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Envelope glycoprotein B (gB)

 T2FL65_9ALPH            Unreviewed;       914 AA.
T2FL65;
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
22-NOV-2017, entry version 22.
RecName: Full=Envelope glycoprotein B {ECO:0000256|HAMAP-Rule:MF_04032};
Short=gB {ECO:0000256|HAMAP-Rule:MF_04032};
Name=UL27 {ECO:0000313|EMBL:AGW01103.1};
Synonyms=gB {ECO:0000256|HAMAP-Rule:MF_04032};
Suid alphaherpesvirus 1 (Pseudorabies virus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=10345 {ECO:0000313|EMBL:AGW01103.1, ECO:0000313|Proteomes:UP000166532};
[1] {ECO:0000313|EMBL:AGW01103.1, ECO:0000313|Proteomes:UP000166532}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=BJ/YT {ECO:0000313|EMBL:AGW01103.1};
Zhong C., Lyu Y.L., Liu L., Zhang L.T., Lu Z.J., Wang J.S.;
Submitted (APR-2013) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AIT55752.1, ECO:0000313|Proteomes:UP000142350}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=TJ {ECO:0000313|EMBL:AIT55752.1};
PubMed=25293398; DOI=10.1016/j.vetmic.2014.09.003;
Luo Y., Li N., Cong X., Wang C.H., Du M., Li L., Zhao B., Yuan J.,
Liu D.D., Li S., Li Y., Sun Y., Qiu H.J.;
"Pathogenicity and genomic characterization of a pseudorabies virus
variant isolated from Bartha-K61-vaccinated swine population in
China.";
Vet. Microbiol. 174:107-115(2014).
[3] {ECO:0000313|EMBL:AKG93978.1}
NUCLEOTIDE SEQUENCE.
STRAIN=HNX {ECO:0000313|EMBL:AKG93978.1};
Zhang J.E., Yang H., Guo J., Deng Z., Luo H., Luo M., Zhao B.;
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:AKP23824.1}
NUCLEOTIDE SEQUENCE.
STRAIN=JS-2012 {ECO:0000313|EMBL:AKP23824.1};
Zhang Q., Liu F., Zheng H., Tong W., Liang C., Tong G.;
Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:AKG93978.1, ECO:0000313|Proteomes:UP000144334}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HNX {ECO:0000313|EMBL:AKG93978.1};
PubMed=26370151; DOI=10.1021/acsami.5b06876;
Ye S., Shao K., Li Z., Guo N., Zuo Y., Li Q., Lu Z., Chen L., He Q.,
Han H.;
"Antiviral Activity of Graphene Oxide: How Sharp Edged Structure and
Charge Matter.";
ACS Appl Mater Interfaces 7:21571-21579(2015).
[6] {ECO:0000313|EMBL:AJW72246.1, ECO:0000313|Proteomes:UP000102606, ECO:0000313|Proteomes:UP000113972}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HeN1 {ECO:0000313|EMBL:AJW72246.1}, and
JS-2012 {ECO:0000313|EMBL:AKP23824.1};
PubMed=25965793; DOI=10.1016/j.virol.2015.04.013;
Ye C., Zhang Q.Z., Tian Z.J., Zheng H., Zhao K., Liu F., Guo J.C.,
Tong W., Jiang C.G., Wang S.J., Shi M., Chang X.B., Jiang Y.F.,
Peng J.M., Zhou Y.J., Tang Y.D., Sun M.X., Cai X.H., An T.Q.,
Tong G.Z.;
"Genomic characterization of emergent pseudorabies virus in China
reveals marked sequence divergence: Evidence for the existence of two
major genotypes.";
Virology 483:32-43(2015).
[7] {ECO:0000313|EMBL:ALT14233.1}
NUCLEOTIDE SEQUENCE.
STRAIN=HN1201 {ECO:0000313|EMBL:ALT14233.1};
Xiang T., Song Y., Huang L., Wang B., Wu P.;
Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:ANR01127.1}
NUCLEOTIDE SEQUENCE.
STRAIN=HB1201 {ECO:0000313|EMBL:ANR01127.1};
Ge X., Li M., Zhou L., Guo X., Yang H.;
"The recently emergent PRV strain isolated from a Bartha-K61-
vaccinated piglet in China.";
Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
[9] {ECO:0000313|EMBL:AMO42731.1, ECO:0000313|Proteomes:UP000157067}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DL14/08 {ECO:0000313|EMBL:AMO42731.1};
Liu H., Hu B., Li X.-T., Zhang L., Xue X.-H., Lv S., Lu R.-G., Shi N.,
Zhang H.-L., Zhao J.-J., Bai X., Yan X.-J.;
"Mink Infection with Highly Pathogenic Pseudorabies Virus, Northern
China, 2014.";
Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AKG94110.1, ECO:0000313|Proteomes:UP000150587}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HNB {ECO:0000313|EMBL:AKG94110.1};
PubMed=26823587;
Yu T., Chen F., Ku X., Zhu Y., Ma H., Li S., He Q.;
"Complete Genome Sequence of Novel Pseudorabies Virus Strain HNB
Isolated in China.";
Genome Announc. 4:e01641-15(2016).
[11] {ECO:0000313|EMBL:ALT14233.1, ECO:0000313|Proteomes:UP000154438}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HN1201 {ECO:0000313|EMBL:ALT14233.1};
PubMed=26988055;
Xiang S., Zhou Z., Hu X., Li Y., Zhang C., Wang J., Li X., Tan F.,
Tian K.;
"Complete Genome Sequence of a Variant Pseudorabies Virus Strain
Isolated in Central China.";
Genome Announc. 4:0-0(2016).
[12] {ECO:0000313|EMBL:AML81193.1, ECO:0000313|Proteomes:UP000104419}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=HLJ8 {ECO:0000313|EMBL:AML81193.1};
PubMed=26874017; DOI=10.1016/j.virol.2016.01.016;
Ye C., Guo J.C., Gao J.C., Wang T.Y., Zhao K., Chang X.B., Wang Q.,
Peng J.M., Tian Z.J., Cai X.H., Tong G.Z., An T.Q.;
"Genomic analyses reveal that partial sequence of an earlier
pseudorabies virus in China is originated from a Bartha-vaccine-like
strain.";
Virology 491:56-63(2016).
-!- FUNCTION: Envelope glycoprotein that forms spikes at the surface
of virion envelope. Essential for the initial attachment to
heparan sulfate moities of the host cell surface proteoglycans.
Involved in fusion of viral and cellular membranes leading to
virus entry into the host cell. Following initial binding to its
host receptors, membrane fusion is mediated by the fusion
machinery composed at least of gB and the heterodimer gH/gL. May
be involved in the fusion between the virion envelope and the
outer nuclear membrane during virion egress. {ECO:0000256|HAMAP-
Rule:MF_04032}.
-!- SUBUNIT: Homotrimer; disulfide-linked. Binds to heparan sulfate
proteoglycans. Interacts with gH/gL heterodimer.
{ECO:0000256|HAMAP-Rule:MF_04032}.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000256|HAMAP-
Rule:MF_04032}; Single-pass type I membrane protein
{ECO:0000256|HAMAP-Rule:MF_04032}. Host cell membrane
{ECO:0000256|HAMAP-Rule:MF_04032}; Single-pass type I membrane
protein {ECO:0000256|HAMAP-Rule:MF_04032}. Host endosome membrane
{ECO:0000256|HAMAP-Rule:MF_04032}; Single-pass type I membrane
protein {ECO:0000256|HAMAP-Rule:MF_04032}. Host Golgi apparatus
membrane {ECO:0000256|HAMAP-Rule:MF_04032}; Single-pass type I
membrane protein {ECO:0000256|HAMAP-Rule:MF_04032}. Note=During
virion morphogenesis, this protein probably accumulates in the
endosomes and trans-Golgi where secondary envelopment occurs. It
is probably transported to the cell surface from where it is
endocytosed and directed to the trans-Golgi network (TGN).
{ECO:0000256|HAMAP-Rule:MF_04032}.
-!- SIMILARITY: Belongs to the herpesviridae glycoprotein B family.
{ECO:0000256|HAMAP-Rule:MF_04032}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_04032}.
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EMBL; KC981239; AGW01103.1; -; Genomic_DNA.
EMBL; KJ789182; AIT55752.1; -; Genomic_DNA.
EMBL; KP098534; AJW72246.1; -; Genomic_DNA.
EMBL; KM189912; AKG93978.1; -; Genomic_DNA.
EMBL; KM189914; AKG94110.1; -; Genomic_DNA.
EMBL; KP257591; AKP23824.1; -; Genomic_DNA.
EMBL; KP722022; ALT14233.1; -; Genomic_DNA.
EMBL; KT824771; AML81193.1; -; Genomic_DNA.
EMBL; KU360259; AMO42731.1; -; Genomic_DNA.
EMBL; KU057086; ANR01127.1; -; Genomic_DNA.
SMR; T2FL65; -.
Proteomes; UP000102606; Genome.
Proteomes; UP000104419; Genome.
Proteomes; UP000113972; Genome.
Proteomes; UP000142350; Genome.
Proteomes; UP000144334; Genome.
Proteomes; UP000150587; Genome.
Proteomes; UP000154438; Genome.
Proteomes; UP000157067; Genome.
Proteomes; UP000166532; Genome.
GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-UniRule.
GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
HAMAP; MF_04032; HSV_GB; 1.
InterPro; IPR035377; Glycoprot_B_PH1.
InterPro; IPR035381; Glycoprot_B_PH2.
InterPro; IPR000234; Herpes_Glycoprot_B.
Pfam; PF17416; Glycoprot_B_PH1; 1.
Pfam; PF17417; Glycoprot_B_PH2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000102606,
ECO:0000313|Proteomes:UP000104419, ECO:0000313|Proteomes:UP000113972,
ECO:0000313|Proteomes:UP000142350};
Disulfide bond {ECO:0000256|HAMAP-Rule:MF_04032};
Glycoprotein {ECO:0000256|HAMAP-Rule:MF_04032};
Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04032};
Host endosome {ECO:0000256|HAMAP-Rule:MF_04032};
Host Golgi apparatus {ECO:0000256|HAMAP-Rule:MF_04032};
Host membrane {ECO:0000256|HAMAP-Rule:MF_04032};
Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04032};
Membrane {ECO:0000256|HAMAP-Rule:MF_04032, ECO:0000256|SAM:Phobius};
Signal {ECO:0000256|HAMAP-Rule:MF_04032};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_04032,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04032,
ECO:0000256|SAM:Phobius};
Viral attachment to host cell {ECO:0000256|HAMAP-Rule:MF_04032};
Viral envelope protein {ECO:0000256|HAMAP-Rule:MF_04032};
Virion {ECO:0000256|HAMAP-Rule:MF_04032};
Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04032}.
TOPO_DOM 1 798 Virion surface. {ECO:0000256|HAMAP-
Rule:MF_04032}.
TRANSMEM 799 819 Helical. {ECO:0000256|SAM:Phobius}.
TOPO_DOM 820 914 Intravirion. {ECO:0000256|HAMAP-
Rule:MF_04032}.
DOMAIN 164 375 Glycoprot_B_PH1.
{ECO:0000259|Pfam:PF17416}.
DOMAIN 377 476 Glycoprot_B_PH2.
{ECO:0000259|Pfam:PF17417}.
REGION 184 190 Involved in fusion and/or binding to host
membrane. {ECO:0000256|HAMAP-
Rule:MF_04032}.
REGION 269 276 Involved in fusion and/or binding to host
membrane. {ECO:0000256|HAMAP-
Rule:MF_04032}.
REGION 743 796 Hydrophobic membrane proximal region.
{ECO:0000256|HAMAP-Rule:MF_04032}.
MOTIF 903 906 Internalization motif.
{ECO:0000256|HAMAP-Rule:MF_04032}.
DISULFID 218 282 {ECO:0000256|HAMAP-Rule:MF_04032}.
SEQUENCE 914 AA; 100291 MW; E8CEA09D7E75FB4C CRC64;
MPAGGGLWRG PRGHRPGHHG GAGLGRLWPA PHHAAAARGA VALALLLLAL AATPTCGAAA
VTRAASASPA PGTGATPDGF SAEESLEEID GAVSPGPSDA PDGEYGDLDA RTAVRAAATE
RDRFYVCPPP SGSTVVRLEP EQACPEYSQG RNFTEGIAVL FKENIAPHKF KAHIYYKNVI
VTTVWSGSTY AAITNRFTDR VPVPVQEITD VIDRRGKCVS KAEYVRNNHK VTAFDRDENP
VEVDLRPSRL NALGTRGWHT TNDTYTKIGA AGFYHTGTSV NCIVEEVEAR SVYPYDSFAL
STGDIVYMSP FYGLREGAHG EHIGYAPGRF QQVEHYYPID LDSRLRASES VTRNFLRTPH
FTVAWDWAPK TRRVCSLAKW REAEEMIRDE TRDGSFRFTS RALGASFVSD VTQLDLQRVH
LGDCVLREAS EAIDAIYRRR YNNTHVLAGD KPEVYLARGG FVVAFRPLIS NELAQLYARE
LERLGLAGVV GPASPAAARR ARRSPGPAGT PEPPAVNGTG HLRITTGSAE FARLQFTYDH
IQAHVNDMLS RIAAAWCELQ NKDRTLWGEM SRLNPSAVAT AALGQRVSAR MLGDVMAISR
CVEVRGGVYV QNSMRVPGER GTCYSRPLVT FEHNGTGVIE GQLGDDNELL ISRDLIEPCT
GNHRRYFKLG GGYVYYEDYS YVRMVEVPET ISTRVTLNLT LLEDREFLPL EVYTREELAD
TGLLDYSEIQ RRNQLHALKF YDIDRVVKVD HNVVLLRGIA NFFQGLGDVG AAVGKVVLGA
TGAVISAVGG MVSFLSNPFG ALAIGLLVLA GLVAAFLAYR HISRLRRNPM KALYPVTTKA
LKEDGVEEDD VDEAKLDQAR DMIRYMSIVS ALEQQEHKAR KKNSGPALLA SRVGAMATRR
RHYQRLENED PDAP


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