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Envelope glycoprotein H (gH)

 G1EUQ7_BHV4             Unreviewed;       707 AA.
G1EUQ7;
19-OCT-2011, integrated into UniProtKB/TrEMBL.
19-OCT-2011, sequence version 1.
28-MAR-2018, entry version 12.
RecName: Full=Envelope glycoprotein H {ECO:0000256|HAMAP-Rule:MF_04033};
Short=gH {ECO:0000256|HAMAP-Rule:MF_04033};
Name=ORF 22 {ECO:0000313|EMBL:AEL29766.1};
Synonyms=gH {ECO:0000256|HAMAP-Rule:MF_04033};
Bovine herpesvirus 4 (BoHV-4) (Movar virus).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Gammaherpesvirinae; Rhadinovirus.
NCBI_TaxID=10385 {ECO:0000313|EMBL:AEL29766.1};
NCBI_TaxID=9913; Bos taurus (Bovine).
NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
NCBI_TaxID=9689; Panthera leo (Lion).
[1] {ECO:0000313|EMBL:AEL29766.1}
NUCLEOTIDE SEQUENCE.
STRAIN=V.test {ECO:0000313|EMBL:AEL29766.1};
PubMed=21846388;
Palmeira L., Machiels B., Lete C., Vanderplasschen A., Gillet L.;
"Sequencing of Bovine herpesvirus 4 V.test strain reveals important
genome features.";
Virol. J. 8:406-406(2011).
-!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is
required for the fusion of viral and plasma membranes leading to
virus entry into the host cell. Following initial binding to host
receptor, membrane fusion is mediated by the fusion machinery
composed of gB and the heterodimer gH/gL. May also be involved in
the fusion between the virion envelope and the outer nuclear
membrane during virion morphogenesis. {ECO:0000256|HAMAP-
Rule:MF_04033}.
-!- SUBUNIT: Interacts with glycoprotein L (gL); this interaction is
necessary for the correct processing and cell surface expression
of gH. The heterodimer gH/gL seems to interact with gB trimers
during fusion. {ECO:0000256|HAMAP-Rule:MF_04033}.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000256|HAMAP-
Rule:MF_04033}; Single-pass type I membrane protein
{ECO:0000256|HAMAP-Rule:MF_04033}. Host cell membrane
{ECO:0000256|HAMAP-Rule:MF_04033}; Single-pass type I membrane
protein {ECO:0000256|HAMAP-Rule:MF_04033}. Host endosome membrane
{ECO:0000256|HAMAP-Rule:MF_04033}; Single-pass type I membrane
protein {ECO:0000256|HAMAP-Rule:MF_04033}. Note=During virion
morphogenesis, this protein probably accumulates in the endosomes
and trans-Golgi where secondary envelopment occurs. It is probably
transported to the cell surface from where it is endocytosed and
directed to the trans-Golgi network (TGN). {ECO:0000256|HAMAP-
Rule:MF_04033}.
-!- PTM: N-glycosylated, O-glycosylated, and sialylated.
{ECO:0000256|HAMAP-Rule:MF_04033}.
-!- SIMILARITY: Belongs to the herpesviridae glycoprotein H family.
{ECO:0000256|HAMAP-Rule:MF_04033}.
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EMBL; JN133502; AEL29766.1; -; Genomic_DNA.
GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-UniRule.
Gene3D; 2.60.40.3190; -; 1.
HAMAP; MF_04033; HSV_GH; 1.
InterPro; IPR003493; Herpes_gH.
InterPro; IPR035305; Herpes_glycoH_C.
InterPro; IPR038172; Herpes_glycoH_C_sf.
Pfam; PF17488; Herpes_glycoH_C; 1.
3: Inferred from homology;
Fusion of virus membrane with host cell membrane {ECO:0000256|HAMAP-
Rule:MF_04033};
Fusion of virus membrane with host membrane {ECO:0000256|HAMAP-
Rule:MF_04033}; Glycoprotein {ECO:0000256|HAMAP-Rule:MF_04033};
Host cell membrane {ECO:0000256|HAMAP-Rule:MF_04033};
Host endosome {ECO:0000256|HAMAP-Rule:MF_04033};
Host membrane {ECO:0000256|HAMAP-Rule:MF_04033};
Membrane {ECO:0000256|HAMAP-Rule:MF_04033, ECO:0000256|SAM:Phobius};
Sialic acid {ECO:0000256|HAMAP-Rule:MF_04033};
Signal {ECO:0000256|HAMAP-Rule:MF_04033};
Transmembrane {ECO:0000256|HAMAP-Rule:MF_04033,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_04033,
ECO:0000256|SAM:Phobius};
Viral envelope protein {ECO:0000256|HAMAP-Rule:MF_04033};
Viral penetration into host cytoplasm {ECO:0000256|HAMAP-
Rule:MF_04033}; Virion {ECO:0000256|HAMAP-Rule:MF_04033};
Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04033}.
TOPO_DOM 1 683 Virion surface. {ECO:0000256|HAMAP-
Rule:MF_04033}.
TRANSMEM 679 700 Helical. {ECO:0000256|SAM:Phobius}.
TOPO_DOM 705 707 Intravirion. {ECO:0000256|HAMAP-
Rule:MF_04033}.
DOMAIN 529 673 Herpes_glycoH_C.
{ECO:0000259|Pfam:PF17488}.
REGION 166 230 Interaction with gL. {ECO:0000256|HAMAP-
Rule:MF_04033}.
SEQUENCE 707 AA; 81546 MW; B40A5FB5D7E5713A CRC64;
MKLFIFILFT LSLCHLSYCN VRGDLGSLEE NLKNLTIHFD DGYKYVINWT RFLDVLSPQI
VQQMWDEANV FENLKDTYNK TTGLYKPLQI KLRNLHENNH HCQGKSQTKV DNISQIHAIQ
DAYLGNFEIQ SRLLFSDNFP REKNVTFGSK DHFFYFFKDY ATIWTWGNEP RISGGVTPSF
SYVTMANKGQ IKDQTTILFG ESFGLPALKG FVNYPNVEVA KYNNLTMVVL ASKNNCFGSA
NLTNFTELFI NIVKQNPAEF IEDIQSDFMA IDSEGGCNTD SMDERKLLLF FRVVVSHFKI
TRTLQKNYYV NMSCISTDLA DLDLLREMIS KCFASGYNLS GFSISTIAID QLNTFFPKFS
EKGNVRYADT IFNTLILSRG EYNVTEDVVR YVKRTLEDMY MEFSYTFTLS GTQRTILFKI
WRILNTFTHD NHTVNVKSLI TSYILMSSMC TNVEIGLMVD KFSRHPIDIH ETFTPCFMSL
RFDFSVDKLQ SNAPQKLRES TTKVNTGTFG FLRVLHDFHK NRVKQVPEIK CIHQAKIQDN
IIAIIPLTNV TYVLSSDKIE NVLTYEITEV FLKSGMFLSV LRPDCTRFPE DHGIVLSIPV
IYNVSNPTLG CPFCDSAVIS YDESIGLESM MYINNTVIQK NLFLDVSPFF DGDNLHVHYL
WLMNNGTVVE IRGAYRKKVY SIILFIMIFN GFTLMIYFLY KMLSYVL


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