target Species Rat, Host Sheep, Format Purified, Isotypes Polyclonal IgG, 0.1 mg
EIAAB12445 EDNRA,Endothelin A receptor,Endothelin-1 receptor,ETA,ET-A,ETA-R,ETRA,hET-AR,Homo sapiens,Human
18-783-77164 RABBIT ANTI HUMAN ENDOTHELIN A RECEPTOR (CYTOPLASMIC) - Endothelin A receptor; ET-A; hET-AR; ETA-R Polyclonal 1 ml
18-783-77157 SHEEP ANTI HUMAN ENDOTHELIN A RECEPTOR (CYTOPLASMIC) - Endothelin A receptor; ET-A; hET-AR; ETA-R Polyclonal 1 ml
EIAAB12442 Ednra,Endothelin A receptor,Endothelin-1 receptor,ET-A,ET-AR,Gpcr10,Mouse,Mus musculus
EIAAB12446 Bos taurus,Bovine,EDNRA,Endothelin A receptor,Endothelin-1 receptor,ET-A,ET-AR
EIAAB12447 Ednra,Endothelin A receptor,Endothelin-1 receptor,ET-A,ET-AR,Rat,Rattus norvegicus
EIAAB12450 Canis familiaris,Canis lupus familiaris,Dog,EDNRB,Endothelin B receptor,Endothelin receptor non-selective type,ET-B,ET-BR
EIAAB12443 EDNRA,Endothelin A receptor,Endothelin-1 receptor,ET-A,ET-AR,Pig,Sus scrofa
18-461-10506 Endothelin-1 receptor - Endothelin A receptor; ET-A; hET-AR; ETA-R Polyclonal 0.05 ml
18-461-10504 Endothelin-1 receptor - Endothelin A receptor; ET-A; hET-AR; ETA-R Polyclonal 0.05 ml


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur