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Enhanced filamentous growth protein 1

 EFG1_CANAL              Reviewed;         550 AA.
Q59X67; A0A1D8PTM1; Q59XB5;
31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
15-MAR-2017, sequence version 2.
07-JUN-2017, entry version 75.
RecName: Full=Enhanced filamentous growth protein 1;
Name=EFG1; OrderedLocusNames=CAALFM_CR07890WA;
ORFNames=CaO19.610, CaO19.8243;
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Debaryomycetaceae;
Candida/Lodderomyces clade; Candida.
NCBI_TaxID=237561;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=15123810; DOI=10.1073/pnas.0401648101;
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S.,
Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T.,
Davis R.W., Scherer S.;
"The diploid genome sequence of Candida albicans.";
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
[2]
GENOME REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
Chibana H., Nantel A., Magee P.T.;
"Assembly of the Candida albicans genome into sixteen supercontigs
aligned on the eight chromosomes.";
Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME
REANNOTATION.
STRAIN=SC5314 / ATCC MYA-2876;
PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
"Assembly of a phased diploid Candida albicans genome facilitates
allele-specific measurements and provides a simple model for repeat
and indel structure.";
Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
[4]
FUNCTION.
PubMed=9298905; DOI=10.1016/S0092-8674(00)80358-X;
Lo H.J., Kohler J.R., DiDomenico B., Loebenberg D., Cacciapuoti A.,
Fink G.R.;
"Nonfilamentous C. albicans mutants are avirulent.";
Cell 90:939-949(1997).
[5]
FUNCTION.
PubMed=9846730; DOI=10.1099/00221287-144-11-2951;
Rademacher F., Kehren V., Stoldt V.R., Ernst J.F.;
"A Candida albicans chaperonin subunit (CaCct8p) as a suppressor of
morphogenesis and Ras phenotypes in C. albicans and Saccharomyces
cerevisiae.";
Microbiology 144:2951-2960(1998).
[6]
FUNCTION.
PubMed=10377153;
Riggle P.J., Andrutis K.A., Chen X., Tzipori S.R., Kumamoto C.A.;
"Invasive lesions containing filamentous forms produced by a Candida
albicans mutant that is defective in filamentous growth in culture.";
Infect. Immun. 67:3649-3652(1999).
[7]
FUNCTION, AND INDUCTION.
PubMed=10456912;
Sonneborn A., Tebarth B., Ernst J.F.;
"Control of white-opaque phenotypic switching in Candida albicans by
the Efg1p morphogenetic regulator.";
Infect. Immun. 67:4655-4660(1999).
[8]
FUNCTION, AND MUTAGENESIS OF THR-208.
PubMed=10496941;
Sonneborn A., Bockmuhl D.P., Ernst J.F.;
"Chlamydospore formation in Candida albicans requires the Efg1p
morphogenetic regulator.";
Infect. Immun. 67:5514-5517(1999).
[9]
FUNCTION.
PubMed=10790384;
Braun B.R., Johnson A.D.;
"TUP1, CPH1 and EFG1 make independent contributions to filamentation
in Candida albicans.";
Genetics 155:57-67(2000).
[10]
FUNCTION.
PubMed=10816502; DOI=10.1128/IAI.68.6.3485-3490.2000;
Phan Q.T., Belanger P.H., Filler S.G.;
"Role of hyphal formation in interactions of Candida albicans with
endothelial cells.";
Infect. Immun. 68:3485-3490(2000).
[11]
FUNCTION.
PubMed=10692363; DOI=10.1128/JB.182.6.1580-1591.2000;
Srikantha T., Tsai L.K., Daniels K., Soll D.R.;
"EFG1 null mutants of Candida albicans switch but cannot express the
complete phenotype of white-phase budding cells.";
J. Bacteriol. 182:1580-1591(2000).
[12]
FUNCTION, MUTAGENESIS OF THR-208, AND PHOSPHORYLATION AT THR-208.
PubMed=11290709;
Bockmuhl D.P., Ernst J.F.;
"A potential phosphorylation site for an A-type kinase in the Efg1
regulator protein contributes to hyphal morphogenesis of Candida
albicans.";
Genetics 157:1523-1530(2001).
[13]
FUNCTION, AND DNA-BINDING.
PubMed=11395474; DOI=10.1128/JB.183.13.4090-4093.2001;
Leng P., Lee P.R., Wu H., Brown A.J.;
"Efg1, a morphogenetic regulator in Candida albicans, is a sequence-
specific DNA binding protein.";
J. Bacteriol. 183:4090-4093(2001).
[14]
FUNCTION.
PubMed=11595734; DOI=10.1074/jbc.M104484200;
Lane S., Birse C., Zhou S., Matson R., Liu H.;
"DNA array studies demonstrate convergent regulation of virulence
factors by Cph1, Cph2, and Efg1 in Candida albicans.";
J. Biol. Chem. 276:48988-48996(2001).
[15]
FUNCTION.
PubMed=12204378; DOI=10.1111/j.1574-6968.2002.tb11330.x;
Ramage G., VandeWalle K., Lopez-Ribot J.L., Wickes B.L.;
"The filamentation pathway controlled by the Efg1 regulator protein is
required for normal biofilm formation and development in Candida
albicans.";
FEMS Microbiol. Lett. 214:95-100(2002).
[16]
FUNCTION, AND INTERACTION WITH CZF1.
PubMed=11973327;
Giusani A.D., Vinces M., Kumamoto C.A.;
"Invasive filamentous growth of Candida albicans is promoted by Czf1p-
dependent relief of Efg1p-mediated repression.";
Genetics 160:1749-1753(2002).
[17]
FUNCTION.
PubMed=11796627; DOI=10.1128/IAI.70.2.921-927.2002;
Staib P., Kretschmar M., Nichterlein T., Hof H., Morschhauser J.;
"Transcriptional regulators Cph1p and Efg1p mediate activation of the
Candida albicans virulence gene SAP5 during infection.";
Infect. Immun. 70:921-927(2002).
[18]
FUNCTION.
PubMed=12065511; DOI=10.1128/IAI.70.7.3689-3700.2002;
Felk A., Kretschmar M., Albrecht A., Schaller M., Beinhauer S.,
Nichterlein T., Sanglard D., Korting H.C., Schafer W., Hube B.;
"Candida albicans hyphal formation and the expression of the Efg1-
regulated proteinases Sap4 to Sap6 are required for the invasion of
parenchymal organs.";
Infect. Immun. 70:3689-3700(2002).
[19]
FUNCTION.
PubMed=11832513;
Dieterich C., Schandar M., Noll M., Johannes F.J., Brunner H.,
Graeve T., Rupp S.;
"In vitro reconstructed human epithelia reveal contributions of
Candida albicans EFG1 and CPH1 to adhesion and invasion.";
Microbiology 148:497-506(2002).
[20]
INDUCTION.
PubMed=12798685; DOI=10.1016/S0022-2836(03)00505-9;
Tebarth B., Doedt T., Krishnamurthy S., Weide M., Monterola F.,
Dominguez A., Ernst J.F.;
"Adaptation of the Efg1p morphogenetic pathway in Candida albicans by
negative autoregulation and PKA-dependent repression of the EFG1
gene.";
J. Mol. Biol. 329:949-962(2003).
[21]
FUNCTION.
PubMed=12492856; DOI=10.1046/j.1365-2958.2003.03300.x;
Sohn K., Urban C., Brunner H., Rupp S.;
"EFG1 is a major regulator of cell wall dynamics in Candida albicans
as revealed by DNA microarrays.";
Mol. Microbiol. 47:89-102(2003).
[22]
INDUCTION.
PubMed=12675809; DOI=10.1046/j.1365-2958.2003.t01-1-03448.x;
Lachke S.A., Srikantha T., Soll D.R.;
"The regulation of EFG1 in white-opaque switching in Candida albicans
involves overlapping promoters.";
Mol. Microbiol. 48:523-536(2003).
[23]
FUNCTION.
PubMed=15728931; DOI=10.1128/AAC.49.3.1213-1215.2005;
Lo H.J., Wang J.S., Lin C.Y., Chen C.G., Hsiao T.Y., Hsu C.T.,
Su C.L., Fann M.J., Ching Y.T., Yang Y.L.;
"Efg1 involved in drug resistance by regulating the expression of ERG3
in Candida albicans.";
Antimicrob. Agents Chemother. 49:1213-1215(2005).
[24]
FUNCTION.
PubMed=16487333; DOI=10.1111/j.1574-6968.2006.00109.x;
Saville S.P., Thomas D.P., Lopez Ribot J.L.;
"A role for Efg1p in Candida albicans interactions with extracellular
matrices.";
FEMS Microbiol. Lett. 256:151-158(2006).
[25]
FUNCTION, AND INTERACTION WITH FLO8.
PubMed=16267276; DOI=10.1091/mbc.E05-06-0502;
Cao F., Lane S., Raniga P.P., Lu Y., Zhou Z., Ramon K., Chen J.,
Liu H.;
"The Flo8 transcription factor is essential for hyphal development and
virulence in Candida albicans.";
Mol. Biol. Cell 17:295-307(2006).
[26]
FUNCTION.
PubMed=17880264; DOI=10.1371/journal.pbio.0050256;
Zordan R.E., Miller M.G., Galgoczy D.J., Tuch B.B., Johnson A.D.;
"Interlocking transcriptional feedback loops control white-opaque
switching in Candida albicans.";
PLoS Biol. 5:E256-E256(2007).
[27]
FUNCTION, DOMAIN, AND INTERACTION WITH CZF1 AND FLO8.
PubMed=18375615; DOI=10.1128/EC.00033-08;
Noffz C.S., Liedschulte V., Lengeler K., Ernst J.F.;
"Functional mapping of the Candida albicans Efg1 regulator.";
Eukaryot. Cell 7:881-893(2008).
[28]
FUNCTION.
PubMed=19346360; DOI=10.1128/AEM.00098-09;
Stichternoth C., Ernst J.F.;
"Hypoxic adaptation by Efg1 regulates biofilm formation by Candida
albicans.";
Appl. Environ. Microbiol. 75:3663-3672(2009).
[29]
PHOSPHORYLATION AT THR-181, AND FUNCTION.
PubMed=19528234; DOI=10.1128/MCB.01502-08;
Wang A., Raniga P.P., Lane S., Lu Y., Liu H.;
"Hyphal chain formation in Candida albicans: Cdc28-Hgc1
phosphorylation of Efg1 represses cell separation genes.";
Mol. Cell. Biol. 29:4406-4416(2009).
[30]
FUNCTION.
PubMed=19197361; DOI=10.1371/journal.ppat.1000294;
Bastidas R.J., Heitman J., Cardenas M.E.;
"The protein kinase Tor1 regulates adhesin gene expression in Candida
albicans.";
PLoS Pathog. 5:E1000294-E1000294(2009).
[31]
FUNCTION.
PubMed=20491944; DOI=10.1111/j.1567-1364.2010.00639.x;
Prasad T., Hameed S., Manoharlal R., Biswas S., Mukhopadhyay C.K.,
Goswami S.K., Prasad R.;
"Morphogenic regulator EFG1 affects the drug susceptibilities of
pathogenic Candida albicans.";
FEMS Yeast Res. 10:587-596(2010).
[32]
FUNCTION.
PubMed=20735781; DOI=10.1111/j.1365-2958.2010.07331.x;
Lohse M.B., Johnson A.D.;
"Temporal anatomy of an epigenetic switch in cell programming: the
white-opaque transition of C. albicans.";
Mol. Microbiol. 78:331-343(2010).
[33]
FUNCTION, DNA-BINDING, AND INDUCTION.
PubMed=21923768; DOI=10.1111/j.1365-2958.2011.07837.x;
Lassak T., Schneider E., Bussmann M., Kurtz D., Manak J.R.,
Srikantha T., Soll D.R., Ernst J.F.;
"Target specificity of the Candida albicans Efg1 regulator.";
Mol. Microbiol. 82:602-618(2011).
[34]
FUNCTION, AND INTERACTION WITH CZF1.
PubMed=22761849; DOI=10.1371/journal.pone.0039624;
Petrovska I., Kumamoto C.A.;
"Functional importance of the DNA binding activity of Candida albicans
Czf1p.";
PLoS ONE 7:E39624-E39624(2012).
-!- FUNCTION: Transcriptional regulator of the switch between 2
heritable states, the white and opaque states. These 2 cell types
differ in many characteristics, including cell structure, mating
competence, and virulence. Each state is heritable for many
generations, and switching between states occurs stochastically,
at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1,
and promotes the white state. In white cells, EFG1 represses WOR1
indirectly through WOR2 to maintain white cell identity. Binds
target gene promoters at the EFG1 recognition sequence (EGRbox)
TATGCATA. Acts as a major regulator of cell wall dynamics and
plays a role in interactions with extracellular matrices. Required
for TOR1-dependent cellular aggregation and adhesin expression.
Required for both normoxic and hypoxic biofilm formation. Hypoxic
biofilm formation is a major cause of perseverance and antifungal
resistance during infections. Contributes to virulence by
regulating hyphal formation and the factors that enable C.albicans
to invade and injure endothelial cells. Required for the formation
of thick-walled big resting spores called chlamydospores, which
survive in unfavorable conditions. Mediates the expression of
virulence factors SAP4, SAP5and SAP6 during infection. Involved in
drug resistance by regulating the expression of ERG3.
{ECO:0000269|PubMed:10377153, ECO:0000269|PubMed:10456912,
ECO:0000269|PubMed:10496941, ECO:0000269|PubMed:10692363,
ECO:0000269|PubMed:10790384, ECO:0000269|PubMed:10816502,
ECO:0000269|PubMed:11290709, ECO:0000269|PubMed:11395474,
ECO:0000269|PubMed:11595734, ECO:0000269|PubMed:11796627,
ECO:0000269|PubMed:11832513, ECO:0000269|PubMed:11973327,
ECO:0000269|PubMed:12065511, ECO:0000269|PubMed:12204378,
ECO:0000269|PubMed:12492856, ECO:0000269|PubMed:15728931,
ECO:0000269|PubMed:16267276, ECO:0000269|PubMed:16487333,
ECO:0000269|PubMed:17880264, ECO:0000269|PubMed:18375615,
ECO:0000269|PubMed:19197361, ECO:0000269|PubMed:19346360,
ECO:0000269|PubMed:19528234, ECO:0000269|PubMed:20491944,
ECO:0000269|PubMed:20735781, ECO:0000269|PubMed:21923768,
ECO:0000269|PubMed:22761849, ECO:0000269|PubMed:9298905,
ECO:0000269|PubMed:9846730}.
-!- SUBUNIT: Interacts with CZF1 and FLO8.
{ECO:0000269|PubMed:11973327, ECO:0000269|PubMed:16267276,
ECO:0000269|PubMed:18375615, ECO:0000269|PubMed:22761849}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00630}.
-!- INDUCTION: Expression is specific for the white growth phase.
Down-regulation under hyphal induction depends on the presence of
EFG1 itself which plays a role of autoinhibitor and the protein
kinase A isoforms TPK1 and TPK2. {ECO:0000269|PubMed:10456912,
ECO:0000269|PubMed:12675809, ECO:0000269|PubMed:12798685,
ECO:0000269|PubMed:21923768}.
-!- PTM: Thr-208 is a phosphorylation target to promote hyphal
induction by a subset of environmental cues. Phosphorylation at
Thr-181 by the CDc28/HGC1 complex represses cell separation genes
and leads to hyphal chain formation. {ECO:0000269|PubMed:11290709,
ECO:0000269|PubMed:19528234}.
-!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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EMBL; CP017630; AOW31479.1; -; Genomic_DNA.
RefSeq; XP_714237.2; XM_709144.2.
ProteinModelPortal; Q59X67; -.
SMR; Q59X67; -.
BioGrid; 1227239; 2.
iPTMnet; Q59X67; -.
PRIDE; Q59X67; -.
GeneID; 3644145; -.
KEGG; cal:CAALFM_CR07890WA; -.
CGD; CAL0000201973; EFG1.
InParanoid; Q59X67; -.
KO; K12763; -.
OrthoDB; EOG092C2R9Z; -.
PRO; PR:Q59X67; -.
Proteomes; UP000000559; Chromosome R.
GO; GO:0000790; C:nuclear chromatin; IDA:CGD.
GO; GO:0005634; C:nucleus; IDA:CGD.
GO; GO:0003677; F:DNA binding; IDA:CGD.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:CGD.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IDA:CGD.
GO; GO:0044406; P:adhesion of symbiont to host; IMP:CGD.
GO; GO:0007155; P:cell adhesion; IMP:CGD.
GO; GO:0036187; P:cell growth mode switching, budding to filamentous; IMP:CGD.
GO; GO:0016477; P:cell migration; IMP:CGD.
GO; GO:0000902; P:cell morphogenesis; IMP:CGD.
GO; GO:0043689; P:cell-cell adhesion involved in flocculation; IMP:CGD.
GO; GO:0031589; P:cell-substrate adhesion; IMP:CGD.
GO; GO:0048869; P:cellular developmental process; IMP:CGD.
GO; GO:0035690; P:cellular response to drug; IMP:CGD.
GO; GO:0097316; P:cellular response to N-acetyl-D-glucosamine; IMP:CGD.
GO; GO:0036244; P:cellular response to neutral pH; IMP:CGD.
GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
GO; GO:0001410; P:chlamydospore formation; IMP:CGD.
GO; GO:0044114; P:development of symbiont in host; IMP:CGD.
GO; GO:0044409; P:entry into host; IMP:CGD.
GO; GO:0020012; P:evasion or tolerance of host immune response; IMP:CGD.
GO; GO:0030447; P:filamentous growth; IMP:CGD.
GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
GO; GO:0036171; P:filamentous growth of a population of unicellular organisms in response to chemical stimulus; IMP:CGD.
GO; GO:0036178; P:filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
GO; GO:0030448; P:hyphal growth; IMP:CGD.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0009405; P:pathogenesis; IMP:CGD.
GO; GO:0036166; P:phenotypic switching; IMP:CGD.
GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IMP:CGD.
GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
GO; GO:1900445; P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
GO; GO:1900439; P:positive regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus; IMP:CGD.
GO; GO:1900442; P:positive regulation of filamentous growth of a population of unicellular organisms in response to neutral pH; IMP:CGD.
GO; GO:1900436; P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
GO; GO:1900241; P:positive regulation of phenotypic switching; IMP:CGD.
GO; GO:2000222; P:positive regulation of pseudohyphal growth; IMP:CGD.
GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0007124; P:pseudohyphal growth; IMP:CGD.
GO; GO:0045595; P:regulation of cell differentiation; IMP:CGD.
GO; GO:1900239; P:regulation of phenotypic switching; IMP:CGD.
GO; GO:1900231; P:regulation of single-species biofilm formation on inanimate substrate; IMP:CGD.
GO; GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:CGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:CGD.
GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.10.260.10; -; 1.
InterPro; IPR018004; KilA_N/APSES_HTH.
InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
Pfam; PF04383; KilA-N; 1.
SMART; SM01252; KilA-N; 1.
SUPFAM; SSF54616; SSF54616; 1.
PROSITE; PS51299; HTH_APSES; 1.
1: Evidence at protein level;
Cell adhesion; Complete proteome; DNA-binding; Nucleus;
Phosphoprotein; Reference proteome; Transcription;
Transcription regulation; Virulence.
CHAIN 1 550 Enhanced filamentous growth protein 1.
/FTId=PRO_0000420156.
DOMAIN 206 312 HTH APSES-type. {ECO:0000255|PROSITE-
ProRule:PRU00630}.
DNA_BIND 240 261 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00630}.
COMPBIAS 22 540 Gln-rich.
COMPBIAS 317 351 Ala-rich.
MOD_RES 181 181 Phosphothreonine.
{ECO:0000269|PubMed:19528234}.
MOD_RES 208 208 Phosphothreonine.
{ECO:0000269|PubMed:11290709}.
MUTAGEN 208 208 T->A: Impairs chlamydospore formation and
hypha formation.
{ECO:0000269|PubMed:10496941,
ECO:0000269|PubMed:11290709}.
MUTAGEN 208 208 T->E: Impairs chlamydospore formation but
causes hyperfilamentation.
{ECO:0000269|PubMed:10496941,
ECO:0000269|PubMed:11290709}.
SEQUENCE 550 AA; 59612 MW; 777B4535B22EA81F CRC64;
MSTYSIPYYN QMNGNYNNGM PQQTTAANQQ AFPQQQQPTT TGNASQQQQQ AAATAAAAAV
QQPYNYMFYQ QQGQPGQQTG QTAGQQQQQQ QQQQQYDYNT YNRYQYPAAT SQGNYYQQTI
PNQLSQPQPQ HYNGSNRNYT SAPSGAPIPS NSTSGPSQQP PLPGQQAVPI PPHVSTMQQP
TPVQDTLNAS STSTVGQFQP PGIRPRVTTT MWEDEKTLCY QVDANNVSVV RRADNNMING
TKLLNVAQMT RGRRDGILKS EKVRHVVKIG SMHLKGVWIP FERALAMAQR EQIVDMLYPL
FVRDIKRVIQ TGVTPNAAAA TAAAAATATS ASAPPPPPPP VAAATTTAAT AISKSSSGNG
NSISATSGGS NVSGASGAGS TTSPVNTKAA TTAGTPQGNY YQTYNQQQYP QQYGQYNAPG
KNQNTPASQP GSTTNDQYLQ QQQQMYGYQS NYYQGGAANS SYYPNYYQQQ QPNYASSYPY
QQQQQKQQQQ QPNQQQQSDQ QQTSTPSGGA GTRSVHQSPQ VQSLTQGSVH PSPQQHQANQ
SASTVAKEEK


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FHA11-S Anti-B. pertussis Filamentous hemeagglutinin (FHA) protein antiserum 100 ul
FHA11-C Purified B. pertussis Filamentous hemeagglutinin (FHA) protein control for Western 100 ul
orb90502 Enhanced chemiluminescence kit (Mouse IgG) Enhanced chemiluminescence kit (Mouse IgG) for Western Blotting For research use only. 1 kit
orb90503 Enhanced chemiluminescence kit (Rabbit IgG) Enhanced chemiluminescence kit (Rabbit IgG) for Western Blotting For research use only. 1 kit
orb90506 Enhanced chemiluminescence kit (Mouse IgM) Enhanced chemiluminescence kit (Mouse IgM) for Western Blotting For research use only. 1 kit


 

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