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Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2)

 EDN2_CANLF              Reviewed;         178 AA.
P12064; Q867C8;
01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
19-JUL-2004, sequence version 2.
12-SEP-2018, entry version 118.
RecName: Full=Endothelin-2;
Short=ET-2;
AltName: Full=Preproendothelin-2;
Short=PPET2;
Flags: Precursor;
Name=EDN2;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Uchide T.;
"Cloning of dog preproendothelin-2 cDNA and quantitative method of the
gene expression by real-time PCR.";
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 19-74.
TISSUE=Kidney;
PubMed=2668883; DOI=10.1093/nar/17.13.5389;
Itoh Y., Kimura C., Onda H., Fujino M.;
"Canine endothelin-2: cDNA sequence for the mature peptide.";
Nucleic Acids Res. 17:5389-5389(1989).
-!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor
peptides.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=CAA40354.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
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EMBL; AB089264; BAC56713.1; -; mRNA.
EMBL; X57038; CAA40354.1; ALT_SEQ; Genomic_DNA.
PIR; S29563; S29563.
RefSeq; NP_001003002.1; NM_001003002.1.
UniGene; Cfa.2; -.
SMR; P12064; -.
STRING; 9615.ENSCAFP00000038061; -.
PaxDb; P12064; -.
Ensembl; ENSCAFT00000045204; ENSCAFP00000038061; ENSCAFG00000002579.
GeneID; 403508; -.
KEGG; cfa:403508; -.
CTD; 1907; -.
VGNC; VGNC:40200; EDN2.
eggNOG; ENOG410J1XQ; Eukaryota.
eggNOG; ENOG410YUMW; LUCA.
GeneTree; ENSGT00530000063310; -.
HOVERGEN; HBG051441; -.
InParanoid; P12064; -.
KO; K16367; -.
TreeFam; TF333184; -.
Reactome; R-CFA-375276; Peptide ligand-binding receptors.
Reactome; R-CFA-416476; G alpha (q) signalling events.
Proteomes; UP000002254; Chromosome 15.
Bgee; ENSCAFG00000002579; Expressed in 1 organ(s), highest expression level in adult mammalian kidney.
GO; GO:0005615; C:extracellular space; IEA:Ensembl.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0031708; F:endothelin B receptor binding; IEA:Ensembl.
GO; GO:0005179; F:hormone activity; IEA:Ensembl.
GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
GO; GO:0019722; P:calcium-mediated signaling; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
GO; GO:0048016; P:inositol phosphate-mediated signaling; IEA:Ensembl.
GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
GO; GO:0048246; P:macrophage chemotaxis; IEA:Ensembl.
GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; IEA:Ensembl.
GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IEA:Ensembl.
GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IEA:Ensembl.
GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
GO; GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl.
InterPro; IPR020475; Endothelin.
InterPro; IPR019764; Endothelin_toxin_CS.
InterPro; IPR001928; Endothln-like_toxin.
InterPro; IPR015658; ET-2.
PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
Pfam; PF00322; Endothelin; 1.
PRINTS; PR00365; ENDOTHELIN.
SMART; SM00272; END; 2.
PROSITE; PS00270; ENDOTHELIN; 2.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Reference proteome; Secreted; Signal; Vasoactive; Vasoconstrictor.
SIGNAL 1 24 {ECO:0000255}.
PROPEP 25 46
/FTId=PRO_0000008084.
PEPTIDE 49 69 Endothelin-2.
/FTId=PRO_0000008085.
PROPEP 70 178
/FTId=PRO_0000008086.
REGION 96 111 Endothelin-like.
SITE 69 70 Cleavage; by KEL. {ECO:0000250}.
DISULFID 49 63 {ECO:0000250}.
DISULFID 51 59 {ECO:0000250}.
CONFLICT 19 20 VA -> AH (in Ref. 2; CAA40354).
{ECO:0000305}.
SEQUENCE 178 AA; 19723 MW; 5BE799BA3B9BB8AA CRC64;
MPAPGVHHPN TASPFLKTVA AGKGQVAAAP EHPAPSARAR GSHLRPRRCS CSSWLDKECV
YFCHLDIIWV NTPGQTAPYG LGNPPRRRRR SLPKRCECSS GGDPACATFC HRRPWAEAVV
VPGSRSPADV FQAGRTWTSA GELLRQLRNI SAAKIRFPRR PQEAGRQLRP THPRRRKR


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