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Endothelin-3 (ET-3) (Preproendothelin-3) (PPET3)

 EDN3_MOUSE              Reviewed;         214 AA.
P48299; Q543L0;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
20-JUN-2018, entry version 132.
RecName: Full=Endothelin-3;
Short=ET-3;
AltName: Full=Preproendothelin-3;
Short=PPET3;
Flags: Precursor;
Name=Edn3;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8001160; DOI=10.1016/0092-8674(94)90018-3;
Baynash A.G., Hosoda K., Giaid A., Richardson J.A., Emoto N.,
Hammer R.E., Yanagisawa M.;
"Interaction of endothelin-3 with endothelin-B receptor is essential
for development of epidermal melanocytes and enteric neurons.";
Cell 79:1277-1285(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Head, and Spinal cord;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
-!- FUNCTION: Endothelins are endothelium-derived vasoconstrictor
peptides.
-!- SUBCELLULAR LOCATION: Secreted.
-!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
{ECO:0000305}.
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EMBL; U32330; AAB60509.1; -; mRNA.
EMBL; AK048006; BAC33211.1; -; mRNA.
EMBL; AK049775; BAC33915.1; -; mRNA.
EMBL; AK079150; BAC37561.1; -; mRNA.
CCDS; CCDS17156.1; -.
PIR; I49351; I49351.
RefSeq; NP_031929.1; NM_007903.5.
UniGene; Mm.9478; -.
ProteinModelPortal; P48299; -.
SMR; P48299; -.
STRING; 10090.ENSMUSP00000029030; -.
PhosphoSitePlus; P48299; -.
PaxDb; P48299; -.
PRIDE; P48299; -.
Ensembl; ENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524.
GeneID; 13616; -.
KEGG; mmu:13616; -.
UCSC; uc008ofi.2; mouse.
CTD; 1908; -.
MGI; MGI:95285; Edn3.
eggNOG; ENOG410IXXK; Eukaryota.
eggNOG; ENOG410YW48; LUCA.
GeneTree; ENSGT00530000063310; -.
HOGENOM; HOG000231110; -.
HOVERGEN; HBG051442; -.
InParanoid; P48299; -.
KO; K05227; -.
OMA; WINTPEQ; -.
OrthoDB; EOG091G0OPZ; -.
PhylomeDB; P48299; -.
TreeFam; TF333184; -.
Reactome; R-MMU-375276; Peptide ligand-binding receptors.
Reactome; R-MMU-416476; G alpha (q) signalling events.
PRO; PR:P48299; -.
Proteomes; UP000000589; Chromosome 2.
Bgee; ENSMUSG00000027524; -.
CleanEx; MM_EDN3; -.
ExpressionAtlas; P48299; baseline and differential.
Genevisible; P48299; MM.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:0005622; C:intracellular; IEA:GOC.
GO; GO:0031708; F:endothelin B receptor binding; ISO:MGI.
GO; GO:0005179; F:hormone activity; ISO:MGI.
GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:MGI.
GO; GO:0006874; P:cellular calcium ion homeostasis; IGI:MGI.
GO; GO:0010961; P:cellular magnesium ion homeostasis; IGI:MGI.
GO; GO:0048016; P:inositol phosphate-mediated signaling; ISO:MGI.
GO; GO:0030318; P:melanocyte differentiation; IDA:MGI.
GO; GO:0046888; P:negative regulation of hormone secretion; ISO:MGI.
GO; GO:0001755; P:neural crest cell migration; IMP:MGI.
GO; GO:0030182; P:neuron differentiation; IMP:MGI.
GO; GO:0030593; P:neutrophil chemotaxis; ISO:MGI.
GO; GO:0030072; P:peptide hormone secretion; ISO:MGI.
GO; GO:0045597; P:positive regulation of cell differentiation; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell proliferation; IDA:MGI.
GO; GO:0010460; P:positive regulation of heart rate; ISO:MGI.
GO; GO:0046887; P:positive regulation of hormone secretion; ISO:MGI.
GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:MGI.
GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:MGI.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; ISO:MGI.
GO; GO:1901381; P:positive regulation of potassium ion transmembrane transport; IGI:MGI.
GO; GO:0030334; P:regulation of cell migration; IMP:MGI.
GO; GO:0048070; P:regulation of developmental pigmentation; IMP:MGI.
GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
GO; GO:0046928; P:regulation of neurotransmitter secretion; ISO:MGI.
GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; ISO:MGI.
GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
GO; GO:0042310; P:vasoconstriction; ISO:MGI.
GO; GO:0014826; P:vein smooth muscle contraction; ISO:MGI.
InterPro; IPR020475; Endothelin.
InterPro; IPR019764; Endothelin_toxin_CS.
InterPro; IPR001928; Endothln-like_toxin.
Pfam; PF00322; Endothelin; 1.
PRINTS; PR00365; ENDOTHELIN.
SMART; SM00272; END; 2.
PROSITE; PS00270; ENDOTHELIN; 2.
2: Evidence at transcript level;
Cleavage on pair of basic residues; Complete proteome; Disulfide bond;
Reference proteome; Secreted; Signal; Vasoactive; Vasoconstrictor.
SIGNAL 1 16 {ECO:0000255}.
PROPEP 17 94
/FTId=PRO_0000008114.
PEPTIDE 97 117 Endothelin-3.
/FTId=PRO_0000008115.
PROPEP 118 214
/FTId=PRO_0000008116.
REGION 159 173 Endothelin-like.
SITE 117 118 Cleavage; by KEL. {ECO:0000250}.
DISULFID 97 111 {ECO:0000250}.
DISULFID 99 107 {ECO:0000250}.
SEQUENCE 214 AA; 23322 MW; 8911260872D6A713 CRC64;
MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV AGPGERIVSP
TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF TYKDKECVYY CHLDIIWINT
PEQTVPYGLS NYRESLRGKR SLGPVPESSQ PSPWTRLRCT CMGADDKACA HFCARTRDVT
SYSGRAERPA AEEMRETGGP RQRLMSRTDK AHRP


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Catalog number Product name Quantity
06-271-83200 Endothelin-3 Human - ET-3; Preproendothelin-3; PPET3 0.5 mg
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E0482p ELISA EDN1,Endothelin-1,ET-1,Pig,PPET1,Preproendothelin-1,Sus scrofa 96T
U0482p CLIA EDN1,Endothelin-1,ET-1,Pig,PPET1,Preproendothelin-1,Sus scrofa 96T
U0482m CLIA Edn1,Endothelin-1,ET-1,Mouse,Mus musculus,PPET1,Preproendothelin-1 96T
E0482b ELISA kit Bos taurus,Bovine,EDN1,Endothelin-1,ET-1,PPET1,Preproendothelin-1 96T
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E0482r ELISA Edn1,Endothelin-1,ET-1,PPET1,Preproendothelin-1,Rat,Rattus norvegicus 96T


 

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