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Endothelin-2 (ET-2) (Preproendothelin-2) (PPET2) (Vasoactive intestinal contractor) (VIC)

 EDN2_MOUSE              Reviewed;         175 AA.
P22389; Q9JME3;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
27-APR-2001, sequence version 3.
12-SEP-2018, entry version 152.
RecName: Full=Endothelin-2;
Short=ET-2;
AltName: Full=Preproendothelin-2;
Short=PPET2;
AltName: Full=Vasoactive intestinal contractor;
Short=VIC;
Flags: Precursor;
Name=Edn2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ICR;
PubMed=1859843; DOI=10.1016/0167-4781(91)90186-P;
Saida K., Mitsui Y.;
"cDNA cloning, sequence analysis and tissue distribution of a
precursor for vasoactive intestinal contractor (VIC).";
Biochim. Biophys. Acta 1089:404-406(1991).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=10708518; DOI=10.1006/geno.1999.6083;
Saida K., Hashimoto M., Mitsui Y., Ishida N., Uchide T.;
"The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene
(EDN2): structure, evolution, production, and embryonic expression.";
Genomics 64:51-61(2000).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Retina;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-70.
PubMed=2768235;
Saida K., Mitsui Y., Ishida N.;
"A novel peptide, vasoactive intestinal contractor, of a new
(endothelin) peptide family. Molecular cloning, expression, and
biological activity.";
J. Biol. Chem. 264:14613-14616(1989).
-!- FUNCTION: Vasoconstrictor.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
{ECO:0000305}.
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EMBL; X59556; CAA42155.1; -; mRNA.
EMBL; AB030303; BAA94208.1; -; Genomic_DNA.
EMBL; BC037042; AAH37042.1; -; mRNA.
EMBL; M26498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS38864.1; -.
PIR; S17194; S17194.
RefSeq; NP_031928.2; NM_007902.3.
UniGene; Mm.284855; -.
SMR; P22389; -.
STRING; 10090.ENSMUSP00000030384; -.
PhosphoSitePlus; P22389; -.
PaxDb; P22389; -.
PRIDE; P22389; -.
Ensembl; ENSMUST00000030384; ENSMUSP00000030384; ENSMUSG00000028635.
GeneID; 13615; -.
KEGG; mmu:13615; -.
UCSC; uc008unb.1; mouse.
CTD; 1907; -.
MGI; MGI:95284; Edn2.
eggNOG; ENOG410J1XQ; Eukaryota.
eggNOG; ENOG410YUMW; LUCA.
GeneTree; ENSGT00530000063310; -.
HOGENOM; HOG000231110; -.
HOVERGEN; HBG051441; -.
InParanoid; P22389; -.
KO; K16367; -.
OMA; PTAWCSV; -.
OrthoDB; EOG091G0WW5; -.
PhylomeDB; P22389; -.
TreeFam; TF333184; -.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-416476; G alpha (q) signalling events.
PRO; PR:P22389; -.
Proteomes; UP000000589; Chromosome 4.
Bgee; ENSMUSG00000028635; Expressed in 58 organ(s), highest expression level in decidua.
CleanEx; MM_EDN2; -.
Genevisible; P22389; MM.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0031708; F:endothelin B receptor binding; ISO:MGI.
GO; GO:0005179; F:hormone activity; ISO:MGI.
GO; GO:0014824; P:artery smooth muscle contraction; ISO:MGI.
GO; GO:0019722; P:calcium-mediated signaling; ISO:MGI.
GO; GO:0019221; P:cytokine-mediated signaling pathway; ISO:MGI.
GO; GO:0097009; P:energy homeostasis; IMP:MGI.
GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:MGI.
GO; GO:0048286; P:lung alveolus development; IMP:MGI.
GO; GO:0042116; P:macrophage activation; ISO:MGI.
GO; GO:0048246; P:macrophage chemotaxis; ISO:MGI.
GO; GO:0046888; P:negative regulation of hormone secretion; ISO:MGI.
GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI.
GO; GO:0001543; P:ovarian follicle rupture; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; ISO:MGI.
GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
GO; GO:0046887; P:positive regulation of hormone secretion; ISO:MGI.
GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:MGI.
GO; GO:0060585; P:positive regulation of prostaglandin-endoperoxide synthase activity; IMP:BHF-UCL.
GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:MGI.
GO; GO:0001516; P:prostaglandin biosynthetic process; IDA:BHF-UCL.
GO; GO:0007205; P:protein kinase C-activating G-protein coupled receptor signaling pathway; ISO:MGI.
GO; GO:0008217; P:regulation of blood pressure; ISO:MGI.
GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; ISO:MGI.
GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
GO; GO:0001659; P:temperature homeostasis; IMP:MGI.
GO; GO:0042310; P:vasoconstriction; ISO:MGI.
GO; GO:0014826; P:vein smooth muscle contraction; ISO:MGI.
InterPro; IPR020475; Endothelin.
InterPro; IPR019764; Endothelin_toxin_CS.
InterPro; IPR001928; Endothln-like_toxin.
InterPro; IPR015658; ET-2.
PANTHER; PTHR13874:SF9; PTHR13874:SF9; 1.
Pfam; PF00322; Endothelin; 1.
PRINTS; PR00365; ENDOTHELIN.
SMART; SM00272; END; 2.
PROSITE; PS00270; ENDOTHELIN; 2.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Reference proteome; Secreted; Signal; Vasoactive; Vasoconstrictor.
SIGNAL 1 21 {ECO:0000255}.
PROPEP 22 43
/FTId=PRO_0000008099.
PEPTIDE 46 66 Endothelin-2.
/FTId=PRO_0000008100.
PROPEP 67 175
/FTId=PRO_0000008101.
REGION 93 108 Endothelin-like.
SITE 66 67 Cleavage; by KEL. {ECO:0000250}.
DISULFID 46 60 {ECO:0000250}.
DISULFID 48 56 {ECO:0000250}.
CONFLICT 151 152 KL -> NV (in Ref. 1; CAA42155).
{ECO:0000305}.
CONFLICT 156 175 RLQPEVTRKAIPAYSRWRKR -> SYSQR (in Ref.
1). {ECO:0000305}.
SEQUENCE 175 AA; 19538 MW; 6BCDD79CAAA0244A CRC64;
MVSAWCSIAL ALLLALHEGK GQAAATLEQP ASAPKGRGPH LRFRRCSCNS WLDKECVYFC
HLDIIWVNTA GQTAPYGLGN PPRRRRRSLP KRCECSTAGD SACATFCHRR HWPEAVVAPS
SQAPAAVLKT GKMWTAEGDL LRKLRDISAT KLRFARLQPE VTRKAIPAYS RWRKR


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