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Envelope glycoprotein H (gH)

 GH_VZVO                 Reviewed;         841 AA.
Q775J3;
22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
24-MAR-2009, sequence version 1.
23-MAY-2018, entry version 33.
RecName: Full=Envelope glycoprotein H {ECO:0000255|HAMAP-Rule:MF_04033};
Short=gH {ECO:0000255|HAMAP-Rule:MF_04033};
Flags: Precursor;
Name=gH {ECO:0000255|HAMAP-Rule:MF_04033}; ORFNames=ORF37;
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus
3).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Alphaherpesvirinae; Varicellovirus.
NCBI_TaxID=341980;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=11162813; DOI=10.1006/viro.2000.0775;
Faga B., Maury W., Bruckner D.A., Grose C.;
"Identification and mapping of single nucleotide polymorphisms in the
varicella-zoster virus genome.";
Virology 280:1-6(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Isolate Human/Japan/P-Oka/1970, and
Oka varicella vaccine Biken (V-Oka-Biken);
PubMed=12388706; DOI=10.1128/JVI.76.22.11447-11459.2002;
Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M.,
Yamanishi K.;
"Comparison of the complete DNA sequences of the Oka varicella vaccine
and its parental virus.";
J. Virol. 76:11447-11459(2002).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
Oka varicella vaccine Varivax (V-Oka-Merk);
PubMed=18787000; DOI=10.1128/JVI.00777-08;
Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
Vassilev V.;
"Complete DNA sequences of two oka strain varicella-zoster virus
genomes.";
J. Virol. 82:11023-11044(2008).
-!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is
required for the fusion of viral and plasma membranes leading to
virus entry into the host cell. Following initial binding to host
receptor, membrane fusion is mediated by the fusion machinery
composed of gB and the heterodimer gH/gL. May also be involved in
the fusion between the virion envelope and the outer nuclear
membrane during virion morphogenesis. {ECO:0000255|HAMAP-
Rule:MF_04033}.
-!- SUBUNIT: Interacts with glycoprotein L (gL); this interaction is
necessary for the correct processing and cell surface expression
of gH. The heterodimer gH/gL seems to interact with gB trimers
during fusion. {ECO:0000255|HAMAP-Rule:MF_04033}.
-!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
Rule:MF_04033}; Single-pass type I membrane protein
{ECO:0000255|HAMAP-Rule:MF_04033}. Host cell membrane
{ECO:0000255|HAMAP-Rule:MF_04033}; Single-pass type I membrane
protein {ECO:0000255|HAMAP-Rule:MF_04033}. Host endosome membrane
{ECO:0000255|HAMAP-Rule:MF_04033}; Single-pass type I membrane
protein {ECO:0000255|HAMAP-Rule:MF_04033}. Note=During virion
morphogenesis, this protein probably accumulates in the endosomes
and trans-Golgi where secondary envelopment occurs. It is probably
transported to the cell surface from where it is endocytosed and
directed to the trans-Golgi network (TGN). {ECO:0000255|HAMAP-
Rule:MF_04033}.
-!- PTM: N-glycosylated, O-glycosylated, and sialylated.
{ECO:0000255|HAMAP-Rule:MF_04033}.
-!- SIMILARITY: Belongs to the herpesviridae glycoprotein H family.
{ECO:0000255|HAMAP-Rule:MF_04033}.
-----------------------------------------------------------------------
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EMBL; AY016446; AAK19939.1; -; Genomic_DNA.
EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; DQ008354; AAY57649.1; -; Genomic_DNA.
EMBL; DQ008355; AAY57720.1; -; Genomic_DNA.
PDB; 4XHJ; X-ray; 3.16 A; A/E=1-795.
PDB; 4XI5; X-ray; 3.90 A; A=1-795.
PDBsum; 4XHJ; -.
PDBsum; 4XI5; -.
SMR; Q775J3; -.
IntAct; Q775J3; 5.
PRIDE; Q775J3; -.
OrthoDB; VOG0900001X; -.
Proteomes; UP000002603; Genome.
Proteomes; UP000008504; Genome.
Proteomes; UP000008505; Genome.
Proteomes; UP000008506; Genome.
GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
GO; GO:0019064; P:fusion of virus membrane with host plasma membrane; IEA:UniProtKB-KW.
Gene3D; 2.60.40.3190; -; 1.
HAMAP; MF_04033; HSV_GH; 1.
InterPro; IPR003493; Herpes_gH.
InterPro; IPR035305; Herpes_glycoH_C.
InterPro; IPR038172; Herpes_glycoH_C_sf.
Pfam; PF17488; Herpes_glycoH_C; 1.
1: Evidence at protein level;
3D-structure; Complete proteome;
Fusion of virus membrane with host cell membrane;
Fusion of virus membrane with host membrane; Glycoprotein;
Host cell membrane; Host endosome; Host membrane; Membrane;
Sialic acid; Signal; Transmembrane; Transmembrane helix;
Viral envelope protein; Viral penetration into host cytoplasm; Virion;
Virus entry into host cell.
SIGNAL 1 17 {ECO:0000255|HAMAP-Rule:MF_04033}.
CHAIN 18 841 Envelope glycoprotein H.
{ECO:0000255|HAMAP-Rule:MF_04033}.
/FTId=PRO_0000385473.
TOPO_DOM 18 802 Virion surface. {ECO:0000255|HAMAP-
Rule:MF_04033}.
TRANSMEM 803 823 Helical. {ECO:0000255|HAMAP-
Rule:MF_04033}.
TOPO_DOM 824 841 Intravirion. {ECO:0000255|HAMAP-
Rule:MF_04033}.
REGION 246 309 Interaction with gL. {ECO:0000255|HAMAP-
Rule:MF_04033}.
COMPBIAS 743 746 Poly-Ile.
CARBOHYD 18 18 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 217 217 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 317 317 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 499 499 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 522 522 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 760 760 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
CARBOHYD 783 783 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255|HAMAP-Rule:MF_04033}.
STRAND 37 42 {ECO:0000244|PDB:4XHJ}.
STRAND 44 47 {ECO:0000244|PDB:4XHJ}.
STRAND 50 54 {ECO:0000244|PDB:4XHJ}.
HELIX 63 66 {ECO:0000244|PDB:4XHJ}.
STRAND 72 81 {ECO:0000244|PDB:4XHJ}.
TURN 84 86 {ECO:0000244|PDB:4XHJ}.
STRAND 90 96 {ECO:0000244|PDB:4XHJ}.
HELIX 99 101 {ECO:0000244|PDB:4XHJ}.
STRAND 121 124 {ECO:0000244|PDB:4XHJ}.
STRAND 130 132 {ECO:0000244|PDB:4XHJ}.
HELIX 138 142 {ECO:0000244|PDB:4XHJ}.
TURN 145 147 {ECO:0000244|PDB:4XHJ}.
HELIX 156 158 {ECO:0000244|PDB:4XHJ}.
STRAND 170 174 {ECO:0000244|PDB:4XHJ}.
STRAND 192 194 {ECO:0000244|PDB:4XHJ}.
HELIX 201 204 {ECO:0000244|PDB:4XHJ}.
STRAND 208 210 {ECO:0000244|PDB:4XHJ}.
HELIX 212 215 {ECO:0000244|PDB:4XHJ}.
STRAND 219 223 {ECO:0000244|PDB:4XHJ}.
HELIX 226 228 {ECO:0000244|PDB:4XHJ}.
STRAND 233 244 {ECO:0000244|PDB:4XHJ}.
STRAND 246 255 {ECO:0000244|PDB:4XHJ}.
STRAND 258 268 {ECO:0000244|PDB:4XHJ}.
STRAND 271 277 {ECO:0000244|PDB:4XHJ}.
STRAND 303 312 {ECO:0000244|PDB:4XHJ}.
TURN 314 317 {ECO:0000244|PDB:4XHJ}.
STRAND 318 320 {ECO:0000244|PDB:4XHJ}.
HELIX 323 327 {ECO:0000244|PDB:4XHJ}.
HELIX 329 332 {ECO:0000244|PDB:4XHJ}.
HELIX 336 351 {ECO:0000244|PDB:4XHJ}.
TURN 354 356 {ECO:0000244|PDB:4XHJ}.
HELIX 361 385 {ECO:0000244|PDB:4XHJ}.
STRAND 386 389 {ECO:0000244|PDB:4XHJ}.
HELIX 390 409 {ECO:0000244|PDB:4XHJ}.
TURN 410 412 {ECO:0000244|PDB:4XHJ}.
HELIX 416 418 {ECO:0000244|PDB:4XHJ}.
STRAND 420 425 {ECO:0000244|PDB:4XHJ}.
HELIX 430 441 {ECO:0000244|PDB:4XHJ}.
HELIX 455 467 {ECO:0000244|PDB:4XHJ}.
HELIX 475 494 {ECO:0000244|PDB:4XHJ}.
HELIX 500 513 {ECO:0000244|PDB:4XHJ}.
HELIX 525 539 {ECO:0000244|PDB:4XHJ}.
HELIX 542 557 {ECO:0000244|PDB:4XHJ}.
TURN 561 563 {ECO:0000244|PDB:4XHJ}.
HELIX 568 570 {ECO:0000244|PDB:4XHJ}.
HELIX 574 576 {ECO:0000244|PDB:4XHJ}.
HELIX 582 584 {ECO:0000244|PDB:4XHJ}.
HELIX 586 595 {ECO:0000244|PDB:4XHJ}.
HELIX 596 598 {ECO:0000244|PDB:4XHJ}.
HELIX 600 607 {ECO:0000244|PDB:4XHJ}.
HELIX 612 628 {ECO:0000244|PDB:4XHJ}.
TURN 629 632 {ECO:0000244|PDB:4XHJ}.
HELIX 634 640 {ECO:0000244|PDB:4XHJ}.
HELIX 642 645 {ECO:0000244|PDB:4XHJ}.
STRAND 646 648 {ECO:0000244|PDB:4XHJ}.
TURN 651 655 {ECO:0000244|PDB:4XHJ}.
STRAND 657 662 {ECO:0000244|PDB:4XHJ}.
STRAND 667 674 {ECO:0000244|PDB:4XHJ}.
STRAND 678 683 {ECO:0000244|PDB:4XHJ}.
STRAND 685 687 {ECO:0000244|PDB:4XHJ}.
STRAND 694 701 {ECO:0000244|PDB:4XHJ}.
STRAND 705 707 {ECO:0000244|PDB:4XHJ}.
STRAND 711 714 {ECO:0000244|PDB:4XHJ}.
TURN 718 720 {ECO:0000244|PDB:4XHJ}.
STRAND 730 735 {ECO:0000244|PDB:4XHJ}.
STRAND 740 742 {ECO:0000244|PDB:4XHJ}.
HELIX 749 755 {ECO:0000244|PDB:4XHJ}.
HELIX 764 766 {ECO:0000244|PDB:4XHJ}.
TURN 768 770 {ECO:0000244|PDB:4XHJ}.
STRAND 775 780 {ECO:0000244|PDB:4XHJ}.
STRAND 786 790 {ECO:0000244|PDB:4XHJ}.
SEQUENCE 841 AA; 93640 MW; 7A22CFA48EDD8F3E CRC64;
MFALVLAVVI LPLWTTANKS YVTPTPATRS IGHMSALLRE YSDRNMSLKL EAFYPTGFDE
ELIKSLHWGN DRKHVFLVIV KVNPTTHEGD VGLVIFPKYL LSPYHFKAEH RAPFPAGRFG
FLSHPVTPDV SFFDSSFAPY LTTQHLVAFT TFPPNPLVWH LERAETAATA ERPFGVSLLP
ARPTVPKNTI LEHKAHFATW DALARHTFFS AEAIITNSTL RIHVPLFGSV WPIRYWATGS
VLLTSDSGRV EVNIGVGFMS SLISLSSGLP IELIVVPHTV KLNAVTSDTT WFQLNPPGPD
PGPSYRVYLL GRGLDMNFSK HATVDICAYP EESLDYRYHL SMAHTEALRM TTKADQHDIN
EESYYHIAAR IATSIFALSE MGRTTEYFLL DEIVDVQYQL KFLNYILMRI GAGAHPNTIS
GTSDLIFADP SQLHDELSLL FGQVKPANVD YFISYDEARD QLKTAYALSR GQDHVNALSL
ARRVIMSIYK GLLVKQNLNA TERQALFFAS MILLNFREGL ENSSRVLDGR TTLLLMTSMC
TAAHATQAAL NIQEGLAYLN PSKHMFTIPN VYSPCMGSLR TDLTEEIHVM NLLSAIPTRP
GLNEVLHTQL DESEIFDAAF KTMMIFTTWT AKDLHILHTH VPEVFTCQDA AARNGEYVLI
LPAVQGHSYV ITRNKPQRGL VYSLADVDVY NPISVVYLSK DTCVSEHGVI ETVALPHPDN
LKECLYCGSV FLRYLTTGAI MDIIIIDSKD TERQLAAMGN STIPPFNPDM HGDDSKAVLL
FPNGTVVTLL GFERRQAIRM SGQYLGASLG GAFLAVVGFG IIGWMLCGNS RLREYNKIPL
T


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